Nature Search

Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells

Philip A. Hieter
Stanley J. Korsmeyer
Philip Leder
Research02 Apr 1981
Nature

Volume: 290, P: 368-372
A water-soluble copolymer for storage and electron conversion in photocatalytic on-demand hydrogen evolution

The study presents a recyclable polymer system that stores solar energy and releases it as hydrogen on demand, offering an efficient and sustainable route for renewable energy storage and fuel generation.

Marco Hartkorn
Robin Kampes
Sven Rau
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-8
Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

T-cell–mediated rejection (TCMR) remains a major cause of kidney transplant failure with incompletely understood mechanisms. Here the authors use single-nucleus RNA sequencing, spatial transcriptomics and immunofluorescence to show that injured kidney epithelial cell states associate with poor transplant outcomes after T-cell–mediated rejection.

Anna Maria Pfefferkorn
Lorenz Jahn
Christian Hinze
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-19
A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

J. G. Seidman
Philip Leder
Research01 Aug 1980
Nature

Volume: 286, P: 779-783
A prophage-encoded abortive infection protein preserves host and prophage spread

A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival phages and avoids self-targeting via tail-tip variation.

Molly R. Sargen
Sadie P. Antine
Sophie Helaine
ResearchOpen Access28 Jan 2026
Nature

P: 1-8
A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation

Centrosome dynamics play a central role in immune regulation. Here, the authors demonstrate that centrosome integrity as well as centriole numbers and spatial organisation emerge as critical determinants of effective T cell responses.

Isabel Stötzel
Ann-Kathrin Weier
Eva Kiermaier
ResearchOpen Access13 Jan 2026
Nature Communications

Volume: 17, P: 1-24
Multi-state detection and spatial addressing in a microscope for ultracold molecules

Detection of ultracold molecules based on absorption imaging have inherent limitations. Here, the authors demonstrate spatially resolved detection of single ultracold 87Rb133Cs molecules in the bulk, extending recent microscopy developments from ultracold atoms to molecules.

Jonathan M. Mortlock
Adarsh P. Raghuram
Simon L. Cornish
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-9
All-optical control of phase singularities using strong light-matter coupling

Phase singularities are known to have applications in various branches of optics. Here the authors demonstrate that phase singularities can be created and controlled, all optically, in a simple thin film of organic molecules using cavity-free strong light-matter coupling.

Philip A. Thomas
Kishan S. Menghrajani
William L. Barnes
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-6
Accurate geometric albedo, shape, and size of Hi’iaka from a stellar occultation

Hiʻiaka is the largest moon of the distant dwarf planet Haumea. Here, the authors report the first multi-chord stellar occultations of Hiʻiaka, revealing its size, shape, and density, suggesting an origin from Haumea’s icy mantle.

Estela Fernández-Valenzuela
Jose Luis Ortiz
Dmitry Monin
ResearchOpen Access01 Dec 2025
Nature Communications

Volume: 16, P: 1-11
Natural mimics

Philip Ball
News30 May 2000
Nature
Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection

Strategies for HIV prevention besides high manufacturing cost neutralizing antibody requires further investigation. Here the authors develop vaginal tissue deliverable mRNA-based antibody approaches, which demonstrate protection of rhesus macaque vaginal tissues against multiple HIV strains with favorable tolerability and prevention efficacy.

Jae Yeon Joo
Peng Xiao
Philip J. Santangelo
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-18
Nature inspires colour-change gel

Chameleon polymer mimics squid and octopi.

Philip Ball
News08 Jan 2003
Nature
Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin

Clade 2.3.4.4b highly pathogenic H5N1 is currently causing a panzootic and has the potential to become a pandemic. Here, Peña Alzua and colleagues develop specific monoclonal antibodies against this virus that could be used to prevent or treat human infections.

Garazi Peña Alzua
André Nicolás León
Florian Krammer
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 17, P: 1-11
Natural amino acids do not require their native tRNAs for efficient selection by the ribosome

Philip R Effraim
Jiangning Wang
Virginia W Cornish
Research25 Oct 2009
Nature Chemical Biology

Volume: 5, P: 947-953
Light as a Factor in Reproductive Periodicity

GRAHAM PHILIP
Research29 Oct 1932
Nature

Volume: 130, P: 665
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cell antitumor potency.

