Medical Biotechnology articles

Time frame: 1 June 2025 - 30 May 2026

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Count: 1977

Article ‘Count’ for Medical Biotechnology.

Journal Count
141
Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment
Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management
Post-Conjugation Process for Antibody-Conjugated Lipid Nanoparticles Enabling Tunable Antibody Surface Density for Targeted RNA Delivery
Optimization of Lipid Nanoparticles for Safe and Versatile Lung-Targeted RNA Delivery and Disease Therapy
Intermittent Cobalt (II, III) Oxide Exposure Exacerbates Inflammatory Injury through Tumor Necrosis Factor-Alpha-Dependent Bone Marrow-Mediated Trained Immunity
β‑Hydroxy Thioether-Derived Ionizable Lipids for Spleen-Tropic mRNA Delivery and In Vivo Chimeric Antigen Receptor T Cell Engineering
A Programmed Streptavidin-Condensed Bifunctional Nucleic Acid Nanoplatform Breaking the Vicious Cycle for Traumatic Brain Injury Therapy
A Straw-Reinforced-Clay-Inspired Composite Hydrogel Promotes Diabetic Bone Regeneration via Driving the Immune-Osteogenic Cascade to Remodel Mitochondrial Homeostasis
Rational Synthesis of Virus-Mimicking Nanocarriers for Enhanced Intracellular Delivery through Polyvalent Interactions with Cells
Anomalous Fluorescence Dynamics Emerge in Densely Labeled Virus-Like Particles
Smartphone-Based Microbubble-Linked Immunosorbent Assay Powered by Classification–Regression Integrated Deep Learning for Portable Quantitative Biomarker Analysis
Modular Functionalized Gates for Field-Effect Transistor Biosensors Enabling Reliable Detection of Trace miRNAs
A Multiplex Digital Polymerase Chain Reaction-Based Platform with a Unified Readout for Multiclass Biomarker Quantification from Low-Volume Blood
Glycan Chemical Structures Dictate Organ- and Cell-Specific Tropism and Immunomodulation of Lipid Nanoparticles
Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery
A Hybrid Phospholipid Monolayer-Based Interface for Interaction-Enhanced Electrical Detection in Biofluids
Direct Activation of Follicular Melanocytes by Polymeric Tyrosinase Nanocapsules for Reversing Hair Graying
Ultrasound-Controlled Nano-Oxygen Delivery Modulates Endothelial Cells to Enhance Tumor Perfusion
Developing Inner Ear Organoids in Ultrasound-Activated Piezoelectric Hydrogel for Assessing Ototoxicity
A Strand-Displacement Enabled DNA Nanomachine for Targeted St6Gal1 Silencing and Immune Reprogramming in Melanoma
Triple-Cascade Responsive Pneumatic Nanomotor Enhance Cancer Immunotherapy by Oncolytic Virus-Triggered Pyroptosis
Aptamer-Driven DNA Framework Switches for Clearing Programmed Cell Death-Ligand 1 Positive Extracellular Vesicles via Macrophage Recruitment
Mucosal-Penetrating Nanovaccine Enhances Mucosal and Systemic Immunity against Respiratory Syncytial Virus Infection
Bioorthogonal Click-Engineered Microneedle Patch Enables Adeno-Associated Virus-Mediated Dermal Acidic Fibroblast Growth Factor Expression for Hair Loss Treatment
Fingerprinting Fluorescent In Situ Hybridization Enables Multiplexed Identification of Pathogenic Bacteria
Dynamic Light Scattering Method Using Derived Count Rate to Accurately Quantify Lipid Nanoparticle Concentration─A Double-Blind Study
Nanozyme Catalysis Restores Hair Follicle Integrity by Reversing Peroxisomal Collapse
Tailored Extracellular Matrix-Biomimetic Coating Favors Tissue Healing by Modulating the Microenvironment
Gravity-Driven Formation of Water-in-Wax Spheres for Efficient One-Pot CRISPR Diagnostics
Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects
A Dual-Hue Recognizable Lateral Flow Immunoassay Corresponding to Distinct Sensitivity Ranges for Timely and Quantitative Diagnosis of Prostate Cancer
Priming the Liver Endocytic Pathway to Accelerate Hepatobiliary Clearance of Nanoparticles
Receptor-Free Cellular Internalization of DNA Micelles Driven by Membrane Interaction
Reactive Oxygen Species-Activatable Topological Transition Nanogel Integrated with cfDNA Degradation Function for Adaptive Barrier Repair in Inflammatory Bowel Disease
Multiscale Simulations and Cryo-Electron Microscopy Reveal the Transition Pathway of Dengue Virus-like Particle Nanoassembly
Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines
Precision pH Sensing beyond the Nernst Limit with MoS2/WSe2 Van der Waals Heterostructure Ion Sensitive Field Effect Transistors
Caveolar Endocytosis Governs Nanoneedle Transfection
Dissolution-Mediated Synthesis of Atomically Thin High-Entropy Hydroxides for Efficient Polyester Glycolysis
Ultrasound-Triggered Charge-Reversal Nanoparticles via Golgi-Dependent Iterative Transcytosis for Enhanced Deep Tumor Penetration
Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles
Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out
“Visualize, Describe, Compare”─Nanoinformatics Approaches for Material-Omics
High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain
A Dual-Fusogenic Virus-like Vector Enables Direct Cytosolic Delivery of mRNA Vaccines to Dendritic Cells
Trans-Endothelial Trafficking in Zebrafish: Nanobio Interactions of Polyethylene Glycol-Based Nanoparticles in Live Vasculature
Piezoelectric Nanofibers Synchronize Mitochondrial Dynamics and Immune Responses for Regeneration of Infected Wounds
Scalable Multiparametric Characterization of Aptamer–Target Interactions
Intracellular Localization of DNA-Wrapped Single-Walled Carbon Nanotube Sensors for Nitric Oxide Detection in Triple-Negative Breast Cancer Cells
Self-Carrier Nanoagonist Enabling Positive Feedback Regulation of Cuproptosis-Immunity for Potent Antitumor Therapy
Self-Powered Gravity Domino Microfluidics for Rapid At-Home Immunoassays with Artificial Intelligence
Phosphorothioate and 2′-Fluoro Ribose Substitution-Mediated Hydrophobic Effect Empowers RNA Probes for Highly Sensitive and Subtype-Selective miRNA Imaging
Bone-Targeted Multifunctional Nanoplatform Combining Osteoimmunoregulation and Mild Photothermal Effect to Promote Fracture Repair
Bioinspired Reconstruction of Polysaccharide Nanofibers Driven by Shear and Cavitation in High-Pressure Microfluidics
An Assembly-Line Mechanism for In Vitro Encapsulation of Fragmented Cargo in Virus-Like Particles
Redox-Responsive Peptide Coacervates for Enhanced mRNA Delivery and Intracellular Release
Shape-Dependent Entropic Forces Govern Synergistic Bystander Nanoparticle Uptake
Single-Particle Multiparametric Microscopy Reveals Structural, Size, and Payload Heterogeneity in mRNA-Loaded Lipid Nanoparticles
Exosome-Infused DTM-MPs Hydrogel Scaffold: A Smart Platform for Tendon Repair with Sustained Bioactivity and Anti-Inflammatory Benefits
Engineering of Metal–Organic Networks as Band-Aid for the Repair of Osteoporotic Bone Fractures
Heparin-Binding Proteins in the Nanoparticle Corona Enhance Cellular Uptake through Glycocalyx Interactions
Bioinspired Face Mask for Exhaled Breath Condensate Collection and Multiplexed Biomarkers Analysis
Bioactive Multifunctional Hydrogel Scaffolds Remodel the Inflammatory Microenvironment and Osteogenic-Osteoclastic Homeostasis to Advance Osteoporotic Bone Defect Repair
A Modular Encapsulation System for Precision Delivery of Proteins, Nucleic Acids, and Small Molecules
Bioinspired miRNA-Responsive Ca2+ Nanoregulator with Dual Interference Pathways and Self-Amplifying Cascade for Tumor-Targeted Mitochondrial Dysfunction
Mechanisms of Adeno-Associated Virus Serotype 9 Vector Characterization and Quality Control through Solid-State Nanopores
Dual-Functional Nanotherapy-Reinforced Hydrogel for Synergistic Antimicrobial and Immunomodulatory Oral Tissue Repair
Double-Emulsion Perfluorocarbon Nanodroplets for Ultrasound and Photoacoustic Image-Guided Drug Delivery and Release
Reactive Oxygen Species-Responsive Glycocalyx-Mimetic Hydrogel-Engineered Bioprosthetic Valves with Integrated Anticoagulant, Anti-Inflammatory, and Endothelialization Properties
All-in-One Nanounit Embedded with Biomimetic Peptide for Comprehensive Caries Repair
Tumor-Specific Delivery of Nanomedicines via a Nutrient Sensing-Driven Pathway Mediated by Niemann-Pick C1-Like 1
Customizable mRNA Lipid Nanoparticles for Transfection of Primary Human T Cells
Oxygenating Nanobubble Hydrogel for Accelerated Surgical Wound Closure and Restoration of Native Skin Architecture
Self-Assembling Protein Materials with Genetically Programmable Morphology and Size
Osteoinductive and Piezoelectrically Malleable Nanocomposite Bone Graft
Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure
Nanopeptides-Loaded Electro-Assembled Oriented Collagen Matrix for the Synergistically Promotes Early Angiogenesis in Tendon Healing
The Structure and Morphology of Single-Component Oligomeric RNA Delivery Vectors Derived from Amphiphilic Charge-Altering Releasable Transporters
Virus-Inspired mRNA Delivery Vehicle Enabled by a Multilayered Nucleic Acid Nanocapsule
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy
Synthetic Rewiring of Virus-like Particles via Circular Permutation Enables Modular Peptide Display and Protein Encapsulation
Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence to Promote Cognitive Recovery after Traumatic Brain Injury
Multiplex Nanopore Detection of Structurally Diverse Per- and Polyfluoroalkyl Substances in Surface Water
Orbital Hybridized MoO3/MoSe2 Heterojunction for Dual-Driven Interfacial Reaction and Charge Transfer Toward Enhanced Electrochemical Response
Selective Enrichment of Full Capsids of Adeno-Associated Virus
Flower-Shaped Lipid Nanoparticles Evade Apolipoprotein E-Mediated Liver Tropism for Safe and Enhanced Cytokine-Based Cancer Immunotherapy
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis
Mass-Ratio-Controlled Organ-Selective Phosphatidyl Polymer Carrier for In Vivo Targeted mRNA Delivery
Intelligent Responsive Zeolitic Imidazolate Framework-8@Copper Oxide Nanocomposite 3D-Printed Scaffolds for Efficient Repair of Infected Bone Defects
Fenton Reaction-Mediated Endolysosomal Disruption for Efficient Cytosolic Protein Delivery
Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on Shewanella oneidensis by Compromising Membrane Protein Functionality
Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate Temporomandibular Joint Osteoarthritis by Suppressing Osteoclast Activity Via let-7a-5p/Integrin β3 Axis
Bioinspired Ultrastable Cu(I)-Bovine Serum Albumin Single-Atom Nanozymes Enable MRI-Trackable Synergistic Catalytic Therapy and Cuproptosis for Tumors
Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy
A Machine Learning Assisted Tool and Numerical Model for Analyzing Lipid Nanoparticles
Directional Biomimetic Scaffold-Mediated Cell Migration and Pathological Microenvironment Regulation Accelerate Diabetic Bone Defect Repair
An Aggrecanase-Responsive Delivery Hydrogel System of miRNA-17 Facilitates Microfracture-Mediated Articular Cartilage Regeneration by Reprogramming Hostile Inflammatory Niche
ZnCe-LDO Nanozyme-Based Multifunctional Hydrogel Promotes Bone Regeneration by Inflammatory Macrophage Reprogramming and Piezo1 Activation
Effects of Oligolysine-Polyethylene Glycol Coating on the Biodistribution of Wireframe DNA Origami Nanosheets in Zebrafish Embryos
Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV-1 Capsid
In2O3 Nanoribbon-Based Field-Effect Transistor Biosensors for Ultrasensitive Detection of Exosomal Circulating microRNA with Peptide Nucleic Acid Probes
Effective RNA Delivery with Aggregation-Induced Lipid Backfolding
Ordered DNA-Wrapped Single-Chirality Carbon Nanotubes Enable an Unparalleled Sensing Platform for Copper Ion Detection
Lumazine Synthase Nanoparticles as a Versatile Platform for Multivalent Antigen Presentation and Cross-Protective Coronavirus Vaccines
M-Sec Overexpressed Stem Cells Growing Abundant Tunneling Nanotubes for Diverse Active Transferring
An Immunomodulating Regenerating Hydrogel That Rescues the Oxidative Microenvironment and Reverses Cell Senescence for Osteoporotic Bone Defects
Computer Simulations Show That Liquid–Liquid Phase Separation Enhances Self-Assembly
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization
Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality
Push-and-Pull Nanotherapeutics for Osteoarthritis with Drug Delivery and Dual Scavenging of Reactive Oxygen Species and Cell-Free DNA
Establishment of a Cochlear Organoid Platform for Remodeling the Extracellular Matrix
Nanoarchitectured CuTe Thin Films: A Next-Generation Platform for Ultra-Sensitive Biosensing
Deep Learning-Enhanced Hand-Driven Spatial Encoding Microfluidics for Multiplexed Molecular Testing at Home
Electrically Driven Chimeric Extracellular Vesicles Crossing the Fundus Barrier for Retinoblastoma Treatment
Wide Dynamic Range Multiplex Digital Clustered Regularly Interspaced Short Palindromic Repeat Chip for Rapid Detection and Absolute Quantification of Nucleic Acids
Kinetically Controlled Mesoporous Silica Films for Quasi-3D Nanoconfinement of Semicrystalline Polymers below Their Lamellae Dimensions
High-Performance Graphdiyne Oxide/Au Nanoparticle Electrode for Electrochemical Non-enzymatic Glucose Sensor
Reversible Adhesive Hydrogel Balancing Conflicting Needs of Strong Adhesion and Painless Removal for Diabetic Joint Wound Healing
Direct Reversible Conjugation of an Adenosine Receptor Antagonist to an Axonal Transport Protein Carrier
Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation–Contraction Coupling
Characterization of a Single-Molecule Sensitive Digital Flow Cytometer for Amplification-Free Digital Assays
Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy
Membrane Fusion Drives Facile Uptake of Cell Membrane-Coated Nanocarriers
Bioinert Albumin Surface Enables Ultra-High Vascular Cell Selectivity Superior to Specific Binding Ligands
Injectable Thymosin β4-Modified Hyaluronic Acid Hydrogel with Exosomes for Stem Cell Homing and Neuronic–Angiogenic–Osteogenic Coupled Cranial Repair
Nanocoding: Lipid Nanoparticle Barcoding for Multiplexed Single-Cell RNA Sequencing
Exploring the Subcellular Localization and Degradation of Spherical Nucleic Acids Using Fluorescence Lifetime Imaging Microscopy
Three-Dimensional Bioprinted Scaffolds Loaded with Multifunctional Magnesium-Based Metal–Organic Frameworks Improve the Senescence Microenvironment Prompting Aged Bone Defect Repair
Flexible Mechanoporation Chips for High-Throughput Intracellular Delivery Based on Controlled Pneumatic Microvalve Array
Enhanced Cuproptosis via Metabolic Reprogramming Using Copper-Delivering Co–N–C Single-Atom Nanozyme
Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization
Rational Design of Safer Inorganic Nanoparticles via Mechanistic Modeling-Informed Machine Learning
Lab on Pipette: Robust Biochemical Sensing with Functional Laser-Induced Graphene Electrode Array for On-Site and Disposable Urine Analysis
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing
Living Microecological Microneedle Patches Enable Proregenerative Microenvironmental Remodeling for Promoting Infected Diabetic Wound Healing
Adipose-Derived Stem-Cell-Derived Exosomes Encapsulated Patch for Modulating Inflammation and Promoting Tissue Regeneration
Differential Mapping of Intracellular Metallic Nanoparticles and Ions and Dynamic Modeling Prediction
Deciphering the Distinct Roles of Molecular and Supramolecular Chirality in Osteogenic Differentiation of Mesenchymal Stem Cells in 3D Hydrogels
Enhanced Nano-Vaccine Utilizing Biomineralized Virus-like Particles for Efficient Glioblastoma Immunotherapy via the Nose-To-Brain Delivery Pathway
Iterative Screening of Vitamin E-Based Functional Lipid Nanoparticles for mRNA Delivery
Ionizable Lipids Drive Subcellular Localization and Immune Cell Targeting of Barcoded Nanoparticles in Lung Cancer
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Non-invasive detection of local microstructural damage in tendon using Diffusion Tensor MRI
Rocket propulsion-inspired two-stage nitric oxide–releasing hydrogel for phase-matched therapy of diabetic wounds
Virtual fluorescent labeling of engineered vascular networks with embedded tracer particles
Postoperative Administration of Mesenchymal Stem Cells Enhances Peri-Implant Tissue Healing in a Medication-Related Osteonecrosis of the Jaw Model
Improved in vivo bone regeneration and mechanical stability in critical-sized defects using WZM211 fluorine coated fibres
A quantitative approach for high-throughput mapping of collagen fibril orientation using polarization-dependent Second Harmonic Generation
Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis
Enhancing in vivo B cell gene delivery using targeted lentiviral vectors and transduction enhancers
Carrier-Free Spherical Nucleic Acids Engineered by Coordination-Competition for Programmable Release and Cancer Immunotherapy
A Nitric Oxide-Releasing Zwitterionic Glycocalyx-Mimetic Hydrogel Armored Bioprosthetic Valve with Integrated Antithrombotic, Endothelialization-Promoting, and Immunomodulatory Capacities
A bioengineered recombinant spider silk provides targeted G-protein-coupled receptor activation
Multifunctional bioactive peptide-laden and adhesion-switchable dual-crosslinked hydrogel for accelerated healing of infected deep burn wounds
In vivo self-assembled DNA vaccine elicits efficient immune protection against viral myocarditis by targeting draining lymph nodes
Biopreservation of a tissue engineered nigrostriatal pathway for tract reconstruction in Parkinson’s disease
The effects of volume exclusion and viscosity on collagen fiber nucleation and network morphology
Preparation of nanofibrous membrane-covered saccule gastric tubes and their treatment of radiation esophagitis
Human cell-derived dermal-specific interwoven extracellular matrix for diabetic wound healing
Kinetic negative-feedback-based barrier membrane attenuates pathological fluctuations and promotes bone regeneration in diabetes
A pH-responsive hyaluronic acid hydrogel facilitates lesion-localized integrin α5β1 agonism to attenuate osteopontin signaling and fibrosis in intrauterine adhesions
Dual Crosslinked Thermosensitive Hydrogel Engineered with Multiple Dynamic Hydrogen Bonds for Enhanced Photodynamic Antibacterial Activity and Wound Healing
Cell-Targeted Nanocomplex Facilitates Direct Reprogramming of Astrocytes into Dopaminergic Neurons in Parkinson’s Disease
Chemical Modifications of RNA Influence the Micellar Assembly Stability and Intracellular Distribution of Polycation/RNA Complexes
Stent-Graft Compliance Modulates Regional Mechanical and Structural Remodeling of the Aorta
PFSSTKT(PFS)-functionalized Hierarchical Porous ECM Scaffolds Facilitate Articular Cartilage Regeneration through the Recruitment of Endogenous Stem Cells and Chondrogenic Induction
The influence of scaffold fibre architecture on tenocyte tissue production under intermittent dynamic culture
Dynamic and static strain levels differentially affect the enzymatic degradation of collagen fibres
Co-delivery of human adipose-derived stromal cells and endothelial colony-forming cells in cell-assembled decellularized adipose tissue scaffolds for applications in soft tissue regeneration
A scaffold-free, collagen-guided self-assembling adipose construct for functional soft tissue reconstruction
Ultrasound-mediated blockade of nociceptive transmission by targeted liposomes for efficient cancer pain therapy
Mitochondrial transfer through tunneling nanotubes inspires an innovative strategy for intercellular drug delivery
Sulfide-based, Pro-regenerative, Anti-inflammatory Vascular Grafts: Impregnation of Slow-released Sulfide Signals into Graft Implants
Minipig costal and knee cartilage structure-function relationships and their use as cell sources for tissue-engineered analogous cellular products for cartilage repair
Helix-Guarded Molecular Clips Confer Robust Scavenging of Intra-Articular Cell-Free DNA for the Treatment of Rheumatoid Arthritis
Smooth muscle cell-like support cells accelerate the autologous endothelialization of a polyurethane scaffold for vascular engineering
Mechanically Responsive Yes-associated protein-Inhibiting Peptide Hydrogel for Scarless Wound Healing
