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Glucose deprivation triggers the secretion of the cytokine LIF, which promotes angiogenesis and immune suppression in lung cancer models.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Alström syndrome (AöS) is a rare genetic disorder characterized by metabolic problems. Here, the authors show that in AöS models, defects in cilia and autophagy lead to ACBP accumulation, which drives obesity. An anti-ACBP antibody reduces weight gain and metabolic dysfunction, highlighting ACBP as a therapeutic target for this ciliopathy.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Data provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key for improved management of forest ecosystems in the region.

Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms and the long-term evolutionary dynamics of cis-regulatory elements in animals.

Maldonado, Lopez-Hernandez, et al. use a matched case-control study to compare E. coli-infected patients with or without sepsis. Their analysis shows that the ST69 clone is associated with risk of sepsis development, and certain genetic factors such as adhesion genes papC and fdeC were associated with a protective effect.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

We show that FOXF2 maintains cerebrovascular function through Tie2 signaling, and that pharmacological activation of Tie2 with AKB-9778 rescues deficits in cerebral small vessel disease and stroke.

Topological systems are limited to low dimensions. Here, authors unveil the topology of orbital angular momentum in two-dimensional skyrmion textures, connecting them to ’t Hooft-Polyakov magnetic monopoles, and in higher dimensions, uncovering a topological spectrum of 17000 invariants.

Creative experiences such as dance, music, drawing, and strategy video games might preserve brain health. The authors show that regular practice or short training in these activities is linked to brains that look younger and work more efficiently.

In flowering plants, DNA–FD–14-3-3 recruits FT to the florigen activation complex both through DNA–FT interactions and by reducing liquid phase condensation of FD protein, which promotes dimerization, leading to FT recruitment.

In this work, authors show that the nucleoside prodrug obeldesivir has potent antiviral activity across respiratory syncytial virus (RSV) clinical isolates with a high resistance barrier. Once-daily obeldesivir treatment was efficacious against RSV in a non-human primate model.

Medical imaging research is limited by data availability. To address this challenge, Tudosiu and colleagues develop a 3D generative model of the human brain that can generate high-resolution morphologically correct brains conditioned on patient characteristics.

Clonal haematopoiesis of indeterminate potential is driven by somatic mutations in hematopoietic stem/progenitor cells and may progress to myelodysplastic syndromes (MDS). Here authors show that the two conditions share a similar pattern of bone marrow remodeling, characterized by the emergence of inflammatory mesenchymal stromal cells and IFN-responsive T cells, reinforcing their shared etio-pathology.

Reducing of dimension is often necessary to detect and analyze patterns in large datasets and complex networks. Here, the authors propose a method for detection of the intrinsic dimensionality of high-dimensional networks to reproduce their complex structure using a reduced tractable geometric representation.

Antarctica is increasingly popular as a site for tourism and scientific research. The growth of marine traffic and the presence of major research stations have increased the anthropogenic deposition of heavy metals into this fragile ecosystem.

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Mechanisms of clonal evolution in myeloid neoplasms remain incompletely understood. Darwinian theory predicts that the (micro)environment of clone-propagating stem cells may contribute to clonal selection. Here, authors provide data fitting this model, establishing a relationship between stromal niche inflammation, inflammatory stress in HSPCs, clonal resistance and leukemic evolution in human myelodysplastic syndrome.

Meta-analyses often rely on reported precision to weigh studies. Here, the authors show that such precision can be overstated, and introduce a method that reduces the resulting bias, using sample size as an instrument for reported precision.

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

This study reveals the atomic structure of RIPK1 fibrils, a type of physiological amyloid that helps control inflammation and regulated cell death in human cells.

Hiʻiaka is the largest moon of the distant dwarf planet Haumea. Here, the authors report the first multi-chord stellar occultations of Hiʻiaka, revealing its size, shape, and density, suggesting an origin from Haumea’s icy mantle.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Understanding the mechanisms of block copolymer crystallization is fundamentally important. Here the authors investigated the crystallization behavior from a miscible melt of a polymeric material composed of five potentially crystallizable and biocompatible, chemically distinct blocks.

This study reveals that interlayer exciton emission in MoSe₂/WSe₂ heterobilayers is shaped by phonon-dressed polarons, challenging the prevailing moiré-trapped model and highlighting strong exciton-phonon interactions.

Phosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphorylated structures, revealing general trends of structural regulation.

Pulmonary large cell neuroendocrine carcinoma is an aggressive subtype of lung cancer. Here, the authors identify distinct subtypes based on genomic alterations and transcriptomic alterations.

The implementation of topological insulators in spintronics requires the control of the topological spin texture. Here, the authors show that noble metal atoms added to the surface enable this controllability by altering the magnetic anisotropy and energy level alignment.

Phosphoproteomics can offer significant insight into cell signalling and how signalling is modified in response to perturbations. Here the authors develop a new tool for the analysis of high-content phosphoproteomics in the context of kinase/phosphatase-substrate knowledge, which is used to train logic models.

How adipose mitochondria activity is fine-tuned in response to obesity is an active area of study. Here, the authors show that mitochondrial protein MCJ can block thermogenesis and that silencing this gene can correct obesity-related comorbidities.

The use of carbon nanotubes in nanoelectronics requires an understanding of their resistive, or Joule, heating at interconnects. Here, Joule heating dynamics are imaged in real time by following the evolution of resistive hot spots with a transmission electron microscope.

Here the authors screen different lipid nanoparticle (LNP) formulations for intramuscular delivery of plasmid DNA and uptake by antigen-presenting cells. The lead LNP exhibits immunogenicity and protection in small animal models that is comparable to approved SARS-CoV-2 mRNA vaccine formulations.

Authors analyzed a large dihydroartemisinin–piperaquine (DHA-PPQ) repetitive treatment efficacy trial including a 2-year follow-up period, monitoring the evolution of the protective effect of this antimalarial over time.

Ibanez et al. introduce multimodal diversity, a synergistic framework integrating multimodal brain metrics, whole-body health, and exposomic data through neurosyndemic computational modeling to advance context-sensitive precision brain health across global settings.

The main multidecadal variations in the PDO index during the twentieth century, including the ongoing, decades-long negative trend, were largely driven by human emissions of aerosols and greenhouse gases rather than internal processes.

Community-based conservation efforts for ecosystems can have manifold effects beyond the direct areas being managed. This study finds that, deep in the Amazon, communities effectively protected an area 36 times larger than the area they were guarding, but also had to bear all of the costs.

Here, authors provide a molecular view of a clustered saccharide patch on mucins as recognized by a bacterial binding module. This work provides insights into how microbes can remain attached to mucins in the mucus while grazing on their glycans.

A wearable hydrogel-based electrochemical platform is presented for on-demand hydrogen gas therapy, enabling localized gas generation, storage and sustained delivery. This device offers a therapeutic modality for treating ischemia–reperfusion heart disease and skin bedsores, expanding bioelectronics applications in gas-phase chemical delivery.

POLG mutations impair mitochondrial DNA replication and cause diverse mitochondrial diseases. Here, the authors show that structural differences in the POLγB subunit between humans and mice modulate mutation severity.

The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers of responses to Greatwall-targeted therapy.

The estimation of low energies of many-body systems is a cornerstone of the computational quantum sciences. This paper demonstrates on a superconducting quantum processor that the Krylov quantum diagonalization algorithm is poised to complement its classical counterparts at the foundation of computational methods for quantum systems.

Image background features can undesirably affect deep networks’ decisions. Here, the authors show that the optimization of Layer-wise Relevance Propagation explanation heatmaps can hinder such influence, improving out-of-distribution generalization.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.