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Multi-chambered structures have attracted great attention due to their ability to create multifunctional partitions in different chambers. Here, the authors prepared mesoporous silica nanoreactors with hierarchical chambers for catalytic cascades.

Single-cell RNA-seq can reveal accurate and precise cell types and states. Here the authors present an scRNA-seq platform, Paired-seq, which uses differential flow resistance to achieve 95% cell utilisation efficiency for improved cell-free RNA removal and gene detection.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models.

Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed with increased condensate size and RNA valency.

Cells use fluid flow to deliver proteins to their leading edge. An actin barrier creates a compartment where contraction drives flow, steering proteins toward growing regions. This mechanism coordinates protein distribution with cell shape changes.

Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition.

Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cell and spatial resolutions.

This meta-analysis of over 2,400 papers tracks the influence of older publications that have ‘echoed’ through the decades, cited in countless publications and creating a potentially false confirmation bias.

Neuropathic pain is commonly treated with opioids due to limited alternatives. Here, authors determine cryo-EM structures of the neuronal glycine transporter GlyT2 and develop a reversible inhibitor that provides analgesia in vivo without side effects.

Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that silencing neural activity in some animals causes partners to compensate in response.

NuMA activates dynein to organize the mitotic spindle by linking motor-driven transport with microtubule (MT) minus-end control. Mitotic phosphorylation relieves NuMA autoinhibition, enabling dynein motility and focusing MT minus-ends into asters.

A tissue-engineered esophageal segment is functional in minipigs.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

This study reveals that the malaria parasite Plasmodium uses a unique Aurora kinase complex to control cell division. This divergent machinery regulates spindle formation and is essential for parasite transmission.

He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO₂-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle.

A modular, point-of-care device combining hemispheric plasmonic nanoarrays and automated microfluidics enables nucleic acid amplification and metabolic cell viability assay for rapid bacterial identification and antibiotic susceptibility testing.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

Operating cavity-based spectrometers at low temperature has several advantages, such as improved sensitivity. Now, a cavity-enhanced spectrometer is demonstrated down to 4 K.

Here, the authors present mtDNA and chronological data for sediments from excavations in the South Chamber of Denisova Cave, from which they construct a timeline of hominin and faunal occupation that fills stratigraphic gaps in other parts of the cave.

DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling real-time visualization and mapping of DNA damage across diverse cellular and organismal contexts.

XCR1+ type 1 conventional DCs (cDC1s) are crucial to mount anti-tumor immune responses, however their infiltration within tumours is often limited. Here the authors show that cDC1 infiltration could be expanded by intratumoral delivery of mesenchymal stromal cells engineered to express the membrane bound form of FLT3L in combination with poly(I:C) or CXCL9 and CCL5, improving anti-tumor immunity in preclinical models.

This study reveals a mechanism where humidity-driven dynamic coordination between iodide ions and iodine molecules enables sustained oscillatory ion migration, providing a robust solution for continuous ambient energy harvesting

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

The role of oxytocin in modulating astrocytes during stress behaviour is not fully understood. Here the authors show that in the amygdala, oxytocin modulates stress related behaviour by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium.

Forest soil is known to be a source of the greenhouse gas N₂O, but the impact of what is planted in that soil has long been overlooked. Here Machacova and colleagues quantify seasonal N₂O fluxes from common boreal tree species in Finland, finding that all trees are net sources of this gas.

Tissue chips with matured human heart, liver, bone and skin tissue niches linked by recirculating vascular flow recapitulate interdependent functions of these organs.

Biofilms are specialized environments where one might predict that evolution demands intense interactions between bacteria. However, by using two species, this paper demonstrates that genomic changes occur to favour species working together to enhance fitness.

Cardiac ryanodine receptors (RyR2) are critical for heart contraction. Here, the authors use 3D MINFLUX microscopy to image receptor subunits and RyR2 orientation with nanometre resolution, thereby providing a molecular view of the organisation and clustering of these cardiac muscle receptors.

Actomyosin networks constrict cell area and junctions to alter cell and tissue shape. Here, Li et al. reveal a morphological cell expansion wave behaviour that coordinates epithelial flattening and tissue elongation during Drosophila oogenesis.

ESPRESSO leverages functional information obtained from organelles for deep spatiotemporal phenotyping of single cells.

Ancient mitochondrial DNA from sediments reveals the sequence of Denisovan, Neanderthal and faunal occupation of Denisova Cave, and evidence for the appearance of modern humans at least 45,000 years ago.

In this work, authors develop a “mini-bladder” model with a perfusable lumen that reveals how urine and its solute composition impact tissue resilience and enables cell-wall-deficient uropathogenic Escherichia coli to persist in tissues and drive recurrence in urinary tract infections.

Understanding heat-induced changes in cardiac function has come primarily from laboratory studies employing encapsulated, water-based heating modalities. Here, the authors show that these studies overestimate cardiac burden compared to the more natural exposures experienced during heat waves.