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A protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.

A key challenge for compact accelerators is boosting an electron beam’s energy without

sacrificing its brightness. Here, the authors demonstrate the concept of a plasma wakefield

‘dual transformer’, which simultaneously increases both beam energy and brightness of an

electron bunch injected from the plasma at SLAC.

Radiation reaction (RR) on particles in strong fields is the subject of intense experimental research, but previous efforts lacked statistical significance due to the extreme regimes required. Here, the authors report a 5σ observation of RR and obtain strong, quantitative evidence favouring quantum models over classical, using an all-optical setup where electrons are accelerated by a laser in a gas jet before colliding with a second, intense pulse.

Nonlinear optical processes involving both vibrational and electronic transitions provide valid tools to resolve vibronic coupling in molecules. Here, the authors demonstrate double-resonance three-photon excitations enabling enantio-selective vibronic coupling and modulation of upconverted emission in a chiral medium.

The study introduces radio interferometric multiplexed spectroscopy (RIMS), a method designed to efficiently monitor the radio emissions of massive samples of stars. Applying it to LOFAR data, the authors identify stellar bursts, offering clues to possible star–planet magnetic interactions.

The authors demonstrate dual-probe multi-messenger imaging of high-energy-density plasmas based on laser-wakefield-accelerated electrons. This enables spatiotemporally resolved simultaneous probing of plasma hydrodynamics and electromagnetic field evolution with both x-ray and electron beams.

There is interest in controlling particle beams using electric fields and using them in compact devices. Here the authors demonstrate guiding and splitting of charged particle (electron and ion) beams on a chip designed with special structures.

An integrated optical parametric amplifier on thin-film lithium niobate achieves more than 17 dB gain with less than 200 mW input power.

A prototype microscope built with self-reconstructing Bessel beams is shown to be able to reduce scattering artifacts as well as increase image quality and penetration depth in three-dimensional inhomogeneous opaque media.

A martensitic alloy with a tensile strength exceeding 3 GPa and a fracture elongation of 5.13% is developed. These mechanical properties arise from interface complexes interacting with dense dislocation networks, which is a mechanism shown to be applicable to other compositions.

Optomechanical crystals are promising building blocks for quantum networks but suffer from thermal mechanical noise. Here the authors demonstrate on-demand conversion of single phonons into high-purity telecom photons with low thermal noise and MHz-scale narrow bandwidth using a quasi-2D optomechanical system.

Visualizing single-molecule reactions using electron microscopy can be difficult because of potential radiation damage from the electron beam. Now, however, it has been shown that a high-energy electron beam can be used to synthesize metallo-azafullerenes. Atomic-resolution, time-resolved transmission electron microscopy, with the help of computational calculations, is used to monitor the metal-encapsulation dynamics.

Flicker noise limits the performance of electronics. Here, the authors demonstrate in nanowires of charge-density wave materials (TaSe₄)₂I and NbS₃ that low-frequency electronic noise is suppressed below the limit of thermalized charge carriers in passive resistors.

The authors report on imaging developments of solid-density plasmas and the current filamentation instability by means of the LCLS-XFEL at SLAC. This offers insights on the instability in the solid density region, stimulating new modelling of laser-solid interactions.

Electron avalanche multiplication can enable an all-optical modulator controlled by single photons.

The first lasing results at SwissFEL, an X-ray free-electron laser, are presented, highlighting the facility’s unique capabilities. A general comparison to other major facilities is also provided.

Compact atomic clocks and atom interferometers are desired for on-chip integration. Here the authors demonstrate a chip-scale atomic beam of 87Rb atoms and its application as an atomic beam clock

Topological edge states offer the prospect of dissipationless transport for nanoelectronics, but a precise method to spatially engineer such nanoscale conducting channels is still lacking. Here, the authors demonstrate patterning of topological boundary states in Sb₂Te₃ using a focused ion beam to create amorphous, topologically trivial regions.

Andersen et al. have demonstrated a new type of beam steering device based on the excitonic response of an atomically thin semiconductor. Using electrostatic gates, the authors achieved tunable steering with switching times on the nanosecond scale.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The low dielectric constants and high porosity of MOFs are of interest for applications in electronics and sensors, but patterning techniques for these materials are in their infancy. Here, direct X-ray and electron-beam lithography at sub-50-nm resolution are reported that leave porosity and crystallinity intact.

A wearable paper-based microfluidic device tracks cortisol in sweat via gold nanoflower colorimetric assays and captures circadian rhythms, stress responses and jet lag disruptions.

The authors report the synthesis of (La_0.9Y_0.1)H₁₀ superhydrides and their characterization using synchrotron-based, spatially resolved x-ray diffraction and electrical transport imaging. They reveal μm-scale structural inhomogeneity with coexisting cubic and hexagonal clathrate phases exhibiting distinct superconducting transition temperatures.

