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Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Using artificial intelligence, authors model how air pollution may increase susceptibility to SARS-CoV-2. NPC1 is identified via genetic and laboratory analyses as a key pathway that enhances viral entry after exposure to fine particulate matter.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Neural mechanisms underlying energy metabolism are not fully understood. Here authors show that Phf6-expressing neurons in the medial preoptic area as key regulators of physical activity and energy expenditure, revealing a neural mechanism underlying obesity in Börjeson-Forssman-Lehmann syndrome.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Protein engineering is often hindered by the gap between modelling and experiment. Here, authors present ORI, a closed-loop computational framework to iteratively optimize proteins, achieving 100-fold higher activity, enhanced thermal stability, and the design of multifunctional enzymes.

MicroRNAs are promising disease biomarkers, yet accurately measuring them remains challenging. Here, the authors develop SE-SPTM-PCR, a method which improves sensitivity 100-fold and eliminates false signals, showing improved diagnostic performances for cancer and viral reactivation.

The function of metal-organic frameworks is governed by their synthesis precision. Here, the authors report a light-driven strategy enabling ambient-temperature synthesis for cobalt-porphyrin frameworks, overcoming traditional thermal constraints.

The core downstream mediator of the Norrin/β-catenin pathway remain elusive, hindering the treatment of familial exudative vitreoretinopathy. Here, the authors show that KIF11 acts as a key effector of this axis by preventing phosphorylation-driven PRDX1 phase separation and subsequent ferroptosis.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.

In this study, the authors present two distinct neuronal subpopulations, sharing a speed encoding model, in the mouse dorsal periaqueductal grey, controlling running and backing away behaviors, respectively.

A soft three-dimensional core–shell cable can form reliable free-standing interconnects between soft, rigid and hybrid electronic components, and can be stretched by up to around 800%.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

The study introduces polyethyleneimine as an additive in a thermocell, enhancing thermopower from 1.4 to 7.76 mV/K. It achieves long-term stability and scalability by enabling thermosensitive adsorption-desorption, selective reactions, and Manning condensation, converting low-grade heat to electricity efficiently.

Ming et. al. reports a memristor with an intrinsic ionic gradient that enables stable second-order dynamics and physically modulated learning rates. The device supports stable, energy-efficient continual reinforcement learning and adaptive decision-making.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

The mycotoxin deoxynivalenol (DON) threatens global human and animal health. Here, the authors identify two key functional enzymes in a bacterium that initiate the complete degradation of DON to CO2, elucidating their core catalytic mechanisms and biotechnological application potential.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

This work effectively addresses the long-standing challenge of competitive kinetics in heterogeneous Fenton-like systems through the synergistic interaction between nitrogen vacancies (Nv) and Fe sites on carbon nitride.

Wu et al. identify circulating proteins associated with cardiovascular and neurological imaging traits and diseases, and validate GDF15 as a shared determinant of heart and brain pathologies in mice.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

Disentangling intertwined orders in quantum materials is challenging. Now, photoemission spectroscopy experiments show that magnetic fields can be used to disentangle such orders in a kagome superconductor.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The stability of perovskite photovoltaics under thermal and light stress remains poorly understood. Wang et al. identify cation segregation and volatilization of formamidinium iodide as the primary degradation pathways at different temperatures.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Xiangdong Fu and colleagues report characterization of a major rice grain yield QTL at the DEP1 locus.

The electron-phonon coupling in organic semiconductors is key to improving performance for devices. Here, the authors show that modulating the penetrated donor-acceptor interface with low electron-phonon coupling, reduces non-radiative voltage loss for high-performance organic solar cell devices.

In this study, the authors show that chandelier cells in the medial prefrontal cortex integrate circuit inputs, encode stimulus salience across sensory modalities, and thus influence associative learning in male mice.

Fabrication of single liquid-metal fibers is challenged by their limited surface area, thus restricting its functional deployment in soft electronic systems. Here, the authors develop a scalable, solution-deposition strategy for stretchable, multifunctional 1D liquid-metal-based bioelectronic fibers.

Human management is vital for ecosystem health, yet its global impact on forest resilience remains unclear. This study shows that while natural forests are generally most resilient, managed forests can be more stable in wet or fertile regions.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Technology advancement is essential for climate action, yet the uneven distribution of technological progress across the world can slow mitigation. Through empirical and scenario analysis, researchers find that participating in trade agreements could enhance technological transfers and lead to emission reductions.

Allogeneic stem cell transplantation (alloHSCT) is approved for the treatment of transfusion-dependent thalassemia but remains limited to the use of matched sibling donors. In this multi-centre, phase-4 prospective clinical trial, the authors evaluate the use of alloHSCT with matched unrelated donors and haploidentical relatives.