Search

This study implicates GSL5 inactivation in high, broad-spectrum resistance to the clubroot pathogen Plasmodiophora brassicae in Arabidopsis thaliana, Brassica napus, Brassica oleracea and Brassica rapa.

Lack of transparency and standardization in experimental design and performance evaluation hinders the real-world applications of advanced oxidation processes — critical technologies in wastewater treatment. Here, we highlight the common pitfalls in advanced oxidation process research and propose practices to guide future studies.

The isolation of a crystalline radical cation carbon(I) species, generated via single-electron transfer between a carbodicarbene and a nitroaromatic compound, is reported. The resulting radical ion pair can mediate various C–O and C–C cross-coupling reactions with electron-deficient arenes bearing a leaving group.

Efficient hydrogen liquefaction requires magnetocaloric materials with robust magnetic-entropy and adiabatic temperature changes across a broad temperature range. Here, the authors demonstrate that two Gd-Si-Ge compounds exhibit highly reversible magnetocaloric effects, suggesting their potential for hydrogen liquefaction at moderate magnetic fields.

Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

The management of ulcerative colitis (UC) remains challenging due to the complexity of its etiology. Here, the authors establish that argininosuccinate synthetase 1 (ASS1) and its metabolite arginine are pivotal inducers of UC, through the triggering of mTOR and iNOS activation, and the induction of gut microbiota dysbiosis by metabolomics and proteomics. Inhibition of ASS1 by C-01 provides a viable strategy for the treatment of UC.

In a transistor configuration, a new germanium/silicon nanowire has characteristics such as conductance, on-current and switching time delay that are better than those of state-of-the-art silicon metal-oxide-semiconductor field-effect transitors.

Using single-cell metabolomics techniques, Chen and colleagues reveal that an aldehyde-dehydrogenase-2-dependent γ-aminobutyric acid synthesis pathway in hippocampal pyramidal neurons suppresses their excitability during long-term potentiation and learning, linking neuronal metabolism to synaptic plasticity and behavioral adaptability.

The authors proposed a Silicon technology-compatible approach to convert Germanium from an indirect bandgap to a direct bandgap via doping. This is done to expand the lattice to produce tunable effective tensile strain, aiming towards the on-chip light sources.

Legionella effector LtpM is found to recognize short two-residue sequons, enabling site-specific O-glucosylation with minimal perturbations to a target protein, and is used to show that O-glucose can act as a constitutively active O-linked N-acetylglucosamine mimic.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

A mechanical design is developed for the fabrication of ultralong, fracture-free and perturbation-free semiconductor fibres to address the increasing demand for flexible and wearable optoelectronics.

By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities to affect vascular inflammation. Reducing accessible cholesterol by statin treatment or blocking its non-vesicular transport by OSBP/ORP inhibition can limit vascular inflammation.

Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.

The RNA binding protein hnRNPL is recruited to chromatin by the PIK3CB promoter-transcribed non-coding RNA and forms phase-separated condensates, which activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression.

tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^Tyr, with cryo-EM confirming direct recognition by the QTRT1/2 complex.

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.

A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

Substrate patterning offers additional degrees of freedom to engineer the structure and function of a semiconductor device. Here, fully-enclosed germanium cavities, with size and position tunable through the initial mask pattern, can be created through an unexpected self-assembly process.

Protein structures are predicted by integrating deep learning potentials with iterative threading fragment assembly simulations.

Kinesin-2 is a motor protein important for cargo transport and ciliogenesis. Here, the authors report the structure of the heterotrimeric kinesin-2 motor tail complex, revealing the interaction mechanisms that assemble the holoenzyme from its subunits.

Fang et al. demonstrate that OsHSFA4d enhances thermotolerance by activating HSP101 and promoting CslF6 expression, which suppresses disease resistance. It is phosphorylated by OsCDPK24/28, increasing its DNA binding ability under heat stress. This trade-off mechanism of abiotic/biotic stress may broadly exist in plant kingdom.

