Search

While atomic disorder normally promotes glassy states, in some rare cases long-range magnetic order can persist. However, the mechanism, and microscopic characters, remain elusive. Here, Shen et al combine neutron diffraction and resonant X-ray scattering to shed light on the formation of long-range magnetic order in a high-entropy honeycomb van der Waals magnet.

Thermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and RUNX2 inhibit thermogenesis by distinct mechanisms.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

Here, the authors establish 1,3-propanediol, a low-cost biomass-derived bulk chemical, as an efficient, green, and sustainable C1 source for the mono-N-methylation of primary amines, via chelation-free C(sp3)−C(sp3) bond cleavage.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

Photoredox catalysis promises transformative advances in proximity labeling and noninvasive therapy, yet photocatalysts rarely combine low-energy light absorption with high excited-state potentials. Here, the authors report Ru-based bio-photocatalysts that integrate greenlight absorption with strong redox power, enabling selective protein and phenol coupling.

Protein engineering is often hindered by the gap between modelling and experiment. Here, authors present ORI, a closed-loop computational framework to iteratively optimize proteins, achieving 100-fold higher activity, enhanced thermal stability, and the design of multifunctional enzymes.

Chromatographic separation is controlled by thermodynamic and kinetics, but engineering both factors remains challenging. Here the authors demonstrate engineering of covalent organic framework from both thermodynamics and kinetics perspectives for chromatographic separation of halogenated isomers.

Robotic grippers struggle to handle fragile and varied objects across environments. Here, the authors introduce a liquid metal gripper that adapts its shape and stiffness for gentle, multiscale grasping and active release.

Slow ion transport limits Li-ion battery performance under fast charging and low temperature. This work establishes an electrolyte design framework based on intermolecular interactions and molecule volume to reshape Li+ solvation structure, enabling Li-ion battery to operate stably at −50 °C and 6 C

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

Functionalization of ZnTeSe quantum dots via ordering arrangement and energy-level modulation enables deep-blue quantum dot light-emitting diodes with a peak external quantum efficiency of 23.6% and a half-lifetime exceeding 50,000 h at an initial luminance of 100 cd m⁻².

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Biomass-based systems for solar evaporation are a promising sustainable method to address global freshwater scarcity; however, current systems are inefficient. Here, the authors report a dual-function lignin-engineered reconstituted wood framework for a biomass-based solar evaporator.

KRAS G12C inhibitors have improved outcomes but mainly in non-small cell lung cancer and colorectal cancer, despite it being a well-established oncogene in a range of cancer types. Here, the authors present a first-in-human phase I/II clinical trial investigating the next-generation KRAS G12C inhibitor, olomorasib, in KRAS G12C-mutant advanced solid tumors.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Au nanowires with an unconventional hexagonal close-packed (4H) phase stabilize the 4H-phase high-entropy alloys grown epitaxially on their surface through a facile chemical synthesis. The resulting core–shell nanostructures demonstrate promising overall water electrolysis performance.

Amur grape (Vitis amurensis) is a hardy vine known for its resilience in cold climates. Here, the authors construct a phased graph-based pangenome based on the eight haplotype-resolved genomes and reveal the association of transposable elements-linked variants with climate adaptation.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Di et al. report a dual-band infrared photodetector employing size-engineered PbS quantum dots as spectrally selective absorbers in a unipolar barrier configuration, which can switch between near- and short-wave infrared region. A 128×128 focal plane array is prepared for practical infrared multispectral imaging.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Chronic non-healing wounds infected with antibiotic-resistant bacteria present a growing global health challenge. Here, Han et al. develop high-entropy alloy-based Janus artificial enzymes with pH-gated redox biocatalysis for sequential therapy of drug-resistant bacteria and inflammatory wounds.

Moiré superlattices are a versatile platform for studying emergent electron and quantum phenomena. Here, the authors demonstrate moiré superlattice formation in complex oxide-WS₂ heterostructures across varying twist angles.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Achieving robustness against a dynamic physiological environment is a challenge for neuromorphic prostheses. An interface made of a self-healing hydrogel and electrodes acts as a physical reservoir of a neuromorphic prosthesis, achieving minimal susceptibility to physical damage.

Magnon transport is confined to a plane by sandwiching BiFeO₃ between layers of non-polar antiferromagnetic LaFeO₃, resulting in efficient magnon transport and a higher voltage output through spin–charge conversion that can be controlled using electric fields. These results have implications for electric-field-controlled spin-based memory and logic elements.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

SLC6A6 localizes to the inner mitochondrial membrane and mediates mitochondrial taurine import, which sustains mitochondrial tRNA modifications and cell growth.

Systemic flavivirus dissemination in mosquitoes following initial infection requires protein–protein interactions within extracellular vesicles, which enable infectious particles to be transported through haemolymph and confer species specificity.

A single-step strategy is reported for the preparation of delaminated MXenes with positively charged surfaces from MAX phases. By combining Lewis acid etching with gas-mediated delamination in deep eutectic solvents, this approach offers a green, scalable and efficient route for MXene synthesis.

Abrupt transitions from drought to extreme precipitation occur more often under higher atmospheric greenhouse gas levels, and are favored through the influence of soil moisture deficits on convective precipitation, revealed by a global assessment based on reanalysis data and climate model projections.

Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology reports, demonstrates strong performance across model architectures, diagnostic and prognostic tasks, and external sites.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

A click-locking strategy inspired by click chemistry is reported that enables automated, high-throughput and industrially scalable synthesis of single-atom catalysts. By combining molecular clicking auxiliaries with robotic platforms, this approach delivers atom-precise catalysts with high activity and stability, as well as kilogram-scale manufacturability across electrocatalytic, photocatalytic and thermocatalytic reactions.

A virus-mimicking micelle selectively delivers drugs to diseased chondrocytes in osteoarthritis, significantly alleviating disease progression in mouse and sheep models.

Vestibular schwannomas that are caused by genetic mutations in the NF2 gene are hard to treat and lead to hearing loss. Here authors show in a mouse model that faithfully represents the human condition that combination therapy with anti-PD-1 and anti-VEGF inhibits tumor growth via normalizing the tumor vasculature and enhances T and NK cell antitumor cytotoxicity via upregulation of NKG2D.