Philip Bucher
Nadine Brückner
Josef Leibold
ResearchOpen Access06 Jan 2026
Nature Cancer

P: 1-16
Variable amplification of immunoglobulin λ light-chain genes in human populations

Rebecca A. Taub
Gregory F. Hollis
Philip Leder
Research14 Jul 1983
Nature

Volume: 304, P: 172-174
Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS

Piol et al. uncover that impaired eukaryotic initiation factor 5a (Eif5a) hypusination disrupts axonal translation and neuronal activity in fused in sarcoma-amyotrophic lateral sclerosis (FUS-ALS) by applying spatial transcriptomics in motor axons. In vitro and in vivo targeting Eif5a hypusination via spermidine supplementation improves ALS model phenotypes.

Diana Piol
Bilal Khalil
Sandrine Da Cruz
ResearchOpen Access22 Dec 2025
Nature Neuroscience

Volume: 29, P: 53-66
The ubiquitin ligase KLHL6 drives resistance to CD8⁺ T cell dysfunction

Integrating computational analyses of T cell exhaustion and mitochondrial fitness atlases with in vivo CRISPR screens has identified KLHL6 as a dual-negative regulator of both exhaustion differentiation and mitochondrial dysfunction, highlighting its potential as a target to enhance anti-tumour immunity.

Hongcheng Cheng
Yapeng Su
Guideng Li
ResearchOpen Access14 Jan 2026
Nature

P: 1-11
6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells

Myeloid derived suppressor cells (MDSC) use different metabolic mechanisms to adapt to the tumour microenvironment. Here the authors show that 6-phosphogluconate dehydrogenase (6PGD) is important for MSDC function and that blockade of 6PGD impaired MDSC function and suppresses tumour growth leading to metabolic and functional changes in the MDSC and a more pro-inflammatory phenotype.

Saeed Daneshmandi
Qi Yan
Hemn Mohammadpour
ResearchOpen Access14 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Light as a Factor in Sexual Periodicity

GRAHAM PHILIP
Research30 Apr 1932
Nature

Volume: 129, P: 655
K isotopes trace temporal silicate weathering intensity

Seasonal variation in K isotopes of rivers that drain the Chinese Loess Plateau indicates that riverine K isotopes can trace changes in silicate weathering intensity over time, offering a tool to track Earth’s climate–rock interactions.

Long-Fei Gou
He Sun
Zhangdong Jin
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-9
Quantum speedup for nonreversible Markov chains

It has been suggested that quantum computers could give a quadratic speedup in sampling from the stationary distribution of reversible Markov chains. Here, the authors extend the result by investigating two quantum methods for accelerating the mixing of nonreversible Markov chains.

Baptiste Claudon
Jean-Philip Piquemal
Pierre Monmarché
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-10
Rapid Leaf Closure of Mimosa in Response to Light

PHILIP B. APPLEWHITE
FRANK T. GARDNER
Research24 Sept 1971
Nature

Volume: 233, P: 279-280
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Atomically accurate de novo design of antibodies with RFdiffusion

The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precisely target chosen disease-related molecules.

Nathaniel R. Bennett
Joseph L. Watson
David Baker
ResearchOpen Access05 Nov 2025
Nature

Volume: 649, P: 183-193
Photography of Bullets in Flight

PHILIP P. QUAYLE
Research14 Oct 1922
Nature

Volume: 110, P: 514-515
Observation of hyperbolic intersubband polaritons in native-dielectric-doped van der Waals semiconductor quantum wells

Confinement effects enable the design of intersubband polaritons (ISPs) in semiconductor quantum wells (QWs), but this type of light-matter excitations has been rarely explored in van der Waals materials. Here, the authors report the observation of hyperbolic ISPs in WO_x/WSe₂ QW heterostructures with electrically tunable dispersions.

Yue Luo
Dapeng Ding
William L. Wilson
ResearchOpen Access19 Nov 2025
Nature Communications

Volume: 16, P: 1-9
Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface

Merlino et al. demonstrate that the cytokine Interleukin-27 contributes to innate antiviral immunity in the placenta and is an important defense against congenital Zika virus infection.

Madeline S. Merlino
Briah Barksdale
Kellie A. Jurado
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Photosynthetic light requirement near the theoretical minimum detected in Arctic microalgae

This study shows that photosynthesis in the Arctic Ocean can occur at lower light levels than previously thought. This finding is based on unique measurements made on microalgae underneath sea ice in the high Arctic at the end of the polar night.