A bioorthogonal click reaction-based platelet-rich plasma delivery system for accelerating wound healing
Effect of stent-graft compliance on hemodynamics and aortic stiffening in an in vivo porcine study
Fabrication and in vitro evaluation of a high-strength, flexible, and bioresorbable warp-knitted silk patch for tendon tissue repair
Self-Adaptive 3D-Printed PCLA/BCP Scaffolds Functionalized using Vapor Etching and Nanocoating for Immunomodulatory and Antibacterial Bone Regeneration
Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming
Learning mechanical inhomogeneity of keloid scars in vivo with shear wave elastography based on physics-informed neural networks
Inflammation-Responsive Biodegradable Nanocomposite Hydrogels for Enhanced Metalloimmunotherapy in Chronic Periodontitis
Near Infrared Excitation of an Upconversion Nanoparticle@TiO2-Nitrate System to Generate Nitrate Radicals for Deep Tissue Penetration in Tumor Catalytic Therapy
Injectable, Antifouling Granular Zwitterionic Hydrogels for Preventing Postoperative Intrauterine Adhesion and Restoring Fertility
A Facile Fabrication and Conjugation Approach for Biopolymeric‒Zwitterionic Hydrogel Microparticles toward Accurate Protein Quantification using Replica Molding and Peptide Ligand Conjugation
Three-dimensional magnetic torque stimulation enhances functional structural maturation in developing human cardiac organoids
Design and evaluation of cationic bottlebrush polymers for advanced messenger RNA therapeutics
In situ pro-regenerative and repair capabilities of human umbilical mesenchymal stem cells and collagen hydrogel complex in mice with thin endometrium
Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening
Modeling of protein networks reveals factors affecting stiffness, yield stress, and strain stiffening in silk fibers
Direct insights into synthesis, protein integrity, and blood microrheology of albumin microbubbles
Copper-Manganese Bimetallic Oxide-Encapsulated Hydrogels with Multienzyme Activities Accelerate MRSA-Infected Wound Healing by Disrupting Bacterial Protein Expression
Dual-functional bioinspired nanospray for accelerated wound healing: Visible light-activated bismuth composites
Electrosprayed hydrogel microsphere dressing promotes vascularization and accelerates wound healing
Local viscoelasticity of denaturing spider silk dope is governed by dynamic hierarchical intermolecular interactions
Minimally Invasive Delivery of Engineered Heart Tissues Restores Cardiac Function in Rats with Chronic Myocardial Infarction
Imaging the mechanical properties of a developing embryonic tendon using Brillouin microscopy
One-step Solid phase Reaction-Induced Hydroxyapatite/Magnesian Whitlockite Bioceramics for Enhanced Bone Regeneration
The Clinic-in-a-Dressing Paradigm: Synchronized Diagnosis and Treatment in Chronic Wounds via Hydrogel-Nanofiber Matrices
Autologous platelet-rich plasma dual-network hydrogel promotes human endometrial regeneration
Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
A viral infection-biomimetic strategy for Antibody-Guided Targeted Protein Degradation
Endothelial function-biomimetic hydrogel-surface engineered non-glutaraldehyde bioprosthetic valve with antithrombotic, immunomodulatory and pro-endothelialization performance
An Immunocompetent Bioengineered Human Dermal Equivalent to recapitulate scar tissue formation in vitro
Characterization of Stability and Shell Elasticity of Monodisperse Microbubbles with Different Pegylated-lipid Content using Pressure-Dependent Attenuation Spectra
The Mo-14Re alloy, a promising candidate material for bioresorbable vascular scaffolds
M2 macrophage-laden vascular grafts orchestrate the optimization of the inflammatory microenvironment for abdominal aorta regeneration
Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate
In Vitro and In Vivo Biocompatibility Study of Fluorinated Polyphosphazene Coatings for Blood-Contacting Medical Devices
Structural and Mechanical Properties of Engineered Silkworm-Spider Composite Silk
Bilayer vascular grafts incorporated with S-nitrosated keratin nanoparticles and resveratrol to enhance long-term nitric oxide release and endothelialization
A costal-cartilage derived stem cell-laden prominin-1-derived peptide collagen hydrogel for angiogenesis and bone regeneration
Magnetic Capture of Autologous Mesenchymal Stem Cells Promotes the Rapid Endothelialization of Peripheral Venous Stents in Rabbits
A hydrated fibrous gene patch codelivers TGF-β1 siRNA/TAT and berberine for the treatment of peritendinous antiadhesion
Biomimetic self-gelling and adhesive powder for seamless sealing and neural regeneration after brain injury
A Tumor Microenvironment-responsive Nanocomposite for Enhanced Copper Retention and Hypoxia Reversal to Promote Cuproptosis in Tumor Treatment
Direct ink writing of sustainable multifunctional biodegradable porous Fe-eggshell scaffolds
Deciphering the heterogeneity of calcified structure in different entheses via high-resolution characterization techniques
Spatiotemporal self-reinforcing hydrogel spray with antibacterial and anti-inflammatory properties for accelerated diabetic wound healing
Anti-inflammatory itaconate-loaded, cell-adhesive peptide-conjugated artificial small diameter vascular grafts for blood vessel regeneration
Mechanically-adaptive Janus hydrogel enhances scarless tendon healing with tissue-adhesion prevention
NIR-II responsive copper-nitrogen doped photocatalysts for pyroptosis and cuproptosis
Nano-carriers mediate reciprocally chained promotion between ROS and mitochondrial calcium overload for enhanced antitumor therapy
An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment
Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia
Muscle-specific acellular ECM fibers made with anchored cell sheet engineering support regeneration in rat models of volumetric muscle loss
Mechano-immunomodulation of macrophages influences the regenerative environment of fracture healing through the regulation of angiogenesis and osteogenesis
Delivery of siGPX4 through a thiol-mediated pathway using a fluorinated cell-penetrating poly(disulfide) for inducing ferroptosis in breast cancer
Poly(ethylene glycol)-norbornene-heparin-piposome composite hydrogels for in situ spraying and ultra-fast adhesion: meeting the challenges of endothelial repair of vascular injury
A biomimetic nanofiber composite hydrogel with tissue adhesion, self-healing and antibacterial ability for infected wound healing
Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells
Coaxial printing of slow-release heparin-binding epidermal growth factor scaffold to avoid the occurrence of intrauterine adhesions
Engineering of bioprosthetic heart valves with synergistic zwitterionic surface modification and zirconium cross-linking for improved biocompatibility and durability
Biodegradable Zn-xY alloys with enhanced osteogenesis and angiogenesis effects for bone implant applications
Flexible beam-based microelectrode arrays integrated with oriented nanofiber scaffolds for electrophysiological monitoring of cardiac tissue
Improving tendon repair through spatiotemporal modulation of TGF-β1 expression using an ultrasound-responsive hydrogel carrying siRNA-loaded nanoparticles
Biodegradable Zn-Li-Mn alloy to achieve optimal strength and ductility for bone implants
Catechol crosslinked bioprosthetic valves derived from caffeic acid and dopamine-conjugated porcine pericardia exhibit enhanced antithrombotic, immunomodulatory and anticalcification performance
Endogenous dysregulated energy and amino acid metabolism delay scaffold-guided large volume bone regeneration in a diabetic rat model with Leptin receptor deficiency
A dissolvable microneedle platform for the delivery of tumor-derived total RNA nanovaccines for enhanced tumor immunotherapy
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An Integrated Zn Battery‐Powered Iontophoresis Patch Enhances Healing of Radiation‐Induced Skin Injury by Inhibiting Ferroptosis
Processing-History-Programmed Silk Fibers Integrating Mechanical Robustness, Ionic Conduction, and Optical Waveguiding for Intelligent Wearables
Temporally Programmed Multifunctional Hydrogel Dressings for Optimized Wound Healing and Symptom Relief
ROS-Responsive Microneedles Loaded With Biomimetic Nanozymes for Rotator Cuff Repair and Adipose Infiltration Prevention
Endogenous Exothermic Reaction-Driven Pyroelectric Osteosarcoma Therapy
Recyclable Biocatalytic Membranes Governed by pH-Gated Supramolecular Switches
Biomimetic Osteochondral Biobattery
Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA-Lipid Nanoparticle Stability When Dried in a Polymer Matrix
An Engineered E. Coli-Based Living Material Platform for Protease Biosensing
Bioresorbable Piezo-Triboelectric Patch Enabled Bioelectric Stimulation for Accelerated Wound Healing
Synergistic Piezoelectricity and Lubrication in an Injectable Hydrogel for Osteochondral Regeneration
Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma
Self-Assembled Nanoclay Gel With Spheroid MSC-Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin-Targeting miRNA for Synergistic Osteogenesis
Multi-Responsive Dendrimer-Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy
Microenvironment-Responsive Nanozyme for all Stages of Infectious Chronic Wound Management through Macrophage Reprogramming
Novel Flexible Wearable Field-Effect Transistor Aptasensor with DNA Hydrogel for In Situ Wireless Detection of Organophosphorus Pesticide Residues
Framework Nucleic Acid Nanoparticles Ameliorate Achilles TENDINOPATHY Through Tissue Penetration and Dual Regulation of the PI3K/AKT and MAPK Signaling Pathways
Microbial Rhamnolipid‐Stabilized mRNA Nanovaccines Enhance Adaptive Immunity via Dendritic Cell Targeting
Bioengineered CBD‐hBD‐3 Fusion Peptide‐Functionalized Collagen Scaffold Reprograms Fibroblast Fate to Attenuate Fibrosis and Promote Multilayer Vaginal Regeneration
Photothermal Hydrogel with Gel–Sol Transition for Programmed Antibacterial and Wound Healing
Multifunctional Hydrophilic Selenium-Polyurea for Controlled Ion Release of Biodegradable Alloys and Immuno-osteogenic Synergistic Modulation
Hierarchical Mineralization Buffer Zone for Dentin Interface Reconstruction via Protein-Guided Nonclassical Mineralization
VIVID: A qPCR-Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles
The Terminal Domains of Collagen-Like Silk Direct Molecular Interactions and Liquid–Liquid Phase Separation-Mediated Material Assembly
Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation
An All-Optical Driven Bio-Photovoltaic Interface for Active Control of Live Cells
Noninvasive, Electro‐Boosted Catalytic Anti‐Inflammation System for on‐Demand Osteoarthritis Treatment
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Mitochondria-Targeting Nanocuproptosis Breaks Immune Resistance
Biomimetic Woven Bone Organoids with Multifocal Centers for Retaining Stemness and Prolonging Osteogenic Activity
A Thermoplastic and Visualizable Bone Scaffold Dynamically Enhances Hemostasis and Osteogenesis in Bone Defects
Overcoming Debye Length Limitations in Electrolyte‐Gated Transistor Biosensors Using Nanoscale‐Grooved Oxide Semiconductors Fabricated by Thermal Nanoimprint Lithography
Rational Design of Lamellar Heterostructural Mg/PLLA Composite Membrane Enables Spatiotemporal-Sequential Neuro-Vascularized Bone Regeneration
Improvement of Paracrine and Tissue Regenerative Functions of Mesenchymal Stem Cells via Nanostructure‐Mediated Localized Mild Photothermal Signals
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis
Atomic‐Precision NiCo Dual‐Atom Nanozybiotic for Drug‐Resistant Infections and Tissue Repair
Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo
3D‐Printed StrontiumSilicate Hydrogel Scaffold Promotes Sensory Innervation and Tissue Regeneration Through Modulating Macrophage Senescence
Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA‐Based Therapeutics
Bioinspired Hydrogel Prepared by Core-Shell Nanofibers: Accelerating Wound Healing via Macrophage Polarization Modulation
Injectable Dual-Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration
Disentangled Hydrogel With Rare Earth-Activated Multi-Enzymatic Activity Reverses the Pathological Vicious Cycle by Establishing a Closed-Loop for Postoperative Melanoma Treatment
Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity
Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue
Bimetallic MOF-Incorporated Hydrogel Scaffolds for Astaxanthin Delivery: Remodeling Bone Microenvironment and Accelerating Bone Repair
Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging
Poly(lactic-co-glycolic acid) Nanoparticles for IL-12 Self-Amplifying RNA Delivery in Glioblastoma Models
Janus Piezoelectric Fibrous Scaffolds with Ultrasound‐Triggered Electroresponsive Drug Release for Dual‐Lineage Induction and Immune Microenvironment Remodeling in Tendon‐Bone Interface Regeneration
Endogenous Glucose/pH Dual‐Responsive PEEK Implant With Cascade‐Amplified Antibacterial and Osteogenic Activities for Infected Diabetic Bone Defects
Photothermal‐Driven Spatiotemporal Delivery of Bioactive Facilitators for Coordinated Cartilage and Subchondral Bone Regeneration in Osteoarthritis
Functionally Designed Liquid Crystal Elastomer Foams for Cartilage Regeneration
An Ultrafast Self-Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine
ROS-Responsive Titanium Implant Coatings Enhance Osteoporotic Osseointegration via Microenvironment Remodeling and Mitochondrial Repair
SI‐bioATRP in Mesoporous Silica for Size‐Exclusion Driven Local Polymer Placement
Crossbow Bioreactors for Studying the Effects of Time-Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues
Hierarchical Silk Fibril Networks Exhibit Structure Dependent Mechanical Performance
A NIR‐Responsive MXene‐Based Hydrogel with Antibacterial and Repair‐Promoting Functions for Treating Infected Wounds
Mitochondrial‐Targeted Ultrasmall Hydrophobic Cationic Graphene Nanosheets Potentiating Tumor Photoimmunotherapy
Spatiotemporally Orchestrated H2S/NO-Releasing Stent for Synergistic Vascular Healing
Dual-Layer Living Hydrogel Enables On-Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy
PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing
A MOF‐based Core–Shell System Enables Controlled Release and Ordered Assembly of Nano‐Hydroxyapatite for Enamel Remineralization
High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation
Mimicking Block Copolymer Self-Assembly with One-Pot Synthesized Polyphosphoester Gradient Copolymers
Ultrasound‐Propelled Antioxidant Nanobowls for the Treatment of Osteoarthritis
Fluorescence/Colorimetric Lateral Flow Immunoassay Based on Dual-Aptamer Domain Recognition and Upconversion Signal Amplification for Sensitive H1N1 Hemagglutinin Detection
A Rapid In Vitro Endothelialization Approach for Small-Diameter Vascular Grafts via Covalent Reaction
Engineered Poly(ethylene glycol)‐Alendronate‐Magnesium Hydrogels Potentiate Site‐Specific Immunomodulation for the Healing of Osteoporosis Fractures
Thermoelectric Bionic Skin Promotes Diabetic Wound Healing by Restoring Bioelectric Field Microenvironment
Dual-Network Bioactive Implant Promotes Weight-Bearing Bone Healing via Mechano-Bioelectric Coupling
Bioinspired Alginate/α-TCP Organic–Inorganic Interpenetrating Network Microspheres for Bone Repair
Nanoparticle Endocytosis Mediated Intracellular Ion/Small Molecule Storm Triggered Mitochondrial Repair Determined Macrophage Reprogramming for Accelerate Diabetic Wound Healing
Piezoelectric Catalysis‐Induced Intratumoral Carbon Monoxide Explosion for Tumor Respiration Inhibition
A Versatile Approach to Synergistically Combine Physical Barriers and Bioactive Agents for Intrauterine Adhesion Prevention
Non-Thermal Plasma-Induced Selective Glycosidic Cleavage in Chitosan Produces Multifunctional Antibacterial Wound Care Biomaterials
Ion‐in‐Conjugation‐Enabled Remineralized Scaffold for Spatiotemporal Control of Infection and Bone Regeneration
An off‐the‐Shelf Injectable MSC Hydrogel with Microenvironment‐Driven Responsiveness for Precision Osteoarthritis Treatment
The Coupling of Gradient Mechano-Electrical Microenvironments Promotes Interface Regeneration via Ca2⁺ Signaling Activation
Simple Zinc Metallic Particle Doping Transforms Ceramic Bone Cement Therapeutic Performance
Band Alignment in TiO2/UiO-67 S-Scheme Heterojunction for Anti-Interference Phosphate Sensing
PEG-Free Monosialoganglioside Lipid Nanoparticles with Spleen-Selective mRNA Delivery for Cancer Immunotherapy
A Morinda Officinalis Extracellular Vesicles‐Encapsulated Redox Homeostasis Modulatory Hydrogel Promotes Growth Plate Injury Repair by Regulating the Oxidative Stress Microenvironment
Stem Cell Fishing at Bone‐Implant Interface: A Cell‐Clicking Bioadhesion Strategy to Enhance Osteointegration
Bioimplantable Bifunctional Zinc/Magnesium–Oxygen Battery for Synergistic Gas Therapy and Hypoxia‐Activated Chemotherapy
Melanin‐derived Biomimetic Nanoparticles Improve Patency and Tissue Regeneration of Vascular Grafts via ROS Scavenging and Immunomodulation in an Atherosclerotic Rat Model
Modular Integration of Self-Adjuvanting mRNA Delivery with Real-Time Vaccine Efficacy Tracking for Timely Optimization of Cancer Immunotherapy
Calcium Imparts Advanced Functionalities to Silk Hydrogels for Biofabrication and Biomedical Innovation
Revealing the Auxetic Behavior of Biomimetic Multimaterial and Region-Specific Nanofibrous Fascicle-Inspired Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration
Development of Multifunctional Smart Polymeric Material for Emerging Applications
Biodegradable Dual-Stimuli Hydrogel Scaffoldoid Synergizing Piezoionic and Lithium-Ion Release for Critical-Sized Bone Defect Regeneration
Biodegradable Anti-Stenosis Microsurgical Implantable Hydrogel Stent for Efficient Vas Deferens Recanalization
Next-Generation Bio-Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Biomimetic Nanofabrication by Silkworm-Inspired Spinning: A Supertough Nano-Skin Fiber Through Sequenced Interactive Fiber-Microfluidics
Engineering a Biomimetic DentinLayer via Light-Responsive Self-Mineralizing Collagen Matrix for Dentin Repair
Ultrafast Electrochemical Biosensor for SARS-CoV-2 Viral Nucleic Acids Sensitive Detection Using Os-Complex/3D Vertical Graphene Dual Signal Amplification
A Biothiol‐Reactive and Mitochondria‐Targeting Photosensitizer for Dual‐Modal Antitumor Treatment Combining Photodynamic and Nitric Oxide Therapies
A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA
A Self‐Reinforcing Metabolic Nanojammer for Activating Cascade‐Augmented Cuproptosis‐Driven Immunotherapy
Multifunctional Nanoparticle Reinforced GelMA Hydrogel for Osteoporotic Pathophysiological Microenvironment Improvement and Bone Defect Regeneration
Advanced Electroactive and Anti‐Inflammatory Sutures for Enhancing Tendon and Bone Regeneration to Promote Repair of Achilles Tendon Sleeve Avulsion
Ultrasound‐Driven Piezoelectric Bi‐Ru Heterojunctions for Water‐Splitting Gas Therapy in Tumors
Regional Cellular Reprogramming via a Non‐Coding RNA Engineered Electrospun Fibrous Patch
Bioinspired Stratified Janus Hydrogel Enables Neuro‐Osteogenic Regeneration via Microenvironment‐Matched Repair After Tooth Extraction
pH‐Triggered Aggregation of Polylysine Nanoparticles Enhances TNF‐α siRNA Delivery for Rheumatoid Arthritis Therapy
Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1
Immunomodulation‐Based Multifunctional Decellularized Matrix Bioink Derived from M2 Macrophages Remodels the Bone Microenvironment via Neurogenesis and Angiogenesis
Vascular Intima‐Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual‐Modal Anti‐Coagulation and Self‐Adaptive Immunomodulation
Biomimetic Microgrooved Methacrylated Silk Fibroin Cartilage Scaffold for Tracheal Injury Repair
In Situ Engineering Mesenchymal Stem Cells for Osteogenic Differentiation to Reverse Inflammaging and Restore Periodontal Bone Homeostasis
Nano‐Interlocking Enhanced Electroactive Dressing: Electromagnetic Induction for Accelerated Diabetic Wound Healing and Wound Microenvironment Monitoring
Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers
