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This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Global forests show extensive tree-cover loss. Here, the authors report that plant attributes and functions can increase under limited tree-cover loss, but also that this safety margin due to edge effects from fragmentation has already been exceeded in 35.7% of forests globally.

Potassium-ion batteries face stability issues at high voltages. Here, authors use nitrogen-doped nanotubes to regulate the interfacial electric field of a polyanionic KVPO₄F positive electrode. This stabilizes the structure and interface, enabling a specific energy of 454.8 Wh kg⁻¹ and a cycling lifespan over 2000 cycles.

Photocatalytic CO₂ reduction is fundamentally limited by inefficient utilization of solar energy, particularly low-energy photons. Here, the authors report a nanoscale greenhouse structure (Bi@Fe₂O₃) that enables cascaded full-spectrum solar utilization and enhances solar-driven CO₂ reduction with water to CH₄.

The authors propose an asynchronous sublattice distortion mechanism to elucidate the complex phase transitions in HfO₂-based materials. The phase transitions among the orthorhombic, tetragonal, and monoclinic phases are governed by the orientation of the orthorhombic phase.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

The cellular pathology of Japanese encephalitis (JE) remains elusive. Here, the authors use spatial transcriptomics in JE mouse model and show that Ackr1⁺ endothelial cells and Ly6c2⁺ monocytes synergistically drive neuroinflammation, revealing potential therapeutic targets for neurotropic virus infections.

MicroFisher identifies fungal taxonomic assignments for metagenomic or metatranscriptomic reads with high precision and abundance estimation by utilizing multiple hypervariable markers to improve mycobiome classification.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

FRIL is an antiviral legume lectin that recognizes complex type N-glycans. Here, authors discover a process to activate the inert recombinant lectins, and engineer a shift of FRIL’s glycan recognition to high mannose N-glycans.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

A chromosome-level brachiopod genome reveals deep conservation of BMP-mediated dorsal–ventral patterning and neural inhibition, suggesting the spiralian ancestor retained the ancestral mechanism in bilaterians.

Sulfation helps shape cartilage, bone and other biological functions. Here, the authors identify MESH1 as the 3′-phosphoadenosine-5′-phosphosulfate-degrading enzyme that controls sulfation in animals and show that blocking MESH1 restores sulfation-linked defects, revealing a potential therapeutic target.

Sweet potato weevils (SPWs) pose one of the most significant challenges to sweet potato production. This study identifies two major SPW-resistant genes, SPWR1/2, and provides new insights into the mechanism of sweet potato defence against SPWs.

Selective activation of aliphatic C–H bonds in complex polycyclic terpenoids remains a significant challenge. Now a bacterial P450 enzyme has been shown to achieve precise functionalization of inert C–H sites in pentacyclic triterpenoids, unveiling a distinctive relay-oxidation pathway mediated by 1,5-hydogen atom transfer and establishing a versatile chemo-enzymatic platform for accessing previously unexplored chemical space.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Sulcal morphometric remodeling during childhood and adolescence, characterized by cortical thinning and widening, predicts cognitive gains in working memory and attention, with gene enrichment linking these changes to synaptic processes.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.

Soil bacterial and fungal necromass carbon is linked with plant species richness with a stronger positive correlation in the topsoil than in the subsoil, according to observations along a 3,000 km transect in grasslands on the Tibetan plateau.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Through integrated multi-omics and experimental validation, this study reveals that altered gut microbiota and bile acid metabolism activate TLR3 to induce urothelial injury in interstitial cystitis, identifying a pathway with therapeutic potential.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Functionalization of ZnTeSe quantum dots via ordering arrangement and energy-level modulation enables deep-blue quantum dot light-emitting diodes with a peak external quantum efficiency of 23.6% and a half-lifetime exceeding 50,000 h at an initial luminance of 100 cd m⁻².

Phylogenetic comparative analysis and behavioral assays suggest white eye-rings coevolved with diurnalism in rodents and enhance visual appeal likely by accentuating facial bilateral symmetry specifically in diurnal but not nocturnal model species.

A multifunctional adsorbent, composed of copper-doped polydopamine-functionalized magnetic silica, enables the simultaneous removal and on-site detection of label-free nano- and microplastics.

Nearly all organisms exhibit codon usage bias (CUB), traditionally thought to reflect a unidirectional selection maximally matching CUB and the cellular tRNA supply. Here, the authors propose alternatively that a slight mismatch optimizes the balance between translational cost and functional payoff.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

The study demonstrated that some exogenous natural polysaccharides could be absorbed in plasma with little degradation after orally administration. Polysaccharide uptake in the intestinal cells relied on clathrin/dynamin 1/Rab5-dependent endocytosis.

Cryogenic transport measurements of CsV₃Sb₅ nanobeams show a zero-field Josephson diode effect and radio-frequency rectification with power-dependent quantized voltage output.

A genus-wide super-pangenome across 16 tomato species generated by integrating 20 telomere-to-telomere genome assemblies and 27 published genomes identifies structural variants associated with salinity or disease resistance for molecular breeding.

Diagnosing breast cancer through MRI is limited by high false-positive rates and inter- reader variability, leading to unnecessary biopsies. In here, the authors find that the BI-RADS 4 Lesions Analysis System (BL4AS) model improves diagnostic accuracy and reduces unnecessary biopsies as well as inter-reader variability

Allogeneic stem cell transplantation (alloHSCT) is approved for the treatment of transfusion-dependent thalassemia but remains limited to the use of matched sibling donors. In this multi-centre, phase-4 prospective clinical trial, the authors evaluate the use of alloHSCT with matched unrelated donors and haploidentical relatives.

Low outcrossing rate of sterile lines limits hybrid rice seed production. Here, the authors report that mutation of a SET domain-containing protein HER1 leads to enlarged stigma, enhanced stigma exsertion, and hybrid seed production in rice.