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Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

This study found COVID-19 vaccination offers added protection against reinfection in children and adolescents with prior infection but variable effectiveness across variants. Findings support vaccination benefits beyond infection-acquired immunity.

Replicating enzyme function with minimal components is a major challenge in abiotic mimicry. Here, the authors show that liquid gallium droplets act as tunable artificial nucleases, cleaving DNA with nucleotide bias via oxide-mediated adsorption and hydroxyl radical-assisted hydrolysis.

Synthetic macrocycles are promising therapeutics; however, most high-throughput discovery platforms rely on genetically encoded libraries of large peptide macrocycles, which are typically not optimized for drug-like properties. Here, the authors report CycloSEL (Cyclic Self-Encoded Libraries), an end-to-end workflow that screens synthetic macrocycle libraries enriched in drug-like ‘beyond rule of five’ features, based on affinity selections and hit identification by tandem mass spectrometry.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

∆9-tetrahydrocannabinol induces anxiety at high doses, but the neural mechanisms remain unclear. Here, authors show that CB1 receptor–mediated inhibition of the ACC → DMS pathway drives anxiety-like behavior and THC aversion in mice.

Many hospitalised children with acute illness in low- and middle-income countries experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. Here the authors report multiomic profiling to investigate biological drivers of hospital in-patient and post-discharge mortality in 3,101 acutely ill children across nine sites in sub-Saharan Africa and South Asia.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

A Hemostatic Tough Adhesive (HTA) is developed and evaluated, achieving hemostasis in both liver and spleen injuries within an in vivo preclinical porcine model.

Less than 15% of people in 862 European cities live in full compliance with the 3-30-300 greening rule. Wealthier areas show higher adherence, highlighting urgent needs for equitable urban planning to improve access to green spaces.

A range of humoral related adverse events can occur after treatment of haematological malignancy with chimeric antigen receptor cell therapies. Here the authors characterise the persistence of humoral immunity and response to vaccination after patients receive B cell targeted chimeric antigen receptor T cell therapy.

Microbial biosynthesis of monoterpene esters remains a major challenge due to the limited repertoire of highly selective alcohol acyltransferases (AATs). Here the authors discovered and engineered AATs for various monoterpene esters using a dual-substrate microbial platform.

Three-dimensional Raman modelling of multiphase inclusions in Sumdo eclogites reveals sulfur rich slab-derived fluids at sub-arc depths, providing direct constraints on deep sulfur cycling and copper mobilization in subduction zones.

Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an endoplasmic reticulum oxidized glutathione (GSSG) exporter in mammalian cells.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Here, the authors examine bird wing planform shape and functional performance using theoretical morphospace and phylomorphospace. They find that, in a sample of 1138 extant bird taxa, planform shape is weakly impacted by phylogeny and that functional optimality varies across birds depending on their flight style.

Microplastic-oil co-contaminants are environmentally concerning, though conventional membranes are typically designed for single pollutant removals. Here the authors design a membrane using a sodium periodate-assisted co-deposition of caffeic acid and ε-polylysine method for the removal of complex mixtures from water.

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.

The genetically encoded voltage indicators JEDI3sub and JEDI3hyp enhance monitoring of subthreshold neuronal activity in the awake mouse brain using a variety of two-photon microscopy techniques.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Mirvetuximab soravtansine (MIRV) is an antibody drug conjugate comprised of a folate receptor alpha-targeted monoclonal antibody and the anti-tubulin maytansinoid payload, DM4. Here the authors report the results of a phase II trial of MIRV in combination with anti-PD1 pembrolizumab in patients with recurrent folate receptor alpha-positive uterine serous carcinoma.

Cells respond to cholesterol levels with increased growth. Here, the authors show that HR3/RORα senses cholesterol to regulate TOR signaling, linking cholesterol availability to cell growth, with implications for cholesterol-related diseases and cancer.

Computationally designing proteins with interfaces that bind small molecules has posed a long-standing challenge. Here, authors combine deep learning and physics-based approaches to design proteins that bind small molecules, and demonstrate their approach by designing a cortisol biosensor.

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

This study identifies extensive lateral interdigitations in the kidney’s ascending thin limb and demonstrates that Claudin-10b regulates both epithelial architecture and urine-concentrating function in this distinct nephron segment.

Methane is a potent greenhouse gas, but can also be used as a source for advanced carbon materials. This work shows a sustainable approach to produce high-value carbon fibres through methane pyrolysis.

Inducible base editors enhance cancer genomic screens in vivo.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

The two species of African elephants are facing severe declines. Here, authors assess their continent-wide genomic diversity, identifying differences in their evolutionary histories and highlighting the formative role of gene flow.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Here, the authors reveal that the mitotic motor KIF11 functions in postmitotic neurons as a microtubule-dynamics rheostat to regulate dendritic arborization. Additionally, they show how MCLID mutations impair KIF11 oligomerization, ATP hydrolysis, neuronal structure, and communication.

ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration.

Scaling correlations, between adsorption energies of chemically related surface species, impose limits on selectivity in chemical processes, as exemplified by constraints in heterogeneous catalysis. Now it has been demonstrated that time-dependent surface polarization under oscillating potentials could overcome static scaling relationships and promote selectivity in acetylene semi-hydrogenation.

Atopic dermatitis is an immune disease driven by cytokines including IL-4/IL-13. This study shows that a topical ITK/TRK inhibitor blocks an array of T cell cytokines, inhibits NGF-induced basophil activation, and reduces inflammation in human skin explants and dermatitis models, indicating therapeutic potential.

Reducing dissipation when generating spin currents remains a central challenge in spintronics. Now, an artificial ferrimagnet is shown to produce spin current output and simultaneously lower magnetic damping.

The authors identify ¹⁷¹Yb³⁺:CaWO₄ as a promising material for quantum technological applications, revealing lifetime-limited optical coherence of 0.75 ms and spin coherence of 0.15 s, highlighting its potential for quantum memories and transducers.

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Plasma phosphorylated tau 217 levels predict future accumulation of Alzheimer’s disease pathology in cognitively unimpaired older adults without elevated brain amyloid-β (“A-”) on positron emission tomography.

Erbium-based fiber lasers are widely used but hard to integrate on chips at an industrial scale. Here, authors demonstrate the first wafer-scale erbium-doped silicon-nitride waveguide lasers with broad C+L-band tunability, high output power, and fiber laser-class coherence.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

The integration of carbon capture and electrochemical conversion is an emerging strategy to valorize CO₂. Here the authors demonstrate that altering CO₂–amine speciation in aprotic media enhances CO₂ uptake and suppresses hydrogen evolution, achieving promising Faradaic efficiency towards CO production, including with flue gas feedstocks.

TDP-43 pathology is a key event in ALS/FTD and selectively affects specific neurons in the motor cortex. Here, the authors report which neuron types are affected and demonstrate that transcriptomic changes are cell-type specific.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

Stable, ultra-low-noise integrated lasers are essential for scalable quantum computers and portable optical clocks. Here, authors demonstrate a chip-scale coil stabilized Brillion laser driving a room-temperature trapped-ion clock and qubit without a bulk reference cavity achieving 99.6% SPAM fidelity.

Cellular underground metabolism plays crucial roles in enzyme promiscuity, metabolism and biological evolution, but it has hardly been investigated. Here the authors combine retrobiosynthesis with deep learning enzyme annotation and enzyme–substrate prediction methods to explore it, reconstructing the yeast metabolic twin model, Yeast-MetaTwin.