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Owing to the lack of precise atomic-level control offered by existing fabrication techniques over the edge structures in bilayer graphene, experimental studies on the edge effects in bilayer graphene structures have so far largely remained unexplored. Here the authors synthesize two fully cove-edged bilayer nanographenes and demonstrate their application in NIR-II bioimaging.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

Here they assemble a cross-species single-cell transcriptomic atlas of mammalian placentas and show that trophoblast diversification underlies placental evolution, while identifying TGIF1 as a regulator associated with preeclampsia and pregnancy loss.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

Here authors present a method combining DFT calculations with experimental synthesis to address the challenges of slow recovery and limited recyclability in chemiresistive sensing MOFs.

Three-dimensional Raman modelling of multiphase inclusions in Sumdo eclogites reveals sulfur rich slab-derived fluids at sub-arc depths, providing direct constraints on deep sulfur cycling and copper mobilization in subduction zones.

Wide-bandgap perovskites offer promise for tandems but suffer from formation-pathway instabilities. Huang et al. use in-situ analysis to guide CsPbX₃ intermediate evolution, enabling uniform α-phase formation and high-efficiency, stable devices.

The study uncovers CBP/p300 as regulators of functional α cell mass via orchestrating Slc7a2/lysine-driven α cell identity gene.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Lithium dendrites are a major barrier to the use of high-energy lithium metal batteries. Now, a highly adhesive polymer electrolyte is designed to suppress lithium dendrites by confining lithium in a continuous nucleation state through strong interfacial binding interactions.

Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.

The first sample of farside lunar soil, collected by Chang’e-6, is strongly cohesive. The high cohesion stems from its fine particle size with intricate shape, probably a result of the high plagioclase abundance and intense meteorite impacts at the sampling site.

Among sorbents used in atmospheric water harvesting, hydrogel salt-composites show exceptional performance at a low cost, but their durability remains unexplored. Here the authors systematically study hydrogel-salt composite degradation and its mechanisms under different conditions.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Robotic grippers struggle to handle fragile and varied objects across environments. Here, the authors introduce a liquid metal gripper that adapts its shape and stiffness for gentle, multiscale grasping and active release.

Tactile sensing to differentiate normal and shear forces remains a challenge. A force microsensor array based on graphene and a liquid-metal composites decouples normal–shear force sensing, achieving a 200 μm scale and a 0.9 μN force detection limit.

Orbital mapping of the Rimae Bode region, a priority candidate for China’s crewed lunar landing, identifies four terrains and landing sites that sample diverse volcanic and impact materials to probe the lunar surface and interior evolution.

C-14 hydroxyl group is critical for the function of ent-kaurane diterpenoids (ent-KTs). Here, the authors report discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-KTs.

A multiomics dataset including genomics, transcriptomics and metabolomic variations across 403 upland cotton accessions identifies MYB genes regulating key metabolites and agronomic traits during cotton ovule and fiber development.

Chirality has long fascinated chemists, but asymmetric synthesis has largely focused on central, axial, and helical chirality to date. Here, the authors synthesize dianthranilides with planar chirality, via cinchona alkaloid-catalyzed (dynamic) kinetic resolution.

A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

An evaluation across 193 countries for the 2026 Global Action Plan update showed that countries with strong multisectoral governance and early surveillance adoption achieved long-term improvements in reducing antimicrobial resistance.

The incorporation of alkali metals in kesterite solar cells enables high efficiency but is challenging to control. Xu et al. show that combining Na and Li ions yields optimal phase formation, enabling efficient solar cells and modules.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.

Lithium metal offers high specific capacity but suffers from dendrite growth and poor cycling stability. Here, authors develop a 3D Li-Zn-Li3N/CNT composite combining ductile Li-Zn alloy and a mechanically robust Li3N-CNTs network, enabling thin, durable electrodes with uniform lithium deposition, demonstrating a pouch-cell with a specific energy of 553 Wh kg-1.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

The formation of α-phase formamidinium–caesium metal halide perovskites is hindered by limited Cs⁺ incorporation. He et al. use caesium 4-(diphenylphosphino)benzoate to enable efficient Cs⁺ doping and achieve solar cells with an efficiency of 26.6%.

Conventional catalyst design guided by thermodynamic descriptors often falls short in solid-phase electrochemical conversion reactions. A study now establishes an electronic property criterion for dual-atom catalysts, revealing that matching orbital symmetry can induce solid-phase metallization to enable continuous and efficient conversion in catalytic batteries.