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Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of morphine, providing precise chronic pain relief without affecting sensory detection.

The topographical features of insect wings result in some interesting surface properties, including hydrophobicity and antibacterial activity. Here the authors identify the surface of black silicon as a mimic of dragonfly wings and show that it too possesses antibacterial activity.

The detection of forsterite and enstatite emissions in EC 53 during accretion bursts marks one of the first pieces of direct evidence of in situ silicate crystallization in young stars.

How is specific ribosomal RNA expression precisely controlled in the malaria parasite? Dr. Couble et al. show that a switch between distinct energy-generating pathways during parasite development directly impacts the accessibility to rDNA chromatin.

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

In a prospective study involving 579,583 women in multiple sites across the USA, a multistage AI-driven workflow for digital breast tomosynthesis mammograms assisted radiologists in identifying 21.6% more cancers with respect to historical data, showing no significant variation across socio-demographic and breast density subgroups.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

Understanding the dual role of neuraminidase and hemagglutinin antibodies in influenza transmission is crucial for enhancing vaccine efficacy. Here, the authors use household transmission studies and mathematical models and find that neuraminidase immunity reduces infectivity, suggesting vaccines targeting both glycoproteins could lower community transmission and offer broader protection.

For pain signaling to be useful, sensory receptors must rapidly detect noxious stimuli and efficiently turn off once the threat has passed. Here, the authors uncover a critical role for the universal calcium sensor calmodulin in properly turning off the TRPA1 pain receptor.

The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

Currently, there is no licensed vaccine for Burkholderia pseudomallei, the causative agent of melioidosis. Here, the authors evaluate the efficacy and safety of an outer-membrane vesicle vaccine in macaques and demonstrate that it prevents lung pathology.

HIV infection and substance use disorders converge in human midbrain. Here, authors show transcriptional impacts using single-nucleus RNA sequencing, linking dopaminergic vulnerability and microglial dysregulation, and in viremia, GABAergic deficits.

Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms and the long-term evolutionary dynamics of cis-regulatory elements in animals.

Analysis of exomes and transcriptomes from 100 African American patients with acute myeloid leukemia identifies ancestry-related variation in mutation profiles and survival. Refined risk classification suggests clinical relevance of these ancestry-associated differences.

With rich, multi-layered baseline data and long-term follow-up through linkage, the HELIOS Study provides a resource to investigate the behavioural, environmental, genomic, and molecular factors impacting health in Asian populations.

Hiʻiaka is the largest moon of the distant dwarf planet Haumea. Here, the authors report the first multi-chord stellar occultations of Hiʻiaka, revealing its size, shape, and density, suggesting an origin from Haumea’s icy mantle.

Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the potential of brain organoids as a model for neuronal circuit assembly.

Henize 2-10 is a nearby dwarf starburst galaxy that may be similar to galaxies in the infant Universe. It is reported that Henize 2-10 contains a compact radio source at the dynamical centre of the galaxy that is spatially coincident with a hard X-ray source, from which it is concluded that Henize 2-10 harbours an actively accreting central black hole with a mass of approximately one million solar masses. The results confirm that nearby star-forming dwarf galaxies can indeed form massive black holes, and by implication so can their primordial counterparts.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Following its internalisation, active endosomal GLP-1R engages with VAPB and SPHKAP at ER membrane contact sites to assemble a local cAMP/PKA condensate for the control of MICOS complex phosphorylation, mitochondrial remodelling and β-cell function.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

The authors report that an AS03-adjuvanted chimeric hemagglutinin-based influenza vaccine induces persistent stalk-specific serum antibody and bone marrow plasma cell responses in nonhuman primates, offering promise for broader and durable flu protection.

An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.

The Galactic Centre is orbited by two objects that look like gas and dust clouds but behave more like stars, and now four additional similar objects are reported.

People typically perceive the motion and depth of objects correctly even during walking or running, when visual inputs change markedly. The authors show that this accurate perception is achieved by inferring the observer’s viewing geometry from optic flow.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts.

DNA origami enables precise nanoscale self-assembly. Authors here show how programmable control of interactions and binding angles yields curved surfaces of diverse geometries, broadening the design space for synthetic nanostructures.

Viral proteins can achieve high multifunctionality, but mechanisms are poorly understood. This study shows structural flexibility of rabies virus P protein enables RNA binding and phase separation to expand functions by infiltrating host condensates.

Ultrathin alumina encapsulation protects the magnetic, magnonic, and optical properties of air-sensitive V[TCNE]ₓ, enabling characterization of intrinsic material properties and integration of this organic-based magnet into cryogenic quantum devices.

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The cytochrome bc₁ oxidase of Mycobacterium tuberculosis is a potential target in the fight against tuberculosis. Here, the authors evaluate the potential of cytochrome bc₁ inhibitors as partner drugs in tuberculosis treatment regimens.

Evidence for exciton coherence in photosynthetic complexes raises questions about whether quantum processes can play a role in biological environments, which are warm and wet. Cassette et al. now demonstrate long-lived electronic coherence in colloidal nanoplatelets in solution and at room temperature.

The adhesion of meningococci to endothelial cells relies on type IV pili, which induce the formation of long tubular structures on the host cell membrane. Here, the authors show that the tubular structures accumulate and trap host membrane-associated proteins, which facilitates their interaction with bacterial ligands and the activation of adhesion and signaling receptors.

Cell Neural Networks on Spatial Transcriptomics (CellNEST) deciphers patterns of communication between cells in spatially resolved transcriptomics data and can detect both signals between individual cells and relay networks of communication.