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In many optical systems with time-reversal symmetry, it is possible to control the output waves by shaping the input fields. Now a scheme is presented that works for multimode fibres that lack time-reversal symmetry due to thermal effects.

Serotonin produced by neuronal and non-neuronal cells has important roles in metabolism and behavior. Here, authors show that serotonin interprets different bacterial diets to guide context-dependent behaviors in C. elegans.

Commercial live attenuated influenza vaccines (LAIVs), usually contain a high proportion of defective interfering particles (DIPs), are not sufficiently protective. With mice models, the authors here reveal that LAIV with low DIPs replicates better, enhances immune response and facilitates cross-neutralization protection against lethal challenge of influenza strains.

Xu et al. report a Pockels photonic memory by integrating ferroelectric field-effect transistor with lithium niobate on insulator micro ring resonator. Through the manipulation of ferroelectric domains and the Pockels effect, the device achieves energy consumption at fJ/state level.

Here, the authors report the characterization of stable few-layer PdSe₂ transistors encapsulated in hexagonal boron nitride, showing field effect mobilities up to 700 cm²/Vs at room temperature and signatures of an 8-fold spin-valley degeneracy of the magnetotransport quantum oscillations at cryogenic temperatures.

In a large multinational cohort study, maternal, gestational or pregestational diabetes was associated with only a small-to-moderate risk of ADHD in offspring, contrary to previous estimates that showed stronger effect sizes, attributing the differences in findings to confounding by shared genetic and familial factors.

The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Herein the authors report an enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones using a chiral Lewis acid catalyst for the synthesis of hetero-bicyclo[3.1.1]heptane.

Electrochemical nitrate reduction is a promising method for greener ammonia synthesis. Here, a CuPd bimetallic catalyst with abundant Cu–PdH_x interfaces is synthesized, enabling efficient electrocatalytic nitrate-to-ammonia conversion. The interface-enhanced intrinsic activity provides a high production rate and long-term stability, and demonstrated scalability in membrane electrode assembly electrolysers.

The function of serotonin receptors and the neuroimmune relationship in psoriasis is not fully understood. Here, the authors find HTR2A antagonistic drugs worsened psoriasis outcomes in a study population, and that HTR2A modulation reduced psoriasis severity in imiquimod mouse models and that this involved HTR2A-expressing monocyte-derived Langerhans cells.

Understanding brain function requires integrating neuronal structure, activity, and genes. Here, authors developed an optogenetic tool they name Pisces, to enable complete labeling of individual neurons’ morphology with functional and molecular profiling, allowing multimodal single-cell analysis in vivo in zebrafish.

TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

The magnetoresistance suggests an exotic topological phase in LaBi, but the evidence is still missing. Here, Nayaket al. report the existence of surface states of LaBi through the observation of three Dirac cones, confirming it a topological semimetal.

TheC. elegans nervous system influences organismal lifespan but mechanistic details are poorly understood. Here, Chun et al. show that the neurotransmitter GABA regulates worm lifespan by acting on GABA_Breceptors in motor neurons, which activate the transcription factor DAF-16 in the intestine.

Biomolecular condensates can adopt complex architectures, including hollow structures linked to disease. Here, the authors combine biochemical assays with mathematical modeling to reveal how the fusion oncoprotein FUS–ERG and DNA drive the formation of hollow condensates.

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

Long-wavelength luminescence from boron-based cations is typically hindered by both intrinsic instability and pronounced non-radiative decay. Now a triadic design that integrates a non-Kekulé polycyclic aromatic hydrocarbon framework, a charge-localizing carbodicarbene ligand and counterion-directed assembly enables stable borenium ions with tunable red-to-near-infrared emission in the solid state.

Electrolyte design aims to promote ion association (the complexation of cations and anions) to boost lithium-ion battery performance, but safety remains a concern. Now, researchers show that ion association can reduce the onset temperature of exothermic reactions that trigger thermal runaway, and propose a solvent-relay strategy to extend cycle life and improve safety.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

Michel et al. report unique localization of non-canonical BAF to CTCF sites and promoters, which confers synthetic lethality in canonical BAF-perturbed synovial sarcoma and malignant rhabdoid tumour cells.

A study of millions of couples shows spouses often share psychiatric disorders. This pattern is consistent across cultures (Taiwan and Nordic countries) and has persisted for generations, impacting how these disorders are inherited.

Rhombohedral-stacked molybdenum disulfide with sliding ferroelectric behaviour can be used to create atomically thin ferroelectric transistors for computing-in-memory device applications.

α-tubulin acetylation is an evolutionarily conserved modification but despite its prevalence, the physiological function of this process remains poorly understood. Here, the authors show that α-tubulin acetylation regulates p38 kinase signalling and expression of the anti-inflammatory cytokine IL-10 in macrophages.

Cross-linkable co-SAMs improve hole-selective SAM stability, preventing defects and thermal degredation in perovskite solar cells, enabling 26.92% efficiency with high heat durability, and guiding the design of more efficient and durable solar cells.

The neural circuits that transmit cool signals remain not fully understood. Here, authors identify a spinal circuit in mice that transmits cool sensations from the skin to the brain, revealing a dedicated neural pathway for detecting innocuous cool temperatures.

The realization and control many-body quantum states in perovskites would extend their application to ultrafast quantum operation. Here, the authors generate a cooperative quantum state of excitons in a lead halide perovskite quantum dot ensemble and control the ultrafast radiation through optical microcavites.

Somatic expansion of a CAG repeat in HTT drives onset of Huntington’s disease. Using a human cell line model and splice modulators, here the authors show that PMS1 is an enhancer of CAG repeat expansion, making it a target for therapeutic intervention.

Stable lithium metal electrodes are needed to produce high-energy batteries. Here, authors reported poly(2-hydroxyethyl acrylate-co-sodium benzenesulfonate) as a lithium metal protective layer and the production of a 490 Wh/kg class Li | |LiNi_0.83Co_0.11Mn_0.06O₂ pouch cell.

As immune checkpoint therapy is more frequently used for cancer, side effects such as Stevens-Johson syndrome / toxic epidermal necrolysis (SJS/TEN) are becoming more common. Here the authors use single cell transcriptomics to implicate TNF and CXCL10 in recruitment of CXCR3⁺ cytotoxic T cell in SJS/TEN skin lesions.

Immunization via the respiratory route is predicted to increase the effectiveness of SARS-CoV-2 vaccines. Here, Kaiser et al. describe a murine pneumonia virus vectored vaccine expressing spike protein, and show that intranasal immunization of male rhesus macaques provides good mucosal and systemic immunogenicity and efficacy.

Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.

Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute neurotoxicity.

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.

Lithium cobalt oxide is widely studied for electrocatalytic applications. Here, the authors develop a technique for delithiating the material in organic electrolyte, and demonstrate that the oxygen evolution catalytic activity is significantly improved after the treatment.

Materials which simultaneously exhibit superconductivity and topologically non-trivial electronic band structure possess potential applications in quantum computing but have yet to be found. Here, the authors find superconductivity in MoTe₂, a material predicted to be topologically non-trivial.