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During lytic regulated cell death, a transitional agonal stage exists between initiation and terminal death. Here, the authors found that agonal cells upregulated uptake and internalization of extracellular vesicles fused with the cell membrane via SNARE complexes to enhance membrane repair.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Proteomic and molecular experiments collectively revealed that RPL35A-mediated translational reprogramming and activation of the PGE2-p38 MAPK-NF-κB/ROS axis contribute to N. atra SVPLA₂-induced muscular inflammatory storm

Hemifacial spasms are hard to monitor and counteract. Here, the authors develop an eyewear-based closed-loop system that detects spasms via triboelectric sensors and triggers facial nerve stimulation, reducing spasm severity.

Effective cross-group collaboration is crucial during crises, yet its evolving dynamics and impact on network effectiveness remain poorly understood. Here, the authors employ a topological framework based on zigzag persistence applied to city-scale datasets associated with pandemic waves in Shenzhen, China, and reveal that higher-order collaborations are a generic feature of effective crisis response, offering insights for optimizing collective action in emergencies.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Electrocatalytic nitrate reduction in acidic wastewater offers a route to produce ammonia, but faces efficiency challenges. Here, the authors report a Ru/WO_3-x catalyst that uses a proton-management strategy to achieve high ammonia production and enables a device that recovers energy.

Here the authors present scLong, a billion parameter foundation model trained on 48M single cells, using self attention across all 28k human genes and Gene Ontology knowledge. It captures long range gene context in single Cell transcriptomics.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Wearable sensors with edge computing are desired for human motion monitoring. Here, the authors demonstrate a topographic design for wearable MXene sensor modules with wireless streaming or in-sensor computing models for avatar reconstruction.

Thermal barrier coatings are vital for gas turbine blades but are prone to debonding and cracking. Here, the authors propose a method for the rapid detection and identification of such defects by combining thermographic and electromagnetic signals.

Zhang et al. report a foundry-compatible γ-ray treatment to induce chemical bond changes of organic contaminants in carbon nanotube transistors, mitigating the imperfections at the carbon nanotube/dielectric interface, reducing the off-state current density to 112.2 pA μm-1, and achieving radiation tolerance up to 100 Mrad(Si).

Cation separation is of great importance or energy and environmental scientists, though it is challenging to design systems with high selectivity. Here the authors report a polyacrylonitrile-chitosan composite sphere-system by humidity controlled to separate cations for lithium extraction.

Single-atom catalysts (SACs) offer high atom utilization and efficiency, but their synthesis is challenging. This work realizes the mass production of sustainable SACs and demonstrates their application in vascular healing.

Wound biomarker monitoring faces challenges in both sensitivity and stability. Here, authors present soft wireless bioelectronic device, using self-confined tetrahedral DNA circuits, that enhance detection limits, resists biofouling, and enables stable and real-time monitoring of diabetic wound healing.

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

A comprehensive phylogeny and taxonomy for the medically and ecologically important genus Artemisia remain unavailable. Here, the authors combine genomic data with morphological analyses to reconstruct the most comprehensive phylogeny and taxonomy of global Artemisia.

Mesenchymal condensation is essential for cartilage development. Here, the authors report on a cell-adaptable supramolecular hydrogel to replicate the hypoxic environment and structural support needed for cartilage organoid formation and study the metabolic reprogramming involved.

Synthesis of urea through the electrochemical co-reduction of abundant CO₂ and nitrates offers an eco-friendly alternative to existing technologies. The authors use ionic liquids to construct molecular bridges between the catalyst’s active sites and the reactants, thereby enhancing urea production.

Shallow NV centers in diamond are promising quantum sensors but suffer from reduced coherence times due to surface spin impurities. Here the authors improve coherence times to over 1 ms through interface engineering by oxygen-terminating the diamond surface and patching it with graphene.

Pleural spread or recurrence of thymic epithelial tumors (TETs) needs further exploration in clinics and there is currently no recognized effective treatment. Here this trial evaluates the perioperative and short-term outcomes of cytoreductive surgery and hyperthermic intrathoracic chemotherapy (S-HITOC) for TETs with pleural spread or recurrence.