Biodegradable Polymeric Nanoparticle Employing a Photodynamic/Photothermal/Thermodynamic Combination Strategy for Treatment of Acute Maxillofacial Wound Infections
From Snapshot to Movie: Visualizing Native Silk Spinning Defines the Paradigm for Bio‐Inspired Spinning
Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery
Amorphous Region Modifications Enhance Genetically Engineered Spider Silk for Advanced Wearable Applications
Label‐Free and Low‐Power Driven Cancer Biomarker Detection Enabled by 2D Hexagonal Titanium Oxide
Biomimetic Grooved Spinneret Enables High‐Performance Regenerated Silk Fibers Surpassing Natural Silkworm Silk
The Rational Design of Pt Single Atoms‐Bridged Nanozyme with Enhancing Direct Electron Transfer Pathway for Glucose Oxidation
Metal‐Organic Nanosheet Gels: Hierarchically Porous Materials for Selective Loading and Differential Release
Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury
Bonyzymes: Efficient Anti‐Inflammatory, Antibacterial and Osteogenic Agents for Peri‐Implantitis Reconstruction Treatment
Alkaline Gradient Induced Hydrogen Bond Stabilized Adhesive Dressings for Gastric Ulcer Healing
Pubertal Bone Matrix Microparticles Support Rapid Generation of Mini‐Bone Organoids and Minimally‐Invasive Injection in Repairing Bone Defect
Metformin‐Induced Fibrillation of Copper Formate into Biocompatible Antibacterial Hydrogel for Enhanced Fungal Infection Wound Healing
Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
Biomimetic Bacterial Framework‐Driven Point‐of‐Care Platform Enables Broad‐Spectrum Bacterial Sensing via PAMPs‐Triggered Competitive Recognition
Machine Learning-Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Streamlined Synthesis of Ga‐Cu Dual Single‐Atom Nanozymes for Advanced Electrochemical Sensing Applications
Engineering Mesenchymal Stem Cells with Antioxidant Catalase‐Loaded Metal–Organic Frameworks for Targeted Spinal Cord Injury Therapy
Electroactive Dressing Induces Piezoelectric Signals and Ca2⁺ Activation to Enhance Osteoblast Differentiation and Bone Regeneration in Negative Pressure Therapy
Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction
Nanofiber-Reinforced Self-Adaptive Hydrogels with Desired Sequential Delivery Capability of Bioactive Factors and Magnesium for Vascularized Osteochondral Regeneration
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A Dual-Targeting Strategy Against ROS and GSK-3β With a PEGylated Fullerene/Smart Hydrogel Synergistic System for Diabetic Bone Regeneration
N-Acetylcysteine–Mediated Surface Remodeling of Inhaled mRNA Lipid Nanoparticles Enables Coordinated Mucosal and Systemic Antitumor Immunity
Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration
A Structurally Stabilized Lipopolymer Nanoplatform Targeting Pan‐Tissue Antigen‐Presenting Cells Enables Durable in situ mRNA Cancer Immunotherapy
Small Diameter Vascular Grafts Made in Minutes
Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration
Viral Infection-Inspired Autonomous Detection of Fusion-Competent Viruses for Screening and Environmental Surveillance
Igniting Endogenous Calcipoptosis via ER-Mitochondrial Calcium Shuttle Hijacking for Potent Antitumor Immunity
Disrupting KAT8 Liquid–Liquid Phase Separation with Hybrid Vesicle–Liposome Platform for Enhanced PD-L1 Blockade Treatment
Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity
Adhesive Microneedle-Nanosheets With Temporally Orchestrated Antimicrobial, Immunomodulatory, and Osteogenic Functions for Periodontal Regeneration
Brake–Drive Osteo System: Sequential Modulation of the Inflammatory Microenvironment and Osteogenesis for Osteoporotic Bone Defect Regeneration
Hydro‐Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double‐Helical Nanostructures
Osteogenic Nanozymes for Diabetic Bone Regeneration via Synergistic Antioxidant and Osteoinductive Functions
Photosynthetic Nanobacteria Drive Metabolic-Immune Synergy for Hypoxia-Resistant Cancer Therapy
Deployable 3D-Printed Vascular Stent with Surface-Catalysed Endogenous Nitric Oxide Generation
A Cryoprotectant-Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals
Surface-Capped Protein Nanoparticles for Nonviral Gene Delivery
Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy
Digital Microneedles for Multiplexed Transdermal Sensing via Fluorescent QR Codes
Micropore‐Confined ROS‐Responsive 3D‐Printed Shell‐Core Scaffolds for Long‐Term NO Release to Orchestrate Immunomodulation and Angiogenesis in Diabetic Bone Defect Repair
Safeguarding VSMC Contractile Phenotype With In Situ circRNA‐mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis
Trace Detection of Multiple Macromolecular Biomarkers in Saliva by Enzymatic Responsive Serial‐Nanofluids Strategy
DNA Supramolecular Hydrogel Alters Exosomal microRNA Atlas and Paracrine Secretory Profile of MSCs to Promote Bone Remodeling and Ameliorate Osteoradionecrosis of the Jaw
Fusion Peptide-Incorporated Lipid Nanoparticles Boost Endosomal Escape and Enhance Cytosolic mRNA Delivery
Engineering Asymmetric and Highly Exposed Fe Single‐Atom Nanozymes for siMMP13 Delivery and Ferroptosis Inhibition in Osteoarthritis Therapy
Modular Supramolecular Polycations Enable Efficient Delivery of Diverse RNA Therapeutics and Vaccines
Bioinspired Engineered Virus-Mimetic Vesicles for Enhanced Cytosolic Delivery of STING Agonists Into Dendritic Cells
A 3D-Printed Piezoelectric Scaffold With Bio-Inspired Gradient and Dynamic Adaptation for Tendon Regeneration
Optimizing Peptide Ionizable Lipids Enables Efficient and Low-Toxicity mRNA Delivery for In Vivo Prime Editing and Protein Replacement Therapy
Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non‐Canonical Amino Acids
Combinatorial Assembly of Biomimetic Janus Membrane with Multiscale Architectures for Guided Bone Regeneration
A Bio‐Orthogonal Engineered Chitosan Platform for Enhanced Mesenchymal Stem Cells Delivery and Function in Peripheral Nerve Repair
High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering
Edge-Driven Fringe-Field Effects, Reduced Screening, and Bandgap Widening in Graphene Nanoribbons Enable Single‑Molecule Sensitivity
Bioinspired Engineering of Living Materials to Reconstruct Stromal-Parenchymal Interactions for Post-Stroke Neural Regeneration
Stiffness‐Gated Cytoplasmic mRNA Delivery Through Engineered Membrane Fusion for Breast Cancer Immunotherapy
Endogenous Metal Ion‐Enriched Immunostimulating Biomimetic Scaffold Improves In Situ Bone Regeneration
Coupling Mitochondrial Homeostasis to Oxi‐Inflamm‐Aging Network Disruption via Peptide‐Functionalized Nanocomposite Hydrogel for Osteoarthritis Intervention
Metabolic Osteoimmune Biodegradable Zn–Mn Alloys: High Strength-Ductility and In Situ Vascular-Osteogenic Coupling
Reprogramming mRNA Delivery Tropism via Nitrogen-To-Sulfur Substitution in Ionizable Lipids
Small Molecule‐Driven Organic Electrochemical Transistors for Rapid, Ultrasensitive and Amplification‐Free Detection of RNA Biomarkers
Lock-and-Shield Strategy Enables Stable and Stimuli-Responsive Tumor-Targeted Gene Delivery
Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism
Engineered Cryo‐Shocked Cancer Cells Deliver Dual‐Function Gene Medicines for Melanoma Immunotherapy
Thermoplastic Molding of Chitosan to Form Living Plastic Materials
Akkermansia Muciniphila-Inspired Oral siRNA Delivery by Active Matrix-Penetration and Intracellular Endoplasmic Reticulum Accumulation
Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation
Resolving the mRNA Encapsulation‐Release Trade‐off via Compensatory Forces in Engineered Ionizable Lipids
Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications
A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration
siAkt2‐Loaded Nanoparticles Reprogramming Macrophages to M2 Phenotype for Effective Bone Defect Repair
Modular Assembly of Lipid Nanoparticles for Targeted mRNA Therapeutics and Vaccines
Mesenchymal Stem Cell-Inspired Microneedle Platform for NIR-responsive Immunomodulation and Accelerated Chronic Wound Healing
Wrinkled Layered Sulfide With Tunable Channels Unlocks Precision in Rare Earth Extraction From Radioactive Wastewater
Intrinsically Disordered Protein-Inspired Nanovector-Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules
DNA-Scaffolded Bispecific Antibodies Enhance Mesenchymal Stromal Cell Therapy for Inflammatory Bowel Disease
Construction of Diverse Calcium-Based Nanomaterials through a Microemulsion Method for Pyroptosis-Initiated Antitumor Immunotherapy
Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases
3D Spatiotemporal Electrophysiology of Cardiac Organoids Using Shell Microelectrode Arrays
Environmental Response Temporal Release Injectable Hydrogel for Controlled Growth Factor Release to Enhance Inflammatory Periodontal Bone Defect Regeneration
Calcium Phosphate Nanoparticle-Immobilized Macrophage-Derived Extracellular Vesicle Nanohybrid Facilitates Diabetic Bone Regeneration
Supramolecular Amino Acids‐Encoded Nanodots (SEND) with pH‐ and Ion‐Responsive Phase Separation for Serum‐Tolerant Cytosolic Protein Delivery
Temporal Immunomodulatory Hydrogel Regulating the Immune-Osteogenic Cascade for Infected Bone Defects Regeneration
Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells
Diatom‐Inspired Scaffold for Infected Bone Defect Therapy: Achieving Stable Photothermal Properties and Coordinated Antibacterial‐Osteogenic Functions
Bio-Orthogonal Engineering of Neural Stem Cells with Membrane-Bound Microsatellites for Enhanced Brain Repair
A Readily Synthesized All‐In‐One Nanowire Hydrogel: Toward Inhibiting Tumor Recurrence and Postoperative Infection
Artificial Transmembrane Oligopeptide-Integrated Interferon mRNA with Monoclonal Antibody to Improve Specificity and Efficacy of Cancer Immunotherapy
Mass‐Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid‐IR Spectrochemical Analysis of Complex Biofluids
Engineered Virus‐Like Nanoparticles Enable Multimodal Protein Degradation for Enhanced Tumor Therapy
Host Cell Membrane‐Cloaked Nanomedicine Reprograms Endothelial Surface for Enhanced Patency in Allogeneic Vascular Grafts
Bringing Attomolar Detection to the Point‐of‐Care with Nanopatterned DNA Origami Nanoantennas
Filamented Light (FLight) Bioprinting of Mini‐Muscles with Self‐Renewal Potential
Piezoelectric Injectable Anti‐Adhesive Hydrogel to Promote Endogenous Healing of Tendon Injuries
High‐Speed Raman Readout of Single Polypeptides via Plasmonic Nanopores
Bioinspired Immunomodulatory Scaffold Based on Mineralized Lotus Stalks Laden with MnCO Microspheres for Accelerated Bone Regeneration
Self-Growing Scaffold for Spatial and Border Expansive Regeneration
An Environmentally Responsive Molecular Engineering Framework for Subcellular Drug Translocalization
Clinically Accurate Diagnosis of Alzheimer's Disease via Single-Molecule Bioelectronic Label-Free Profiling of Multiple Blood Extracellular Vesicle Biomarkers
Inflammation‐Activatable Nanoscavengers for Sustainable Cell‐Free DNA Capture and Cleavage
Dual‐Selective Terahertz‐Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations
Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas
Nanozyme‐Reinforced Hydrogel Spray as a Reactive Oxygen Species‐Driven Oxygenator to Accelerate Diabetic Wound Healing
Biocatalytic and Redox‐Regulated Nanoarchitectures for Precision Inflammation and Immune Homeostasis Modulation to Combat Rheumatoid Arthritis
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Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS)
1
Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1
8
Anti-RANKL improves muscle dysfunction and strengthens bone in laminin-α2-deficient dy2J/dy2J dystrophic mice.
Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia
Targeting Skeletal Muscle in Duchenne Muscular Dystrophy: Integrating In-Silico and Experimental Approaches to SGLT2 Inhibition
Delayed bone fracture healing in Hybid (hyaluronan-binding protein involved in hyaluronan depolymerization)-deficient mice
The D2.B10-Dmd mdx /J mouse model of DMD exhibits a severe mitochondrial deficiency not observed in the C57BL/10ScSn-Dmd mdx /J mouse
Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies
Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy
Pharmacological inhibition of glutamate dehydrogenase 1 (GLUD1) improves functional recovery of neuromuscular junctions and muscle function in Duchenne muscular dystrophy.
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Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil
Prostaglandin I2 Receptor Activation Promotes Alveolar Regeneration via the JUN/p53 Pathway
Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis
Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT).
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Unlocking Ultrasensitive MicroRNA-21 Signals with a Dual-Output Strand Displacement Biosensor
Real-Time Label-Free Monitoring of Nanoparticle–Cell Interactions in Single Tetrahymena thermophila by Mass Cytometry
Ultrasensitive miR-451 Detection via DNAzyme-Mediated Etching with In Situ Single-Nanoparticle LSPR Monitoring
A NASBi–Cas13a E‑Sensor for Accurate Diagnosis of Acute Promyelocytic Leukemia: RNA and DNA Cotargeting LbuCas13a by Cell-Free Transcription Amplification
Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling
Selection of Aptamers To Detect Lean Meat Agents: Ractopamine and Clenbuterol
Deep-UV Resonance Raman Spectroscopy Enables Direct Quantification of mRNA in Intact Lipid Nanoparticle Formulations
Aptamer-Coupled Droplet CRISPR/Cas12a Enables Ultrasensitive sPD-L1 Detection
Dual-Signal Capillary Sensor Based on Viscosity Variation for Bacterial Endotoxin Detection
Dual Paper-Based Electrochemical Device for Multiplex Detection of Triple-Negative Breast Cancer miRNA Signatures
Discovery of NMP22-Targeting Aptamers for Point-of-Need Test of Bladder Cancer
Sortase-Mediated Dual-Display Phage Bioluminescent Immunoassay for Detection of Vibrio parahemolyticus Using Affinity-Enhanced Nanobody
Second Flowing Type Lateral Flow Assay for High-Fidelity Detection
Quantitative Multiplex Digital PCR with Fluorescence-Encoded Nanoreactor Beads
Rapid and Accurate Diagnosis of Bacterial Infections via Profiling of Metabolic Volatile Organic Compounds Using Proton Transfer Reaction Mass Spectrometry
Dual-Competitive Turn-On SERS-Lateral Flow Immunoassay for Ultrasensitive Cortisol Detection in Saliva
Noninvasive Diagnosis of Parkinson’s Disease via High-Coverage Exhaled Metabolomics: A Proof-of-Concept Study
Quantitative Detection of Hepatitis B Virus Particles via Dual-Targeting HBsAg and Nucleic Acid with Immunomolecular Assay
Quantitation of Diastereomer Content in PS-Modified Synthetic Oligonucleotides using cIMS-MS
CRISPR–Cas12a2-Based Multiplexed Diagnostic for Rapid and Highly Sensitive Detection of Respiratory Viruses
Cumulative Spectroscopic Detection for Taylor Dispersion Analysis of Nanoparticles
Machine Learning-Assisted Portable Ai BOX Based on RPA-CRISPR/Cas12a for Rapid On-Site Detection of Foodborne Pathogens
Label-Free Electrochemiluminescence Detection of Urinary AD7c-NTP Using Structurally Optimized Iridium(III) Complexes on Boron-Doped Diamond Electrodes
A Programmable Carbon Nanotube-Based Diagnostic Toolkit: Modular Architecture for Universal Multitarget Biosensing through Synergistic Surface Engineering
Immunomagnetic Sample Preparation Targeting Host- and Viral-Derived Antigens for HIV-1 Isolation from Limited Plasma Volumes
Sensitive and Robust One-Pot RPA-CRISPR/Cas12a Assay with Elimination of cis-Cleavage
Robust Radical-Mediated Electrical Enzyme Assay (REEA) Cartridge FET Sensor toward Practical Applications
Sensitive Colorimetric Biosensors Based on Perovskite Heterojunction Phototransistors
Biosynthetic Toxin Mimics Meet Nanophotonics: A Rapid, Label-Free Biosensor Platform for Real-Time Detection of Bongkrekic Acid in Urine
Label-Free Fluorometric Split Aptasensor for the Specific Detection of Uric Acid from Xanthine and Hypoxanthine
Smartphone-Based Peptide Nucleic Acid (PNA) Probe-Assisted Potentiometric Biosensor for Point-of-Care Testing of SARS-CoV-2 Nucleic Acid
Multiplexed PfAgo-Based Digital Platform for Clinical Testing of High-Risk HPV Subtypes
Synergistic Light-Harvesting and Heat Transfer in Platinum-Confined Gold Nanocages for Sensitive Photothermal Lateral Flow Immunoassay
DNA-Antibody Conjugation Clamp-Mediated Coordination Quenching for the Ratiometric Detection of CA242
Target-Activated and Movable Toehold-Assisted Proximal Catalytic Hairpin Assembly Amplification for Low-Leakage and Ultrasensitive Fluorescent Aptamer Sensing of Glycated Hemoglobin A1c
Integrating Acridinium Ester with a Soluble Macromolecular Amplification Carrier for Ultrasensitive Detection of Aβ1-42 in Plasma
Mitochondria-Targeted Fluorescent Probe for Super-Resolution Imaging of HNO in Lung Cancer
Digital Counting of Quantum Dots Nanobeads on Lateral Flow Test Strips Enables Ultrasensitive Point-of-Care Diagnostics
One-Pot Ligation-Recombinase Polymerase Amplification-Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a-Powered Trimode Lateral Flow Assay for Sensitive MicroRNA Detection
Localized Dual-Cycle Amplification Integrating Entropy-Driven Reaction and Catalytic Hairpin Assembly for miRNA Imaging in Living Cells and Tissues
The Specific Low-Interference dsDNA Copper Nanoclusters for Visual Fluorescent Detection and Quantification of the EGFR L858R Point Mutation in Whole Single-Tube Magnetic Purification System
His-Tag-Aptamer-Liposome-Conjugates as a Multipurpose Tool for Recombinant Protein Screening and Protein-Based Bioassays
A Disposable CRISPR-Nanozyme Electrochemical Biosensor for Rapid and Sensitive Detection of Breast Cancer Circulating Tumor DNA
Target-Induced Tandem Built-In Electric Fields in the Hollow SnS2/ZIS@ZnS Heterojunction for the Photoelectrochemical Immunoassay
Single-Atom Fe/Au Nanozymic Electrode to Accelerate Glucose Oxidation for Self-Powered Sensing
Rapid and Specific Detection of Gastric Cancer EVs Using a Cas12a-Powered Aptasensor with a Novel Targeting Aptamer
A Tailored Monoclonal Antibody for Visual Detection of an Emerging Insecticide Chlorfenapyr: Rational Hapten Design and Molecular Insights
Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes
One-Step Chemiluminescent Immunoassay for the Key Synthesis Protein of Ochratoxin A Using a Shark Single-Domain Antibody-Alkaline Phosphatase Fusion Protein
Integrated Microfluidic SERS Sensor Featuring Au NPs@Cu MOF/Hydrogel for Label-Free and Specific Creatinine Detection
Hydrogel RT-LAMP Enables Rapid, Quantitative Assessment of Mycobacterium tuberculosis Immune Responses
Rational Hapten Engineering Enables a Monoclonal Antibody for the Masked-Mycotoxin Zearalenone-14-Glucoside and Field-Deployable Digital Immunoassays
Self-Hybridization Chain Polymerization-Driven Transcriptional Synthesis of Fluorescent Aptamers for One-Step Detection of Cancer-Associated RNA Biomarkers
Clustered Regularly Interspaced Short Palindromic Repeat-Based Colorimetric Aptasensor Combined with Smartphone Imaging and Deep Learning Enables Selective Recycling and Visual Prediction of Microplastics in the Environment
Paper-Based Tests with a Rapid Plug-and-Play Aptameric Switch for Metabolic Disease Diagnosis at the Point of Care
Single-Cell Analysis of Zinc Ions During Electrical Stimulation-Induced Pyroptosis by DNAzyme-Functionalized Glass Nanopipettes
A Droplet-Free and Oil-Free Microfluidics Based on Self-Pumping Hydrogel for Point-of-Care Multiplex Digital Nucleic Acid Detection
An All-in-One Microfluidic Platform for POCT-Ready Nucleic Acid Extraction from Heterogeneous Clinical Samples
Highly Improved Sensitivity of FET Sensors Based on a Pulsed Temperature Profile for Lead Ion Detection
Engineering High-Performance Aptamers via Optimized SELEX and Structure-Guided Dimer Assembly for Clinical Malaria Diagnostics
Double-Stranded Universal Probe Strategy Enables Cost-Effective and Versatile Nucleic Acid Amplification Tests
Electrocontrolled Injection-Coupled Droplet Microfluidic Platform for Antimicrobial Resistance Screening
Target-Amplification-Free Detection of Pathogenic Bacteria Via a Cascaded Nuclease Reaction
