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Acidic CO₂ electroreduction enables high CO₂ utilization but suffers from competing hydrogen evolution. Here, the authors present selective CO₂ conversion on asymmetric C₃-Ni-Cl single-atom sites, which achieves carbon-efficient CO production in strong acid.

Garnet-type LLZO electrolytes are considered among the most promising solid-state electrolytes for all-solid-state batteries; however, numerous challenges need to be addressed before they are integrated into a cell. By precipitating amorphous zirconium oxide onto grain boundaries, increased ionic conductivity is observed and dendrite growth is suppressed.

Drought stress threatens global food security. This study shows that drought-induced changes in wheat metabolites selectively enrich drought-tolerant bacteria in the rhizosphere, which enhance plant growth through key functional traits, offering promising avenues to strengthen crop resilience and sustain food production under climate change.

Phenotypic screening of an endophyte-derived compound library led to identification of a potent anti-non-small cell lung cancer (NSCLC) lead compound, the 3,4-diisobutyryl derivative of auxarthrol A, uncovering dynein light intermediate chain 1 as a druggable vulnerability and a key regulator of autophagy in NSCLC.

NaHCO₃ production is energy- and cost-intensive. Here the authors report an operando electrosynthesis system by embedding nitrate reduction reaction into Solvay system, achieving high NaHCO₃ productivity even up to 4.58 times of benchmark industrial route.

Enteropathogenic Escherichia coli produces bundle-forming pili that facilitate bacterial adhesion and colonization. Here, the authors report a high-resolution structure of the BfpB-BfpG secretin channel complex, which enables pilus translocation across the outer membrane, revealing an unusual 17:17 stoichiometry and providing insights into its assembly mechanism.

Commercial lithium-ion batteries still have the issue of the uncontrollable dendritic Li under extreme conditions. Here, authors demonstrate a MXene-configured graphite, enabling homogeneous growth of Li, achieving high-capacity retentions in Ah-level pouch cell at −20 °C and high rates.

Uncontrolled crystallization of perovskite limits the performance of solar cells. Zhou et al. address this through aromatic interactions between naphthalene ammonium salts and naphthalenesulfonates, achieving improved efficiency in cells and modules.

A nanoengineered, zero-volume-change, complete-sealing Li-based composite electrode, comprising multilayer reduced graphene oxide and zinc oxide, is developed, achieving Li plating/stripping Coulombic efficiencies of ≥99.99%.

In a hybrid superconductor–ferromagnet device, the dynamic stray fields of current-driven vortices unidirectionally excite coherent short-wavelength magnons.

Here, Ni-anchored Ru/RuO₂ heterostructure nanosheets serve as CO-tolerant hydrogen oxidation catalyst delivering a peak power density of 1.76 W cm^-2, along with long-term stability in an alkaline exchange membrane fuel cell operating under H₂/Air conditions.

An Ohmic contact interface engineering strategy was proposed by loading copper nano islands on indium hydroxide nanocubes, which could trigger and stabilize the polarized Cu0 -Cuδ+ active sites. Such catalyst enabled effective ammonia electrosynthesis with nitrate under ambient conditions

Thermal stability remains a key challenge for organic photovoltaics. Qin et al. now propose a strategy that stabilizes multiple components of the devices, enhancing their resilience under damp heat and thermal cycling conditions.

Here the authors reveal how an incoherent feedforward C/EBPα–Notch circuit times lung cell fate, guiding alveolar development, repair after injury, and shifts between protective and reparative states.

Virus-like particles (VLPs) offer powerful gene delivery but face limits in targeting and complexity. Here, the authors create a streamlined SFV-based VLP platform that delivers mRNA, protein, or RNP cargos and can be engineered for customizable tissue targeting, including to brain and muscle.

Whether higher-order visual areas exhibit a fine-grained functional organization remains poorly understood. Here, the authors use high-resolution fMRI to reveal that category-selective regions in macaques are organized into mesoscale functional units which form distinct long-range mesoscale functional networks.

The mechanisms resulting in muscle satellite cell dysfunction in diabetes are not well understood. Here, the authors show that AS160 functions in the nucleus to regulate satellite cell proliferation and that its impaired nuclear entry is linked to diabetic myopathy.

