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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non-canonical nuclear metabolic roles in cancer.

‘Populations residing near nuclear power plants may experience low-level chronic exposure to ionizing radiation through environmental release pathways. In here the authors find higher cancer mortality rates in U.S. counties closer to operational nuclear power plants, with the strongest relative risks observed in older adults.’

The authors present bioinspired solid-state proton diode membranes that achieve rectified proton transport by constructing an inherent water-content gradient and asymmetric transport pathways, enables efficient force-electric conversion.

A few anisotropic van der Waals materials have been shown to host hyperbolic polaritons in the visible and infrared ranges. Here, the authors characterize the complex dielectric function of hexagonal boron nitride in the deep-ultraviolet regime, supporting a natural hyperbolic dispersion and predicting hyperbolic exciton polaritons.

Most H₂ used in the chemical industry is derived from fossil fuels. Now it has been shown that coupling native microbial H₂ pathways with engineered alkene biosynthesis and membrane-bound Pd catalysis enables biocompatible hydrogenation of metabolic intermediates in living bacteria. This hybrid chemo-microbial platform supports the carbon-negative synthesis of industrial chemicals from waste-derived feedstocks.

Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highlight its role in maintaining proteome stability and enabling dynamic stress responses in plants.

Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

Climate action could avoid over 1 million deaths globally from air pollution in 2040. However, it is suggested that cooperation is needed between developed and developing nations to ensure that disparities in air pollution are not perpetuated in the future.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

N-terminal acetylation shapes protein fate during protein biosynthesis at the ribosome. Here the authors show that the NatA enzyme forms dynamic multi-factor complexes at the ribosome, acting as an interaction hub that coordinates cotranslational protein maturation.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Although river protection is core to social and environmental well-being, the extent to which river conservation policies are effective is difficult to assess. This study reveals that, under all relevant protection mechanisms in the contiguous USA, only 12% of rivers are adequately protected.

Geographical proximity risk assessment for natural disasters overlooks the role of intercity economic linkages. We showed that spillover effects of natural disasters on intercity economic networks account for one-third of the total economic losses. Focusing solely on geographical proximity to natural disasters may underestimate economic losses to cities by over 50%.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

Controlled generation of 3D molecules with desired properties can speed up drug discovery. Here, the authors propose a semantics-guided diffusion model to achieve precise and data-efficient multi-properly control.

Particle processing plays a critical role in advancing solid state batteries. Here, authors show how solvent-free mechanofusion enables mixed conducting matrix coatings on cathode particles and relate coating quality to macroscopic mixing stresses for scalable solid state battery manufacturing.

An analysis of satellite data follows ~1 km³ of flood water drain over only 3 weeks from a glacier-covered lake along a 50 km path beneath the ice to the glacier margin, providing important insight for predicting the future of glaciers and ice sheets.

Here they show that a subpopulation of distal SOX9+ lung progenitors controls lung size through lung bud bifurcation and undergoes transitional states to generate cell types in the conducting airways and the gas-exchange unit, the alveolus.

Social rewards hold therapeutic potential for alleviating drug relapse, yet the neural substrates remain unclear. Here, authors show that social reward and drug relapse activate distinct dopaminergic populations within the VTA, which dynamically compete to regulate behavioral outcomes.

Characterizing the information transmitted between structures is key to studying function. Using optogenetically identified neurons in monkeys, the authors show that cortical projections to the basal ganglia encode expected reward and selected actions.

Hot electrons, ignited by interlayer regulation in two-dimensional covalent organic frameworks, exhibit characteristic carrier dynamics and contribute to wavelength-dependent photocatalytic efficiency, as revealed by ultrafast spectroscopy and energy-band calculation.

Understanding how large language models solve complex problems is vital for their safe use. Using a historical case, this study shows that human analogies unlock latent knowledge, while disrupting key internal representations completely blocks reasoning.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Antibody mediated prevention (AMP) trials with the broadly neutralizing antibody VRC01 showed protection against VRC01-sensitive viruses. Here, by deep sequencing plasma samples from 172 participants of the AMP trials, the authors show a high frequency of multilineage HIV infections (38%), including coinfection with both sensitive and resistant viruses, and demonstrate that VRC01 doesn’t alter the transmission bottleneck.

