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Early identification of high-risk trauma patients in prehospital settings is essential for effective triage and improved survival. Here the authors show that a real-time ensemble AI model accurately predicts emergency department mortality using only prehospital data, outperforming traditional triage tools.

Single-crystalline layered oxides can reduce capacity decay in nickel-rich cathodes, but controlling both the particle size and cation disorder is challenging. This work reports cation-disorder-free ~10-μm single-crystalline cathodes that deliver high volumetric capacity and cycle stability as well as improved safety.

A hydrogel matrix fabricated by cryo-photocrosslinking enables the direct, scalable isolation of extracellular vesicles from diverse biofluids without preprocessing, allowing for in-gel preservation for long-term storage and biomedical applications.

Conventional therapies can induce cancer cell senescence. Here the authors show that therapy-induced senescent cancer cells can escape T-cell immunity by upregulating PD-L1, whose expression and glycosylation levels are regulated by ribophorin 1.

The strength and stability of silk proteins is thought to be related to the high content of β-sheets within their structures. Here, the authors show that when heated at high temperature, and above that of thermal degradation, these β-sheets are transformed into an ordered hexagonal graphitic structure.

Clusterin is widely distributed in tissues and body fluids, and is implicated in various physiological processes. In this study the authors investigate the role of hypothalamic clusterin, and find that clusterin regulates energy metabolism and body weight through the lipoprotein receptor LRP2.

Glutamine addiction is a hallmark of many cancers. iMQT_020, a first-in-class allosteric inhibitor of the mitochondrial glutamine transporter SLC1A5_var, disrupts glutamine-dependent mitochondrial metabolism, selectively killing cancer cells and enhancing immune checkpoint inhibitor efficacy.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Kim et al. report the medium n-phase pinning for quasi-2D perovskites by forming strong cation-π interaction complex. The homogeneous phase distribution leads to peak efficiency of 22.5% for sky-blue perovskite LEDs. The phase-pinning strategy also extends to pure- and deep-blue spectral region.

Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

The transcriptional coregulators YAP/TAZ are shown to directly control leptin gene transcription, thereby uncoupling adipose tissue mass from leptin levels.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

In this study, the authors introduce the concept of a unique cellular subtype within the organic stroma, which does not conform to a typical young or senescent but is significantly associated with age-related organic dysfunction among the elderly.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Dickkopf-related protein 1 (DKK1) is a secreted protein associated with poorer outcomes in patients with gastric cancer. Here, the authors report part B of the DisTinGuish phase II trial reporting the safety and efficacy of DKN-01 (DKK1 neutralising antibody) in combination with tislelizumab (anti-PD-1) in patients with advanced gastric/gastoesophageal junction cancer and elevated DKK1 expression.

Soluble fumarate reductases are essential for eukaryotic cell survival under anaerobic conditions but their mechanism is not fully understood. Here, the authors present structural and enzymatic analyses of yeast fumarate reductase Osm1, elucidating the molecular basis of maintaining redox balance during anaerobiosis.

Controlling defect states and impurity incorporation in oxide semiconductors is essential for enhancing thin-film transistor performance. Here, the authors reveal that hydrogen impurities act as deep-level electron traps, limiting device efficiency; by suppressing hydrogen incorporation in In–Ga–Zn oxide transistors, they achieve improved bias stability, high field-effect mobility, and superior switching speeds, advancing low-power, high-speed oxide electronics.

Extracellular vesicles are released from cells and permit communication between different cell types. Here, the authors identify that the FDA approved antibiotic sulfisoxazole, can block the release of these vesicles in breast cancer cells resulting in reduced cell growth in vitro and in vivo.

Monolithic 3D integration of electronics based on fully 2D materials is demonstrated in the performance of artificial intelligence tasks.

Lithium-rich layered oxides, promising high-energy-density cathode materials, face electrochemical degradation due to structural disordering. Here, the authors report that slab gliding is a key trigger of this disordering and a pivotal unexplored avenue for a reversible anionic redox reaction.

Obesity can be associated with an increased risk of metabolic complications. Here, the authors show that adipocyte-specific ablation of the phosphatase PHLPP2 improves glucose homeostasis in high-fat diet fed obese mice, and that this may be due at least in part to PHLPP2 dephosphorylation of HSL.

Kim et al. reveal that TFEB expression is protective in the setting of diet-induced obesity by activating the expression of GDF15 in adipose tissue macrophages in mice and humans.

Bacteria of the SAR202 clade are ubiquitously distributed in the ocean, but their biology is poorly understood due to the lack of cultivated isolates. Here, Lim et al. report the cultivation of marine SAR202 bacteria and provide insights into the physiology of these enigmatic microorganisms.

Time-resolved femtosecond crystallography (TR-SFX) is a powerful technique to monitor structural transitions in protein crystals at the atomic level, but its use in non-protein synthetic materials remains limited. Now TR-SFX has been used to visualize the structural dynamics of metal–organic frameworks, showing the potential of this tool to study the dynamic motion of crystalline porous materials.