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Analyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive actions.

Fractional Chern insulators have been observed in moiré MoTe₂ at zero magnetic field, but the expected zero longitudinal resistance has not been demonstrated. Now it is shown that improving device quality allows this effect to appear.

A new quasi-non-volatile 2D semi-floating gate memory with high speed and long refresh time could bridge the gap between volatile and non-volatile memory technologies.

There is a trade-off between achieving fast qubit control and preserving long qubit lifetimes. In this work, the authors demonstrate single qubit gates by driving a transmon qubit parametrically at 1/3 of its frequency, creating fast, high-fidelity gates while protecting the qubit lifetime and mitigating heating.

In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

Intrinsic molecular resources are used to implement a two-qubit iSWAP gate using individually trapped X¹Σ⁺ NaCs molecules.

This study reports coherent Aharonov–Bohm interference, including statistical phase contributions, in a Fabry–Pérot interferometer at two even-denominator fractional quantum Hall states in high-mobility bilayer-graphene van der Waals heterostructures is reported.

The efficiency of running quantum algorithms can be improved by expanding the hardware operations that a quantum computer can perform. A high-fidelity three-qubit iToffoli gate has now been demonstrated using superconducting qubits.

In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

The coherent bunching of anyons and their dissociation was observed in an interference experiment. 

The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.

Comparison of electrochemically gated charge transport through diphenyl benzene structures in meta and para configuration leads to the identification of anti-resonance features typical of destructive quantum interference.

In the standard Si transistor gate stack, replacing conventional dielectric HfO₂ with an ultrathin ferroelectric–antiferroelectric HfO₂–ZrO₂ heterostructure exhibiting the negative capacitance effect demonstrates ultrahigh capacitance without degradation in leakage and mobility, promising for ferroelectric integration into advanced logic technology.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Ion channels open and close to allow the regulated passage of ions through the membrane. Here the authors use selective ion channel blockers to analyse this regulation in a potassium channel and show that the gate is in the selectivity filter, past the entrance to the channel.

Gate reflectometry on an ancillary dot coupled to an electron reservoir is used to read the spin of a qubit in a CMOS device in a single shot with an average fidelity above 98% within 0.5 ms.

Coherent control of plasmon wavepackets is essential for quantum information processing using flying electron qubits. Here, the authors demonstrate a method to isolate and select electron channels contributing to a plasmon using a cavity formed by local constrictions, enabling precise control of plasmon eigenstates.

In order to locate the voltage-dependent gate in the MthK potassium channel, intracellular quaternary ammonium blockers are used for electrophysiology and crystallographic analyses. The data conclusively show that the inactivation gate is located at the selectivity filter and not at the cytoplasmic bundle crossing entrance.

NBCn1 plays an important role as a base loader allowing breast cancer cells to survive in an acidic environment. Here, Wang et al report its near atomic structure and transport cycle involving minimal structural changes associated with an exceptionally high turnover rate, enabling efficient cellular base loading and tumor survival

The authors use a combination of perceptual decision making in rats and computational modeling to explore the interplay of priors and sensory cues. They find that rats can learn to either alternate or repeat their actions based on reward likelihood and the influence of bias on their actions disappears after making an error.

Strontium titanate is a common substrate for growing oxide heterostructures—from superconductors to interfaces that support several phases of matter. But in an all-strontium-titanate device with a liquid electrolyte and metal-oxide gate, the results are anything but common.

The present study shows that maternal presence beyond early life remains crucial for brain, behavioural and physiological development in young horses, highlighting the importance of the mother–offspring relationship during a childhood-like stage.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

The integration of 1,024 independent silicon quantum dot devices with on-chip digital and analogue electronics, all of which operate below 1 K, allows characteristic data across the quantum dot array to be acquired and analysed in under 10 min.

Stabilizing non-trivial magnetic spin textures at room temperature remains challenging. Here, the authors propose introducing magnetic atoms into the van der Waals gap of 2D magnets Fe₃GaTe₂ to stabilize the magnetic spin textures beyond skyrmion.

In this work, the authors report Cryo-EM imaging revealing diversity in amyloid fibril structures among ATTR patients with the same genetic mutation I84S. Further study is warranted to grasp the implications in ATTR amyloidosis pathology.

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.

Qutrits, or quantum three-level systems, can provide advantages over qubits in certain quantum information applications, and high-fidelity single-qutrit gates have been demonstrated. Goss et al. realize high-fidelity entangling gates between two superconducting qutrits that are universal for ternary computation.

Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene regulatory networks to identify lineage restriction within multilineage progenitors.

Instead of using capacitively coupled charge sensors, which imply additional complexity in the device architecture, radiofrequency reflectometry on the gate defining the quantum dot can read out the spin state of a double quantum dot in a single shot.

The effects of disorder on the electrical characteristics of graphene are found to change drastically in a magnetic field. At zero field, disorder simply causes charge scattering. But at high fields it induces the formation of a network of quantum dots.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

Electron pairing is of fundamental interest in condensed matter physics. Here, the authors demonstrate electrons forming not only pairs - but also triplets - in graphene quantum Hall Fabry-Pérot interferometers.

Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

A cavity-array microscope is realized using intra-cavity lenses to create a two-dimensional array of over 40 modes, each coupled to a single atom in free-space.

An interferometer design allows systematic investigation of the anyonic statistics of bulk fractional quantum Hall states.

Field-effect transistors based on semiconductor nanocrystals are promising candidates for low-cost, flexible electronics. This work demonstrates fabrication on flexible substrates and low-voltage operations of integrated circuits based on nanocrystal transistors, including amplifiers and ring oscillators.

In this alternative approach to quantum computation, the all-electrical operation of two qubits, each encoded in three physical solid-state spin qubits, realizes swap-based universal quantum logic in an extensible physical architecture.

Knots reduce the tensile strength of macroscopic threads and fibres. Now it has been shown that the presence of a well-defined overhand knot in a polymer chain can substantially increase the rate of scission of the polymer under tension, as deformation of the polymer backbone induced by the tightening knot activates otherwise unreactive covalent bonds.

Pseudomonas aeruginosa survives extreme acidity by importing lysine through the LysP transporter to regulate acid-resistance genes. Here, authors reveal the cryo-EM structure of LysP and show how specific hydrogen bonds enable lysine recognition.

Many phototransistors are multi-component systems with inorganic materials or involve faradaic processes that can be irreversible. Using a single photoactive polymer, Druet et al. report a reversible, water-compatible n-type photoelectrochemical transistor with potentiometric photodetection and current modulation.

Electrolyte gating enables the accumulation of large carrier densities in two-dimensional electron systems. Here, the authors demonstrate that a few-atom thick layer of hexagonal boron nitride can dramatically improve carrier mobility in an electrolyte-gated system by limiting chemical reactions and disorder.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.