Chemiluminescent Nanoflower with Inherent Oxygen Vacancies for Coreactant-Free and Label-Free Immunoassay of pTau181
A Wearable Supramolecular Fingertip Sensor for Colorimetric Detection of Food-Derived Tyramine
Cell Probe Cocktail Enables Ratiometric miRNA Detection with Enhanced Sensitivity and an Extended Dynamic Range
Site-Specific Evolution of DNA Aptamers to Detect ADAR1p150 in Complex Biological Samples
Sponge-Based Flow Control in Laminate Capillary-Driven Electrochemical Microfluidic Devices for Viscous Sample Analysis
PEG-Modified Selenium Nanoparticles Dramatically Increases Antibody Binding Sites for Ultrasensitive Point-of-Care Detection of NT-proBNP
Organic–Inorganic Core–Shell Satellite Nanostructures for Dual-Readout Detection of Escherichia coli O157:H7
Graphene Field-Effect Transistors Loaded with DNA Walkers for Detection of miRNAs
SIMPLE-CRISPR: A Sample-to-Result Platform for Point-of-Care Detection of Nucleic Acids via a Functionalized Magnetic-Bead-Based CRISPR Assay
Electrochemiluminescence Biosensing Platform Based on CRISPR/Cas12a and DNA Nanotweezer-Mediated Catalytic Hairpin Assembly Amplification
Direct RNA Triggering of Cas12a through the Native crRNA Architecture Enables Clinical Nucleic Acids Diagnostics
One-Pot CRISPR/Cas12a Assay Based on Ultrashort HDA for Ultrasensitive and Universal Nucleic Acid Detection
Bacterial Metabolism-Driven Dual-Enzyme Cascade Colorimetric Sensor for Antimicrobial Susceptibility Testing with Readily Interpretable Signals
High-Speed, Label-Free Antimicrobial Susceptibility Testing in Picoliter Droplets: Combining Cage-Based Phase Contrast Microscopy with YOLO-SAM Algorithm
Side-Port Puncture Needle-Assisted, Multistep Vacuum-Driven Microfluidic Chip for Multiplexed Molecular Analysis
Influence of Molecular Crowding on Aptamers and Application in Lateral Flow Assays
Hydroxyl Radical–Activatable NIR-II Ratiometric Fluorescence Probe for Visualization In Vivo Tracking of Oxidative Stress and Therapeutic Response in Arthritis
TOI-IGRA: A Fingertip Blood Biosensing Technology for Decentralized Quantification of Pathogen-Specific T-Cell Responses
DYNAMIC: A Novel Software Implementation of a Kinetic Model of TaqMan PCR
High-Affinity Three-Way Junction Aptamers for Sensing Cationic Polymyxin Antibiotics
Rigid Restriction-Enabled Ultrabright Luminescence through Feather-like Metal-AIEgens Frameworks and Coupling the Collaborative Interfacial Recognition Mechanism for Pathogen Diagnosis
Microwave-Assisted Synthesis of PNA@AuNRs with Temperature Gating for Precise Amplification of Nucleic Acids
Culture-Free Microfluidics for Ultra-Rapid Antimicrobial Susceptibility Testing with AI in Resource-Limited Settings
A Hydrogel-Based 3D Microfluidic Platform with Optimized Flow and Mass Transfer for Rapid Antimicrobial Susceptibility Testing
Breathomics-Guided Solid-State Sensor for Noninvasive Point-of-Care Diabetes Screening
pH-Responsive 1,8-Naphthalimide Probe for a One-Step Loop-Mediated Isothermal Amplification Assay
Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing
Bridging Target Recognition with Direct Molecular Counting: A DNA Framework Converter-Mediated nFCM Assay Platform for Quantifying Diverse Biochemical Analytes
Aptamer-Mediated Proximity Labeling (ApMPL) for Spatially Resolved Deciphering of Cell Membrane Protein Interactomes
Fluorescence-Enhanced Immunoassay (FEIA) Platform by Combining AIE Nanobeads on a Plasmonic Device for Selective Detection of IL-6 Cytokine
Atomic Fe-Centered Hemin–TiO2 Graphdiyne Nanozyme Sensor for Colorimetric Fingerprinting of Bacterial Extracellular Vesicles
Copper-Based MOF Derivative with Enhanced Electrocatalytic Activity for Highly Sensitive and Ultrafast Detection of Salivary Glucose
d-Lactate SELEX Yielding Aptamers Binding Stronger to l-Lactate: Implication of Intrinsic Chiral Preference
SERS-Based Universal AST: Rapid Treatment Guidance for Blood-Culture Bacteria before Species Identification
Real-Time Acoustic Spectroscopy of Nanoparticle Sedimentation in Microfluidic Systems Using Phononic Crystal-Based Ultrasonic Interferometry
Catalytic Amplification-Mediated Single-Nanotag Assembly for Sensitive Detection of Circulating microRNAs
Pronounced Fluorescence Polarization Enhancement Driven by RPA-CRISPR/Cas12a Induced Nucleoprotein Assembly for Salmonella Analysis in Animal-Derived Food Matrices
DNA-Fueled Molecule Machine-Mediated Atom Transfer Radical Polymerization Amplification for 17β-Estradiol Assay in Clinical Samples
Feedback-Guided SERS-Photothermal Patch for Maintaining Redox Homeostasis in Diabetic Foot Ulcers
Laser-Printed Electrochemical Microfluidic Aptasensing Chip for Simultaneous Detection of Multiple Pesticides
Aptamer-Mediated Protein Corona In Situ Multiplex Microfluidic Detection for Cancer Diagnosis
Ultrasensitive Electrochemiluminescence Detection of Dual Tumor Markers on Living Cell Surface with a Closed Bipolar Electrode Array Chip
Micropore Confinement in Flow Systems Enables Subsecond Bipolar ECL Biosensing
An Integrated 3D-Printed Portable Device Coupling Bimetallic FeCo-MOF Nanozymes with Freeze-Dried Hydrogel Carriers for Point-of-Care Testing of Serum Acid Phosphatase
One Blow To Obtain Integrated Information on Metals, NO, and Metabolites in Breath Gas by Mass Spectrometry
A High-Sensitive Photothermal-Readout Strategy for Commercial Lateral Flow Immunoassays with an Optical Microfiber Mach–Zehnder Interferometer
Sensor ToolKit (STK): Compact Multiplexing Potentiostat for Point-of-Care Applications
Eutectogel-Based Antifouling Interface: Addressing Sensitivity and Accuracy Challenges in Complex Serum
Wettable Porous Arrays with Structural Color Barcodes Integration for Multiplex Urinary Tract Infection Bacteria Screening
A Real-Time, Programmable, and Multiplex Ligation Chain Reaction-MNAzyme Platform for Single-Nucleotide Variant Detection
Selection of a High-Affinity Aptamer for Phalloidin and Application in a Dual-Mode LRET/Colorimetric Aptasensor
Integrated Dual-Modality Biosensor for Antimicrobial Susceptibility Testing and Antibiotic Prescription Guidance
Development of a Paper-Based SERS Platform for On-Site Separation and Detection of Mercury Species in Aqueous Environments
Push-Button Microfluidic Platform with Dual-Signal Nanoprobes for Enhanced Sensitivity Detection of Healthcare-Associated Infection Pathogens at Point-of-Care
A Robust Nonfouling Biosensor Based on an Engineered Multifunctional Monocyclic Peptide for Electrochemical Detection of Biomarkers in Human Blood
Quantification of Hydrogen Sulfide in Single Living Cells by Azido-Functionalized Glass Nanopores
DNAzyme-Powered Rolling Circle Amplification for the Synthesis of Hairpin DNA-Templated Fluorescent Copper Nanoclusters: A Label-Free miRNA Sensing Platform
An Integrated Centrifugal Microfluidic Point-of-Care Low-Cost Chip for Rapid Pathogen Nucleic Acid Detection and Diagnosis of Bloodstream Infections
Three-Dimensional Fluorescence Fingerprint Integrated PCR Enables Accurate Analysis of 9 Pathogens
Wet–Dry–Wet Experiments Enable Simultaneous Aptamer Isolation and Critical Binding Domain Identification
Long-Lived Phosphorescent CDs@SiO2 Coupled with Magnetic Quencher Fe3O4@PDA: A Dual-Mode Lateral Flow Immunochromatographic Assay for Sensitive Determination of Acetamiprid
Rapid and Sensitive Visual Detection of Gene Mutations via LIVE-SNP
Multicolor Amplification-Free RNA Detection with Cas13a and Cas13b
Sensitivity Enhancement of Multiplex Lateral Flow Immunoassays by NIR-II Fluorescence and Thermal Contrast
Self-powered Photoelectrochromic Biosensor for Visual Detection Using a Distance-Based Signal Readout
Conjugated-Polymer-Based Electronic Tongue for Breast Cancer Discrimination: from Artificial to Clinical Urine Samples
Electrochemical Gating of d-Band Engineering in Hierarchically Bridged Dual-Site Nanozymes for Synergistic Cascade Catalysis and Wearable Biosensing
Dual-Mode Lateral Flow Assay for Simultaneous Quantification of Antibiotic and Bacteria
Novel One-Pot Detection of Tumor mRNA Vaccine by the Target Serving as crRNA of the Split Cas12a System and Synergistically Triggering an Entropy-Driven Reaction
Exploring the Feasibility of Paper-Based Substrates for User-Friendly Electrochemiluminescent Sensors
Fabricating a SMVF@GO@Ag Composite Aerogel SERS Sensor for the Enrichment and Label-Free Detection of Urinary VOCs
Gold-Coated Optical Fiber Electrode for In Situ Monitoring of Hydrogen Peroxide Released from Living Cells via Transmitted Electrogenerated Chemiluminescence
CRISPR-AD: Combinational Detection of Blood Protein and miRNA with Digital CRISPR-Based Assay Enable to Improve the Diagnostic Performance of Alzheimer’s Disease
Rapid and Sensitive Pathogen Detection and Viability Evaluation: A Lateral Flow Assay Based on One-to-Multiple Signal Amplification
Controlled Nanozyme-Substrate Accessibility for Ultrasensitive Electrochemical Detection of miRNA
A Wearable Microneedle-Integrated Multiplexed Photonic Aptasensor for the Detection of Illicit Drugs in Interstitial Fluid
Chitosan-Functionalized Magnetic Graphene Oxide Nanocomposites Enable High-Purity mRNA Enrichment To Avoid False Positives in LC-MS/MS Modification Profiling
A Novel 2-Chloro-4-Nitrophenol Photoelectrochemical Sensor Based on MWCNTs@MIL-68(In) Derivatives and In2O3 Composite Films
Aptamer-Functionalized Microchannel-Gated Field-Effect Transistor Biosensor for In Vivo Detection of Dopamine
Optical-Antenna-Enhanced LED Biochips for Femtomolar Detection of Protein Biomarkers
Ultrasensitive CRISPR Platform Enables Rapid and Extraction-Free Detection of Viral Nucleic Acid
UV-DOAS Combined with Spectral Projection Decoupling Neural Network (SPDNN): An Online System for the Simultaneous Detection of Ammonia and Isoprene at Sub-ppb Levels
Rapid Single-Cell Phenotypic Antifungal Susceptibility Testing on a SlipChip Enabled by Deep Learning
An AND-Logic Gate-Based Biosensor for Simultaneous Detection of SARS-CoV-2 Nucleic Acids and Nucleocapsid Proteins
Extraction-Free Scalable Sample Preparation for the Rapid Detection of HIV in Blood Plasma
From Hapten Design to Mechanism Exploration: Developing a High-Specificity Immunochromatography Strip for Fluridone Detection
Synergistic CRISPR/Cas12a-Nanozyme System for Iontronic Sensing of Site-Specific Septin9 Methylation
A Simple and Rapid Bst Polymerase-Catalyzed Isothermal Exponential Amplification Reaction for Multiplex Detection of MicroRNAs
A Reusable Dual-Mode Aptasensor Based on Bipolar Electrode for Sensitive Detection of Live Clostridium perfringens
AI-Assisted Multiplex SYBR Green I-Based qPCR for the Identification and Quantitative Analysis of Oral Microbiota
Encapsulation of mRNA in Therapeutics Like Lipid Nanoparticles Probed by Deep-UV Resonance Raman Spectroscopy
Wettability-Enhanced Photothermal Vertical Flow Biosensor on a Syringe for PSA Detection Using TaTe2 Nanosheets
Recruitment of Enzymatic Labels via Glycan-Lectin Interactions for Electrochemical Immunosensing of Anti-dsDNA Antibodies
Combined Confocal Dynamic Light Scattering and Fluorescence Correlation Spectroscopy as an Advanced Technique to Characterize Colloidal Quantum Dot-Gold Nanoparticle Hybrid Systems
Application of Engineered Split Aptamers in Fluorescence-Colorimetric Dual-Mode Detection of Chloramphenicol
Novel Ultrafast Sample-to-Answer Microfluidic Platform for Highly Sensitive On-Site Quantification of Avian Influenza Virus
Ultrasensitive Fluorescence Detection of Lung Cancer-Related miRNAs Based on DNA Tetrahedron and DNAzyme Catalytic Reaction
Rapid Analysis of Pacific Ciguatoxins in Fish Extracts with a Lateral Flow Assay
Metal–Organic Framework@Gold Nanoparticles Enables Point-of-Care Diagnostics To Have Comparable Analytical Performance to Chemiluminescent Immunoassays
Ultrasensitive Electrochemical Biosensor for DNA Methylation Detection Based on Fe-MOF/PANI and Catalytic Hairpin Assembly Cascade Reaction
A Relay CRISPR/Cas12a System for Extraction-Free and Ultrasensitive Detection of Staphylococcus aureus in Complex Food Samples
Capacitive Lateral Flow Test for Sub-fM Analysis of Serum HER-2/neu Using a Magnetic Cellulase-Linked Aptamer Sandwich Strategy
Hyaluronic Acid-Gentamicin Hydrogel and pH Indicator Mediated by Mesoporous Silica Nanoparticles as Antibacterial and Indicatable Wound Dressings for Real-Time Monitoring of the Healing Process
Lateral Flow Strip-Compatible Nucleic Acid Testing for Facile Diagnosis of Infectious Pet Diseases
Device Simplification: Example of the Application of a Bifunctional Molecularly Imprinted Polymer Membrane in a Visual Photoelectrochromic Chip
Dopamine Self-Polymerization-Assisted Oriented Antibody Immobilization on a Transistor for Alzheimer’s Disease Diagnosis
A Highly Sensitive Multiplex Immunosensor for Detecting Three Sulfonylurea Herbicides: From Hapten Design to Molecular Recognition Mechanism
Fluorescent Microneedle Sensor Array for Continuously Monitoring Sodium and Hydrogen Ion Concentrations in Interstitial Fluid and Its Application in Diabetes Complication Management
Janus Metal-AIEgen Framework@Hydrogel Patch for Ultrasensitive, Multivariate Responsive, and Intelligent Point-Of-Care Sensors
Plasmonic Skin as a Wearable SERS Substrate for Direct Chemical Identification
Assessment of Particle Size-Resolved Surface-Charge Density Distributions of Polymer Nanoparticles by Capillary Zone Electrophoresis
Molecular Simulation Guided Optimization of Multi-Epitope Nanobody Affinity for Enhanced Förster Resonance Energy Transfer System Performance
Integrated Biosensing Platform Based on Bi2S3/BiFeO3 Heterojunction and BiVO4 for Ultrasensitive Organic Photoelectrochemical Transistor and Colorimetric Dual-Mode Detection of Prostate-Specific Antigen
Engineering Aptameric Responsive Photonic Biosensor Based on Cholesteric Liquid Crystal Network for the Detection of Anatoxin
Direct Single-Molecule Detection of mRNA–LNP Drugs in Blood
Simultaneous Detection of SARS-CoV-2 Nucleocapsid Protein and RNA by Aptamer-Based Proximity Ligation and Quantitative PCR
Single-Tube Instantaneous Generation of CTAB-Stabilized Gold Nanoparticles for the On-Site Molecular Identification of Foodborne and Multidrug-Resistant Pathogens
Magnetic Rolling Circle Amplification-Assisted Automated Electrochemiluminescence Immunoassay for Ultrasensitive Determination of Protein Biomarkers
Ultrasensitive Detection of Multiple Foodborne Pathogens Using CRISPR–Cas12a on a Finger-Actuated Microfluidic Device Integrated with a Modular Pressurizing Pump
Highly Specific Detection of miRNA Mutants Using a Combined Analysis of Functionalized Micropipette and Hybridization Free Energy
Development of a Self-Activating Dandelion-Shaped DNA Nanodevice for Amplified Imaging of mRNA and Precise Gene Silencing
A Smart Dual-Amplification Electrochemical Analyzer: Product-Activated Tripedal DNA Walker for Glioma Grading
A Versatile CRISPR/Cas12a Autocatalytic Cascade System via Structure-Switching V-Type Split Probe for Highly Sensitive DNA Diagnostics
Utilizing Engineered Monobodies for the Electrochemical Quantification of Lysozyme
Hierarchically Porous Amino-Functionalized Microporous Organic Networks Coated Fiber for Sensitive Breath Metabolite Profiling: A Noninvasive Strategy for Gastric Cancer Diagnosis
Combined Use of Engineered PfAGO and LbCas12a for Nucleic Acid Detection
Selection of Allosteric DNAzymes for Theophylline Sensing by Expression-SELEX
Sniffing Out Lung Cancer: Biomimetic Breath Analysis via a Deep Eutectic Solvent-Driven Colorimetric Sensor Array
Catalase-Driven Microflow Displacement for Rapid, Visual Antimicrobial Susceptibility Testing
A Dual-Signal Amplification Detection of Tumor mRNA Vaccines Based on the Novel Full-Length Catalytic Loop Initiating DNAzyme
Deprotonated Nanofilms-Enabled Fluorescence-Colorimetric Dual-Mode Sensing of 3-Hydroxy-2-butanone
Culture- and PCR-Free Femtomolar Detection of Antibiotic Resistance Genes in Clinical Urine via Cascaded Molecular Machines and Electrokinetic Enrichment
Digital-to-Droplet Microfluidic Platform Powered Digital Isothermal Nucleic Acid Amplification for On-Demand Detection of Post-Transplantation Infection-Causing Viruses
AI-Assisted Microfluidic Paper-Based Analytical Device with Au–Pt Nanoparticles for Multiplex, Interference-Resistant Quantification of Urinary Biomarkers
Ultra-Fast Laser Marking of TiO2/Ti Arrays on Titanium Foils for Scalable Construction of All-Metal Light-Addressable Photoelectrochemical Sensors
Efficient 2D HOF@Au SERS Substrates Synergized with the G-quadruplex Network-Based Catalytic Amplification Strategy for Low-Background Trimode Detection of Lomefloxacin
Rapid Phenotypic Antimicrobial Susceptibility Testing with Multichannel Large-Volume Scattering Imaging and a Bayesian Gaussian Process Model
A Pre-Amplification-Free Modular Dual-CRISPR System for Enhanced Pathogen Detection Sensitivity
Homogeneous Femtomolar Detection of P-tau181 via Proximity Extension and CRISPR/Cas Technique
Allosteric Regulation of Spherical Nucleic Acid for Facile Discrimination of Patients with Different Heart Failure Severity
Time-Lapse Deep Learning for Single-Cell Subcellular Structural Phenotypic Antimicrobial Susceptibility Testing
Ultrahigh-Power Sonicator Lysis Enables Deep Proteomic Profiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery
Ultra-Sensitive 3D Lateral Flow Assay Device for SARS-CoV-2 Detection Based on One-Step Dual-Signal Amplification
Electrochemical Biosensing Platform Based on MOF Carrier Signal Probes and CRISPR/Cas12a Cleavage for Sensitive Detection of MicroRNAs
Rapid Bacterial Identification and Antimicrobial Susceptibility Testing Directly from Urine Samples via an Asymmetric Polymerase Chain Reaction-Cas12a Platform
Single-Cell Super-Resolution Quantification of Oxidative DNA Damage via Aptamer-Assisted DNA-PAINT
Amplification-Free CRISPR-Cas System Integrated Centrifugal Digital Microfluidic Platform Developed for Multiplexed Respiratory Pathogen Nucleic Acid Analysis
Aggregation-State Engineered Melamine-Carbon Dots: Ultrasensitive Ethanol Quantification for Diagnosing and Classifying of Auto-Brewery Syndrome
Deep Learning-Decoded Raman Spectroscopy for Hour-Scale iPSC Pluripotency Assessment via Lipid–Protein Biomarkers
Interrogation of Small Molecules to Surface-Bound Aptamer Binding Kinetics with Electrochemical Aptamer-Based Sensors Using Intermittent Pulse Amperometry
Adjuvant Tracer Strategy Combined with a Portable Steam Penetration Gas Membrane Separation Device for Peroxynitrite Detection
Aptamer-Gated Organic Photoelectrochemical Transistor Biosensor Based on a TiO2-Embedded Vertically Ordered Mesoporous SiO2 Film for Sensitive Detection of Carcinoembryonic Antigen
Spatially and Multivalent Matched Neutralizing Aptamer-Based DNA Nanostructure Alleviates Shiga Toxin Type 2 Infection
The Dual Nondestructive Amplification Strategy Realizes the Ultrasensitive Detection of Soluble TRAIL in Human Plasma
Integrated Workflow for the Quantification of Urinary Exosomes Isolated via C–CP Fiber Tips with Lanthanide Chelation Labeling and ICP-MS Detection
Paper Matters: Technical Evaluation of Paper-Based Substrates for Enhanced Preconcentration of Biomolecules in Liquid Biopsy Diagnostics
Capillary Flow-Driven, Disposable Device for Dissolved Oxygen Sensing in Water Samples
Deep Learning-Enabled Real-Time Single-Shot Refocusing of Microwell Array for Digital Melting Curve Analysis
Scatter-Free UV–Visible Spectroscopy for Accurate and Precise RNA Quantification in Complex RNA Nanoparticle Formulations
Monitoring Vaccine-Induced Antibody Levels Using Carbon Nanotube-Based Field-Effect Transistors
Feasibility for Real-Time Monitoring of Bacterial Growth in Raw Milk Using a New Contactless Sensor
Field-Deployable Photoelectrochemical Biosensor Using Atomically Defect-Engineered Heterojunction for Ultrasensitive Microcystin-LR Monitoring via Aptamer-Mediated Fe–S Conduction
The Cu Nanocluster-Sensitized and Filter-Concentrated Strategy for Rapid and Ultrasensitive Naked-Eyed Colorimetric Detection of Pathogens
Is Digital Drying an Effective Method for Infrared Spectroscopy of Gaseous Biofluid?
