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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Daratumumab, an anti-CD38 monoclonal antibody, was recently approved for patients with high-risk smoldering myeloma to prevent progression to overt myeloma. Here, the authors present results on a Phase II trial of daratumumab in patients of earlier stage to determine response and safety in that population.

Placenta plays a central role in prenatal development, yet it has been notably underrepresented in large-scale tissue-specific genomic and transcriptomic initiatives. Here, the authors generate a comprehensive placental transcriptome reference using long-read sequencing, revealing unexpected transcriptional complexity. Applied to gestational diabetes data, the reference identified pregnancy hormone isoforms mediating effects on newborn birth weight.

The impact of cooling through the Eocene-Oligocene transition on the marine biosphere is not well constrained. Here the authors construct a high-resolution record of foraminiferal species richness history spanning this transition that reveals differential diversity trends depending on foraminiferal habitat and life mode.

Analyses of epidemiological, clinical and molecular data from a prospective cohort of 3,100 patients with esophageal carcinoma suggest intestinal metaplasia as a single precancer pathway preceding the disease.

Convergent mutations in hot spots of the spike proteins of currently circulating SARS-CoV-2 Omicron variants increase the binding affinity for the host receptor and promote more efficient fusion with host cell membranes.

Remote sensed information and population data for continental Africa are used to assess how migration acts as an adaptation response after drought event. The effect on mobility is amplified with drought frequency and poverty.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

As a key AI hardware foundation, state-of-the-art electronics still face core scalability and compatibility limitations. Pradhan et al. present a LaAlO₃/SrTiO₃ heterostructure device integrating transistor, memristor, and memcapacitor, enabling complex circuits for reservoir computing and reconfigurable synaptic logic.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Chimaeric antigen receptor macrophages including the MyD88 activation domain target mesothelin for treatment of lung cancer brain metastases.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Chen, Cai et al., present a rigorous human-in-the-loop framework for evaluating the medical performance of AI-generated responses to real clinical questions, using a scale aligned with physician career stages. Although some models perform at levels comparable to early-career physicians, substantial rates of incompetent answers and hallucinations demonstrate that unmonitored clinical deployment remains risky, underscoring the continuing need for expert oversight.

A low-cost, modular self-driving laboratory platform (RoboChem-Flex) is designed to democratize autonomous chemical experimentation. This platform combines customizable hardware with Python-based control software to make advanced Bayesian optimization more accessible. Photochemical, biocatalytic and thermal processes are demonstrated, showcasing a broad range of potential applications in both fully closed-loop and human-in-the-loop approaches.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

The response of soil carbon to warming is critical feedback that has been difficult to constrain. This study uses a long-term experiment to show that precipitation modulates microbial and therefore carbon dynamics; drought leads to carbon loss with warming, but wet conditions increase soil carbon.

In this work, authors show that candesartan cilexetil acts as a potent antibiotic potentiator, disrupting Staphylococcus aureus membranes and markedly enhancing the activity of clinically used antibiotics against drug-resistant infections.

A new method for performing genome-wide fine-mapping with functional annotations outperforms current methods across several metrics, including error control, mapping power, resolution, precision, replication rate and cross-ancestry phenotype prediction.

Visible-light-mediated intramolecular [2+2] cycloaddition of aza-1,6-dienes gives bridged, not fused, heterocycles, in violation of the ‘rule-of-five’, which dictates that five-membered rings are preferentially formed. This method allows a variety of bridged bicyclic scaffolds to be accessed, enabling drug-relevant properties to be readily tuned.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Designing monovalent anion-selective membranes is challenging due to the need to balance trade-offs between flux and selectivity, membrane stability, and cost-effective fabrication. Here, the authors synthesized a polymer via superacid polymerization and designed a membrane using in-situ interfacial polymerization to optimize membrane properties.

The operational stability of perovskite solar cells remains a challenge. Zhang et al. incorporate photoswitchable isomers at grain boundaries to improve their resilience and the stability of the solar cells under light cycling and ultraviolet exposure.

In a phase 1 trial enrolling six patients with heterozygous familial hypercholesterolemia, treatment with lipid nanoparticles designed for base editing and inactivation of PCSK9 in hepatocytes showed preliminary evidence of reduced low-density lipoprotein levels without the occurrence of serious adverse events or evidence of off-target editing.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Soil fauna is an important but often neglected component of terrestrial food webs. Here the authors use a large dataset of stable isotope observations to analyse how soil animal trophic diversity varies across climates and land-use types and identify potential biotic mechanisms.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.