Cryo-EM structures of circularly permuted group II introns determined at 2.5- to 2.9-Å resolutions reveal dynamic D6, unexpected interactions and metal ions for catalysis, which elucidate conserved mechanisms of back-splicing to generate circular RNAs.

The Seebeck effect causes an electrical potential across a temperature gradient in a material, and is therefore useful for generating useful current from waste heat. Here, the authors show that the Seebeck effect can arise due to charge-carrier relaxation in addition to the conventional mechanism.

The extracellular matrix (ECM) is assembled through liquid–liquid phase separation and directed phase transition. Now—inspired by tropoelastin—a designer minimalistic model incorporating alternating hydrophobic moieties and crosslinking domains can template the assembly of a biomimetic matrix that mimics the ECM, promoting the mechanosensing of stem cells.

P-selectin has been considered as a biomarker of hematopoietic stem cell (HSC) aging. Here, Yang et al. uncovered a new functional role of P-selectin engagement in regulating HSC regeneration and driving stem cell aging when perturbed.

Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

The interconversion of spin and charge is fundamental to the operation of spintronic devices. Here the authors demonstrate spin-to-charge conversion in the correlated material vanadium dioxide, and show that the efficiency changes dramatically across the metal-insulator transition.

Jiahao Sha, Xinru Wang, Hongbing Shen and colleagues report a genome-wide association study of non-obstructive azoospermia in Chinese men. They identify common variants near three genes (PRMT6, PEX10 and SOX5) associated with this form of male infertility.

The electrosynthesis of amino acids is hindered by inefficient oxime intermediate conversion. Here, a relayed electron transfer mechanism is proposed using an ionic-liquid@Bi catalyst. Electrons are accepted by the ionic liquid to generate related radicals, which then transfer electrons to oxime, enabling efficient amino acid production.

Whether, how and to what extent integrating crop production, livestock production and bioenergy systems can enhance the sustainability of specialized farming remains poorly understood at downscaled regional levels. This study quantifies life cycle impacts of agricultural integration in China, including bioenergy provision.

The incorporation of fluorine-doped tin oxide nanoplatelets on the substrate of perovskite solar cells contributes to uniform light harvesting across different incidence angles of sunlight. The best devices show a power conversion efficiency of 26.4% (certified 25.9%), 95% of which is maintained after 1,200 hours of operation.

Here, the authors identify lysine-specific demethylase 1 is a homologous recombination (HR) regulator. Its inhibitor induces HR deficiency and sensitizes HR-proficient ovarian cancer cells to PARP inhibitors, which expand the use of PARP inhibitors.

Manipulation of the quantum-metric structure to produce topological phenomena has rarely been studied. Now, flexible control of the quantum-metric structure is demonstrated in a topological chiral antiferromagnet at room temperature.

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

Imaging methods, such as CT or MRI, cannot provide accurate diagnosis between malignant thymomas and other thymic abnormalities. Here the authors show that the levels of IL-8 in circulating naive T cells are elevated in patients with thymoma compared with other thymic masses, proposing IL-8 as a candidate biomarker for thymoma diagnosis and recurrence surveillance.

Physical activity is ameliorative for individuals with type 2 diabetes, but most previous studies have relied on self-reported data, which are subject to recall bias. Here, the authors show L-shaped associations of accelerometer-derived physical activity with all-cause mortality, and a negative linear association with cardiovascular disease mortality in diabetic patients.

The authors report on a 2D anion-rich NaCl₂ crystal with a Na:Cl ratio of approximately 1:2, which exhibits room-temperature ferromagnetism originating from the spin polarization of electrons in the Cl elements of these crystals.

Due to the deformable nature of soft robots, developing robust sensors that can sustain stability and performance is a challenge. Here, the authors report a computational strain sensor design based on a programmed crack array for predictable, tunable, and stable sensing performance.

High-quality genome of the modern soybean cultivar Nongdadou2 and deep resequencing of 547 accessions provide insights into the role of structural variations in soybean improvement.

Wu et al. developed SkySense++, a multi-modal remote sensing foundation model pretrained on 27 million multi-modal images, which achieved robust generalization and few-shot capabilities across several Earth observation tasks and domains, including agriculture and disaster management.