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A structural templating method transforms layered oxide materials to achieve stable ferroelectric phase with vertical polarization and thermal stability up to 350 °C, facilitating high-performance data storage for future computing technologies.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Programmable supramolecular COF/MXene assemblies integrate convenient H₂O₂ photoproduction with photothermal units, realizing long-term O₂ capture, in situ H₂O₂ synthesis and utilization toward decentralized green chemical manufacturing.

Introns, non-coding parts of genes, can hide critical functions. Here, the authors find a 9-nucleotide intronic RNA element that acts as a sensor, reading cell growth signals to control alternative splicing and fly ovarian development via a mechanism also conserved in human cells.

Excavated bamboo slips from East Asia hold crucial archeological information, but many are fragmented, making their restoration challenging. To facilitate this process, Zhu et al. introduce a physics-driven deep learning framework named WisePanda, to rejoin fragmented pieces with improved accuracy.

Polybrominated diphenyl ethers (PBDEs) are linked to dyslipidemia, but why individuals respond differently is unclear. Here, the authors use a national biomonitoring cohort to reveal how specific genetic variants interact with PBDE exposure to increase risk, identifying a key mechanism that disrupts cholesterol metabolism.

Lithium-metal batteries promise high energy but dendrites limit life. Here, authors introduce a 90 wt.% lithium multicomponent solid solution alloy negative electrode that drives lithium into the bulk, enabling 3100 mAh g − 1 capacity and a 385 Wh kg−1 pouch cell that retains 82% capacity after 600 cycles.

Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Tunnel oxide passivating contact solar cells face unresolved questions about the atomic scale nature of pinholes that limit performance. The authors use aberration corrected transmission electron microscopy to reveal two pinhole types and showing that oxygen-based passivation rather than pinholes geometry drives efficiency.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

The physics of resonant electro-optic microcomb generation is underexplored, limiting their potential applications. Now several technological advances are realized by studying the state space of a thin-film lithium niobate photonic frequency comb.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

Random access memory has multiple data registers and uses addresses to specify which register should be read or modified. Now a quantum random access memory has been demonstrated that uses quantum addresses to return data in superposition.

The details of how the DNMT3A regulatory domains cooperate with its methyltransferase domain and with histone marks remained unclear. Here, the authors use structural biology and molecular dynamics to better understand this interaction.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Bilayer CrTe₂ films grown via molecular beam epitaxy are found to host room-temperature multiferroicity and strong magnetoelectric coupling.

The absence of odd Shapiro steps in microwave-irradiated Josephson junctions (JJs) is considered to be a possible indicator of 4π-periodic supercurrents that are induced by Majorana bound states. Here, by conducting measurements on Al/WTe₂ JJs, the authors suggest that the missing first Shapiro step can instead arise from the intrinsic non-linearity of the current–voltage characteristics in low-to-moderate transparency junctions.

Small cell lung carcinoma (SCLC) neuroendocrine (NE) subtypes often transdifferentiate to the more aggressive non-NE cell state during disease progression. Here, the authors discover that eIF6 is a regulator of SCLC plasticity, driving non-NE transdifferentiation via regulation of the CD104/FAK complex.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

A foundation model validated in a prospective multi-centre cohort of 21,601 patients undergoing low-dose computed tomography screening for breast and lung cancer showed comparable performance to existing screening by radiologists.

Continuous monoculture of banana can result in proliferation of parasitic nematodes. Here the authors show that in the long term, soil can become suppressive to disease and this is associated with enrichment of free-living nematodes and Bacillus bacteria.

It was shown that early-day stem cell infusions reduced the severity of acute graft-versus-host disease (aGVHD). Our result suggested early morning cord blood transplantation reduces aGVHD severity and correlated with circadian sCD26 fluctuations.

A nonlinear Hall rectenna based on the type-II Weyl semimetal niobium iridium tetratelluride (NbIrTe₄) can offer 27th-order nonlinear frequency comb generation and high-bandwidth mixing exceeding 100 GHz.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Turning biogas into high-quality methane is limited by inefficient catalysts and complex processing. This study shows that a CeZrO_x/Ni inverse catalyst enables near-complete conversion in a simpler single stage, lowering costs and boosting viability.