A CRISPR-Cas12a Fluorescent Aptasensor for Point-of-Care Drug Concentration Detection: A Synergistic Regulation by DNA Aptamer and RNA Blocker
Engineered Nanobodies-Based Sandwich-Competitive Immunoassay Broadens the Detection Range for Aflatoxin B1
Programmable Fluorescent RNA with a Catalytic Hairpin Assembly System Enables Label-Free Monitoring of MicroRNA in Living Cells
Photoresponsive HOF-Based Platforms for Large Language Model-Assisted Multimodal Diagnosis of Metabolic Diseases
Ultrasensitive Multiplexed Detection of Protein Biomarkers via Aptamer-Driven T7 RNA Polymerase Amplification
An Ultrasensitive and Robust CircRNA Nanobiosensor via Magnetic Control Depuration and Catalytic Hairpin Assembly Cascade Amplification for Clinically Accessible Liquid Biopsy
AI-Enhanced Lateral Flow Assay Enables 3-Minute Quantitative Detection with Laboratory-Grade Accuracy
Automated Microchannel Resistance Readout of Immunorecognition via Programmable Nuclease Mediation for On-Site Biosensing
Immuno-RAFT Fluorescence Array Sensing for High-Throughput Analysis of CD81 Protein
Digital Microfluidic Platform Based on Printed Circuit Board for Affinity Evaluation of Mertansine Aptamers
One-Step, Signal-On, and Modification-Free Electrochemical Sensing Platform Based on Aptamer Switch Hydrogel
Allosteric Genetically Encoded Dual-Color Fluorogenic RNA Biosensor Simultaneously Illuminates miRNA and Its Precursor
Bifunctional Fluorescence Aptasensor Based on Target-Induced Strand Displacement Enables Simultaneous Detection of Dopamine and Serotonin in Multiple Body Fluids
Programmable Hairpin Argonaute–Nanopore Detection System for Multiplex Mycotoxin Analysis
Arginine-Rich Gold Silver–Nanoprobe for Rapid Virus Imaging and Real-Time Tracking in Infected Live-Cells
Dual-Gate Carbon-Based FET Trace Gas Sensors: Enhancing Sensitivity through Work Function Modulation
StratoLAMP-2: A Microfluidics-Free, Deep-Learning Platform for Multiplex Digital Molecular Diagnostics
A Microfluidic Colorimetric Biosensor Integrated with Water-Soluble Nonwoven Fabrics for Collection and Detection of Bacterial Aerosols
Dual-Polarity Switching Photoelectrochemical Biosensor Based on Z-Scheme Bi2S3/Bi2WO6 Heterojunction for Clinical Thalassemia Screening: Cascade Signal Amplification via 3D DNA Walker and Target Recycling
Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor
Flow-LAMP: Label-Free Digital LAMP Using Scatter-Based Flow Cytometry on Vortex-Generated Polydisperse Gel Beads
AI One-Click-Processing-Assisted Ratiometric RTP Paper-Based Sensor Array for the Rapid Discrimination and Detection of Mixtures of Oxolinic Acid and Flumequine
Ultrafast Detection of Small Molecules Using a U-Shaped Transmission Terminal and Straight Plasmonic Sensing Region Fiber Probe Biokinetic Platform: A Case Study of Label-Free Hcy Detection via Indirect Competitive Immunoassay
Critical Factors Affecting Digital PCR Quantification Accuracy in HBV DNA Reference Material for In Vitro Diagnostics
Machine Learning-Enhanced Analysis of miRNA Biomarkers for Accurate Breast Cancer Diagnosis Using DNA Seagrass
Wearable Fingernail-Based Microfluidic Paper Analytical Device for Naked-Eye Detection of γ-Hydroxybutyric Acid in Beverages
IDSP-IA: Immunotriggered Double Stem-Loop Probe-Mediated Isothermal Amplification for Attomolar Protein Quantification
Monitoring Chemotherapeutic Drugs Release from the Single Core–Shell Nanocarrier at a Monolayer Graphene-Based Total Internal Reflection Imaging Platform
Broad-Spectrum Aptamer Selection of Challenging Retronecine-Type Hepatotoxic Pyrrolizidine Alkaloids for Biosensor Construction
Clicking Fluorometric Probes on Micropatterned Glass Microfiber Filters for ppb-Level Copper Quantitation
One Assay, Nine Targets: Advancing Viral Surveillance with Multiplex RT-ddPCR
CRISPR-Programmed CuO Nanocatalyst Release for Ultrasensitive Detection of Pathogens in Sterile Body Fluids
Graphene Oxide Nanofluidic Ion Channels with Two-Gene Rolling Circle Amplification for Ultrasensitive and Specific Detection of SARS-CoV-2
Machine Learning-Assisted Terahertz Metagrating Biosensor for Label-Free Bacterial Identification Based on Spectral Fingerprinting
A Composite Hydrogel for Simultaneous SERS Detection of Glucose Concentration and Drug Therapy on Chronic Wound Surfaces in Diabetes Mellitus
A Dual-Response Quantum Dot Biosensor for Viral Protease and Nucleic Acid Detection
Glycan-Evoked Silver Deposition for Highly Sensitive Electrochemical Assay of Anti-dsDNA Antibodies
Infrared Spectroscopic Profiling of Volatile Metabolites from Uropathogenic Bacteria: Basic Investigations toward Rapid UTI Diagnostics
Peptide-Conjugated Dual-Photoelectrode Platform for Enhanced Anti-Interference Photoelectrochemical Cytosensing
Palindrome-Mediated Isothermal Cascade DNA Amplification and Effortless Nanosignal Transduction for One-Pot and Ultrasensitive miRNA Sensing
One-Pot and Enzyme-Free Analysis of mRNA Vaccines Based on a Double Amplification System Featured by Adjustable Structure MNAzyme
Breath Analysis Based on Advanced Photoinduced Charge Transfer Resonance-Assisted Strategy for Oxidative Stress Monitoring
Organic Photoelectrochemical Transistor/Visual Sensing Platform Based on CS/MCS Schottky Heterojunction and CRISPR/Cas12a-Driven Triple-Modal Synergistic Signal Amplification
Paper-Based Fast-Flow Electrochemical Device Enabling Self-Calibrated and High-Throughput NADPH Measurements
Streamlined Probe-Melt PCR for Multiplex Detection of Wheat Fungal Pathogens
Tile-Based Fisher Ratio Analysis with Support Vector Machine Regression Modeling of GC×GC-TOFMS Data of VOCs Produced by Malassezia pachydermatis Grown at Variable pHs
Hydrogel-Bead Particles Enable Activity-Based Identification of Nucleic Acid Aptamer Enzyme Inhibitors
Beyond RGB: Integration of an 8-Channel Digital Light Sensor into a Fully Automated Platform for Colorimetric Sensor Arrays
Field-Deployable Immuno-Solid-Phase Microextraction Coupled with Photothermal Imaging for Rapid Pathogen Surveillance in Environmental and Clinical Matrices
3D-Printed Array Helical Monolithic Column Chip with Hierarchical Porous Structure for High-Throughput ICP-MS Analysis of Trace Rare-Earth Elements
Background-Free Rolling Circle Amplification for SERS Bioassay Using a Chimeric Hairpin-Integrated CRISPR/Cas12a System
Programmable Dual-Phase Electrochemical Biosensor Combines Homogeneous CRISPR/Cas12a Activation with Interfacial Poly-G Signaling for miRNA-21 Detection
Smart Lateral Flow Strip Biosensor for Visual and Portable Sensing of Antibiotic Residues Based on Cascaded Logic Circuits and DNA Biocomputations
Ligand Engineering-Based High-Efficiency Photothermal Sensors Powered Sensitive Lateral Flow Immunoassay Platform
Thioflavin T Is a More General and Less Interfering Probe for Aptamer Binding Assays Than SYBR Green I
Metabolite Fusion between Breath and Blood Enables More In-Depth Understanding of the Endogenous Metabolome
High-Affinity Aptamer Selection for Microbial Transglutaminase and Application in Colorimetric–SERS Dual-Mode Detection
A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates
Dual-Probe Strategy-Enabled Multiplex Photoelectrochemical Sensor for Highly Sensitive Screening of Diabetes and Related Complications
Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action
An Electroanalytical Approach for Advancing Cancer Diagnosis and Therapy by Tracking Globally DNA G-Quadruplex Noncanonical Structures
Assessment of Nanoplastic-Induced Disruption in Cellular Glutathione Metabolism Using a Bubble-Assisted Photothermal Capture SERS Sensor
Investigation of Characteristic Volatile Organic Compounds in Esophageal Cancer Organoids by Mass Spectrometry
Intelligent Visualization of Single Microbead Bubbling Enables Attomolar Protein Quantification
One-Pot Rlock-Mediated CRISPR/Cas12a-Driven RCA Cycle for Rapid and High-Sensitive APE1 Detection
Multiple Loci DNA Methylation Profiling for Rapid Colorectal Cancer Diagnosis Based on a Smartphone-Integrated Microfluidic Biosensing Platform
Application of Rapid Evaporative Ionization Mass Spectrometry (REIMS) to Identify Antimicrobial Resistance in Uropathogenic iEscherichia coli/i (UPEC) Isolates via Deuterium Isotope Probing
Anion Exchange Chromatography to Determine mRNA Encapsulation in Lipid Nanoparticles
In Situ Plasmonic Gold Staining-Boosted Paper Test Kits of Human Albumin for Urinary Healthcare Monitoring
“Bio-inspired Nanoeye” Localizes Potentiated Antibody Binding Capacity for Driving Salmonella typhimurium Detection
Acryloyl Gelatin as Polymer Additive to Droplet Digital LAMP for DNA Quantification
Assessing the Activity of Single Bacteria through Extracellular Recording of the Dynamical Extrusion of Protons
Construction of a Self-Enhanced Fluorescent Aptasensor Based on Lanthanide Ligand Self-Assembly and Catalytic Hairpin Assembly for Highly-Sensitive Detection of Anatoxin-a
CRISPR/Cas12a-Mediated Electrochemical Aptasensor for Simultaneous Determination of Alzheimer’s Disease Biomarkers in Human Blood
Single-Cell Detection of Circulating Tumor Cells by a Proximity-Enabled Singlet-Oxygen Chemiluminescence Assay
Spatially Layered Dual-Porous Nanohybrids Enabling a Colorimetric-Fluorometric-Catalytic Continuous Gradient Signal Response for High-Performance Immunochromatographic Diagnosis
CRISPR/Cas12a-Mediated Rolling Circle Amplification for the Development of Liquid Crystal-Based Sensors
Spectroscopic Characterization and Differentiation of SARS-CoV-2 Virus-like Particles
Advancing Microfluidic Photoelectrochemical Aptasensing Platform with Photogenerated Carrier Regulation for Protein Biosynthesis Inhibitors Detection
Dual DNAzyme-MoS2/GDY Catalytic Assembly Enables Smartphone-Based Multiplex Detection of Sugarcane Pokkah Boeng Pathogens at Sub-Femtomolar Levels
A Finger-Actuated Microfluidic System for Point-Of-Care Detection of SARS-CoV-2 and Influenza A
Broad-Specificity Immunochromatographic Strip Assay for Alkaloids: From Hapten Design to Antibody Recognition
Ultrasensitive Detection of Nucleic Acid and Protein at Ambient Temperature by Using an Engineered CRISPR-Cas12a-Based Digital Assay
Rapid and Continuous Simultaneous Monitoring of Interleukin-6 and Lactate Using a Bioelectronic Sensor Platform: toward Early Sepsis Prediction
Reusable Visualization Photoelectrochromic Molecularly Imprinting Chip Lower-Voltage Driven by Photoassisted Fuel Cells
Fast, Simple Electrochromic Biosensors for Point-of-Use Infectious Disease Diagnosis
Integrating Fluorogenic DNAzymes with Photonic Crystals for Bacterial Detection on a Microfluidic Biochip
Metabolism-Driven Colorimetric “Read-to-Answer” Sensor Array for Bacterial Discrimination and Antimicrobial Susceptibility Testing
Multifunctional Amyloid-Like Porous Nanofilm-Decorated Transistor-Based Biosensor for Accurate Detection of Alzheimer’s Disease Biomarker
A Selective and Sensitive Method for Colistin Detection by G-Quadruplex Ligand Competition
Hollow Cu/Zn-MOF@Au/Ferrocene Nanoarchitectures: A Universal Leap from Colorimetric to Dual-Mode Colorimetric/Electrochemical Lateral Flow Assays
Self-Sustaining miRNA Amplification Diagnostics via Catalytic Hairpin Assembly and Split Activator-Initiated CRISPR/Cas12a Hybrid Feedback Circuit with Target Regeneration and Recycling
Synergistic Catalysis in Ni/Pt Dual-Atom Systems for Dynamic Sweat Metabolite Tracking
Novel Self-Powered Biosensor Based on Highly Efficient Cosignal Accelerator and Multiple Signal Amplification Strategies toward Ultrasensitive miRNA-141 Assay
Selective Interfacial Assembled Asymmetric Porous Nanomotors as Maneuverable Labels for Boosting Capture and Ultrasensitive Detection
EDTA-Masked Tl+ Detection Using a Pair of Non-G-Quadruplex Aptamers with Opposite Fluorescence Responses
An All-in-One Sustainable Smartphone Paper Biosensor for Water Toxicity Monitoring Combining Bioluminescence Detection with Artificial Intelligence
Mitochondria-Targeted Polymeric Liposomes for Pre-miRNA Imaging and Gene Therapy
Benzonase-Based Closed-Tube DNA Degradation Strategy for Elimination of Nucleic Acid Contamination
Glycosylation-Engineered Chitosan Bioelectronic Interfaces for P. aeruginosa Gradient Analysis
Condensation-Enhanced DNA Nanotracker on Facilitating Spatially Selective Intracellular miRNA Profiling and Robust Gene Therapy/Chemotherapy
Ultrasensitive Quantum Weak Measurement Biochemical Sensor via a Porous Anodic Alumina Nanostructure
Enhancing 29Si Hyperpolarization Efficiency in Silica Nanoparticles via Multishell Design with Selective 29Si-Isotope and Radical Enrichment
Attomolar Nucleic Acid Detection Using CRISPR Enhanced Phase-Sensitive Surface Plasmon Resonance Imaging
Ru(phen)32+-Sensitized GaN-Gated Organic Photoelectrochemical Transistor for Sensitive and Selective Detection of Human Papillomavirus DNA
Development of a CRISPR/Cas-Based Detection Platform for Tracking Decreased Susceptibility to Cephalosporins in Neisseria gonorrheae
Development of a Femtosensitive Electrochemical Aptasensor for Tuberculosis Ag85B Detection
Hyperbranched Rolling Circle Amplification Enabled Nanopore Sensing Platforms for Ultrasensitive Multiplex MicroRNA Detection and Logic-Gated Molecular Diagnostics
Drone- and Paper-Based Analytical Devices: A Powerful Combination for the Colorimetric Detection of Tropospheric Ozone
Paper-Droplet Hybrid Strategy for Highly Selective Blood Plasma Separation in Multiplex Diagnostics
A 3D Printed Meridian-Arrayed Microfluidic Device for Dual-Physical Fields Induced Highly Efficient Intracellular Delivery
Fully Integrated Wearable Biosensor for Multiple iIn Situ/i Phosphorylated Tau Protein Detection
Ultrasensitive Label-Free Biomarker Detection Utilizing a Large-Core Biconical Fiber-Embedded Optofluidic Biochip with Optimized Optical Architecture and Multimodal Signal Amplification
A Monolith-Based μHPLC-SERS Integrated Microplatform Featuring Mg2+-Regulated Dual-Capture Mechanism for Real-Time Online ATP Monitoring
Flexible and Reusable Biochip Platform for miRNA Quantification via Dual-Signal Amplification on 3D Au Substrate
A Novel Hand-Held Spinning Platform with Centrifugal Microfluidics for Rapid, Cost-Effective Urinary Total Protein Detection at the Point of Care
Direct, Selective, and Rapid Measurement of HCN at Sub-ppb Levels Using HiT-CD-IMS: Applications to Cell Culture and Breath Analysis
Simultaneous Bioelectrochemical Detection of Nitrate and Nitrite with a Whole-Cell Hydrogel Electrode
Hapten Design and Antibody Production for a Highly Sensitive Broad-Spectrum Immunoassay for Detection of Seven Organochlorine Pollutants in Soil and Oilfield Chemicals
One-Step Detection of RNA in Small Extracellular Vesicles from Plasma for Diseases Diagnosis by a Multisatellites@planets Molecular Imprinting Platform
Prussian Blue Nanozyme-Based Dry-Dipstick Reflectometry for Multiplex Detection of Low Molecular Weight Metabolites
Enhancing Classification Robustness in Real-Time Digital PCR via Amplification Curve Regulation and Clustering Analysis
Temperature-Modulated SERS Fusion Enables Accurate Diagnosis of Clinical Fungal Pathogens
Sensitive Detection of Exosomal Biomarkers via a Drop-Shaped Porous Microfluidic Chip for Potential Diagnosis of Alzheimer’s Disease
Accurate and Sensitive Detection of Pathogenic Bacteria Living in Wastewater via Aptamer-Loaded GFET for Sewage Treatment Analysis
An All-in-One Microfluidic Device for Blood Plasma Separation and Fluorescence Detection of Cocaine in Whole Blood
A Paper/Polymer Hybrid Microfluidic Nanosensing Rotary Chip: From Efficient Reagent Delivery to Multiplexed Detection of Toxins
Real-Time Fluorescence Aptasensor Based on Programmable Switch-Coupled Exponential Amplification Transduction for Ultrasensitive and Specific Vibrio parahemolyticus Determination
Smart-Plexer 2.0: Leveraging New Features of Amplification Curves to Enhance the Selection of Multiplex PCR Assays in Multi-Target Identification
Modification-Free Oligonucleotide-Utilized Lateral Flow Assay System for On-Site Detection of Foodborne Pathogens
Selection of Aptamers Targeting Different Epitopes of Recombinant Thyroid-Stimulating Hormone Receptor Protein
Real-Time Detection of Trace Breath Isoprene Based on Circular Domain Spectral Reconstruction Filtering Combined with Convolutional Neural Network
Electrokinetically Driven On-Fiber Active Lateral Flow Assay for MicroRNA Detection
On-Site Therapeutic Drug Monitoring for Program Death-1 Antibody Using a Quantum Dot Nanobeads-Based Lateral Flow Immunoassay
Liquid-Phase Barrier Modified Nitrocellulose Membrane: A Strategy for Boosting Chemiluminescent Detection in Lateral Flow Assays
Small-Molecule Binding-Guided Nucleic Acid Amplification and Its Ultrasensitive Electrochemical Detection of Aflatoxin B1: A Split Aptamer Ligation Chain Reaction via Click Chemistry
Studying the Effect of Receptors Clustering on Hyaluronic Acid Binding with CD44 and the Cell Entry of Hyaluronic Acid Targeting Nanodrugs at Single Molecule/Particle Level
Slice-Inference-Assisted Lightweight Small Object Detection Model for Holographic Digital Immunoassay Quantification
A Woundplast of Hydrogel Microneedles with In Vivo ATP-Responsive Therapeutic Logic for Bacteria-Infected Wound Healing
Precise Determination of CpG Methylation through Entropy-Driven Cascade Circuit
Mutually Activated Dual-Exponential Amplification DNA Machine Enhances Robust CRISPR/Cas12a Feedback Propagation for Ultrasensitive miRNA Detection
Microarray-Based Nanoextraction Combined with Ambient Ionization Mass Spectrometry for Analysis of Drugs of Abuse in Wastewater
Levodopa Sensing with a Nanosensor Array via a Low-Cost Near Infrared Readout
A Real-Time Enzyme-Linked Aptamer Assay (RT-eELAA) for Rapid and Sensitive Detection of Viral Antigens in Saliva Using Electrochemical Readout
Smartphone-Powered Automated Image Recognition Tool for Multianalyte Rapid Tests: Application to Infectious Diseases
Split G-Quadruplex-Integrated CRISPR-Cas Biosensor for One-Pot, Signal-On Visual Detection of Pathogen Nucleic Acids
Application of Non-G-Quadruplex Hemin Aptamers to Hemin Detection and Heme Oxygenase 1 Activity Evaluation via Spatial Conformational Constraint
Self-Powered and Sensitive Assay of Caspase-3 Activity Based on an Ultralarge Photocathodic Current Amplified by Polydopamine Modification and a CdIn2S4/CdS Heterojunction Photoanode
Elimination of Carryover Contamination during Nucleic Acid Amplification Based on Damaged Base Excision by DNA Repair Enzymes
Construction of a Near-Infrared-Light-Triggered Dual-Signal Biosensing Platform for Microcystin-RR Detection Based on the Z-Type Heterojunction of Bi2S3/In(OH)3
Understanding Fast and Slow Signal Changes in a Competitive Particle-Based Continuous Biosensor
High-Output Droplet Electricity Generator for Intelligent Self-Powered Biochemical Analysis
Spectroelectrochemical Fiber-Optic Sensor Based on Localized Surface Plasmon Resonance for Simultaneous Multiselective Electroactive Species Detection
An Artificial Intelligence Olfactory-Based Diagnostic Model for Parkinson’s Disease Using Volatile Organic Compounds from Ear Canal Secretions
Enhanced Intracellular Delivery via Stainless Steel Filters and Viscoelastic Fluids: A High-Efficiency Alternative to Conventional Transfection
4D-Printed Redox-Responsive Needle-Flow Reactors Enabling Online Quantitative Profiling of Living Rat Brain Extracellular Lactate and Glucose
High-Performance Selection of Small-Molecule Nucleic Acid Aptamers and Their Applications
Cascade Signal Amplification of Time-Resolved Fluorescence Immunoassay through Enzyme Catalysis Coupled with Dissolution Enhancement
A Rapid Electrochemical DNA Biosensor for Serum Uric Acid Using the Pre-equilibrium Binding Mechanism
Reversible Ligand–Receptor Interaction-Induced “Tango”-like Dancing of Nanodisks on Living Cell Membrane
Development of an Electrochemical Biosensor to Detect miRNA Encapsulated in Lipid Nanoparticles
Pheno-Molecular Testing Enabled by Multiplex Droplet Digital PCR for Rapid and High-Content Detection of Carbapenem-Resistant Enterobacterales
rHuEPO-α Biosensing by Porous Silicon Integrated into Microchannels via Reflectometric Interference Fourier Transform Spectroscopy
Reconfiguration/Immobilization “Dual-Free” Self-Powered Multiplex Photoelectrochemical Strategy for Dual Magnetic Bead-Mediated Dimension Differentiate Type Complex Sample Assay
Breaking the Sensitivity-Specificity Trade-Off: A Nanoconfined Dual-DNA Aptamer Synergy Strategy
Development of a Cell Membrane-Anchored Aptamer Sensor for IL-2 Detection In Situ
Property Characterization of Leucine-Integrated Oligonucleotide
Diagnosis On-Demand: Field Evaluation of Microfluidic Paper Device for the Detection of Asymptomatic Malaria
Real-Time Bacterial Monitoring and Drug Screening Using the Interdigitated Wave-Shaped Biosensor (IWE), Combined with FEM and Molecular Docking Studies
Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device
Dual-Amplification CRISPR Biosensor for Ultrasensitive miRNA Detection: A Powerful Tool for Cancer and Immune Monitoring
Highly Sensitive Detection of Let-7a in Different Tumor Cells Based on a Dual Cascade Signal Amplification Strategy
Reliable Post-SELEX Design of Promising Bivalent Aptamers through the Systematic Capillary Electrophoresis Exploration of Ternary DNA–Protein Complexes
Pericyte Biomarkers for Ischemic Stroke: Potential and Prospects
Expanding Carbon Electrode Area and Drifting Reference Electrode Potential in Screen-Printed Electrode Strips
Digital SERS Nanostructured Platform for Amplification-free Single-Molecule DNA Detection and Pre-Symptomatic Diagnosis of Kiwifruit Soft Rot
67
Manganese Pyrophosphate Mineralized DNA Nanovaccine Elicits Potent Humoral and Cellular Immunity
Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection
Mitochondria-Targeting Moieties Based on N-Tethered Pyridinium Cations
An Oxygen Self-Sufficient Nanozyme Engineered From Metal–Organic Cage for Dual-Modal Self-Reporting Theranostics
A Portable Colorimetric Device for Rapid Bacterial Detection with Cleavable Functional Nucleic Acid Probes for A Common Bacterial Endoribonuclease
Dual‐Channel Interdigitated Aptamer‐Based Sensors for Rapid Small‐Molecule Detection in Biofluids
SPECTRAL: An Intelligent and Ultra-Sensitive Photonic Hydrogel Platform for Biomarker-Based Cancer Prediction
Structure-Encoded Oxidation Enables Nucleotide-Resolved RNA Editing, Conjugation, and Structural Probing
A NIR-Gated Nanogenerator Enables Low-Dose Nitric Oxide-Potentiated Phototherapy
Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry
A Real‐Time Antifouling Multivalent Aptamer Platform for Wash‐Free Electrochemical Detection of Low‐Abundance Biomarkers in Human Plasma
Mechanism-Guided Precision Hydrolysis of Early Transition Metals to Access (Mixed-Metal) Oxo Clusters
Rapid Discrimination of Single-Virus Entry Pathways via a Bioorthogonal Activatable Fluorescent Probe
Remote Molecule Activation in Living Mice Triggered by Therapeutic Ultrasound
The Precise Modulation of Probe Effective Charges by Debye Length for Enhancing Performance of Aptamer–FET Biosensors
Near‐Infrared‐Activated Multiphoton Photocatalytic System for Synergistic Therapy via CO Generation and •OH Production
Enhanced-mRNA Delivery Using Ultrasound-Delivered Anchors for Bioorthogonal Ligation
Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering
Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples
Manganese-Coordinated Polyvalent Aptameric System (COMPASS) Enables DC-Targeted mRNA/Mn2+ Co-Delivery for Cancer Immunotherapy
Thiourea-Functionalized Ionizable Lipids Enable Systemic mRNA Delivery to Secondary Lymphoid Organs and Dual-Modal Lymphatic Metastasis Imaging
A Nonviral Neo-Nucleocapsid for Cell-Specific RNA Delivery Developed by Pseudo-Cyclic Peptide Grafting and Directed Evolution
Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction
A Label-Free Phosphate-Transfer DNAzyme for the Cost-Effective Point-of-Care Detection of Influenza Virus
Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters
CO/H2S Dual Prodrugs Activated by Proximity-Enhanced Chemiexcitation for Suppression of Tumor Growth and Metastasis
Point-of-Care Diagnosis of Respiratory Viruses at Single-Nucleotide Resolution with an Autocatalytic Rolling Circle Amplification System
Microcondensate-Mediated Intracellular Infusion of mRNA Across the Plasma Membrane
Harnessing Deaminated DNA to Modulate mRNA Translation for Controlled and Sequential Protein Expression
DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica
Small-Molecule Probes Enhance in Vivo Field-Effect Transistor-Based Biosensing by Overcoming Debye Length Limitations
Bioorthogonal RNase L Recruitment Enables Targeted Inducible Degradation of SARS-CoV-2 RNA
Zinc‐Coordinated Lipids: Facilitators for Enhanced mRNA Delivery Efficacy
Tungstotellurate(VI)-Based Nanocomposite Inhibits Breast Cancer Proliferation and Metastasis by Enhancing Cuproptosis and Apoptosis
ATP-Powered Signaling Between Artificial and Living Cells
Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides
