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This work presents a recyclable dual Z-scheme LaFeO₃/LaCoO₃/g-C₃N₄ heterojunction that effectively enables nickel/photoredox dual-catalyzed cross-electrophile coupling between aryl iodides and alkyl halides.

Overexpression of Engrailed-1 in donor cells enhances mitochondrial transplantation’s efficacy by upregulating PDGFC-mediated mitochondrial fusion, offering a novel strategy to improve neuroprotection in spinal cord ischemia–reperfusion injury.

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

Fibroblast heterogeneity is a hallmark of fibrosis including in the kidney, but their precise roles in driving renal fibrosis are incompletely understood. Here the authors report that a switch to a CD248⁺ extra cellular matrix -producing fibroblast subset contributes to kidney fibrosis, and blocking CD248 with a monoclonal antibody mitigates the phenotype in male mice.

2D photodetectors hold potential for several applications, but they are normally limited by an intrinsic sensitivity-speed trade-off. Here, the authors report the realization of 2D PdPSe/WSe₂ photodetectors with a monolayer tungsten oxyselenide interlayer, leading to a detectivity up to 3.78 × 10¹⁵ Jones and a bandwidth of 0.055 GHz in the visible range.

The manuscript describes two pathogenic mutations in GTPBP3 that cause defects in mitochondrial tRNA taurine modification, mitochondrial translation, structure and function. Mutant mice reproduce certain clinical features seen in patients and this can be reversed by virus-mediated exogenous expression of Gtpbp3.

RASSF4 associates with PKD2 to enhance its channel function and suppress RAS/MAPK signaling, mitigating polycystic kidney disease phenotypes and highlighting a potential therapeutic target for ADPKD.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Hybrid perovskites show promise for spintronics but suffer from fast spin relaxation. The authors use isotope engineering, replacing hydrogen with deuterium, to suppress hyperfine interactions, boosting spin lifetime and enabling strong room-temperature spin transport and spin photovoltaic effects.

Epitaxial CuO thin films exhibit crystal-symmetry-dependent orbital Rashba–Edelstein effects, enabling anisotropic orbital torque generation. The work reveals how crystal symmetry governs orbital angular momentum transport in oxide spintronic systems.

The breast cancer intelligent non-invasive diagnosis system (BINDS) integrates multimodal medical imaging data for breast cancer risk assessment and subtype classification, improving diagnostics and reducing the need for biopsies of benign lesions.

Façade-integrated photovoltaics (FIPV) present a promising yet early-stage solution for mitigating building emissions. Combining global building datasets, climate projections and façade-scale simulations, researchers estimate that FIPV could deliver substantial economic and climate benefits.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

QuadPE—a quadruple paired prime editing guide RNA strategy—enables efficient and programmable insertion of large DNA fragments.

Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.

Nested skyrmion bags are topological magnetic structures with tunable topological charge that offer promise for spintronic devices. By combining micromagnetic simulations, Thiele equation analysis, and machine learning, the authors reveal the stability, current-driven dynamics, and efficient prediction of the skyrmion Hall angle in these structures, and demonstrate a proof-of-concept demultiplexer device.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Lin et al. identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer’s disease mice, via induction of skeletal muscle-derived vesicles containing miR-378a-3p, taken up by microglia to regulate metabolism and enhance plaque clearance.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

ARID1A-deficient bladder cancer exhibits heightened sensitivity to the ferroptosis inducer RSL-3 due to impaired NRF2-SLC7A11-GSH axis, establishing a targetable vulnerability and precision therapeutic strategy for this common mutant subtype.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Revealing the structural features governing ergodicity breaking is critical to understanding glass formation. Here, the authors synthesise a family of hybrid metal halide glasses, and show that the molecular shape and polarity determine rotational disorder, enabling diverse glass-forming abilities.

Late-stage specific and selective modifications of peptides and proteins at target residues under ambient conditions are the most facile routes to various bioconjugates. Here, the authors report an orthogonal modification of cysteine residues using alkyl thianthreium salts, which proceeds with excellent chemoselectivity and compatibility under mild conditions, introducing a diverse array of functional structures.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

In this study, authors reveal an evolutionary strategy in bacteria, where multidrug resistance are stably maintained through multicopy heterogeneous genes on a single plasmid, conferring an adaptive advantage under fluctuating clinical drug pressures.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Achieving simultaneous control of multiple transport pathways within single-molecule junctions remains challenging. Here, Sun et al. report light-controlled modulation of two distinct conductive pathways in single donor-acceptor Stenhouse adduct molecule with three thiomethyl anchoring sites.

While many catalytic modes of palladium have been able to be supplanted by nickel catalysis, which is more Earth-abundant, enantioselective nickel-catalysed C–H activation remains unexplored. Here, the authors report an enantioselective C–H activation of metallocenes via a nickel–1′-bi-2-naphthol catalytic system.

Zygotic genome activation coincides with extensive chromatin remodeling coordinated by maternal transcription factors. Here, by mapping accessible chromatin during early embryonic development of Xenopus tropicalis, the authors show how maternal factors E2f1 and Otx1 work together to control zygotic genome activation.

Here, the authors show that mechanical loading promotes subchondral bone osteocytes to secrete extracellular vesicles containing miR-23b-3p, which accelerates osteoarthritis progression by inhibiting mitophagy and disrupting cartilage metabolism.

Volcano plots are useful catalyst design tools for acidic oxygen reduction reaction, but have proved less successful for alkaline oxygen reduction reaction. Here, a modified volcano plot for this environment is developed and used to design PdH_x@Pt nanosheets with high oxygen reduction reaction performance.

The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in regulating T cell function.

This study shows that rising incomes and hotter climates are driving a boom in air conditioning use, which adds to global warming. This highlights the need for clean, efficient and equitable cooling solutions.

Climate models overestimate greenhouse gas effects on the temperature difference between Earth’s hemispheres, with this bias strongest in high climate sensitivity models, suggesting future tropical rainfall shifts may be less severe than projected.

Multi-omics data are readily integrated using quartet reference materials.

Presenilin isoforms (PS1 and PS2) containing γ-secretase show contrasting sensitivity to MRK-560. Here, the authors determined cryo-EM structures of PS1/PS2-complexes treated with MRK-560 and identified key residues responsible for the isoform-dependent selectivity.

Droplet microlasers are emerging as powerful tools for label-free biosensing. Here, the authors demonstrate a new method for creating liquid photonic-molecule microlasers that combine low lasing threshold and enhanced sensitivity, achieving biomolecular detection limit down to attoMolar level.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.