Search

Despite the efficacy of artemisinin against Plasmodium falciparum, young intraerythrocytic ring stage parasites may survive and persist in a dormant state. In this study, Yu et al elucidate the epigenetic regulatory mechanism of artemisinin resistance in P. falciparum ring-stage survival.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Copper component is introduced into MOR zeolites via in situ high-temperature crystallization to tune pores for N₂/CH₄ sieving. MOR-Cu-210 exhibits high N₂ adsorption capacity and N₂/CH₄ uptake ratio, alleviating the capacity-selectivity trade-off.

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition. This study presents a drug-free treatment strategy for IBD that targets bacterial adhesion, utilizing mannan oligosaccharide-loaded porous microgels to selectively capture adherent-invasive E. coli and competitively inhibit bacterial colonization on the gut epithelium.

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

The authors reveal the activation mechanism of non-basal slip systems in a medium entropy alloy, offering new insights for the design of advanced structural alloys with enhanced ductility and high strength.

The lack of efficient and diverse synthesis strategy has hindered the study of perifused cycles. Here, the authors report a metal-catalyzed cascade electrocyclization to access 5,6,7-perifused cycles, and demonstrated the versatility of this protocol in the late-stage modification of pharmaceuticals.

Metadevices that are based on quasi-one-dimensional surface plasmon polariton structures can offer optical and radiofrequency transparency, and can be used to create a wireless communication scheme for image transfer.

Gluconeogenesis produces glucose from non-carbohydrate carbon substrates, particularly occurs during fasting. Here, the authors show lysine methyltransferase KMT5C promotes gluconeogenesis by decreasing PGC-1α degradation, which is independent of its methyltransferase activity.

Personalized antibacterial agents against diverse bacteria strains are promising for combating antimicrobial resistance, but a balance between strain specificity and broad-spectrum bactericidal activity is elusive. Here, the authors report an antibacterial nanoagent TiOx@C with bacterial cell wall specificity, multi-targeting and bactericidal effect against S. aureus and P. aeruginosa.

Microglia play a critical role in Alzheimer’s disease progression. Here, the authors show that knockout of microglial Cx43 or inhibition of Cx43 hemichannels by nanoparticle-delivered peptide mitigates cognitive deficits and neuropathology in APP/PS1 mice by inducing microglia into a neuroprotective state.

Divergent catalytic asymmetric reactions for the selective formation of C(sp3)−H insertion and formal C(sp3)−O insertion products from the same precursors are rarely explored. Here, the authors report a ligand-controlled divergent asymmetric C(sp3)–H insertion and formal C(sp3)–O insertion reaction via vinyl cations, leading to the assembly of a range of chiral spiro and fused polycyclic pyrroles.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

The mechanism through which auxin regulates chilling tolerance remains unclear. Here, the authors discover a negative regulator of chilling tolerance in japonica rice, which encodes an ABCB transporter with auxin efflux function, and show its potential to increase indica rice chilling tolerance.

Hybrid quantum systems offer increased functionality, however, they require strong coupling between components. Here, Shen and coauthors achieve strong coupling between polaritons, formed by strongly coupled magnons and photons, and phonons, paving the way for polaromechanical hybrid systems.

Wang et al. demonstrate that the vascular smooth muscle cell–dependent expression of TRPM7, an ion channel with kinase function, increases the levels of calcium and zinc and, thus, increases the MMP2 activity and contributes to the formation of abdominal aortic aneurysm.

Efficient storage of crude hydrogen, through toluene hydrogenation to methylcyclohexane, is often inhibited by CO impurities. Here, the authors develop a RuNi/TiO₂ catalyst which avoids deactivation through promoting simultaneous CO methanation.

The encapsulation of supported metal nanoparticles by a thin oxide support overlayer under reducing conditions is commonly referred to as a strong metal–support interaction. Now, by controlling the composition of the reducing agents at the catalyst activation stage, an adsorbate-induced strong metal–support interaction is reported for the commercial Cu/ZnO/Al₂O₃ catalyst during methanol steam reforming.

Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell membrane anchorage and use it to distinguish different cancer cells.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

Only a few genetic variants have been identified to mediate salt tolerance in major crops and their molecular mechanisms are largely unknown. Here, the authors identify WRKY53 as a negative regulator of salt tolerance in rice, and show that it directly trans-regulates expression of MKK10.2 and HKT1;5 to meditate salt tolerance.

Multi-omics analysis of mouse livers shows that protein β-hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation, a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified.

The study identifies transcription factor OsGATA8 as a negative regulator of nitrogen uptake and tiller formation in rice and OsGATA8-H as an elite haplotype with reduced expression and enhanced nitrogen use efficiency.

Improving crop nitrogen use efficiency can facilitate sustainable production, however, the genetic mechanisms have not been fully revealed. Here, the authors discover the NAC42-NPF6.1 signaling cascade mainly derives from indica and wild rice and demonstrate the potential of using the allele for cultivar improvement.

Using animal models to mimic Parkinson’s disease can advance our understanding of pathogenesis. Here, the authors combine single-cell genomics with a primate model of parkinsonism to provide insights into neuronal vulnerability and resilience.

The chitosan utilization regulator, ChsR, positively regulates Vibrio cholerae virulence factor expression, which can be inhibited therapeutically by chitosan oligosaccharide administration in mice.

De novo genome assembly and analyses of 12 maize FILs provide insights into genomic and phenotypic differentiation of various heterotic groups and the molecular basis of heterosis in maize.

Divacancy color centers in SiC are promising candidates for a spin-photon interface, but typically show charge-state instability under optical excitation. Here the authors show that modified divacancies created by a focused helium ion beam are robust against photoionization and have promising properties.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

The authors realize a high piezoelectric charge coefficient in a self-poled ferroelectric film, addressing the persistent challenge of piezoelectric property degradation during industrial packaging and shaping the landscape of commercial ferroelectrics for micro-electro-mechanical systems.

Phenotyping depression anxiety comorbidity is prominently heterogeneous. Authors established a common bridging (cb) factor model to identify homogeneous neurogenetic signatures of general structure of these bridging symptoms in this comorbidity.

This study reveals a regulation mechanism of the ALR1 aluminium receptor involving phosphorylation switching by PP2C phosphatases and PBL27 kinase. This mechanism modulates ALR1–BAK1 complex formation, thereby controlling plant aluminium sensing and resistance.

Histopathology can be limited by the time-consuming and labour-intensive preparation of slides from resected tissue. Here, the authors report DeepDOF-SE, a deep-learning-enabled microscope to rapidly scan intact tissue at cellular resolution without the need for physical sectioning.

Droplet generators convert mechanical movements of droplets into small-scale electricity. Here, Tang et al. report a humidity-driven power generator by utilizing daily humidity fluctuation in atmosphere enabling continuous generation of electricity upon moisture absorption and desorption cycles.

The Chinese tree shrew, Tupaia belangeri chinensis, has been proposed as a potential animal model in biomedical research and drug safety testing. This study presents the full genome of the Chinese tree shrew, identifying common features between the tree shrew and primates.

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide. In this Review Yan Li, Zhao-You Tang and Jin-Xuan Hou provide an overview of animal models that are relevant to HCC development, metastasis and treatment. Viral hepatitis is the single most important cause of HCC and the authors describe transgenic mouse models of HBV and HCV infection that have provided experimental evidence that viral genes could initiate or promote liver carcinogenesis. The criteria for establishing ideal HCC animal models are also discussed.