Clara J. M. Hoppe
Niels Fuchs
Jonas Wloka
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-10
Searching for Interstellar Communications

GIUSEPPE COCCONI
PHILIP MORRISON
Research19 Sept 1959
Nature

Volume: 184, P: 844-846
Stable intracranial imaging of dura mater-engrafted pancreatic islet cells in awake mice

Imaging pancreatic islets in living animals is often limited by poor optical access and motion instability. Here, the authors show that transplanting islets onto the brain’s dura mater enables stable, long-term, and functional imaging in awake mice.

Philip Tröster
Montse Visa
Per-Olof Berggren
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania

Engineering of local Anopheles gambiae under containment enables the generation of a transgenic strain equipped with non-autonomous gene drive capabilities that robustly inhibits genetically diverse Plasmodium falciparum isolates obtained from naturally infected children.

Tibebu Habtewold
Dickson Wilson Lwetoijera
George K. Christophides
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 442-448
Seismotectonics of the El Asnam earthquake

M. Ouyed
M. Meghraoui
H. Philip
Research02 Jul 1981
Nature

Volume: 292, P: 26-31
Immunoglobulin light-chain structural gene sequences cloned in a bacterial plasmid

J. G. SEIDMAN
MARSHALL H. EDGELL
PHILIP LEDER
Research01 Feb 1978
Nature

Volume: 271, P: 582-585
Magnetic reconnection in the plasma disk at 23 Jupiter radii

Ion diffusion region is an indicator of active magnetic reconnection, but it had not been detected in Jupiter’s magnetosphere previously. Here, the authors show a magnetic reconnection event in Jupiter’s inner magnetosphere that presents the detection of an ion diffusion region.

Jian-zhao Wang
Fran Bagenal
Licia C. Ray
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

Georgios Kanellos
Chiara Giacomelli
Owen J. Sansom
ResearchOpen Access18 Dec 2025
Nature Genetics

Volume: 58, P: 100-115
Effect of climate on traits of dominant and rare tree species in the world’s forests

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Iris Hordijk
Lourens Poorter
Thomas W. Crowther
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-15
Terrorists’ affinity towards borders: an Indian perspective

Prabal Pratap Singh
Deepu Philip
Manindra Agrawal
ResearchOpen Access07 Nov 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-11
Dual phase high temperature Si₃N₄/Al(Ti)N films with tunable thermal conductivity

Amorphous films with tunable thermal conductivity are needed for semiconductor/aerospace fields. Amorphous Al(Ti)N nanoparticles have negligible effect on thermal conductivity of Si₃N₄ 2 W m⁻¹K⁻¹, while incorporating crystal TiN phases increases to 15 W m⁻¹K⁻¹.

Zhaohe Gao
Han Liu
Ping Xiao
ResearchOpen Access22 Dec 2025
Nature Communications

Volume: 16, P: 1-8
Ultraviolet light sensitivity and delayed DNA-chain maturation in Bloom's syndrome fibroblasts

F. GIANNELLI
P. F. BENSON
P. E. POLANI
Research01 Feb 1977
Nature

Volume: 265, P: 466-469
Convergent genome evolution shaped the emergence of terrestrial animals

Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.

Jialin Wei
Davide Pisani
Jordi Paps
ResearchOpen Access12 Nov 2025
Nature

Volume: 649, P: 638-646
Physicists squeeze laser light from silicon

A silicon solid-state laser that would transform information technology is one step closer, Philip Ball reports. .

Philip Ball
News23 Nov 2000
Nature
Molecular basis of base substitution hotspots in Escherichia coli

Christine Coulondre
Jeffrey H. Miller
Walter Gilbert
Research24 Aug 1978
Nature

Volume: 274, P: 775-780
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Melinda Soeung
Xinmiao Yan
Pavlos Msaouel
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-23
Electromagnetic Phenomena of Natural Origin in the 1.0–150 C./S. Band

PHILIP A. GOLDBERG
Research30 Jun 1956
Nature

Volume: 177, P: 1219-1220
Elliptical-like light profiles in infrared images of merging spiral galaxies

Gillian S. Wright
Philip A. James
Ian S. McLean
Research29 Mar 1990
Nature

Volume: 344, P: 417-419
Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson’s and inflammatory bowel disease

MacKenzie L. Bolen
Marc Buendia
Malú Gámez Tansey
ResearchOpen Access16 Jan 2026
npj Parkinson's Disease

Volume: 12, P: 1-14
A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa

Philip J. Rosenfeld
Glenn S. Cowley
Thaddeus P. Dryja
Research01 Jun 1992
Nature Genetics

Volume: 1, P: 209-213
Making light of the Earth

Philip Ball weighs up new evidence about Big G.

Philip Ball
News03 May 2000
Nature

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