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molQTL mapping helps link genetic variants to molecular traits, but common tools overlook relatedness. Here, the authors develop OmiGA, a mixed‑model toolkit that increases power, fine‑mapping accuracy, colocalization performance, and efficiency for complex populations.

The molQTLs of porcine peripheral blood mononuclear cells and neutrophils provide insights into the regulatory mechanisms of immune traits.

Imaging the immune activation status of tumor-associated neutrophils (TANs) provides insights for improving cancer immunotherapeutic strategy. Here this group reports a ratiometric nanoprobe responding to tumor microenvironment and enabling NIR-IIb quantitative fluorescence imaging of TANs with overexpression of neutrophil elastase.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Characterizing the genetic architecture underlying egg production is important for chicken breeding. Here, the authors integrate RNA and whole-genome sequencing data to better understand the genetic regulation of egg production in chickens.

A manually operated portable water disinfection system can rapidly inactivate pathogens in water, offering a promising approach for safe water treatment in low-resource settings.

Researchers discover remodeling harmful Alzheimer disease-associated Amyloid-β species, rather than activating immune cells, enables their effective and safer removal in models, suggesting an alternative therapy design approach.

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

Here, the authors report a homonuclear cooper dual-atom electrocatalyst with high activity designed for synchronously boosting the sulfur and lithium evolutions.

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors stratify these patients via a semi-supervised learning approach using multi-omics input data and functionally validate T-bet+ CD8 + T cells as crucial factor in the immunotherapy response.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

Cycling of the sulfur compound DMSOP by dimethylsulfoniopropionate lyase enzymes in the most abundant marine bacteria, algae and fungi is diverse and prevalent in Earth’s oceans and sediments and probably impacts climate-active gas production.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose of vaccine can improve these antibody levels.

Here, the authors show that Lactobacillus acidophilus supplementation enhances oncolytic virus VSVΔ51 effect through restoring gut barrier integrity and microbiota homeostasis in mice.

Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.

In proteomics, identifying differentially expressed proteins (DEPs) is critical for uncovering biomarkers and drug targets. However, constructing optimal workflows to achieve maximal identification of DEPs is challenging. Here, the authors performed 34,576 combinatorial experiments on 24 gold standard spike-in datasets to discern optimal workflows.

Dimethylsulfoniopropionate (DMSP) is an osmolyte produced by marine microbes that plays an important role in nutrient cycling and atmospheric chemistry. Here the authors go to the Mariana Trench—the deepest point in the ocean—and find bacteria are key DMSP producers, and that DMSP has a role in protection against high pressure.

The number and diversity of organisms known to produce the environmentally important sulfur compound dimethylsulfoniopropionate (DMSP) is expanded with the discovery of a family of DMSP synthesis enzymes.

The defect-rich surface of wide-bandgap perovskite solar cells leads to severe interfacial carrier loss and phase segregation. Here, the authors reconstruct the surface through nano-polishing followed by passivation, achieving certified efficiency of 33.1% for perovskite/silicon tandem solar cells.

The disease-causing pathogen Coxsackievirus A10 (CVA10) is a human type-A Enterovirus. Here the authors present the cryo-EM structures of the mature CVA10 virion and the empty- and A-particles of CVA10, which is of interest for CVA10 vaccine development.

Loss of the E3 ubiquitin-protein ligase ARIH1 has been associated with cancer escape from anti-tumor immunity. Here the authors show that ARIH1 mediated ubiquitination and degradation of DNA-PKcs trigger activation of STING pathway in tumor cells, sensitizing tumors to immune checkpoint blockade.

Balance between growth and stress response is critical for plants to adapt to high salinity. This study shows that receptor-like kinase FERONIA takes advantage of phyB-mediated light signalling pathway to coordinate plant growth and salt tolerance.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

While inducing strain to noble metal nanomaterials can modulate catalytic activities, the strain is often spatially dependent. Here, authors manipulate the planar strain in noble metal nanosheets for hydrogen evolution electrocatalysis by constructing amorphous–crystalline phase boundaries.

Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.

Marginal zone lymphoma (MZL) is a common subtype of B-cell non-Hodgkin lymphoma. Here the authors carry out a two-stage genome-wide association study in over 8,000 Europeans and identify two new MZL risk loci at chromosome 6p, implicating the major histocompatibility complex in the disease for the first time.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

Multiple morphological abnormalities of the sperm flagella (MMAF) is a cause of male infertility. Here the authors identify homozygous nonsense mutations of the glutamine rich 2 (QRICH2) gene in two MMAF patients from 2 consanguineous families and show using QRICH2 knockout mice that the protein is required for sperm flagellar formation and motility.

Systematic methods for evaluating progress towards the 17 United Nations Sustainable Development Goals are developed and tested using 119 indicators at China’s national and subnational levels during 2000–2015, showing improvement overall.

The hydrogen evolution reaction is a promising route to produce clean hydrogen fuel; however, its efficient electrolytic generation relies on expensive platinum. Here, the authors show how modulating electron density in a metal sulfide, NiCo₂S₄, boosts hydrogen desorption to achieve high catalytic activity.