This study presents FolTAC-dual, a folate receptor-mediated platform for dual degradation of EGFR/HER2 and PD-L1/VISTA, offering a strategy to overcome drug resistance and enhance antitumor immunity for cancer treatment.

The precision of determining the phase of an optical atomic clock is increased above the standard quantum limit in a new spectroscopic method.

The inherent scaling relationships among the adsorption energies of intermediates limit the efficiency of oxygen electrocatalysis. Here, a dual-atom catalyst with aligned orbital energy level is developed, driving the dissociative pathway to bypass scaling relationships towards enhanced performance.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

Integrating CO₂ capture and electrochemical conversion avoids the thermal release of CO₂ and thus could potentially lower the energy needed to make useful products from CO₂, but choosing optimal system components is still challenging. Here the authors use piperazine alongside a nickel catalyst for capture and achieve high energy efficiency and stable CO production.

Fuel cell catalysts meet increasing durability demands for heavy-duty applications. This study reveals that sub-angstrom strain in high-entropy intermetallics enhances both catalytic activity and long-term stability for the oxygen reduction reaction

Gong et al. report an all-perovskite photovoltaic-powered battery using ethyl viologen diiodide and its derivative to modify the perovskite solar cell and the battery cathode, enabling an overall energy conversion efficiency of 18.54%. The flexible version powers a wearable glucose monitor for 24 h.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Oxaloacetate is sensed by MDH1, which primes innate immune antiviral defence against influenza virus infection, thus resulting in the activation of ETS2 to promote TBK1-centred type I interferon signalling.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg⁻¹ pouch-cell energy density.

Printable mesoscopic perovskite solar cells are a promising device design, yet their efficiency is limited by charge collection. Ma et al. use hexamethylene diisocyanate to eliminate unreacted organic cations at grain boundaries, enhancing hole collection.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems yet face detrimental parasitic reactions. Here, authors develop a durable cadmium-metal battery employing a fast-kinetics dual-structure-breaking electrolyte.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Augmin is essential for microtubule nucleation during cell division. This study reveals how the conserved calponin homology domain of the augmin subunit HAUS6 binds to microtubules to orient augmin for microtubule branching.

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Here, Li et al. develop a human liver organoid model to elucidate Dengue virus infection dynamics and identify oxyresveratrol as a potential antiviral candidate, highlighting the NRF2 pathway’s crucial role in mitigating mitochondrial damage and enhancing cellular resistance.

A new p-type small molecule enhances defect passivation and improves interfacial charge transport in perovskite solar cells, enabling devices with a certified power conversion efficiency of 26.72%, 97% of which is maintained after 2,500 h of continuous operation.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

Graphene is often used as parts of electrodes in batteries and stacking of graphene layers is problematic. Here, Zhao et al.synthesize graphene on mesoporous layered double oxide flakes so that the stacking is effectively prevented, and show high-rate performance when used in Li–S batteries.

The authors identify one emerging H2N2 AIV, reveal the molecular basis of human-type receptor binding of the H2N2 AIV and pandemic strains, and evaluate the public risk of H2N2 AIV by its infection, transmission and mammalian-adaptation features.

In this large-scale study, the authors used multimodal neuroimaging and cognitive data from UK Biobank participants to examine the relationship between regional adiposity and brain health.

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

CRISPR-Cas9-based screens have allowed the study of gene-drug interactions. Here, the authors develop CRISPR-Cas9 knock-out, activation and repression screens in human gastric 3D organoids, also integrating single-cell CRISPR screens, to identify genes involved in the response to cisplatin in gastric cancer.

The lack of reliable coating methods for amorphous zeolitic imidazolate framework (aZIF) materials hinders their development for applications such as photolithography and separation membranes. Supported by computational fluid dynamics modeling, the authors develop a spin-coating technique to deposit aZIF films from dilute precursors and demonstrate their wafer-scale use in advanced lithographic processes.

A high-resolution astrochronological framework for the early Ediacaran refines the timing of key events, linking glaciation, carbon isotope excursions, and fossil assemblages to gradual ecosystem complexity and rapid biogeochemical transitions.