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Glioblastoma multiforme (GBM) recurrence driven by residual glioma-initiating cells (GICs) and immunosuppressive microenvironment presents a significant clinical challenge. Here, they report an injectable therapeutic platform that targets remaining GICs and reverses the immunosuppressive microenvironment after postoperative resection to prevent the recurrence of GBM.

Systematic 3D mapping of molecularly defined neurons is lacking, hindering understanding of brain organization and connectivity. Here, authors show a comprehensive single-cell resolution atlas of 20 cell types across the entire adult mouse brain.

Short circuits from separator failure threaten lithium metal battery safety, but ultrafast temperature-responsive materials are lacking. Here a thermo-responsive electrolyte solidifies in seconds, preventing thermal runaway and enabling stable operation up to 90 °C.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

The retention of galactose-deficient IgA1 (Gd-IgA1) in the mesangium leads to pathogenesis in IgA nephropathy. Here the authors report that Gd-IgA1 is internalized by mesangial cells potentially via transferrin receptor 1, forming aggregates that disrupt lysosomal function and elicit inflammation.

The precise control and transition between multiple stochiometric phases is challenging. Here, the authors grow and characterize four wafer-scale stoichiometric phases of a Pd-Te binary compound through a sequential multi-step nucleation process.

Rosacea is a common chronic inflammatory skin disorder mainly affecting the central face. Here, a single-cell atlas of facial skin from rosacea patients and healthy individuals reveals the molecular and cellular changes in skin-resident cell populations and identifies fibroblasts as a determinant in rosacea development.

The authors examine the effect of long-term experimental warming on the complexity and stability of molecular ecological networks in grassland soil microbial communities. They find warming increases network complexity, which is strongly correlated with network stability.

The mechanism of soil microbial consortia resistant to aluminium toxicity is unclear. Here, the authors show that the quorum sensing signaling molecular HHQ produced by one member of the consortium can server as the nutritional resource for the other consortium member for aluminium tolerant cell wall component synthesis.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

Understanding plant–microbe–soil interactions enables the design of effective solutions for agriculture under suboptimal conditions. This study reports the identification of aluminium-resistant bacteria and their potential contribution to increased rice yields in acidic soils.

Cycloaddition reactions play a pivotal role in synthetic chemistry for the direct assembly of cyclic architectures. However, hurdles remain for extending the C4 synthon to construct diverse heterocycles via programmable [4+n]-cycloaddition. Herein, the authors report an intermolecular cycloaddition using furan-fused cyclobutanones as a C4 synthon.

Phosphoantigen-mediated BTN2A1 association drives BTN3A1 intracellular fluctuations outwards in a thermodynamically favourable manner, thereby enabling BTN3A1 to push off from the BTN2A1 ectodomain to initiate T cell receptor–mediated γδ T cell activation.

The authors investigate the response of Archaea to experimental warming in a tallgrass prairie ecosystem. Warming was linked to reduced diversity and convergent succession, with further links to changed ecosystem function. Stochastic processes dominated community changes but decreased over time.

Smart temperature-responsive materials could enhance battery thermal safety management; however, current designs lack the necessary responsiveness for both performance and safety. Here the authors demonstrate a material that swiftly transitions from thermal transmission to isolation during thermal runaway in battery modules, thereby ensuring battery safety.

Chen et al. present a deep learning-based lead optimization model that combines generative artificial intelligence with structure-based approaches. The method is successfully applied to the design of drug-like molecules targeting the recently identified LTK protein target with high potency and selectivity.

Soil microbes control the cycling of carbon, but how these communities will respond to climate changes is unknown. Here, 7 years of artificial warming decreased microbial richness and diversity, driven mostly by soil moisture loss.

Non-precious metals used at the anode of anion-exchange-membrane fuel cells to catalyse hydrogen oxidation are prone to self-oxidation. Here Zhou and colleagues report that a quantum well-like catalytic structure containing Ni nanoparticles within a C-doped MoO_x/MoO_x heterojunction can mitigate such degradation by a gating operation.

cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.

Primary tumors “spread the spark” by establishing a pre-metastatic niche. Here the authors develop an in-situ assembled peptide FR17 to serve as a “flame-retarding blanket” to extinguish the “fire” of the pre-metastatic microenvironment.

Xu Tan, Yong Yang and colleagues identify patients with epidermolysis bullosa harboring mutations in KLHL24, which encodes a cullin 3–RBX1 ubiquitin ligase substrate receptor. They find that truncating mutations stabilize the protein by abolishing autoubiquitination, leading to enhanced ubiquitination and degradation of KRT14, the target substrate of KLHL24.

Tang et al. utilized proximity labelling to assemble the Arabidopsis nuclear pore-associated proteome and revealed the nuclear pore as an integrated platform coupling multiple steps in gene expression regulation, beyond its conventional transport role.

Mechanisms and consequences of the acclimation of soil respiration to warming are unclear. Here, the authors combine soil respiration, metagenomics, and functional gene results from a 7-year grassland warming experiment to a microbial-enzyme decomposition model, showing functional gene information to lower uncertainty and improve fit.

A tumour vaccine leveraging the targeted degradation of antigens isolated from tumour lysates augmented antigen processing and cross-presentation, and inhibited tumour growth, metastasis and recurrence in multiple mouse models of cancers.

ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.

Here, the authors target intratumoral T_reg cells to enhance antitumor immunity without affecting systemic T_reg cell function and identify JMJD1C as a critical epigenetic regulator of tumor T_reg cell fitness.

High temperature thermal instability and low temperature kinetics sluggishness of electrolytes pose significant barriers towards wide-temperature sodium-ion batteries. Here, the authors report a temperature-adaptive electrolyte by regulating the dipole-dipole interactions at various temperatures.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

The orphan GPR84 plays important roles in inflammation, fibrosis, and metabolism. Here, authors report cryo-EM structures of the receptor bound to two ligands, with insights into ligand binding and entry from the extracellular milieu.

Delivering the correct concentration of drugs to the correct location is a challenge in cancer therapy. Here, the authors generate a drug loaded nanoparticle that enlarges following contact with the internal tumour cell environment, resulting in the retention of the nanoparticle and loaded drugs in cancer cells.

Macadamia is a recently domesticated nut crop. Here, the authors report the genome assembly of Hawaiian cultivar ‘Kau’ and conduct population genomic analyses to reveal the origin of Hawaiian cultivars and the genomic basis for one-step operation for the clonal crop domestication.

Studies of microbial community assembly mechanisms typically use metrics for turnover within the whole community. Here, the authors develop an alternative approach based on turnover within lineages and dissect mechanistic change in grassland bacterial assembly under experimental warming.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Using a multifactorial global change experiment, the authors show that warming grassland plots by +3 °C over 6 years accelerates the scaling rate of both taxonomic and phylogenetic diversity in soil bacterial and fungal communities.

There is a rapidly growing appreciation of the complexities of 3D genome organization, as well as associations with gene expression and wider cellular and organismal phenotypes, including diseases. In this Review, the authors describe diverse experimental methods for manipulating 3D genome organization — from fine-scale control of DNA contacts to large-scale nuclear repositioning — which are facilitating detailed testing of the biological functions of 3D genome organization.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.