Silicene is a silicon-based analogue of graphene, but with subtle and potentially useful differences. Wei-Feng Tsai and colleagues show that these differences could be exploited to build electrically-gated silicene devices that generate and control spin-polarized currents with near perfect efficiency.

The intrinsic high-concentration Ge vacancies in GeTe-based thermoelectric materials hinder their performance maximization. Here, the authors find that defect structure engineering strategy is effective for performance enhancement.

A superconducting diode bridge based on superconducting diodes can function as a full-wave rectifier with an efficiency up to 42 ± 5%, and can offer alternating current to direct current signal conversion capabilities at frequencies up to 40 kHz.

A wafer-scale self-rolled-up membrane platform is developed for radio-frequency on-chip passive components like inductors and capacitors on a 4-inch sapphire wafer. The authors demonstrate compact metal self-rolled-up membrane inductors with improved inductance and higher quality factor achieved by post-electroplating.

Polyploidy and subsequent post-polyploid diploidization (PPD) contribute to evolutionary success of plant species. Here, using 11 genomes from all nine subfamilies of Malvaceae as an example, the authors provide evidence to support the “polyploidy for survival and PPD for success” hypothesis.

Flores et al. show that brain-penetrant eIF2B agonists suppress ISR activation in cellular and mouse models of ALS and reduce ISR biomarkers in humans, enabling further clinical studies of ISR inhibition in individuals with neurological diseases

Regulatory T cell therapy has shown some success therapeutically in the context of autoimmunity and transplantation. Here the authors explore the impact of IL-6, TGF-β and IL-2 on pathogenic Th17 cell generation post regulatory T cell therapy, and show therapeutic blockade of IL-6/STAT3 can reduce their generation in murine models of inflammatory disease.

SiGe nanowires exhibit ballistic thermal conduction at room temperature with a long phonon mean free path.

Phenomena that bridge magnetism and extremely large magnetoresistance in materials have the potential to expand fundamental research towards practical technological innovations. The authors synthesize Fe-Ge single crystal demonstrating high temperature ferromagnetism and magnetoresistance. These results disclose novel pathways to implement advanced spintronic devices.

Phase-change materials are a route to high-density data storage, but changes in their properties in time are a limiting factor. Here, the authors combine numerical simulations, photothermal deflection spectroscopy and impedance spectroscopy experiments to investigate the aging process in germanium telluride.

Electronic spins in Si are potentially useful in the development of solid-state quantum devices, but its degenerate valley states limits this potential. Zhang et al.use a genetic algorithm to identify a Ge/Si-multilayer-clad Si quantum structure whose valley splitting is increased by an order of magnitude.

Zika virus impairs male fertility by utilizing its NS2A protein to block the translation of CYP17A1 mRNA in Leydig cells, thereby suppressing testosterone synthesis and sperm production in vivo.

Spatiotemporal beams differ from standard spatial structured light. The authors introduce 2D spacetime duality to uncover the conventional–spatiotemporal beam connection, enabling the development of high-fidelity spatiotemporal beams.

The crystallization of phase-change materials is relevant to their applications in memory and neuromorphic computing devices. Cheng et al. show that the β-relaxation in Ge₁₅Sb₈₅ can be controlled by thermal annealing, leading to the tunability in its crystallization kinetics by one order of magnitude.

Understanding the sensing mechanism of metal oxide semiconductors is imperative for developing high-performance sensors. Here, the participation of lattice oxygen, caused by additional Ge, boosts the hydrogen sensing ability of SnO₂.

Carbyne anions are under explored and poorly understood, owing to their isolation being unknown. Now, the synthesis and isolation of copper phosphinocarbyne anion complexes are reported. Displaying the reactivity of a carbyne anion, these complexes provide access to singlet carbenes, alkenes and ethenimines.

PM_2.5 pollution partially counteracts vegetation greening trends by delaying green-up dates and reducing photosynthetic activity. This study shows that the negative feedback between PM_2.5 pollution and terrestrial carbon uptake introduces unforeseen uncertainty in China’s carbon neutrality goals.