Review Articles

Chang and Yu review recent knowledge of how lncRNAs regulate immune cell specification and function.

In this Review, Ho and colleagues focus on how myeloid cells detect and respond to oxygen availability in the local tissue microenvironment and discuss how acute and chronic hypoxia modulate myeloid cell functions.

Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.

In this Review, the authors cover the immunology of cancer vaccines and how they can be used to boost the efficacy of immunotherapies for cancer.

In this Review article, Vince et al. focus on recent developments in necroptotic cell death in health and disease.

Here Iliev et al. review the interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlighting the impact on health and disease.

Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.

In this Review, the authors update us on the immunology and clinical options for treating asthma.

Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity.

Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology.

In this Review, the authors discuss the gene–environment interactions including microbial perturbations that shape the early events of inflammatory bowel disease.

In this Review, Boeckxstaens and colleagues discuss the roles of neuron-associated macrophages in development and inflammation of the gut.

In this Review, the authors discuss the latest in skin immunology research with a special focus on the role of skin-resident T cells.

Tak Mak and colleagues review the role of cholinergic T cells in the tumor immune microenvironment.

In this Review, Shakiba and Tuveson provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages and how they collaborate to establish an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4⁺ and CD8⁺ T cells during development and differentiation.

In this broad Review, the authors describe how the immune response to leukemias develops, how these cancer cells avoid it and how various immunotherapies have been designed to overcome resistance.

In this Review, Matarese and colleagues discuss how immunometabolism controls the physiology and pathophysiology of B cells.

Karin and colleagues review the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control.

In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.