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An automation tool has been designed that enables partitioning of an algorithm into subcircuits split across cells for biological computing. The tool was applied to a hashing algorithm requiring 110 logic gates across 66 cells.

Two-qubit logic gates in a silicon-based system are shown (using randomized benchmarking) to have high gate fidelities of operation and are used to generate Bell states, a step towards solid-state quantum computation.

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

Several transmission-blocking vaccine candidates based on Pfs230 and Pfs48/45 are in clinical development, but it remains unclear whether they will demonstrate high efficacy. Here, the authors develop a stabilized chimeric antigen presenting potent epitopes from Pfs230 and Pfs48/45 in a single construct and demonstrate induction of transmission-reducing antibodies when female mice are immunized with the antigen in a self-assembling protein nanoparticle formulation.

Central charge, a key quantity in conformal field theories, is crucial in the study of critical phenomena, yet its measurement has remained elusive. Here, the authors extract the central charge of several quantum critical models by accurately preparing their ground states on a superconducting quantum processor.

The growing complexity of quantum computing devices makes presents challenges for benchmarking their performance as previous, exhaustive approaches become infeasible. Here the authors characterise the quality of their 11-qubit device by successfully computing two quantum algorithms.

Practical quantum computers will require protocols to carry out computation on encrypted data, just like their classical counterparts. Here, the authors present such a protocol that allows an untrusted server to implement universal quantum gates on encrypted qubits without learning about the inputs.

In a quantum simulation of a (2+1)D lattice gauge theory using a superconducting quantum processor, the dynamics of strings reveal the transition from deconfined to confined excitations as the effective electric field is increased.

2D semiconductors hold promise for the fabrication of high-density flexible integrated circuits, but they often require high-temperature processing or transfer steps. Here, the authors report the low-temperature ( ≤ 150 °C) fabrication of wafer-scale 3Dintegrated flexible complementary circuits based on 2D semiconductor inks.

2D p-type transistors are essential for the realization of complementary circuits for post-silicon electronics. Here, the authors report a chloroform doping strategy to fabricate p-type monolayer WSe₂ transistors with high performance and long-term stability.

The creation and purification of magic states can be a limiting step in quantum computing. Now an error correcting code has been found where the overhead of this process is the lowest value possible, showing that optimal performance can be achieved.

This study describes design automation and predictable gene regulatory network engineering in a eukaryotic microorganism.

Ambipolar transport, necessary to realise PN-junctions, is unfortunately missing from most two-dimensional semiconductors. Here, the authors fabricate few-layer black phosphorous field-effect transistors, define PN-junctions and demonstrate full electrostatic control of the device by means of local gating.

WIN332 is an HIV-1 Env protein designed to elicit a new class of Asn332-glycan-independent antibodies (type II) to the V3-glycan site of Env. WIN332 immunization rapidly induces type-II V3-glycan antibodies with low inhibitory activity indicative of a neutralization activity in macaques.

K⁺ channels can convert between conductive and non-conductive forms through mechanisms that range from flicker transitions (which occur in microseconds) to C-type inactivation (which occurs on millisecond to second timescales). Here, the mechanisms are revealed through which movements of the inner gate of the K⁺ channel KcsA trigger conformational changes at the selectivity filter, leading to the non-conductive C-type inactivated state.

Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process.

A programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits is described, in which improvement of algorithmic performance using a variety of error-correction codes is enabled.

Alternative splicing generates diverse protein isoforms, yet the functions of most exons remain unknown. Here, the authors introduce scCHyMErA-Seq, a scalable single-cell CRISPR exon-deletion platform that maps exon-specific transcriptional functions shaping gene expression and cell-cycle states.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

Personal priorities are often trumping real needs and skewing where charitable funding goes.

In this study, the authors investigate the impact of noise on quantum computing with a focus on the challenges in sampling bit strings from noisy quantum computers, which has implications for optimization and machine learning.

Colour code on a superconducting qubit quantum processor is demonstrated, reporting above-breakeven performance and logical error scaling with increased code size by a factor of 1.56 moving from distance-3 to distance-5 code.

CLASSIC is a high-throughput genetic profiling platform that combines long- and short-read next-generation-sequencing modalities to quantitatively assess pools of constructs of arbitrary length containing diverse genetic part compositions.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Screening by a graphite gate placed at 1 nm proximity to graphene produces transformative improvement in its electronic quality, reducing charge inhomogeneity by two orders of magnitude.

Biological computation is becoming a viable and fast-growing alternative to traditional electronic computing. Here the authors present Trumpet, which uses DNA and enzymes to build logic gate circuits with amplified fluorescent readout.

Quantum error correction is essential for reliable quantum computing, but no single code supports all required fault-tolerant gates. The demonstration of switching between two codes now enables universal quantum computation with reduced overhead.

Topological phases in quantum many-body systems emerge from long-range entanglement rather than symmetry breaking, giving rise to properties such as topology-dependent degeneracy, protected edge modes and anyonic excitations. This Review discusses recent advances on how to realize and study such interacting topological states on digital quantum computers.

Although antiretroviral therapies (ART) have expanded the life expectancy of patients with HIV, they are not curative due to the presence of latently infected cells. Here, the authors present IMC-M113V, a bispecific soluble TCR targeting the HIV peptide Gag_77-85 complexed to HLA-A*02:01 as an approach for targeting HIV reservoirs and test safety, tolerability and pharmacodynamics in a first-in-human clinical trial on 12 HLA-A*02:01-positive male individuals on ART.

Solutions of computations can be encoded in the ground state of many-body spin models. Here the authors show that solutions to generic reversible classical computations can be encoded in the ground state of a vertex model, which can be reached without finite temperature phase transitions.

MK-7762 is a new oxazolidinone antitubercular agent that is structurally similar to linezolid, and demonstrated in vivo efficacy, lesion penetration and limited toxicity compared to linezolid, indicating it could be used in broad tuberculosis regimens.

Bacteria secrete polysaccharides essential for colonization and infections. Here, the authors reveal the structure and mechanism of WzaB, a Class-3 OPX protein, uncovering a distinct trans-envelope secretion complex driving critical polysaccharide export in diderm bacteria.

Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Coherent control of plasmon wavepackets is essential for quantum information processing using flying electron qubits. Here, the authors demonstrate a method to isolate and select electron channels contributing to a plasmon using a cavity formed by local constrictions, enabling precise control of plasmon eigenstates.

An anti-HIV-1 antibody that targets an N332_gp120 glycan-independent V3 epitope, a site of Env vulnerability, can decline viremia in HIV-1-infected humanized mice while overcoming classical V3 escape mutations.

Quantum simulations of chemistry and materials are challenging due to the complexity of correlated systems. A framework based on reconfigurable qubit architectures and digital–analogue simulations provides a hardware-efficient path forwards.

Authors use metagenomic environmental surveillance in Cambodian live-bird markets and found that air sampling captured the greatest diversity of poultry viruses. It outperformed traditional swabs, identifying undetected H5N1 clades.

Optical spin orientation of itinerant ferromagnets in twisted MoTe₂ homobilayers is demonstrated, enabling control of topological Chern numbers with circularly polarized light.

Training deep neural networks by backpropagation consumes significant energy in digital hardware. Boon and Cassola et al. show that homodyne detection can be used to extract gradients directly in a physical device, enabling efficient gradient descent and offering a scalable route to material-based learning.