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This study shows that tropical cyclone heavy rainfall has extended inland along the coasts of the Northern Hemisphere with a rate of 3.8 km per decade since 1980. Nearshore sea-surface warming drives this expansion, with coastal urbanization further amplifying the effect. These findings highlight increasing flood risk for inland populations as cities grow.

Chronic diabetic wounds heal poorly due to impaired tissue repair and persistent inflammation. Here, authors demonstrate that a Smad7-based topical biologic accelerates diabetic wound healing by improving epithelial regeneration and reducing inflammatory neutrophil activity.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

The human genome contains approximately 800 G proteincoupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, the authors show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemical properties.

Annotating regulatory elements in domestic animal genomes is important to understand the mechanisms underlying gene regulation. Here, the authors use multi-omics data from sheep to map regulatory elements in the sheep genome.

This study shows that CrSBr hosts Frenkel-like and Wannier-Mott-like excitons whose distinct spatial character explains their contrasting sensitivity to magnetic order and lattice vibrations, challenging the standard dichotomy in describing excitons.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

A trispecific T cell engager has been developed to redirect bystander T cells, overcoming immunosuppression and enhancing antitumour immunity across multiple solid tumour types, alongside a machine learning-based tool to predict its efficacy.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The role of the complement system (CS) - part of the immune system - in pancreatic ductal adenocarcinoma (PDAC) remains underexplored. Here, the authors evaluate the association of genetic variants in CS-related genes with PDAC risk, and explore their potential role in prognosis and immune infiltration.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Iron pnictide compounds have recently been shown to have superconducting properties. Xuet al. show that the superconducting gap of underdoped pnictides scales linearly with the transition temperature, and that a pseudogap develops with underdoping.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

The origin of superconductivity enhancement in FeSe monolayer grown on SrTiO₃ compared to bulk FeSe is still a debated issue. Here, Shi et al. report a further 15 K jump of T_c accompanying a second Lifshitz transition triggered by electron doping in FeSe/SrTiO₃monolayer films.

It remains to be seen if high-T_c superconductors rely on similar Fermi-surface instabilities as their BCS counterparts. Miao et al. study the high-T_c compound LiFe_1−xCo_xAs with high-resolution ARPES and find a robust gap with Co doping that suggests the order parameter is not tied to such instabilities.

Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous cell carcinoma subtypes that display prognostic differences.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the head-on orientation, and an RNA–DNA hybrid can form in front of Pol II, creating a topological lock trapping Pol II at the fork.

Weyl semimetals exhibit exotic properties owing to the presence of Weyl fermions. Here, Xu et al. show that tantalum phosphide is an ideal platform for studying the transport properties of these particles because its low-energy properties are dominated by a single type of Weyl fermion.

Feedbacks between desert dust and climate might have amplified past climate changes, yet their role in future climate change is unclear. Here the authors find that dust feedbacks could play a key role in the future climates of Northern Africa, the Sahel, the Mediterranean, the Middle East, and Central Asia.

In this study, the authors combine interpolation techniques and deep learning methods, introducing Interpolating Neural Networks (INNs) to model complex systems with high accuracy and low computational cost.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Data obtained from the MicroBooNE liquid-argon time projection chamber are used to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.

Carbon dioxide conversion into chemicals is essential for carbon capture and utilization. Here, the authors present a novel iron-based catalyst, synthesized from the thermal treatment of a parent metal-organic framework (MIL-88B), to produce a dual-active site for carbon dioxide reduction into acetic acid.

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Axons have always been assumed to be cylindrical. Using in silico modeling and cryopreservation of tissues, Griswold et al. demonstrate that unmyelinated axons of the mammalian central nervous system exhibit pearls-on-a-string morphology through their entire length.

Metagenomic data and network analyses are often used to predict microbial interactions in complex communities, but these predictions are rarely explored experimentally. Here, Hessler et al. combine experiments with metagenome-informed, microbial consortia-based network analyses to identify interactions in microbial consortia grown under dozens of conditions.

A metasurface composed of pixels of optically switchable phase change material yields a photonic platform that can be configured on demand to perform a variety of optical tasks.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

The advances in artificial intelligence are permeating most scientific domains, and heterogeneous catalysis is no exception. This Perspective discusses the current state and future prospects of AI in heterogeneous catalysis, from the development of an AI-ready data ecosystem to multimodal foundation models and autonomous labs.

MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

Somatic small variants in cancer genomes are identified in both short-read and long-read data.

Polymersomes are used as a delivery vehicle for protein, nucleic acid adjuvant and siRNA payloads by enhancing the encapsulation efficiency through copolymer design.

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Lau and colleagues show that the dietary addition of the sugar l-fucose enhances immunotherapy response in melanoma models. This is mediated via the fucosylation and cell surface enrichment of HLA-DRB1 and induction of anti-tumor immunity.

Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13⁺ T_PH/T_FH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Tetrandrine is one of the most potent inhibitors of Ebola Virus infection. Here the authors identify LIMP-2 as a direct cellular target of Tetrandrine and establish a functional connection between lysosomal sphingosine homeostasis and calcium regulation.

RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.