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This study achieves precise atomic-scale control over ferroelectric polymer chains through facet modulation, significantly enhancing ferroelectric phase stability, thereby enabling efficient and tunable multiband electromagnetic attenuation.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

This study reports self-wrinkling MXene films with lattice structures achieving exceptional electromagnetic interference shielding (81.5 dB at 17 μm), offering ultra-thin protection for sensitive electronics.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Mislocalized and aggregated TDP-43 drives neurodegeneration in several diseases. The current work shows that RAD23A contributes to TDP-43 toxicity by driving pathological re-distribution of key proteins into an insoluble fraction of cells and thereby leading to loss of function phenotypes.

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Synthetic biology enables sustainable chemical production. Here, authors develop a modular enzymatic platform to biosynthesize non-natural amino acids with C–S, C–Se, and C–N side chains from renewable substrate glycerol, achieving high efficiency and scalability.

DNA in many bacteriophages contains unusual chemical modifications. Here, the authors discover that carboxymethylcytosine is a natural DNA base and reveal its role as an intermediate enabling further DNA hypermodification.

Symmetry breaking is key to numerous notable effects, for instance, the emergence of a Rashba interaction at interfaces between two materials. Here, Zhang, Ding, and coauthors succeed in breaking in-plane mirror symmetries via crystallographic engineering, and observe a giant non-linear Hall effect and current induced magnetization at room temperature.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

Mitochondrial fatty acid β-oxidation is essential for cellular energy production. Here the authors show that mutations in Testis-Expressed Protein 44 (TEX44) are associated with misregulated fatty acid β-oxidation and male infertility.

High-temperature resistant dielectric polymers are promising for electrostatic capacitors, though often have poor mechanical strength or energy storage. Here the authors design a hydrogen bonding polymer balancing mechanical and dielectric properties.

Metronomic photodynamic therapy is a long-term, low-dose treatment strategy limited by the need of continuous photosensitizer administration. Here this group reports combining the self-bioluminescent bacteria with a neutral red photosensitizer in alginate microcapsules as a self-driven metronomic photodynamic therapeutic system with preclinical anti-cancer effects.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

Monomethylation of histone H4 lysine 20 (H4K20me1) contributes to DNA replication but the mechanism is not well understood. Here, the authors identify a conserved tandem Tudor domain of BAHCC1 as a H4K20me1-specific reader, which promotes the recruitment of MCM complex to chromatin for efficient DNA replication.

Here, authors present cryo-EM structures and simulations of urea transporter members in resting-, transport-, or inactive-states bound with synthetic competitive, uncompetitive or noncompetitive inhibitor.

Physical activity is ameliorative for individuals with type 2 diabetes, but most previous studies have relied on self-reported data, which are subject to recall bias. Here, the authors show L-shaped associations of accelerometer-derived physical activity with all-cause mortality, and a negative linear association with cardiovascular disease mortality in diabetic patients.

Somatic mutations in blood cells (CHIP) are linked to diseases like heart disease, but the mechanisms are unclear. Here, the authors show that different CHIP driver genes alter unique sets of plasma proteins, some of which are validated in mouse models.

How aging induces aortic aneurysm and dissection (AAD) remains unclear. Here, the authors show that aging induces miR-1204 to inhibit MYLK, promoting vascular smooth muscle cells to acquire senescence-associated secretory phenotype, resulting in vascular inflammation, and the aggravation of AAD formation.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

Bacteria of the genus Streptomyces have complex life cycles involving cellular differentiation and multicellular structures that have never been observed in archaea. Here, the authors show that several halophilic archaea display a life cycle resembling that of Streptomyces bacteria, undergoing cellular differentiation into mycelia and spores.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.

The mechanisms whereby METH yields strong addiction potential is not fully understood. Here, authors show that METH may impair the function of the endogenous OXT system, particularly the PVN^OXT-NAc core pathway, suggesting OXT-based therapies for METH use disorder (MUD).

Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide production of caffeine-free tea.

The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.

Acoustic communication is important for the reproductive behaviour of frogs. Using acoustic playback experiments, Shenet al. show that calls from male concave-eared frogs (Odorrana tormota) evoke vocal responses and phonotaxis from females, but the females show no ultrasonic sensitivity.

Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.

The implementation of asymmetric Heck/cross coupling cascades of highly flexible haloalkene substrates remains a challenging and long-standing goal. Here the authors report an asymmetric domino Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes enabled by palladium catalysis.

Vertically assembled graphene devices have received less attention than the typical two dimensional arrangements. Chen et al. show that an Au/graphene/Au assembly exhibits a large magnetoresistance ratio of up to 400%, while a Co/graphene/Co device displays a spin valve effect at room temperature.

The applicability of the circularly polarized luminescence emitted from chiral substances is limited by their poor performance. Here, the authors describe the sequential amplification of circularly polarized luminescence of metal clusters to trigger enantioselective photopolymerization.

The authors reveal that stabilization of PYL dimer can relieve ABA-induced inhibition of seed germination using a computationally designed compound DBSA. Crystal structure and other experiments show that DBSA selectively binds to the dimeric PYL.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

The ability to form complex molecular architectures from simpler precursors is important for drug discovery and medicinal chemistry. Here, the authors report a cascade reaction giving access to tricyclic products and apply it in the total synthesis of two natural products.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Dirac semimetals are a three-dimensional analogue of graphene that can support massless Dirac fermions in their bulk and Fermi-arc surface states. Here, the authors observe Aharonov–Bohm oscillations in transport measurements on Cd₃As₂nanowires, revealing these exotic surface states.