Single-Cell Antimicrobial Susceptibility Testing via Stimulus-Responsive Resonance Raman Scattering Imaging
Ultrasensitive Digital Immunoassay in Homogenous Format by Singlet‐Oxygen Activated Up‐conversion Luminescence
Stabilizing Cu3+ Active Center by Intramolecular Electron Transfer for Boosting Complete Glucose Electrooxidation
A Reusable Substrate for Capture and Red Light‐Responsive Release of Circulating Rare Cells with High Cytoactivity
A Modular Platform for Enhanced Drug Delivery to Glioblastoma Using Targeted Multidomain Protein Assemblies
Individual Virus Detection by Peptide–Gold Nanocluster-Assembled Artificial Binder
Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator
A Versatile DNAzyme-Amplified Protease-Sensing Platform for Accurate Diagnosis of SARS-CoV-2 and Reliable Classification of Colorectal Cancer
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
Sub‐1 nm CuO‐Phosphomolybdic Acid Nanosheets for Ultrasound‐Controlled Pyroptosis Activation and Tumor Immunotherapy
Accelerating Responsive RNA Release Through Structural Optimization of Disulfide‐Containing Acyl Groups
Engineering Neural Stem Cells with Micropatches for Improved Therapy of Traumatic Brain Injury
Green Fluorescent Protein SELEX: Immobilization Chemistry and His‐Tag Epitope Bias
Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block iN/isup1/sup‐Methylpseudouridine Triphosphate
Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions
Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors
Dual‐Responsive Ultrathin Polymersomes with Reversible Transitions on Acidochromism and Fluorochromism Performances for Multiple Information Encryption
Supramolecular Polyanions as Effective Interphase Layers for Anode‐Free Lithium Metal Batteries
Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the piK/isuba/sub of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo
Surface Engineering of Hollow Microreactors with Catalytic Nanobrushes for Orthogonal Tandem Catalysis
Enhancing Clinical Detection Accuracy of Large Structured Viral RNA via DNAzyme Cleavage and Antisense‐Assisted Rolling Circle Amplification
Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry
Stimuli‐Responsive Catenane‐Branched Dendrimers with Tunable Dimension for Reversible Guest Binding
Chiral Supramolecular Clamps for the Passive Cell Diffusion of DNA and siRNA
A Combined Aptamer Pulldown‐DNAzyme Cleavage Assay for Intact Methicillin Resistant iStaphylococcus aureus/i Cells
Erasable Fluorescence Imaging Technology Enables Continuous Tracking for Identical Living Cells
Synthesis of Sensitive RNAs Using Fluoride‐Cleavable Groups as Linkers and Amino‐Group Protection
An Engineered Multivalent TMV Nanodisk Platform for Modulating Integrin Clustering and Cell Signaling
DNA Nanotubule‐Based Nanodevices with ATP‐Responsive Gating for Direct Cytosolic Delivery of Nucleic Acids and Proteins
AM-DMF-ddRPA: an All-in-One Digital Microfluidic Platform for Rapid and Automatic Digital Nucleic Acid Analysis
High‐Fidelity In Vitro Packaging of Diverse Synthetic Cargo into Encapsulin Protein Cages
9
Association between Plasma P‐tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease
Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media
Electrical Impedance Myography Detects Disease Progression over 12 to 24 Months in Facioscapulohumeral Muscular Dystrophy
When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ-PET Centiloid 15, Mean Age of 66 Years
Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease
A Novel Transcriptional Slippage Mechanism Rescues Dystrophin Expression from a DMD Frameshift Variant
Predictive Value of Plasma Biomarkers in Tau-PET Transitions
Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau scpPET/scp Clocks
Co‐Opting scpMBNL/scp‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy
7
A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease
TBXAS1 deficiency causes autoinflammation responsive to IL-6 inhibitor
Blocking the neonatal Fc receptor as a novel approach to prevent cardiac neonatal lupus: a proof-of-concept study
Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models
Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial
Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature
Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis
1
Combustion structuring of 3D nano- and microspheres: Advances and prospects for catalysis and energy storage
5
Performance enhancement of Love wave sensor via a cost-effective and robust dual-layered waveguide
Rapid malaria detection using a spin Hall magnetoresistance sensor
Early diagnosis of Parkinson's disease by highly sensitive monitoring of glucose using an atomic-level defect-enriched MoS2/Au SERS sensor enabled by LSPR-PICT synergy
CoSe2 nanoparticles catalyzed the formation of Cu-BTC polyhedral nanoframes enabling biosensing of endogenous opioid peptides
Label-free and ultra-low concentration detection of gastric cancer biomarker miRNA 106a using In-Sn-Zn-O thin-film transistor biosensor
3
Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis
Single‐cell transcriptomic analysis on multi‐subtypes of idiopathic inflammatory myopathy reveals pathological hallmarks associated with stromal stem and immune cells in damaged skeletal muscles
Mesenchymal Stromal Cell Therapy Alleviates Lupus Nephritis Through Inhibiting Caspase‐4/5/11‐mediated Noncanonical Pyroptosis in Macrophages
14
High-dimensional spatiotemporal single-cell atlas and 3D imaging of the bone marrow microenvironment during CML progression
Defective cerebrovascular development in mice lacking TFPI is restored by activated protein C
Von Willebrand factor deficiency impairs angiogenesis via angiopoietin-2: relevance for gut angiodysplasia
NXTAGE: a phase 1/2 study of NXT007 to assess safety, pharmacokinetics, and efficacy in hemophilia A without inhibitors
Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming
A compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/−-mediated clonal hematopoiesis
Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease
CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis
The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy
An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells
Factor IXa and Factor X Influence Factor VIIIa Stability and Inactivation Mechanisms In Vitro and In Vivo
Marstacimab Prophylaxis in Hemophilia A/B Without Inhibitors: Results from the Phase 3 BASIS Trial
Tracking iclusterin/i expression in hematopoietic stem cells reveals their heterogeneous composition across the life span
Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study
16
Benchmarking long-read sequencing approaches to resolve facioscapulohumeral dystrophy locus complexity
Plasma pTau 217:β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology
Combined magnetic resonance imaging and serum analysis reveals distinct multiple sclerosis types
Muscle transcriptomics of alpha-sarcoglycanopathy highlights inflammatory pathways driving disease
Neurofilament light chain as a prognostic marker in cerebral adrenoleukodystrophy
iIn vivo/i self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease
Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle
Aberrant lysosomal dynamics disrupt myogenesis via mTORC1 signalling in X-linked myotubular myopathy
CSF proteomic profiles related to cognitive decline in MCI A+ depend on tau levels
Interleukin-17B is a new biomarker of human muscle regeneration in dystrophinopathies
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum
Remyelination of chronic demyelinated lesions with directly induced neural stem cells
Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy
Deciphering iDST/i-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy
Disease spectrum and long-term prognosis of patients with iBAG3/i-associated neuromuscular diseases in Europe
Neuropathologic correlates of distinct plasma biomarker profiles in community-living older adults
1
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions
1
Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration
16
2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency
Hyperinnervation inhibits organ-level regeneration in mammalian skin
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
Fertilization triggers early proteomic symmetry breaking in mammalian embryos
RNA innate immunity constitutes a barrier for interspecies chimerism
Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson’s disease
Tumors hijack macrophages for iron supply to promote bone metastasis and anemia
Fibroblast bioelectric signaling drives hair growth
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells
A mechano-resistance mechanism in skin adapts to terrestrial locomotion
An alternate receptor for adeno-associated viruses
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
A percolation phase transition controls complement protein coating of surfaces
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling
1
Divergent viral phosphodiesterases for immune signaling evasion
3
The gut microbiota shapes the human and murine breath volatilome
A closed-loop cholesterol shunt controlling experimental dyslipidemia
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
19
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo
Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification
Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness
A peripheral glial niche orchestrates the early stages of skin wound healing
Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
Hypoxia promotes airway differentiation in the human lung epithelium
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
An inducible model of human post-implantation development derived from primed and naive stem cells
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease
Chemical reprogramming of human blood cells to pluripotent stem cells
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity
Human airway submucosal gland organoids to study respiratory inflammation and infection
40
Beyond the cell membrane: subcellular organelle-targeted nanomedicines
Cation-exchange-derived Cu1.8S–Fe0.8S nanocomposites for the construction of a photothermal immunoplatform toward sensitive alpha-fetoprotein assay
Photocatalyst encapsulation and amidation-mediated cell anchoring for advancing photosynthetic biohybrids
Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins
Chemical proteomics-based identification of artesunate as a POLH–PHB1 interaction disruptor
A multiplexed self-powered biosensor for ultrasensitive on-site detection of trace cisplatin via catalytic repurposing
Traceable gene delivery using minimalistic far-red fluorescent pseudodendrimers
Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems
ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy
A dual-mode aptasensor integrating ratiometric fluorescence and colorimetry for on-site Cu2+ detection
A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox
Potassium ion fluorescent sensing in chemically stimulated mammalian cells using a GINKO2-encapsulated sensor fibremat
Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies
Mitochondria targeting by a nonionic and emissive push–pull type chromophore or its polymer conjugate
Differential self-assembly of sequence-isomeric phosphoestamers
A DNAzyme-induced disposable strip biosensor for visual detection of trace levels of UO22+ in remote areas
Functionalized nanopipettes for pH-gated single cell DNA delivery
Photoelectrochemical assay for E. coli based on CBT–Cys-guided rolling circle amplification
Coupling calcination with sulfidation strategy to fabricate a hydrophilic bimetallic transition nanozyme for boosting antibacterial efficiency
Fluorescent protein display on cellular mimic enables rapid and accurate identification of natural killer cell phenotypes
CRISPR-coupled triple cascade amplification for simultaneous lateral flow detection of Mycoplasma pneumoniae and H1N1
Intracellular biosensors by functional nanomaterial-integrated CRISPR technologies for real-time molecular sensing
Combining aptamers for thiamphenicol and chloramphenicol for detecting both antibiotics
Unraveling the mechanisms behind porous calcium phosphate ceramics-instructed osteoinduction: a systematic review
A pseudo-circular DNA walker-mediated electrochemical biosensor for sensitive detection of the apolipoprotein E4 gene
Epitope bias in antibody affinity assays arising from charge-dependent orientation in carbodiimide-mediated protein immobilization using β2-microglobulin as a model antigen
Continuous ethanol monitoring in skin gas using a screen-printed biosensor
Systematic evaluation of 2′-O-methyl RNA antisense oligonucleotides with limited phosphorothioate linkages for efficient splice switching
C–SiO2 hollow nanostructures by a pseudo-hard-template route for outstanding perfluorooctanoic acid removal
Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity
FLOWER: a frequency-locked optical whispering evanescent resonator for label-free molecular detection
Maximising the translation potential of electrochemical biosensors
Nucleus-targeted protein delivery via lysine dendron conjugation
Rapid detection of antibiotics using self-developed electrochemical analyzer and sensor chip
Smartphone-assisted tuberculosis detection by a smart amplification process and lateral flow immunoassay with a 3D-printed device
Revealing the effects of the cell cycle on cellular uptake of nano-drugs at single particle level
Amino-modified high-surface-area radial-pore silica microspheres for efficient perfluorooctanoic acid removal
Single nanoparticle analysis-based CRISPR/Cas12 bioassay for amplification-free HIV detection
Ferrocene-functionalized COF-derived Fe single-atom dispersed N-doped porous carbon for enhanced electrochemical sensing of chloramphenicol
iS/i-Nitrosylated Au@COF nanohybrids for synergistic light-nitric oxide killing of bacteria
18
A high-affinity dopamine aptamer: implications of library diversity and negative selection
A platform to design and optimise fluorogenic scFvs for detection of interleukin 33
A robust Au–C≡C anchoring group greatly improves the signal stability of electrochemical aptamer-based sensors for in vivo measurements
Time-ordered-expression mRNA (TOE mRNA) for melanoma RNA vaccines
Degradable polyphosphoester-based aqueous two-phase systems and water-in-water emulsions
Atomic Ce sites promote a four-electron pathway of Pt as NADH oxidase mimics for in situ coenzyme regeneration
Emergence of fluorescent aggregates through hierarchical self-assembly
A preliminary profile of RNA bound on the cell surface
Ultrasound-triggered prodrug activation via sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold
A simple epoxide modification strategy to construct amino-functional poly(2-oxazoline) mRNA delivery vectors
Self-assembled block copolymer domains as macromolecular ion transport systems in biological membranes
A nanozyme that can go beyond an enzyme: the selective detection of two species in the same whole blood sample
A general transition metal binding aptamer following the Irving–Williams series
Multi-dimensional analysis of single particles with sequential dual-nanopipette sensors
A mitochondria targeted nitroreductase-sensitive self-immolative spacer as an efficient shuttle for uncharged amine-based molecules
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking
Multi-site orbital coupling in Ru-based high-entropy alloy-enabled hydroxyl spillover for enhanced peroxidase-like activity
Aptamer single-molecule dispersion on single-atom anchoring sites for high-selectivity in vivo detection
2
MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis.
Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.
7
Performance Evaluation of the Xpert® HCV test on Fingerstick Blood in a Prospective Observational Clinical Study at CLIA-Waived Sites in the United States
Diagnostic Accuracy of Molecular Testing on Saliva and Oral Swabs for Pulmonary Tuberculosis
Microbial Detection in Community Acquired Pleural Space Infection Using the BioFire Joint Infection Panel and Individual PCR Assays
Predicted Preferences for Tuberculosis Point-of-Care Tests among Tuberculosis-Affected Individuals in Five High Burden Countries
Independent Testing to Accelerate the Development of Lateral Flow Assays for Influenza A, Influenza B and SARS-COV-2
Cost-effectiveness of Targeted Next-Generation Sequencing for Tuberculosis Drug-resistance Testing as an Alternative to the Standard of Care in South Africa
Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting
1
Diagnostic Performance of Point-of-Care Immunoassay Measurements of Pancreatic Stone Protein for Sepsis Detection in ICU Patients: A Prospective, Multicenter, Biomarker-Blinded Study.
7
Songbird connectome reveals tunneling of migratory neurons in the adult striatum
Drift of positional identity drives reproductive aging in a long-lived regenerative animal
Totipotency and high plasticity in an embryo with an invariant, fate-specifying cleavage program
Ectopic head regeneration after nervous system ablation in a sea anemone
Ultrastructural reconstruction of the endodermal nerve net of Hydra vulgaris
Transcriptional interference gates monogenic odorant receptor expression in ants
Live imaging endogenous transcription factor dynamics reveals mechanisms of epiblast and primitive endoderm fate segregation
9
A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy
Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation
MYRF controls mesothelium specification, signaling, and plasticity in lung development
Dual role of Oct4 and Sox2 in controlling the developmental capacity and timing of tissue morphogenesis in the embryonic lineage
Proteomics-based multi-omics identifies the roadmap of transcription-translation-protein dynamics in planarian regeneration
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Efficient stem cell-derived mouse embryo models for environmental studies
TAF1 is required for fetal but not adult hematopoiesis in mice
Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues
1
Baseline Risk and Longitudinal Changes in kidneyintelX.dkd and Its Association With Kidney Outcomes in the CANVAS and CREDENCE Trials.
1
Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.
6
Subchronic, low-frequency polystyrene microplastic or nanoplastic exposure elicits molecular perturbations but minimal clinical phenotypes in the mouse gut-brain axis
CuO Nanoparticles Trigger Cuproptosis-Linked Mitochondrial Damage and Gut Microbiota–Metabolome Disruption in Zebrafish
Machine learning frameworks for predicting pulmonary cell toxicities induced by metal ions in the atmosphere
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization
A sensitive colorimetric immunosensor for clozapine, norclozapine, and clozapine-N-oxide simultaneous detection based on monoclonal antibodies preparation with homogeneous cross-reactivity☆
Amplified toxic effects of nanoplastic composite norfloxacin on liver cells in mice: Mechanistic insights and multiscale evaluation
3
Immunomodulatory effects of Tritan copolyester on human neutrophils
Immune profiling of human blood cells after indirect exposure to crystalline silica particles
Integration of the exposome concept into health risk assessments: a challenge for health safety agencies
17
Deposition Patterns of Carbon Black Nanoparticles in Pulmonary Lobes and Airway Generations: Implications for Lung Remodeling
MXene-Based Nanoconfined Ion Channels for Ultratrace Detection of Short-Chain Per- and Polyfluoroalkyl Substance Trifluoromethanesulfonic Acid and Its On-site Application
Usage Analysis and Multicriteria Alternative Assessment of Alternative Plasticizers: Are They Safer Alternatives?
Method Development and Sensitivity Optimization Paradigm for One-Step RPA-CRISPR/Cas12a Rapid Detection of the Hard-to-Amplify Gene blaNDM
Biotransformation of Atmospheric-Aged Metal-Sulfide Nanosheets in Respiratory Tract Fluids Potentiates Ferroptosis toward Alveolar Macrophages
Nucleation-Mode-Particle Emissions from Biosolid Processing Plants
The Analysis and Assessment of Exhaled VOCs in Adults under Ambient Ozone Exposure
Polysaccharide Hydration Networks Suppress Pyrophoricity and Preserve Reactivity of Iron Nanoparticles for On-Demand Environmental Remediation
Highly Sensitive Bioactivity Assessment of Thyroid-Disrupting Chemicals in Human Samples across the Entire Exposome Landscape
Deep Learning-Enabled Unbiased Precision Toxicity Assessment of Zebrafish Organ Development
Advanced Breathomics Reveals Human Absorption of Exogenous Volatile Organic Compounds
ZnO-NPs Neurotoxicity to iCaenorhabditis elegans/i: Disorders of Fatty Acid Synthesis and Glutathione Metabolism
Portable Real-Time Detection of Hydrogen Sulfide in Wastewater Using a Pt/CrWN2-Based Electrochemical Sensor
Ultrasensitive Nanofluidic Detection of 17β-Estradiol in Natural Water by DNA Circuit-Mediated Hyperbranched DNA Nanowire Dual-Signal Amplification
Continuously Responsive Surface-Enhanced Raman Scattering Sensors for Long-Term On-Site Free Chlorine Monitoring in Aquatic Environments
Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials
ExposomeX: Development of an Integrative Exposomic Platform to Expedite Discovery of the “Exposure−Biology−Disease” Nexus
1
Heart allograft rejection: molecular diagnosis using intra-graft targeted gene expression profiling
1
KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity
4
Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation
OMKar automates genome karyotyping using optical maps to identify constitutional abnormalities
A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress
A new compression strategy to reduce the size of nanopore sequencing data
1
CD177+ neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration
1
GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses.
2
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo
6
Breaking the “Industrial Vitamin” Paradigm: La-N4 Single-Atom Sites Enable Highly Active Multicomponent Electrochemical Sensing in Tear Fluid
Ru Nanoparticles Ligated by an N-Heterocyclic Carbene Derived from Uracil Nucleoside as Selective Antimicrobial Agents
Biodegradable Ca-MOF Nanoplatform with Intracellular H2O2-Triggered CO Release to Augment Mitochondrial Ca2+ Overload for Synergistic Cancer Therapy
Fluorescent Microneedle Sensors Based on Tb3+@Hydrogen-Bonded Organic Frameworks for Real-Time Food Freshness Monitoring
Polyethylenimine-Mediated Assembly of Dual-Emissive CsPbBr3@SiO2@EuW10 Composite Nanospheres for Ratiometric Detection of 2,6-Dipicolinic Acid
Metal–Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO2@PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing
1
Benefits and Harms of Dementia Screening for Family Members of Older Adults
20
Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation
A comprehensive discovery platform for ELOVL1 small-molecule inhibitors targeting very long-chain fatty acid synthesis in adrenoleukodystrophy
Profiling of fatty acids and lipids in animal and human tissues yields new leads for disease progression biomarkers of X-linked adrenoleukodystrophy
Sustained β-catenin activation via GSK3 inhibition promotes direct fibroblast-to-cardiomyocyte reprogramming
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines
The RING E3 ligase RLIM drives oxidative stress-induced stem cell dysfunction through MDM2-p53 signaling
Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers
Oligomer-dependent and -independent pathogenesis of muscular dystrophy-associated mutations within the penta-EF-hand domain of calpain-3
Topologically associating domains define the 3D genome architecture of mouse totipotent-like stem cells
Transient receptor potential vanilloid four in macrophages mediates TGF-β activation to drive myofibroblast differentiation and pulmonary fibrosis
Structural and Functional Insights into Calmodulin-Mediated Lipid Binding and Proteolytic Cleavage of the M-PMV Matrix Protein
Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors
Calcitonin gene-related peptide inhibits macrophage migration and differentiation via the GTPase Rap1
Scalable purification enables high-quality virus-like particles for therapeutic translation
Mutations in Hsp40 co-chaperone change the canonical interdomain interactions stimulating LGMDD1 myopathy
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins
The growth factor FGF21 maintains neuromuscular junction through histone deacetylase HDAC4 in denervation-induced skeletal muscle atrophy
The impact of pH on proteolytic activity in wound fluid: Implications for acid therapy
SMAD1/5-mediated recruitment of the histone demethylase KDM1A controls cell fate programs in embryonic stem cells
Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis
4
Comparative Efficacy of Surgical Versus Nonsurgical Management for Acute Achilles Tendon Rupture in a Novel Mouse Model.
Prevascularized Bone Marrow-Derived Mesenchymal Stem Cell Sheets Promote Tendon-Bone Integration in Rotator Cuff Repair.
Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament.