This study reveals high-spin state formation and quintet-mediated emission in diphenylhexatriene oligomers. Quintet states dominate delayed fluorescence up to room temperature, establishing a spin-selective platform for quantum technologies.

Cardiac ryanodine receptors (RyR2) are critical for heart contraction. Here, the authors use 3D MINFLUX microscopy to image receptor subunits and RyR2 orientation with nanometre resolution, thereby providing a molecular view of the organisation and clustering of these cardiac muscle receptors.

Silk can be used as a negative or positive biofunctional resist in an all-water electron-beam lithography process.

Core excitons are strongly localised excitonic states impacting x-ray absorption and resonant inelastic scattering (RIXS) spectra. Here, the authors demonstrate an application of free electron laser-driven ultrafast RIXS spectroscopy to study previously unclear aspects of core exciton-phonon interactions in graphite.

Modulation of random heteropolymers results in globular polymer clusters with catalytic activity mimicking proteins.

Bringing chiral molecules in contact with metal nanoparticles enables interfacial charge transfer. Here the authors show that when optically resonant, such complexes can show collective chiroptical responses beyond traditional plasmon-exciton coupling.

THz integrate light sources represent an important building blocks for various applications. Here the authors report an electrically driven topological laser based on photonic Majorana zero mode that can convert electricity directly into THz single-mode laser with topologically nontrivial beams.

Non-uniform noise introduces bias in multivariate analysis of mass spectrometry data. Here, the authors study the noise structure of the widely used Orbitrap to develop a data scaling method that reduces this bias resulting in clearer separation of chemical information from noise in biological data.

Controlling light at scales smaller than its wavelength is attractive to manipulate light using small device footprints. Here, the authors propose a scheme to modify light on such small scales using a combination of metamaterial nanocavities coupled to nonlinear semiconductor heterostructures.

Researchers generated 16.7 nm wavelength extreme-ultraviolet Poincaré beams at the FERMI free electron laser without relying on optical elements. The method of in situ Poincaré beam production in free electron lasers enables straightforward flexibility in the orientation and balance of polarization states, and can be extended to other vector beams and to shorter wavelengths.

Bennu comprises components of intra- and extra-Solar System origins. The parent bodies of Bennu, Ryugu and CI chondrites likely formed from a shared but heterogeneous reservoir in the outer parts of the solar protoplanetary disk.

Some next-generation computing may be based in physical systems that respond directly and reciprocally to environmental stimuli. Here, the authors describe a photoresponsive material that autonomously performs computations with incident beams of incoherent white light.

When molecules collide with atoms or other molecules their quantum mechanical character can lead to the diffraction of matter waves. Making use of advances in molecular beam technology, such diffraction oscillations have now been observed with unprecedented sharpness and angular resolution in the benchmark NO + He, Ne, or Ar systems.

X-ray free-electron laser is a power probe for materials, but it is challenging to measure the spectro-temporal characters of individual pulses. Here, De Ninno et al.implement an interferometric method allowing one to characterize and control the ultrashort XUV pulses seeded by a femtosecond laser.

X-rays are used for imaging and sterilisation of bone but cause damage due to ionising radiation. Here, the authors study the degradation of collagen caused by photon-electron excitations and show that damage is initiated from onset which has implications for X-ray imaging and the levels of safe exposure.

The propagation of light in photonic crystals with a honeycomb structure mirrors the behaviour of charges in graphene, therefore allowing for the investigation of electronic properties that cannot otherwise be accessed in graphene itself. This approach is now used to predict unexpected edge states that localize in the bearded edges of hexagonal lattices.

Feng et al. report a dynamic template-assisted strategy for depositing perovskite nanowire arrays across areas 12 times larger than the template itself, on diverse substrates. Large-area pixelated photodetectors with a responsivity of 1660A W⁻¹, detectivity of 3.9E14 Jones, and linear dynamic range of 160.3 dB are achieved.

Via high-throughput imaging and tracking over 140 million single mycobacteria, the authors show that drug- and strain-specific killing predict treatment outcomes, with potential to improve drug development and personalized therapy.

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

Regrowth of lost enamel in tooth decay and sensitivity is a major obstacle to overcome. Here, the authors report on a protein-based material that mimics features of natural enamel formation, allowing for epitaxial growth of apatite nanocrystals to restore enamel structure and function.

Electron correlations are important for superconductivity in layered copper oxides. Here, the authors use Auger photoelectron coincidence spectroscopy to directly determine the oxygen 2p hole-hole Coulomb energy in the undoped cuprate La₂CuO₄.

Hysteresis in the transfer characteristics of 2D transistors is considered an important metric to evaluate their performance, but its characterization process is often inconsistent among different studies. Here, the authors propose a standardized scheme to measure and analyze hysteresis in different 2D devices, facilitating systematic comparisons and performance projections.