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This study identifies the retromer–SNX27 complex as a key regulator of stress-induced Golgi-bypass trafficking, enabling membrane proteins including CFTR and the SARS-CoV-2 spike protein to reach the cell surface.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Whether dopaminergic modulation of synaptic transmission can vary by the anatomical location of striatopallidal synapses in the GPe (external globus pallidus) is not fully understood. Here authors demonstrate that dopamine fine-tunes striatopallidal synaptic transmission by acting on presynaptic D2 and postsynaptic D4 receptors across subregions of the GPe. In addition, dopamine depletion reshapes this modulation in the opposite direction.

Haptic interfaces for full-body scale requires a balance of high-resolution tactile simulation and breathability. Here, the authors present a breathable, full-body electrical stimulation suit for prolonged use in extended reality applications.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

Here, using multi-omics, the authors show that MASLD is associated with alterations in gut bacteria, viruses, and fungi, and identify potential disruptions in phage-bacteria-metabolite interactions, highlighting microbial signatures and ecological changes linked to disease.

High-resolution displays require precise patterning of quantum dots without compromising their performance. Here, the authors report on a process for manufacturing dense RGB pixel arrays with a resolution exceeding 4,000 pixels per inch and high fidelity for future displays.

Logic-in-memory is a promising approach to break the von Neumann bottleneck in conventional skin electronics. Park et al. report a wafer-scale stretchable photoelectric memory transistor array that integrates non-volatile memory with in-situ logic reconfiguration, enabling stable operation even under strain.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Non-linearity leads to remarkably rich physics across a wide variety of length and energy. Here, You and coauthors study the non-linear behaviour of a magnonic system, specifically a synthetic antiferromagnet, where they observe hysteretic mode hopping between the optical and acoustic magnon branches.

Osteoarthritis is a marked by cartilage loss and limited by the absence of effective disease modifying treatments. Here, the authors show that orphan nuclear receptor small heterodimer partner (SHP) protects cartilage by suppressing IKKβ dependent NF κB signaling, highlighting it as a potential therapeutic target.

Modulating synaptic connections remains challenging. Here, the authors show that SynTrogo (Synthetic Trogocytos) is a synthetic astrocyte-neuron interaction system, and reduces synaptic connectivity, which is associated with enhanced plasticity and improved memory.

This study shows that while both zero and negative CO₂ emissions lead to a further rise in land precipitation compared to CO₂ doubling in idealized climate model simulations, extremes in the terrestrial hydrological cycle can only be effectively alleviated under negative emissions.

Brain metastases are a common complication of advanced non-small cell lung cancer (NSCLC) and affect responses to immune checkpoint inhibitors (ICI). Here the authors perform single cell transcriptomics on samples from NSCLC and brain metastases and implicate transcriptomic signatures associated with responsiveness to ICI.

Hydrogel encapsulation prevents dehydration, but maintaining interfacial stability with hydrophobic shells remains challenging. Here, the authors use a multi-layered marble strategy composed of two hydrophobic particle layers with sandwiched oil layer that stabilizes the interface.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

As soft electronic waste becomes an urgent concern, biodegradable yet high-performance devices are emerging as a promising solution. Here the authors fabricate durable and multifunctional soft robotic fingers in which both polymers and inorganic electronics are fully compostable.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Stretchable liquid-metal electronics is limited by high surface tension, fluidity, and poor wettability. Here, Lee et. al. presents a universal cryogenic transfer method for liquid metal particles, enabling high-throughput fabrication of wafer-scale stretchable integrated electronics with robust electrical performance.

The authors present a computational adaptive optics framework for multiphoton structured illumination microscopy, enabling deep-tissue super-resolution imaging with minimal hardware modifications. Their dual deconvolution algorithm independently corrects excitation and emission aberrations, and they achieve a lateral resolution one-fourth of the emission wavelength at a depth of 180 µm in mouse brain tissue.

A cold-injection method based on pseudo-emulsion enables scalable synthesis of stable, pure-green perovskite nanocrystals with near-unity photoluminescence quantum yield, achieved through defect-suppressing slow polybromide plumbate assembly at cold temperatures.

Solution processing of 2D/3D perovskite structures for solar cells offers limited control over layer formation. Lee et al. propose a dry approach, bringing the 2D and 3D perovskite layers into physical contact, to enhance the quality of the perovskite film.

Leber hereditary optic neuropathy (LHON) is caused by mtDNA mutations. Here, authors generated a mouse model with the common LHON mutation and showed that optimized TALE-like deaminases restored both phenotype and genotype via high-fidelity mitochondrial base editing.

Nanoscale thickness strongly enhances the converse flexoelectric effect, as the electric field gradient scales quadratically with decreasing thickness. This study demonstrates a two-dimensional material-based converse flexoelectric actuator.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Fluorine-containing binders in battery dry electrode processing raise environmental concerns regarding restrictions on per- and polyfluoroalkyl substances. Here, authors show that a fluorine-free binder, Parafilm, can be an alternative to enable primer-free high-loading electrodes with stable cycling for sustainable lithium-ion batteries.

This study develops and validates a prognostic staging framework for Alzheimer’s disease by integrating cognitive status with blood-based biomarkers, and neuroimaging data, to improve risk stratification across the disease continuum.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

In this study, the authors identify the role of astrocytic phagocytic receptor MEGF10 in regulating corticostriatal synapse remodeling in the striatum, enabling dopamine- and activity-dependent plasticity in D1 and D2 medium spiny neurons and supporting motor skill acquisition.

Resonant inelastic X-ray scattering interferometry reveals a highly entangled electronic phase in Nd₂Ir₂O₇, enabling extraction of its entanglement structure and confirming the cubic-symmetry-breaking order predicted from complementary Raman spectroscopy.

Nitrate electroreduction loses selectivity as accumulated hydrogen recombines to form H₂. Nanoconfinement in carbon nanotubes reorganizes interfacial water, accelerates proton transfer, reduces hydrogen accumulation and enhances ammonia production.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Mitochondrial ROS are thought to be involved in NLRP3 inflammasome activation, but how this occurs is unclear. Here, the authors show that cofilin-1 negatively regulates NLRP3 activity by binding it at baseline, but cofilin-1 oxidation by ROS results in dissociation from the complex, thereby releasing NLRP3 activity.