Bezeotermin Alfa (rhBMP-6) Administration in Lumbar Interbody Fusion Surgery Using a Posterior Approach
4
Implementing Safe and Sustainable by Design (SSbD) into pharmaceutical innovation
Structure-guided and sustainable engineering silk sericin powder with improved storability, redissolution, and biocompatibility
Life cycle assessment of enzymatic and non-enzymatic electrochemical sensors: A comparative study using glucose oxidase and metal nano-catalysts
Selenium-doped NiCo2O4 drives nanozyme innovation: new ideas in water disinfection
2
Insulin Receptor Family Autoantibodies in Patients with Type B Insulin Resistance
Effect of rhGM-CSF in promoting wound healing via macrophage immunomodulation
23
Deficiency of muscular dystrophy-related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells
Modulation of WNT and FGF18 enhances yield and subtype identity of hPSC-derived midbrain dopamine neurons
Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy
BM-derived mesenchymal stem cell microvesicles protect enteric neural precursor cells and alleviate diabetes-associated enteric neuropathy
Type 2 deiodinase–dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice
Hyperactivation of mTORC1 signaling mediates folliculin deficiency–induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration
Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation
PDGFRβ signaling restrains myocyte function to limit the regenerative capacity of skeletal muscle
Combined FXIII-C3 autoantibodies elicit bleeding and complement dysfunction in autoimmune FXIII deficiency
Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and Promote Hematopoietic Stem Cell Fitness
Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair
Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice
Five-year analysis of efficacy and safety of a bidirectional AAV gene therapy in Tay-Sachs sheep
TFIIH-p52∆C defines a ninth xeroderma pigmentosum complementation-group XP-J and restores TFIIH stability to p8-defective trichothiodystrophy
Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model
Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice
Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss
Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy
The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice
Sarcospan protects against LGMD R5 via remodeling of the sarcoglycan complex composition in dystrophic mice
Expression of full-length dystrophin reverses muscular dystrophy defects in young and old mdx4cv mice
2
Canine Olfaction Combined With Bayesian Modeling for Multicancer Detection From Breath Samples: A Phase II Study in India.
Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026).
2
Mechanometabolism instructs hematopoietic stem cell specification
Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system
3
IFRD1 orchestrates hepatocyte metabolism and macrophage interactions to facilitate liver regeneration
Setd4-expressing cells drive regenerative recovery in chronic liver injury
Transcriptomic and epigenetic mechanisms controlling cholangiocytes transdifferentiation into hepatocytes
1
Whose line is it anyway? Defining sero-positivity cut-offs for infectious disease surveillance
3
Noninvasive suppression of responses to threat using focused ultrasonic waves
Muscle derived BMP4 regulates morphology and function of endplates on extrafusal and intrafusal muscle fibers in adult mice
The Development of Neural Inhibition across Species: Insights from the Hurst Exponent
9
Regimen-dependent glucocorticoid effects improve muscle performance without altering CNS physiology in mdx mice
Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects
Transcranial photobiomodulation with near‐infrared laser induces analgesia in rats
Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis
Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain
Early adaptive and late degenerative tendon response to overload in rat model of synergist ablation
Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons
Efficient in vivo targeting of the myocardial scar using Moloney murine leukaemia virus complexed with nanoparticles
Obligatory and accessory respiratory muscle structure, function and control in early and advanced disease in the mdx mouse model of Duchenne muscular dystrophy
77
A Zeolite-MOF Synergy: Multi-Shell Nanoreactors for Tandem Catalysis
Architecture-Encoded Degradation Kinetics and Pathways through the Shape and Size of Polymeric Vesicles
Diffusion-Mediated Synthesis of Durable High-Entropy Sulfide Nanocrystals: Le Chatelier-Driven and Electron Configuration Effects
Site-Specifically Modified Circular Ribonucleic Acid Serves as Multitarget miRNA Sponge with Low Immunogenicity
Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity
Bioinspired Diffusion-Limited Silicification in Coacervate Assemblies Enables Smart Nanotoroids for Deep and Sensitive Tumor Penetration
High-Affinity Six-Letter DNA XenoAptamer Generation by Genetic Alphabet Expansion
Ultrasensitive Enzyme-Free Detection of Proteins on Magnetic Beads
High-Throughput Aptamer Characterization via Real-Time Nuclease Digestion
Ultrasound-Activated Prodrugs for Tumor-Specific Immunotherapy
Vapor-Induced Negative Expansion of Porous Cross-Linked Polymers Observed by Optical Resonance
Unraveling the Role of Ionizable Lipid Isomerism in Modulating Lipid Nanoparticles for mRNA Delivery
Engineering Polymer–Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery
Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo
Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing
FAP-Synergistic Organ-Targeted mRNA-LNP for Overcoming Delivery Barriers in Hepatic and Pulmonary Fibrosis
Structure–Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia
Electrochemomics Profiling Metabolic Dynamics in Biofluids
Aromatic Ionizable Lipids Enhance mRNA Delivery via Coordinating Multiple Mechanisms
Synchronous 3D-DNA Walking-Driven Dual-Color RNA Aptamers Lighting-Up for Label-Free and Attomolar Profiling of Multiple circRNAs in Breast Cancer
Mirror-Image L-DNA Aptamers Enable Stable In Vivo Dopamine Sensing
BODIPY-Doped Nanocarrier Engineering (BONE) Improves Bone Marrow mRNA Delivery by NIR-II Bioimaging Guided Screening
Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry
Tailoring Square-Shaped 2D Mesoporous Nanosheets via an Interface-Confined Anisotropic Assembly Strategy
Characterizing the Impact of the Cell Cycle on mRNA Lipid Nanoparticles
Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity
A General Approach to Stereoregular Pseudo-Polysaccharides: Cationic Ring-Opening Polymerization of Monosaccharide Cyclic Thionocarbonates
Evolution of Cross-Linking Aptamers for Long-Lasting Membrane Protein Labeling
Active Polymer-Templated Porous Metal Oxide Nanospheres with Tailored Single-Atom Modification for Olfactory Intelligence
oShark: A Modified Nuclease-Resistant Light-Up Aptamer
Autonomous Exponential Amplification via Rolling Circle–DNAzyme Feedback Programming
From Bits to Bonds: High-Throughput Virtual Screening of Ribonucleic Acid Nanocarriers Using a Combinatorial Approach of Machine Learning and Molecular Dynamics
Lipid Nanoparticle Chaperone with Redox-Adaptive Intracellular Microenvironment Modulation Potentiates the Potency of mRNA Vaccines
Thioketal-Incorporated Biodegradable Lipid Nanoparticles Deliver mRNA to Ductal Epithelial Cells for Improved Pancreatic Cancer Treatment
An O2-Independent Copper(II) Phototherapeutic Agent for Photoactivating H2O2 to Enhance Antitumor Immunotherapy
Hydrogen Bond-Assisted Two-Component Lipid Nanoparticles for Spleen-Specific mRNA Delivery
Glycolipids Substitute PEG lipids in Lipid Nanoparticles for mRNA Delivery
A General Synthesis Strategy for Alkali Metal Halide Nanosalts
Fluorinated Ionizable Lipids for Efficient Spleen-Targeted mRNA Delivery in Cancer Immunotherapy
Personalized Cancer-Specific Protein-Aptamer Corona for Orthogonal Multiplex Cancer Diagnosis
Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for In Vivo Targeting of Prostate Cancer Xenografts in Mice
Quantum Defects Engineered in Chirality Pure Single-Wall Carbon Nanotubes for Enabling Ratiometric Sensing of Insulin
Targeted RNA Degradation via LipoSM-RiboTAC Nanoparticles: A Versatile Platform for Cancer Therapy
Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA Accumulation
Cleavable Hydrophobic Anchors Optimize Immunomodulatory Effects of Oligonucleotides
Spatial Conformation of Ionizable Lipids Regulates Endosomal Membrane Disruption
Tuning Core Flexibility and Curvature in Azine-Linked Covalent Organic Frameworks for Attomolar-Level Impedimetric Sensing of Glucose
Nitric Oxide Oxygenation Reaction in Water at Room Temperature inside a Cage
Structural Analysis of Valine Residues in Silk Fibroin by Solid-State NMR
Programming Aptamer–Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure
Strain-Promoted mRNA Transdermal Delivery by Lipoic Lipid Nanoparticles for Therapeutic Skin Genome Editing
Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks
Localized 2′-OH Acylation at Poly(A) Extends RNA Translation
Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy
Exploring the Structural Divergence of HIV and SRLV Lentiviral Capsids
mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid Nanoparticle Endosomal Escape and Membrane Damage
Ultrasound-Activatable Lipid Nanoplatform for Region-Confined Innate Immune Stimulation and mRNA Vaccination Therapy of Cancer
Controlled Dimerization of Cellular Nanodiscs via Click Chemistry to Enhance Immune Compatibility
Ternary Interactions Balance Enabled Sequential Assembly toward the Synthesis of Hierarchically Mesoporous Metal Hydroxide Nanoparticles
Carbonate-Bearing Ionizable Lipids for mRNA Delivery to Splenic NK Cells
Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides
The Overlooked Stereoisomers of the Ionizable Lipid ALC315
Amplifying Engineered Bacterial Outer Membrane Vesicle Production Using Functional Peptidoglycan Inhibitors
De Novo Design of High-Performance Cortisol Luminescent Biosensors
Structurally Dynamic Polyplexes Enhance Sentinel Lymph Node Delivery of Antisense Oligonucleotides to Inhibit Breast Cancer Recurrence and Metastasis
Combinatorial Synthesis and Evaluation of Trialkyl Galloyl Amidoamine Ionizable Lipids for mRNA Formulation
Compartmentalized Suspension Array for the Isothermal, Digital, and Multiplex Detection of microRNAs
Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery
DNA Aptamer-Guided Glycomimetics for Developmental Stage-Specific Glycocalyx Engineering to Control Stem Cell Differentiation
Speed Matters: Directed Assembly of Icosahedral HPV Virus-Like Particles
Harnessing the Electron-Withdrawing Inductive Effect of One-Component Ionizable Amphiphilic Janus Dendrimers Unveils Cation−π Interactions and Their Important Roles to Targeted mRNA Delivery
Ultrasound-Triggered Activation of p-Azidobenzyloxycarbonyl-Based Prodrugs via Radical-Mediated Cascade Elimination
High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells
Open the Pores: Particles with Fully Accessible Hierarchical Pore Networks by Controlling Phase Separation in Confinement
Degradable Diblock Copolymer Vesicles via Radical Ring-Opening Polymerization-Induced Self-Assembly in Aqueous Media
A Multi-Threshold Micelle Improves Tumor Accumulation and STING Immunotherapy
RNA Editing-Mediated Correction of TP53 Nonsense Mutations via Lipid Nanoparticle-Delivered Circular ADAR-Recruiting RNAs
1
<atl>Longitudinal Associations Between Neurodegenerative Biomarkers and Cognitive Decline in Older Adults: Insights From the scpLASI/scp ‐ scpDAD/scp Study</atl>
1
Overexpression of Thrombomodulin in Adipose-Derived Mesenchymal Stem Cells Reduces Thrombogenic Risk and Enhances Therapeutic Efficacy.
3
Architecting Well-Defined Glyco-Nanoparticles from pH- and Temperature-Responsive Glycosylated Triblock Terpolymers
Robust Artificial Spider Silk via Synergistic Cross-Linking of Slide-Ring and Covalent Bonds
Efficient Access to Functionalized Mesoporous Materials with Bicontinuous Morphologies via a Kinetic Approach
2
Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development
5
Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing
Long-lived adult-born hippocampal neurons promote successful cognitive aging
Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders
Diagnostic performance of Alzheimer’s disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment
Associations between trajectories of plasma biomarkers for Alzheimer’s disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank
51
Nanocarrier-Based Cell Nucleus Delivery of Therapeutic Proteins
Meta-Learning as a Promising Strategy for Lipid Nanoparticle Optimization and Ionizable Lipid Discovery
Mitofusin-Decorated Extracellular Vesicles Enable Targeted Nucleic Acid Delivery to Mitochondria
Chemotaxis of ATPase-Powered Nanoparticles up Extra- and Intracellular ATP Gradients
On-Demand Switching of a pH/ROS-Responsive Ce Single-Atom Nanozyme Spray for Infected Wounds
Evolution of Aptamer Materials Maps Exosomal Surface Proteins at the Nano–Bio Interface
High-Curvature Features Improve Targeting of Nanoconstructs with Small-Molecule Ligands
Single Microbead Floating/Sinking-Enabled Digital Biosensing
Polyphenol-Engineered Bimetal Oxides Promote Stem Cell Differentiation via Immune Microenvironment Reprogramming
Balancing Multivalent Avidity and Receptor Availability Governs mRNA Delivery by Antibody-Functionalized Lipid Nanoparticles
Bioengineered Protein Stabilized Perovskite Nanoplates in Polar Solvents
Mass Spectrometry-Assisted High-Throughput Discovery of Lung-Specific Lipid Nanoparticles for In Vivo Protein Delivery
Nanoconfinement of Hydrophobic Domains Facilitates Strong Mesoscale Networks in Silk-Inspired Materials
Toward Breath-Based Diagnostics via Water-Mediated Capture of Synthetic Breath Biomarkers in SERS-Active Plasmonic Nanogaps
Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal–Organic Framework Nanoparticles
Adhesive Conductive Hydrogel Interface for Noninvasive Electrochemical Sensing of Nitric Oxide in Plant Leaves and Fruits
Interfacial Electric Locking of the Aptamer Conformation for Accurate Liquid Biopsy Detection
Noninvasive Salivary Ketone Monitoring: A Ratiometric Pdot Biosensor toward Personalized Ketogenic Management
Encapsulation of RNA with DNA Six-Helix Bundle Nanostructures
Label-Free Nanoparticle Characterization via Electrical Impedance-Based Submicrofluidic Analysis
Spatially Controlled DNA Hydrogel–MXCT Nanofluidic Biosensor for Noninvasive Iontronic Detection of Estradiol across the Menstrual Cycle
Continuous and Scalable Production of Multifunctional Phenolic Resin Beads in a Flow System for Portable Water Treatment
Targeted SERS Nanoparticle Accumulation on Bacteria Enables On-Site Accurate Vibrio Typing in 10 min with AI-Powered SERS
A Universal Framework Nucleic Acid Platform for Kidney-Targeted Delivery of Natural Bioactive Compounds
RNA Resolution in an Electric Double Layer Generated by Metal–Organic Frameworks
Single-Atom-Engineered Implant Materials with Lactate Dehydrogenase-Like Activity for Sustainable Bone Repair and Regeneration
Engineering the Size of Bicontinuous Nanospheres via Multi-Inlet Vortex Mixing
A DNA Origami-Based Uricase Nanovehicle for Reducing Blood Uric Acid Levels
Nanopore Fingerprinting of Structurally Diverse Amino Acid-Conjugated Bile Acids
Natural Ginger-Derived Exosomes as Effective Therapeutics for Glioblastoma
Silica Nanobottles Filled with Photo-cross-linked GelMA for the Sustained Release of Hydrophilic Biomacromolecules
All-Polymer and Adhesive Electrodes as Electroceuticals for Chronic Wound Healing
A Pipette-Tip-Based Point-of-Care Test Platform for Detection of MicroRNA at Subfemtomolar Concentrations Using Upconverting Nanoparticles on Microbeads
Smartphone-Based Immune Response Measurement Using a Colorimetric Self-Assembled Plasmonic Biosensor
Fluorinated Covalent Organic Framework Films Modified Graphene Field-Effect Transistor Biosensors with Size-Dependent Sieving and Antibiofouling Effect
High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH)
Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair
Nebulized Lipid Nanoparticles Deliver mRNA to the Liver for Treatment of Metabolic Diseases
Topology Determines DNA Origami Diffusion in Intestinal Mucus
Laser–Ultrasound Responsive Nanoreactor to Remodel the Microenvironment of Antibiotic-Resistant Bacterial Infection for Diabetic Wound Healing
Spatiotemporal Characteristics of the Hierarchical Relaxation Dynamics for Topological Soft Nanoparticles
Multiparametric Characterization of Individual Suspended Nanoparticles Using Confocal Fluorescence and Interferometric Scattering Microscopy with Microfluidic Confinement
Target-Mediated EV-SNA Clustering as an Amplifier for In Situ miRNA Imaging in Living Cells
Crystal-Phase Engineering Enables Al3+ Liberation from Nanoclay for Ion Interference Tumor Therapy
An Ultrasensitive Wearable Nanosensor for Minimally Invasive Self-Screening of Alzheimer’s Disease
Nanopore-Based Electroporation Enables High-Efficiency, Rapid RNA-Mediated Reprogramming of Primary Fibroblasts into Human iPSCs
Engineering DNA Condensate Droplets as a Versatile Nanovector
Acoustic Field Enabled Polymeric Nanoparticle Deposition onto Vessel Walls for Enhanced Drug Delivery
Imaging Low-Abundance, Short Cellular RNAs Using G-quadruplex FISH
Circularization of Aptamer Nanomedicine Improves Nuclease Resistance, Targeted Recognition, and Transdermal Effect for Topical Psoriasis Therapy
A Hybrid Molecule/Graphene van der Waals Heterostructure for DNA Immobilization and Detection
7
Design of one-component quasisymmetric protein nanocages
De novo design of quasisymmetric two-component protein cages
Multicentre gene therapy for -related deafness followed up to 2.5 years
Rete ridges form via evolutionarily distinct mechanisms in mammalian skin
Modelling late gastrulation in stem cell-derived monkey embryo models
Haematopoietic stem cell number is not solely defined by niche availability
Therapeutic genetic restoration through allogeneic brain microglia replacement
14
mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression
A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery
Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments
In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery
Hemodynamics-driven magnetoelastic vascular grafts for stenosis diagnosis
An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery
RNA stability enhancers for durable base-modified mRNA therapeutics
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Elucidating lipid nanoparticle properties and structure through biophysical analyses
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells
Derivation of embryonic stem cells across avian species
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes
Lipid nanoparticle screening in nonhuman primates with minimal loss of life
12
Transcription-independent induction of rapid-onset senescence is integral to healing
A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures
Programmable macromolecule delivery via engineered trogocytosis
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis
Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells
1
A cell-permeable nanobody to restore F508del cystic fibrosis transmembrane conductance regulator activity
1
Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations
279
Polypeptide-engineered lipid nanoparticles for mRNA delivery with limited immunogenicity
Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds
4D metallic metamaterials for bone implants via biodegradation
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice
Global protein-ligand binding affinity profiling via photocatalytic labeling
The perijunctional zone is a molecularly distinct muscle subdomain altered in Duchenne muscular dystrophy
Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury
Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA
Silk-Inspired Design and Manufacturing of Robust Plantymers
Direct carbapenemase typing from disc diffusion antibiograms with MALCA (MAchine Learning CArbapenemase)
Mechanically-activated electrochemical implantable micro-supercapacitors boosting wound healing in the small intestine
ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)
Alzheimer’s Disease blood biomarkers measured through remote capillary sampling correlate with cognition in older adults
CD248 acts as a mechanosensory switch in fibroblast subsets to establish distinct pathological niches in renal fibrosis
Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture
NELFA supports naïve pluripotency and drives 8C-like state in human embryonic stem cells
Cell-free DNA fragmentomics for preeclampsia risk assessment
Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods
Heritable immunization of mice against Lyme disease enables ecological disease prevention
Lifetime chemical sensor arrays of organic fluorophores for bacterial fingerprinting
Epitranscriptomic regulation of mRNA stability in pivotal transcription factors modulates the second cell fate decision
Circulating extracellular microRNAs as tissue-specific biomarkers of human health and disease
A network-based map of the chemical exposome connects molecular interactions to public health
Non-destructive transcriptomics via vesicular export
CAR-CD34 (+) hematopoietic stem/progenitor cells produced in vivo protect against thoracic aortic aneurysm and dissection
Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy
Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida
Single-molecule readout of reversible nanoswitches enables continuous monitoring of low biomarker concentrations
Structure of a contractile injection system in Salmonella enterica subsp. salamae
Mitophagy promotes lung repair and regeneration by restoring epithelial metabolic fitness
Restorative macrophage-derived RNAseT2 stimulates muscle stem cell fusion via an SLK/N-WASP/actin bundling dependent axis
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults
Medullary cavity expansion is mediated by distinct cell populations during fetal bone development
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6
Ultrahigh strength magnesium via solidification of nanocolloid
Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer’s disease continuum
BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation
Gmppb-mutant mice exhibit dystroglycanopathy symptoms that are rescued with GSK3β inhibition or AAV-mediated GMPPB gene replacement
De novo-designed ribozyme-controlled riboregulator for cell-free diagnostics
Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses
Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging
Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation
Engineering multiple levels of specificity in an RNA viral vector
Preventing peritendinous adhesions using lubricious supramolecular hydrogels
Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components
Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness
Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity
Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs
Reinforced biotubes as readily available and regenerative vascular grafts
Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration
Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief
Aptamers with magnetically tunable affinity for divalent cobalt ions
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors
Olfactory cleft biopsy analysis of Alzheimer’s disease pathobiology across disease stages
FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis
A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs
Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations
Label-free mass and size characterization of few-kDa biomolecules by hierarchical vision transformer augmented nanofluidic scattering microscopy
PTBP1 inhibition reprograms myogenesis to rescue impaired muscle regeneration in mdx mice through correcting E2A splicing
Endogenous VEGF signaling acts as a guardian of human primed pluripotency
Compact mid-infrared fiber probe for in vivo multi-compound monitoring demonstrated using ex vivo human skin
Cryo-ET comparison of the hierarchical ultrastructure of silkworm, spider, and artificial silk fibers
Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice
Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment
Reversible surface modifications of functional proteins for accelerated cytosolic delivery via cell-penetrating peptide clusters
Hybrid macrophage-mitochondria extracellular vesicles for mitochondrial ROS regulation in diabetic wounds
Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides
An engineered linear cap-independent mRNA vaccine with intrinsic adjuvanticity induces potent anti-tumor immunity in mice
Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia
Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool
Sono-mechanical nanostructures-enabled sustained precise ultrasound brain stimulation
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling
Structural organization of HBV pgRNA genome driven by phase separation in capsid confinement
Histidine-rich coiled-coils promote zinc-dependent self-assembly and curing of porous mussel glues
Spatiotemporal interplay between epithelial and mesenchymal cells drives human dentinogenesis
Do-it-yourself protein arrays as high-throughput immunoassays enabled by confined droplets on patterned plasmonic chips
FOXF2 regulates pericyte–endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury
PRICE: direct and robust detection of microRNAs at single-nucleotide resolution
Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis
Virus glycoprotein nanodisc platform for vaccine analytics
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice
A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina
Zebrafish macrophages convert physical wound signals into rapid vascular permeabilization
Paper-based fluorescent assay for blood typing and antibody titer determination using long-term ambient-stored bioengineered RBCs
Template-in-template assembly nanostructured microspheres for high performance chromatography
Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model
Organic di-selenide hydrogel microspheres for multimodal treatment of osteoarthritis
Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry
Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation
Multistep receptor binding of the hepatitis B virus preS1 domain
Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair
Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery
Impaired stem cell migration and divisions in Duchenne muscular dystrophy revealed by live imaging
Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo
In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis
Homotypic membrane-powered electrochemical microfluidic analysis of extracellular vesicles for precise cancer diagnosis
RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a
Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer’s disease
Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions
Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering
Ependymoglial cells are critical for cortex regeneration in axolotls
OTX2 inhibits human pluripotent stem cell reprogramming toward 8-cell-like and morula-like states
Molecular heterogeneity of the non-human primate cochlea
CHAMP1 is an essential regulator for human myoblast fusion and muscle development
Chamber-specific chromatin architecture guides functional interpretation of disease-associated -regulatory elements in human cardiomyocytes
Binary mineral nanoparticles enable intravascular delivery of metal ions to tumors for metalloimmunotherapy
Wearable textile-based phototherapy platform with customized NIR OLEDs toward non-invasive hair loss treatment
Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice
Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals market
Tumor agnostic drug delivery with dynamic nanohydrogels
Highly efficient expression of DNA-peptide conjugates in growth-arrested cells
Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones
Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen
Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial
Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk
FGF7 promotes load-bearing tendon regeneration and suppresses fibrosis
Lymphatic–stem cell crosstalk promotes tendon regeneration via Notch1–Srebp2–mediated cholesterol metabolism
Morpholino–RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection
A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines
A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases
Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy
IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3
AAV-delivered engineered suppressor tRNA rescues visual function in mice with an inherited retinal disease
S100B triggers neuroendocrine macrophage networks to drive airway regeneration in mice
Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea
Rapid culture-free diagnosis of clinical pathogens via integrated microfluidic-Raman micro-spectroscopy
Targeted CRISPR-Cas9 screening identifies core transcription factors controlling murine haemato-endothelial fate commitment
Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice
Revealing heterogeneity and damage response in the adult human utricle
Whole body regeneration deploys a rewired embryonic gene regulatory network logic
Dynamic magnetic fields transform pivoting H2SiO3 particles to hollow microspheres with nanofibrous interior
mRNA vaccine developed for sequential selective organ-to-cell targeting of glioma
Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation
Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis
Wnt signaling restores evolutionary loss of robust foot regeneration rates in Hydra
Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation
