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Microsatellite-stable/proficient mismatch repair colorectal cancers are resistant to immune checkpoint blockade immunotherapy due to their immune suppressive tumour microenvironment. Here the authors show in mouse models that the transcription factor Arid3b contributes to the suppression of CD8 + T cell infiltration and activity in these tumours via suppressing Runx3, a known regulator of tissue resident memory phenotype in CD8 + T cells.

This work develops laser-engraved Janus microcavity surfaces to overcome the angular limitation of photothermal de-icing. The structure enables ice removal under oblique or weak sunlight and sustains superhydrophobicity, offering a thermal management solution for nonplanar infrastructures in extreme environments.

Pacific records show that, since about 430,000 years ago, stronger northward heat transport from Southern Ocean waters warmed the Indo-Pacific Warm Pool and contributed to warmer interglacials after the Mid-Brunhes Transition.

Co locating solar power with fisheries could deliver large energy climate and income benefits worldwide with over forty percent of ponds and tidal flats suitable shown using five-kilometer global mapping with feasibility screening.

The ophthalmic video foundation model learns the spatiotemporal motion features of ophthalmic procedures, improving surgical performance in cataract surgeries on wet-lab porcine eyes in real time.

The Earth’s mantle transition zone may play a key role in large-scale intraplate magmatism and plate tectonics. Here, the authors provide evidence for the origin of continental flood basalts in this zone, by combining oxygen isotope and geochemical evidence from the late Cenozoic Chifeng volcanics of East Asia.

The rewiring of amino acid utilisation pathways in liver cancer requires further investigation. Here, the authors show that liver cancer promotes tyrosine translational utilization, thereby enhancing oxidative phosphorylation and ferroptosis resistance in tumour cells.

This work develops a reconfigurable heterojunction with coupled charge tunneling and ferroelectric polarization, enabling the integration of memory, sensing, and logic computation within a single device.

Nano-confinement between a capping layer composed of graphene or hexagonal boron nitride and a substrate directs the growth kinetics during chemical vapour deposition, which enables the atomically precise synthesis of 2D transition metal dichalcogenide monolayers, Janus monolayers and van der Waals heterostructures with ultraclean interfaces.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Wang, Huang, Nelson, Gao, and colleagues perform a head-to-head comparison of multiple platforms for imaging spatial transcriptomics, determining their relative sensitivity, specificity, and ability to identify major cell types in clinical pathology samples.

Micromitophagy is found to occur in plant male germline cells, mediated by ATG5–HSP90.2 signalling, and is evolutionarily conserved in angiosperms. This mechanism underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Solvent co-intercalation into graphite anodes for sodium-ion batteries is common; however, intercalation into cathodes is much less explored. Here, using operando experiments as well as theory, solvent co-intercalation in a range of layered sulfides is investigated.

Integrating semiconductor p-n junctions with magnetic materials yields van der Waals heterojunctions as an ideal low-power spintronic platform. Zhu et al. report an abnormal zero-bias spin voltage effect arising from non-equilibrium spin diffusion.

This study benchmarks four cutting-edge spatial transcriptomics platforms using human tumour tissues, performs multi-metric evaluation with multi-omics references, and presents the SPATCH portal for visualisation and download.

Information on how oxygen ions transport is crucial to understanding field-induced phase transformations in materials. Here, Zhang et al. directly image atomic-scale oxygen migration and the subsequent structural reconstruction in a SrCoO_2.5-σ film in the presence of an electric field.

Subwavelength focusing of electromagnetic fields often uses evanescent waves and nanostructures to aid confinement. Here, the authors localize a microwave field to 6 orders of magnitude smaller than the wavelength, by coupling to confined electron oscillations in a hybrid nanowire-bowtie antenna.

Molecular mechanisms determining soybean seed weights remain largely elusive. Here, the authors identify a 14-3-3 protein encoding gene GmSMS6 negatively regulates soybean seed weight and size via the possible interactions with the transcription factor GmbZIP151 and the RING-type E3 ligase GmUBQ1.

