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The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

By linking axial coordination chemistry to spin-state control and reactive oxygen species selectivity, this study delivers mechanistic insights and a versatile design principle for single-atom catalysts in environmental catalysis.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Structural complexity often hinders the efficient conversion of lignin into sustainable high-value products. This bifunctional core–shell catalyst enables a relay reaction that transforms lignin into jet-fuel range cycloalkanes with high yields.

Designing complex carbon frameworks for specific applications often relies on trial-and-error. Here, authors integrate machine learning and interfacial mechanisms to evolve graphene quantum dot carbon frameworks, enabling selective detection and clearance of metabolically reprogrammed senescent cells.

Controlling the morphology of dendritic nanostructures is crucial for enhancing their functionality, but remains a challenge. Here, the authors demonstrate that the local electric field between gold nanoparticles and iron oxide branches promotes directional and accelerated growth.

This work develops a reconfigurable heterojunction with coupled charge tunneling and ferroelectric polarization, enabling the integration of memory, sensing, and logic computation within a single device.

This work proposes a strategy to fabricate textured piezoelectric ceramics with greatly reduced grain size (~7.8 μm), enabling to maintain high piezoelectric and dielectric properties of textured ceramics at the sample thickness below 100 μm.

Grassland canopy height shapes plant community structure and grazing efficiency, yet large-scale trends remain poorly quantified. Using nationwide data, this study suggests that canopy height has declined across China, in association with asymmetric biomass allocation.

Mitochondrial genomes of bilateral animals exhibit high variability in architectural rearrangement rates, but the reason for this disparity remains unknown. This study provides evidence that purifying selection mediated by locomotory capacity and species ecology is a major driver of mitogenomic architectural evolution.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

Methanotrophic growth on methane and N₂-derived ammonia is inhibited by a toxic intermediate, hydroxylamine, generated via ammonia oxidation. Here the authors ameliorate this toxicity through genetically engineering M. sanxanigenens and feed the biomass to mice to reduce colitis symptoms.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Solid-state molecular motion is an important feature of a number of compounds, but visualization of these dynamics is challenging. Here, the authors report a molecular diffusion method for visualization and regulation of solid state molecular motion, and application in purity testing.

This study reveals how the cBAF chromatin remodeling complex organizes stem cell environments and guides cell fate decisions by recruiting distinct partner proteins to maintain adult tissue homeostasis.

The stability of perovskite photovoltaics under thermal and light stress remains poorly understood. Wang et al. identify cation segregation and volatilization of formamidinium iodide as the primary degradation pathways at different temperatures.

Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Electronic chirality is a fascinating but still poorly understood phenomenon. Here, the authors show that CuPc molecules on bilayer graphene exhibit electronic chirality driven by twisted π–π interactions, which can be reversibly switched using an STM tip.

This study reports graphene–amorphous carbon with interwoven networks, achieving a flexural strength of 203 MPa. Microscopy shows that crack deflection at graphene/amorphous interfaces underlies its superior performance.

Ge, Liu et al. develop and validate a survival model (SM-CRT) using multicentre data from 30,947 cancer patients to predict catheter-related thrombosis (CRT) risk. The model accurately identifies high-risk patients and high-risk time periods, supporting personalised thromboprophylaxis and optimised catheter removal timing.

Functionalization of ZnTeSe quantum dots via ordering arrangement and energy-level modulation enables deep-blue quantum dot light-emitting diodes with a peak external quantum efficiency of 23.6% and a half-lifetime exceeding 50,000 h at an initial luminance of 100 cd m⁻².

Two-dimensional boridene supports neuromorphic optoelectronic computing through anomalous electrical anisotropy. Its low-temperature deposition supports back-end-of-line-compatible fabrication of twelve-inch wafer arrays.

Floquet engineering in monolayer graphene reveals a gap opening at Floquet band crossings and coherent Floquet sidebands resolved by time- and angle-resolved photoemission spectroscopy.

Voltage losses at the perovskite/C₆₀ interface limit the efficiency of perovskite solar cells. Mubai Li et al. design an electron-selective charge-transport self-assembled monolayer that balances electron extraction and the interfacial charge-carrier density.

Neurogenic bladder dysfunction impairs bladder sensation and contraction. Here, the authors report an implantable soft bladder-machine interface that integrates with the bladder providing monitoring and electrical stimulation.

Food loss and waste (FLW) is a major source of global GHG emissions, yet its drivers and mitigation potential remain understudied. By attributing FLW to techno-economic and misbehavioural drivers, this study shows misbehaviour dominates FLW emissions and offers substantial mitigation potential.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Morphodynamic modelling reveals how timing and fate shape diverse grass inflorescences, including wheat supernumerary spikelets. Using this model, the authors identify an early-heading paired-spikelet mutant, which exhibits robust yield gains.

Ubiquitin tagging controls protein fate, but how the COP1-DET1 E3 ligase works was unclear. Here, the authors present cryo-EM structures of an inactive stacked assembly that switches to an active dimer on substrate binding, with DET1 guiding enzymes to start and co-workers to extend ubiquitin chains.

Nontrivial topologies are long believed to survive only in gapped systems, yet recent progress suggests their existence even at quantum critical points. By preparing low-lying states on a superconducting processor up to 100 qubits and applying entanglement Hamiltonian tomography, the authors experimentally observe these nontrivial topological properties and suggest low-lying states as useful quantum resources.

The majority of microbial metabolites remain cryptic or minimally expressed under laboratory conditions. Here authors show that high-energy pulsed electron beams (HEPE) can be used to induce extensive structural variation, activating secondary metabolite biosynthesis.

Xiaolu et al. evaluate the efficacy and safety of eribulin plus gemcitabine treatment for HER2-negative metastatic breast cancer patients. The combination treatment is effective in patients with HER2-negative metastatic breast cancer needing second-line or later treatment and has a predictable, manageable side effect profile.

The rapid degradation during operation of perovskite solar cells may be caused by the limited durability of passivation by ammonium-terminated ligands. Here, the authors reveal the depassivation mechanism of perovskites induced by violet/ultraviolet light, validated in cells with 26.44% efficiency

The rewiring of amino acid utilisation pathways in liver cancer requires further investigation. Here, the authors show that liver cancer promotes tyrosine translational utilization, thereby enhancing oxidative phosphorylation and ferroptosis resistance in tumour cells.

Using dietary data from 8,931 participants in the WELL-China cohort, this study identifies a new diet rooted in traditional Chinese food elements associated with better adherence, favourable gut microbial profiles, lower rates of central obesity and reduced incidence of major cardiovascular events, and confirms these findings in an independent Achieving Better Omics validation cohort (n = 1,851).