Multiplexed detection of febrile infections using CARMEN
Breaking the durability barrier with d band optimized Cu Fe twin crystal nanozymes for long term suppression of Botrytis cinerea
Inflammation-specific DNA origami nanodevice for delivery of siRNAs to treat ulcerative colitis
Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines
Mitochondria-targeted gene delivery using fluorinated lipid nanoparticles to alleviate Leber’s hereditary optic neuropathy
Metagenomic sequencing enables accurate pathogen and antimicrobial susceptibility profiling in complicated UTIs in approximately four hours
Demonstration of CMOS-compatible memristor-based electrochemical biosensor transducer with threshold-sensing functionality
An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection
Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity
Controlled microphase separation and strain programming in hydrogel fibers toward biomimetic architectures and properties
The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity
Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance
Porin A and α/β-hydrolase are necessary and sufficient for hemolysis induced by
Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity
Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy
Autocrine ECM molecules establish MSC quiescence during incisor development by disrupting WNT ligand trafficking process
Plastic hepatocyte states limit liver cancer development
1q gain bypasses the selective barrier against aneuploidy in RPE differentiation via wild-type co-culture rescue
Transient overexpression of hPKM2 in porcine cardiomyocytes prevents heart failure after myocardial infarction
Directed rescue strategy for enhanced implant osteointegration in aged rats
Blood biomarkers of Alzheimer’s disease and progression across different stages of cognitive decline in the community
Thermally programmed one-pot CRISPR assay for on-site pandemic surveillance
Multiscale red blood cell hitchhiking for targeted deep tissue gene delivery in lungs
Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth
Epithelial-mesenchymal cell competition coordinates fate transitions across tissue compartments during lung development and fibrosis
Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxo8G
Lab-in-a-cartridge for real-time detection of tuberculosis via precise measurement of urinary lipoarabinomannan
Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation
A newly evolved small secretory peptide enhances mechanical properties of spider silk
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Spatial single-cell atlas reveals regional variations in healthy and diseased human lung
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1 study
Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex
Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation
Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics
Common genetic variation influencing the human lung imaging phenotypes
Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration
Targeted high-resolution sensing of volatile organic compounds by covalent nanopore detection
Visualizing influenza A virus assembly by in situ cryo-electron tomography
Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke
Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states
A multimodal cross-species comparison of pancreas development
Advancing sleep health equity through deep learning on large-scale nocturnal respiratory signals
Tetrahedral DNA dendritic nanostructure-enhanced FISH for high-speed, sensitive spatial transcriptomics
CRISPR anti-tag-mediated room-temperature RNA detection using CRISPR/Cas13a
Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration
Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles
Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy
Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions
EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases
Ddx61-enriched condensates refine heart regeneration programs
Programmable afterglow tuning in monodisperse SiO2 microparticles through spatially confined emitter doping
Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacy
A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway
Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo
Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo
Engineered exosomes with Kras specific siRNA in pancreatic cancer: a phase I study with immunological correlates
Stage-specific and cell-autonomous functions of Delta-like 1 in skeletal muscle stem cells and myogenesis
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
Metal-organic polyhedra maintain the self-renewal of embryonic stem cells
Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties
Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice
Facilitating analysis and dissemination of proteomics data through metadata integration in MaxQuant
Sensitive pathogen DNA detection by a multi-guide RNA Cas12a assay favoring trans- versus cis-cleavage
Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk
Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease
An electrochemiluminescence device powered by streaming potential for the detection of amines in flowing solution
Unraveling the regulative development and molecular mechanisms of identical sea urchin twins
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration
Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis
Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity
Segregation of endoderm and mesoderm germ layer identities in the diploblast
Multiplex bead assays enable integrated serological surveillance and reveal cross-pathogen vulnerabilities in Zambezia Province, Mozambique
Engineering kidney developmental trajectory using culture boundary conditions
Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations
drives a fate switch between hair cells of different mechanosensory organs
Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation
RKIP regulates bone marrow macrophage differentiation to mediate osteoclastogenesis and H-type vessel formation
Space-confined synthesis of sinter-resistant high-entropy nanoparticle library
Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential
Gut microbiota mitigate the reproductive toxicity of silver nanoparticles through thiamine-derived metabolites
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells
Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring
The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth
Stem cell secretome armed magneto-actuated micromotors as spatio-temporal manipulators for wound healing acceleration
Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms
Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction
Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism
Stem and progenitor cell proliferation are independently regulated by cell type-specific genes
Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway
Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications
Kit hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment
Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion
Sono-activable and biocatalytic 3D-printed scaffolds for intelligently sequential therapies in osteosarcoma eradication and defect regeneration
Immunocompetent cell targeting by food-additive titanium dioxide
Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent manner
Self-reinforced piezoelectric chip for scaffold-free repair of critical-sized bone defects
Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing
An mRNA vaccine encoding five conserved Group A Streptococcus antigens
Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis
Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration
Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma
Evaluating cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles
Generation of mature epicardium derived from human-induced pluripotent stem cells via inhibition of mTOR signaling
Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
Production of live monkeys and their genetically matched embryonic stem cells from single embryos
A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity
In vivo self-renewal and expansion of quiescent stem cells from a non-human primate
In vitro generation of a ureteral organoid from pluripotent stem cells
Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
Direct detection of 8-oxo-dG using nanopore sequencing
Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle
Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells
Serotonergic neurons regulate the vascular niche to control immune stress hematopoiesis
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice
2
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Maternal factor OTX2 regulates human embryonic genome activation and early development
1
Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling
7
Condensate corona–nanoparticle complexes transfer functional biomolecules between cells
Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung
Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination
Monolithic cell-on-memristor architecture enables wafer-scale integration of oscillatory chemoreceptors for bio-realistic gustatory chips
Peptide codes for organ-selective mRNA delivery
Tissue-specific mRNA delivery and prime editing with peptide–ionizable lipid nanoparticles
Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation
13
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks
Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy
A multimodal sleep foundation model for disease prediction
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology
Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials
Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trial
Cardiotropic AAV gene therapy for heart failure: a phase 1 trial
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial
A personal health large language model for sleep and fitness coaching
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial
AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial
A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics
10
Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production
Ultra-rapid nanoplasmonic colorimetry in microfluidics for antimicrobial susceptibility testing directly from specimens
Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines
Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation
Designing lipid nanoparticles using a transformer-based neural network
Compact polyethylenimine-complexed mRNA vaccines
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape
A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles
Nanopore detection of single-nucleotide RNA mutations and modifications with programmable nanolatches
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications
1
An open science resource for accelerating scalable digital health research in autism and other neurodevelopmental conditions
1
Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization
1
Hierarchical materials from fused silk
1
Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases
2
New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase
Image-Based Machine Learning Using Inkjet-Printed Chemicals: Mixing Ratio Prediction and Metal Ion Detection
9
The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning
SVASCilia is an open-source, deep learning-based tool for 3D analysis of cochlear hair cell stereocilia bundles
Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms
The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice
Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation
Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone
The planarian dorsal–ventral boundary regulates anterior–posterior axis growth and patterning
Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates
Sox5 controls the establishment of quiescence in neural stem cells during postnatal development
4
Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics
Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression
Dynamic transcriptional and epigenetic changes define postnatal tendon growth
The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice
7
Systemic Delivery of Functional Proteins Into Plants Using an Engineered Membrane Translocation Domain
<atl>Molecular Targeted Suppression of Male Fertility in scp iAmaranthus palmeri/i /scp S. Watson: Function and Layered Double Hydroxide Nanosheets‐Based Delivery System of scpApmiR319/scp</atl>
An Ultra-Sensitive Quarantine Pathogen On-Site Detection Based on a One-Pot Asymmetric Recombinase Polymerase Amplification and MNAzyme-Assisted Target Recycling Biosensor (OAR-MNA)
High-Efficiency and Eco-Friendly Management of Multiple Fungal Diseases by a Novel Carbon Dots sCDP Delivered RNA Nano-Pesticides
Nicotiana benthamiana as a Source of Cowpea Mosaic Virus-Derived Particles That Specifically Package Designer RNAs
Toward Translation of Cowpea Mosaic Virus Intratumoral Immunotherapy With a Scalable Production Process
Generation and plant production of recombinant fluorescent immunoglobulin G as innovative immunodiagnostic reagents
77
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
FGFR1–ETV1–CXCL1 signaling in dermal fibroblast orchestrates fibroblast-associated itch
TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15
A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing
ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal
Self-adjuvanting α-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors
Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides
Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice
Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation
Humanized extracellular vesicles for efficient RNA delivery
A regulatory axis for tonotopic MYO7A expression in cochlear hair cells
Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential
Convergence of external and internal stressors on a stress-responsive enhancer of the Sonic hedgehog gene to induce hair disorders
Versatile SMAD2 and SMAD3 epitope–tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9–SMAD2/3 targets
Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic
Ultrasound-responsive liposomes: A mechanistic framework to decode the effects of acoustic parameters
Endogenous ATP–powered nanomotors directing neural stem cell differentiation for Parkinson’s disease treatment
m6A epigenetic modification of viral RNA is critical for the transmission cycle of mosquito-borne flaviviruses
Phosphorylation and DNA damage resolution coordinate SOX2-mediated reprogramming in vivo
SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs
Charge-reversal proteolysis polymers enable tissue-specific STING degradation in rheumatoid arthritis
Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly
Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification
Persistent adaptation through dual-timescale regulation of ion channel properties
Unraveling the maturation pathway of a eukaryotic virus through cryo-EM
Artificially constructed collagen-targeting receptors on mesenchymal stromal cells promote anoikis resistance and tissue repair
In vitro sex-specific function–structure relationship in neonatal rat cardiac monolayers
Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis
A c-Cbl/Cbl-b antagonist inhibits EGFR ubiquitylation and sustains EGFR phosphorylation to enhance corneal re-epithelialization
Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling
CCR5 marks a subset of mouse hematopoietic stem cells that are myeloid primed and expand with age
Multiple modes of AFM reveal distinct mechanical properties for dystrophin and utrophin not manifest by small fragments
Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy
A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1
Targeting C1q signaling in fibro-adipogenic progenitors prevents regenerative fibrosis of aged muscle
Optimizing mRNA delivery with targeted elastin-like polypeptide–based LENN formulations: Insights into the endocytosis mechanism
Adult neural stem cells mediate hippocampal synapse elimination for circuit homeostasis through MERTK
Fluorinated lipid nanoparticles enable real-time tracking of mRNA delivery and uncover spatiotemporal mechanisms of immune activation
Dysregulated NAMPT signaling underlines the immune-suppressive microenvironment in venous leg ulcers
Cryo-EM structure of the Rift Valley fever virus envelope protein in complex with a potent neutralization antibody
Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis
Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis
Lrig1-expressing quiescent stem cells maintain vocal fold mucosal homeostasis via Notch signaling
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees
An adipo-osteoprogenitor population in the endosteal niche contributes to bone and fat formation in adult mouse bone marrow
Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoral Xenia umbellata
MC1R determines healing outcomes in acute and chronic cutaneous wounds
Pollen-inspired biopolymer-based multifunctional films
Glycolipid nanoparticles target the spleen and detarget the liver without charge
Controlling intracellular processing to enhance spherical nucleic acid immune stimulation
Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy
Intrinsically disordered linkers and terminal domains codrive aciniform spidroin self-assembly through liquid–liquid phase separation
The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size
Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice
Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models
Circular RNA lipid nanoparticle vaccine against SARS-CoV-2
Pdgf mediates a transient regeneration-activated cell state in planarian tissue regeneration
The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development
Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy
Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depression
Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse Nucleocytoviricota phylum
Structural basis and affinity improvement for an ATP-binding DNA aptamer
Measuring the selective packaging of RNA molecules by viral coat proteins in cells
Can we still use the Michaelis–Menten model for enzymatic microneedle sensors?
SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo
SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing
EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants
Osteoinductive low-dose 3D porous calcium phosphate graphene oxide–integrated matrices enhance osteogenesis and mechanical properties
Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis
A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells
Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis
A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection
MyD88 knockdown by RNAi prevents bacterial stimulation of tubeworm metamorphosis
1
Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms
2
Microbubble-based Radiosensitization of Hepatocellular Carcinoma: Evaluation of Safety and Efficacy in a Phase II Randomized Trial.
CRISPR/Cas9-Engineered Triple-Fusion Reporter Gene Imaging System for Monitoring Transplanted Neural Progenitor Cells in Ischemic Stroke.
13
B lymphocyte protein factories produced by hematopoietic stem cell gene editing
Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling
Deep generative models design mRNA sequences with enhanced translational capacity and stability
Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA
High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Human neuron subtype programming via single-cell transcriptome-coupled patterning screens
Identification of proliferating neural progenitors in the adult human hippocampus
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
77
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle–mediated infection in humanized liver chimeric mouse models
Bioelectric calcium transport and activation in mammalian cells using field-focused DNA-carbon nanotube meshes
Active protein-capturing hydrogel for broad-spectrum pathogen defense
Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair
Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access
HSPCs and Treg cells cooperate to preserve extramedullary hematopoiesis under chronic inflammation
Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis
Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes
Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation
Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity
One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development
Targeted intracellular oral RNA delivery through tea polyphenol nanovesicle to outer membrane vesicle transfer for colitis treatment
A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger
Immunometabolic resistors of aging in long-lived golden spiny mice
Activation of the YAP1/pSTAT3/NRP1 axis in peritendinous sensory nerves promotes tendon healing
E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines
Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism
Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians
Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells
Developmental regulation of Erk signaling by mitotic kinases
Control of airway basal stem cell–mediated lung repair by TGF-β signaling
Conserved stromal EMT program controls regenerative capacity of mesenchymal stromal cells across multiple tissues
Facile active gel–enhanced synthesis of molecular-sieving membranes with record-breaking performance
Asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus
Spectral fingerprint diagnosis: Spatially independent analysis of biomarker patterns in homogeneous systems
Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants
Rbfox2 selectively governs hematopoietic stem cell self-renewal by regulating proteostasis
Ultrasonic cavitation shock wave exfoliation dynamics of 2D materials revealed in situ by MHz XFEL imaging and multiphysics modeling
Role of CEBPa in trophectoderm competence installment
Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy
Blocking nuclear receptor Nr4a3 unlocks the senescence barrier to promote direct cardiac reprogramming
Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy
Single-nucleus profiling highlights the all-brain echinoderm nervous system
Alveolar macrophages initiate the spatially targeted recruitment of neutrophils after nanoparticle inhalation
Xenopus IgX informs engineering strategies of IgM and IgG hexamers
Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging
Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture
Cascade-targeting pH/ROS microneedles promote scarless diabetic wound healing by macrophage metaboimmune reprogramming
GENRISE-induced superior extracellular vesicles for scalable therapeutic cargo delivery
Activation of the coagulation cascade as a mechanism for selective nanoparticle-mediated RNA delivery to the endothelium in vivo
Ionizable guanidine-based lipid nanoparticle for targeted mRNA delivery and cancer immunotherapy
Lysosomal damage is a therapeutic target in Duchenne muscular dystrophy
A multistep platform identifies spleen-tropic lipid nanoparticles for in vivo T cell–targeted delivery of gene-editing proteins
Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models
Replacing cholesterol and PEGylated lipids with zwitterionic ionizable lipids in LNPs for spleen-specific mRNA translation
Enhancing mRNA therapy through iterative delivery
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases
From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly
The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
Retinal gene therapy using epiretinal AAV-containing fibrin hydrogel implants
Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential
Magnetoresistive detection of spin waves
A streamlined CRISPR-based test for tuberculosis detection directly from sputum
Integrated horizontal convective PCR system for clinical diagnostics
An energy-embodied paralleled liquid manipulation for equipment-free, quantitative multiplexed liver function monitoring
Dual-function polyester nanoparticles for amplified anti-inflammatory effects
A wearable spatiotemporal controllable ultrasonic device with amyloid-β disaggregation for continuous Alzheimer’s disease therapy
Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy
Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3
Noninvasive real-time monitoring of cellular spatiotemporal dynamics via machine learning–enhanced electrical impedance spectroscopy
Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds
A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid
Size matters: Micro- versus nanobubbles in ultrasound imaging and therapy
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors
Anabolic indices of matrix proteins identify regenerative small RNA intrinsic to human cartilage
Dynamically covalent lipid nanoparticles mediate CRISPR-Cas9 genome editing against choroidal neovascularization in mice
Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis
Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers
<atl>Droplet microfluidics–based detection of rare antibiotic-resistant subpopulations in iEscherichia coli/i from bloodstream infections</atl>
Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates
Widespread presence of bone marrow–like hematopoietic stem cell niche in invertebrate skeletons
Mechanochemical patterning localizes the organizer of a luminal epithelium
Tuning hydrogen bonds and electrostatics with convection for purifying mRNA: A paradigm shift
Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian
Sequential transcriptional programs underpin activation of hippocampal stem cells
A spatially organized Cd24a+/Pax9+ stem cell core governs postnatal tooth establishment
14
Aberrant bone marrow granulopoiesis generates neutrophils that promote B cell activity in neuromyelitis optica spectrum disorder
Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models
Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice
Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment
HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healing
A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models
Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma
Incorporation of 5-methylcytidine alleviates RIG-I–mediated innate immune responses to a self-amplifying RNA vaccine
Extracellular vesicle–mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice
A complete Sigmodon hispidus genome and dynamic single-cell transcriptomics reveal evolutionarily conserved responses to RSV infection
Periadventitial delivery of mesenchymal stem cells improves vascular remodeling and maturation in arteriovenous fistulas
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy
13
Quiescent neural stem cells transiently become neuron-like to coordinate long-range reactivation
Interferon-γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model
Elucidating the protein interaction network of one of the largest icosahedral capsids in the virosphere
Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential
TET knockout cells transit between pluripotent states and exhibit precocious germline entry.
Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development.
NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction.
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors
Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate
Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis.
A capsular myofibroblastic niche maintains hematopoietic stem cells in the spleen
Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation.
6
Receptor Targeting Amplifies Curvature-Driven Cooperative Nanoparticle Internalization under Redox Control
Structural Passivation Engineering of Montmorillonite Nanoclay Attenuates the ROS–HIF-1α–Ferroptosis Axis for Enhanced Biosafety
Release-Independent Transcription from Covalently Cross-Linked Hierarchically Folded DNA Condensates
Distinct Dimerization Mechanisms in Silkworm and Spider Silk Proteins Revealed by Mass Photometry
The Deprotonation Sites of Gas Phase Uridine and Pseudouridine: Implications for mRNA Vaccines
Physicochemical Properties of a Water-Soluble Adduct of Csub60/sub with scpl/scp-Cysteine for Biomedical Applications
2
Overall survival with relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): a phase 3 randomised controlled trial
Relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial
1
Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial
1
Colorimetric RT-LAMP for SARS-CoV-2 detection from nasopharyngeal swabs or crude saliva: a multicountry diagnostic accuracy study in Africa
4
Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study
Safety and efficacy of fordadistrogene movaparvovec in ambulatory participants with Duchenne muscular dystrophy (CIFFREO): a phase 3, double-blind, randomised, placebo-controlled study
Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study
1
Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial
9
Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery
Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors
Adenoviral Inciting Antigen and Somatic Hypermutation in VITT
Final Analysis of a Study of Etranacogene Dezaparvovec for Hemophilia B
Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk
DB-OTO Gene Therapy for Inherited Deafness
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia
Sustained Clinical Benefit of AAV Gene Therapy in Severe Hemophilia B
3
Analysis of the removal process of residual tetrachloroethylene from simulated aquifer by a novel anionic-nonionic gemini surfactant
Click Chemistry-Empowered Multi-Channel Biosensing for Highly-Efficient Detection of Antibiotic Resistance Genes in Aquatic Environments
Benchmarking a massively parallel nucleic acid hybridization platform for monitoring biomarkers of public health significance in wastewater

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