Researchers report a sustainable nanofluidic osmotic energy harvester made from natural montmorillonite clay nanosheets and recycled cellulose. Scaled-up films of 700 cm² show power output of 8 W m⁻² with stability over 30 days

Terahertz control of polar skyrmions—topological textures of electric dipoles—is key for fast optoelectronics. Now, ultrafast excitation of polar skyrmions is achieved across two orders of magnitude of temperature in an oxide heterostructure.

This study reveals that ion displacement–induced antiferroelectricity in CuBiP₂Se₆ enables polymorphic functionalization, allowing a single device to achieve multilevel conductance and synaptic behavior for energy-efficient neuromorphic computing.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.

Polymer dielectrics are key for capacitors in energy applications but are hard to improve for high temperatures. This work uses artificial intelligence to design fillers with a large bandgap and high affinity, enabling durable, high-energy polyimide composites for harsh environments.

Nanomechanical resonators behave as resonant filters for driving forces. Here, the authors employ a few-layer graphene nanomechanical resonator as a filter for multifrequency forces modulated by a video signal. They demonstrate that the modulated vibrations encode an accurate copy of the video.

Solid oxide ionic conductors typically require elevated temperature to activate ionic transport. Here the authors report unusually high proton conductivity close to room temperature in a hydrogenated oxide, HSrCoO_2.5, which they attribute to the intrinsically ordered oxygen vacancy channels and high proton concentration.

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors stratify these patients via a semi-supervised learning approach using multi-omics input data and functionally validate T-bet+ CD8 + T cells as crucial factor in the immunotherapy response.

Endochondral ossification is hard to recapitulate with human cells. Here, the authors generated SOX9+ sclerotomal progenitors from hPSCs, modeling key developmental stages of bone development and growth plate-like structures.

Wang et al. report large nonvolatile polarization in stretchable polymer ferroelectrics incorporating perovskite nanocrystals. The built-in electric field from poled ferroelectrics stabilises Frenkel defects via interfacial coupling, which can also enhance the polarization of nonferroelectrics.

Ferroelastic switching in thin films is typically restricted by constraints from the substrate or occurs around twin-like domains. Here, the authors show reversible and non-volatile ferroelastic switching avoiding substrate constraints in layered-perovskite Bi_2WO_6 epitaxial films.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

Complex environments with varying temperatures remain a major challenge for batteries. Here, authors develop a polymer composite binder with dynamic active sites and phase change properties, enabling lithium sulfur batteries to operate stably over a wide temperature range of −40 °C to 60 °C.

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

Plant embryos are connected to maternal tissue by a filamentous suspensor, analogous to an umbilical cord, but which is severed during early embryo development. Here, Shi et al. show that gibberellins can trigger suspensor cell death in tobacco via a DELLA protein that regulates expression of cell death factors.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Gut microbiome has been linked to neurogenerative diseases. Here, the authors present a metagenome-wide association study of schizophrenia (SZ) in human cohorts and identify SZ-associated specific gut-brain functional modules and pathways including SCFAs and neurotransmitters.

Zhang et al. demonstrate that the smooth muscle-specific deficiency of the mitochondrial NAD⁺ transporter SLC25A51 impairs the biosynthesis of proline and type III collagen and results in thoracic and abdominal aortic aneurysm.

Radiation-hardened electrostatic dielectric capacitors are critical components in advanced electronic and electrical systems. Here, the authors demonstrate a high-energy-density and radiation-tolerant capacitor by constructing a dendritic-like structured ferroelectric embedded in an insulator.

Electric modulation of second harmonic generation finds applications in integrated photonics. Here, authors introduce electric field-induced second harmonic generation by polar skyrmions in PbTiO₃/SrTiO₃ superlattices with giant modulation depth.

Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical profiles.

Here the authors propose an atomic-scale electron avalanche breakdown model to investigate the dynamic behaviors of excited electrons under extremely high electric fields in various dielectrics ranging from simple oxides to perovskites.