In this work, authors present genetic and atomic insights of the Mycobacterium abscessus cytochrome bcc:aa₃, enabling the design of ND-011458 as a potent QcrB inhibitor, with the inhibitor bound enzyme structure paving the way for the development of a lead compound.

Fragile X-related protein 1 (FXR1) is a potential therapeutic target for ovarian cancer. Here, the authors show that RNA interference of FXR1 using a locked nucleic acid (LNA) form enables efficient inhibition of ovarian cancer growth and metastasis; single-cell RNA sequencing reveals the impacts on tumour proliferation pathways and the immune microenvironment.

Landform assemblages co-develop with ecosystems to distinguish fundamental permafrost properties across a continental-scale ecoclimate gradient, combining into finer-scale permafrost landsystems that vary with geological and climatic legacies to define predictable consequences of thaw.

Extracellular vesicles carrying diverse molecules circulate the body. Here, the authors show that blood-borne vesicles containing specific miRNAs boost synaptic function and sociability in mice, revealing a non-canonical pathway for social behavior.

Mucosal barriers play critical roles in the interaction with commensal and pathogenic microbes. Here the authors show non-canonical IL-22 signalling results in mucosal remodelling in a murine model during the immune response to Candida albicans.

Core-shell structured quantum dots such as AgIn_xGa_1−xS₂ are promising materials for optoelectronics, but their compositional distribution remains poorly understood. Here, the authors characterize their structure at the atomic scale in 3D and reveal nanoscale compositional gradients.

Oncogene-induced replication stress is a major endogenous driver of genomic instability. Here, the authors show that replication fork stalling induced by oncogenic RAS is caused by ROS-driven alterations of replisome architecture, leading to R-loop dependent fork reversal.

Photovoltaic-thermoelectric (PV-TE) hybrid systems offer a platform for enhancing the energy conversion efficiency of photovoltaic devices. Here, the authors present solution-processed PV-TE hybrid systems optimized for heat utilization and current matching, experimentally demonstrating a maximum efficiency of 50.28%.

The origins of life are steeped in mystery, but the AI revolution could transform this field. Here, the authors use AI-based protein design software to uncover a broad range of protein folds that can be formed from small, primordial amino acid libraries constrained by asteroid and prebiotic chemistry data.

The authors demonstrate a dual-functional antiferroelectric device that combines sensing, memory, and neural activation in a single architecture, enabling compact and low power in-sensor computing for medical image recognition.

G-protein-coupled receptors (GPCRs) function as monomers and in multiple oligomeric forms. Here, authors present a set of 12 assemblies of the apelin receptor (APLNR), providing a detailed view of the monomer-dimer transition.

Recent studies have shown that probing the heating and ionization dynamics of solid-density plasmas with x-ray free-electron laser (XFEL) beams is inherently challenging. Here, the authors demonstrate sub-picosecond time resolution of solid-density Cu plasmas driven by an optical laser pulse, by combining resonant x-ray emission spectroscopy and absorption imaging from an XFEL probe beam.

The authors report a metamaterial robot that integrates mechanical intelligence into robotics through embodied versatile computing. The robot performs analog and logic tasks, supports serial and parallel operations, and enables flexible spatiotemporal modulation and self-regulating locomotion.

Lethal heatwaves are traditionally identified using wet-bulb temperature thresholds, which fail to capture vulnerability and adaptability. Here, a model using thermo-temporal trends and public health predicts lethal heat with more than 10x accuracy.

Fear generalization allows learned threats to extend to similar stimuli, but the early sensory mechanisms involved are unclear. Here, authors show that fear conditioning reduces GABAB inhibition in the olfactory bulb scaled to odor similarity, and that bidirectional manipulation of this inhibition controls breadth of fear generalization.

Type I interferons play important in the innate immune response to HIV-1 infection. Here the authors suggest that nuclear RNA binding protein ZFP36L2 is induced by interferon-β and acts to restrict the nuclear export of HIV-1 transcripts.

Exchange only qubits encode a logical qubit in three physical spins and are controlled solely by exchange interactions, but their dependence on sequential exchange pulses leads to large gate depths. Here the authors demonstrate high fidelity quantum control of an always on exchange only qubit in a Si/SiGe quantum dot array using simultaneous exchange pulses.