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In this work, authors use whole genome tracking in a neonatal intensive care unit to reveal a strong link between Staphylococcus aureus colonization and invasive infection, pinpointing critical new targets for infection prevention in high-risk infants.

Radical protein footprinting reveals protein structure and interactions, but has not – to the best of the authors knowledge - been applied in whole blood. Here, authors demonstrate in-blood footprinting in mice, uncovering diabetes-associated protein conformational changes that were validated by orthogonal assays.

Amundsen Sea records show warm Circumpolar Deep Water drove major West Antarctic Ice Sheet retreat from 18,000–10,000 years ago. Subsequent cooling stabilized the grounding line, indicating ocean heat—not atmospheric warming—controlled long-term WAIS change.

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

The study introduces radio interferometric multiplexed spectroscopy (RIMS), a method designed to efficiently monitor the radio emissions of massive samples of stars. Applying it to LOFAR data, the authors identify stellar bursts, offering clues to possible star–planet magnetic interactions.

Chondrosarcomas are rare cartilaginous neoplasms with limited treatment options. Here this trial evaluates the safety and efficacy of olutasidenib (mIDH1 inhibitor) on 23 patients with locally advanced or metastatic mIDH1 chondrosarcoma.

Changing fire regimes, leading to higher likelihood of high severity fire, are having unknown impacts on biodiversity. This study identifies regions of high avian biodiversity and individual bird species predicted to be highly exposed to future high severity.

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

Conventional type 1 dendritic cells (cDC1) can boost the precursor exhausted T cell population thought to be essential for efficacy of immune checkpoint therapy. Here the authors enhance this cellular network using Flt3L to expand cDC1s and then map the movement of T cells and DCs between tumors and lymph nodes.

Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of complex behavioural traits.

Molecular dynamics models for predicting the behavior of metallic nanostructures typically do not take into account polarization effects in metals. Here, the authors introduce a polarizable Lennard–Jones potential that provides quantitative insight into the role of induced charges at metal surfaces and related complex material interfaces.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

The authors developed a highly sensitive skin-conformal NIR organic photodetector with fast photoresponse speed that achieves MHz-speed, angle-free, and long-range (100 m) wireless optical communication with stable performance under mechanical deformation.

Crystal structures of HIV Env trimer with native glycosylation in complex with neutralizing antibodies reveal a glycan shield of high-mannose and complex-type N-glycan and indicate a path for germline-targeting vaccine design.

Topologically protected vortex knots are shown to undergo fusion and fission, with electric pulses acting as a switch between the two processes. This might enable applications in electro-optics and photonics.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The lowest-frequency gravitational wave background may be shaped by supermassive black hole binaries that scatter nearby stars or dark matter. In this case, the NANOGrav 15-year dataset favours dense galactic centres with 10⁶ solar masses per cubic parsec.

Membrane ion channels can be responsive to a variety of stimuli such as pressure, temperature, or pH. Here, the authors show that simply shining 365 nm light activates a native potassium channel in rodent pain-sensing neurons, delivering powerful analgesia without drugs or genetic manipulations.

A national classification system of wetland hydrologic connectivity to streams, which could be applied globally, demonstrates and advances current understanding of how wetland connectivity affects surface water quality.

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support ancestry-informed genetic testing.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

An empirical correlation between the fragility of glass forming liquids and the broadness of their relaxation spectrum is believed to be universal. Van Lange et al. report an inverted correlation in a class of polymeric materials, implying a special role of long-ranged ionic interactions in vitrification.

Ribas and colleagues report the results of a phase 2 clinical trial of neoadjuvant PD-1 blockade in patients with surgically resectable desmoplastic melanoma.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated in clinical samples. Concomitantly blocking TGFβ signaling with chemotherapy reduces tumor burden and increases survival in mice.

Richard Fortey questions the level of derring-do in an account of the life curatorial.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The authors identify flip probability as a universal quantity in random explorations. Here, the authors show it follows a simple inverse law across Markovian, non-Markovian, and real-world systems.

Here, the authors create a high-quality-factor chiral metasurface that enables record-high room-temperature valley-selective emission in MoSe₂ monolayers, independent of excitation polarization.

The atomic-scale dynamics underlying fluid viscosity, the resistance of a fluid to flow, remain poorly understood. Here, authors demonstrate that the process by which an atom loses or gains a neighbor is the microscopic mechanism of viscosity in two-dimensional liquid-like fluids.

A wide survey of pesticide effects on soil biodiversity across 373 sites in Europe reveals that pesticide residues occur in 70% of sites and have major effects on soil biodiversity and functional ecology.

Existing Moiré materials are mostly van der Waals heterostructures. Here the authors show that hydrogen-bond adaptability allows spontaneous formation of twisted bilayer ice at magic angles in 2D confinement, establishing a new class of Moiré materials.

This Resource paper presents a global SARS-CoV-2 phylogenetic tree of 4,471,579 high-quality genomes consistently constructed by Viridian, an efficient amplicon-aware assembler.

This study presents an approach to enhancing the local field of avalanche photodetectors by integrating the lightning-rod effect with localized surface plasmon excitations.