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Zhang et al. report a strategy of using short chain ligands to simultaneously manipulate the charge transfer dynamics and stabilize the lead bromide octahedra of quasi-2D pure-bromide perovskites, enabling pure-blue LEDs with efficiency of 16.3% and extending the operational lifetime up to 393 mins.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Elebsiran plus PEG-IFNα improved hepatitis B surface antigen (HBsAg) loss rates compared with PEG-IFNα alone in patients with chronic hepatitis B virus infection. Furthermore, prior response to the BRII-179 vaccine was associated with higher HBsAg clearance, suggesting its potential as a predictive tool for identifying patients more likely to benefit from therapies.

High-entropy alloy (HEA) nanoparticles, self-supporting HEA aerogels and HEA coatings with up to 11 metal elements and uniform elemental distributions have been synthesized at subzero temperatures using a bilayer ice recrystallization method. The process is observed by cryo-transmission electron microscopy and fused multimodal electron tomography.

Convective flow can enhance solar evaporation performance but requires external components and power input. Here, authors develop a Dyson sphere-like evaporator capable of self-generating internal convection to significantly improve evaporation rates. Energy allocation for direct water evaporation and vapor removal is investigated.

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

Alpha-fetoprotein is a known biomarker for hepatocellular carcinoma. Here, the authors analyse differences between AFP positive and negative patients to identify alterations in androgen receptor signalling.

Uterine perivascular cells were identified as progenitors for endometrial re-epithelialization via mesenchymal-to-epithelial transition, whereby cellular quiescence and activation were mediated via Notch signaling and estrogen, respectively.

A temperature-controlled vacuum quenching method enables the fabrication of perovskite solar modules with a power conversion efficiency of 22.69% and an area of 11.7 cm², while the corresponding cells maintain over 93% of their initial efficiency after 3,500 h of operation.

Simultaneously capturing polarization and frequency is challenging. This work develops a metasurface-based intelligent photodetector, which can detect arbitrary polarization and frequency within 0.3-1.1 THz with a total error smaller than 5.1%.

Decommissioned power semiconductor devices often still have useful life, creating opportunities to reuse rather than discard them. This Perspective outlines how careful screening and creative upcycling, including artificial intelligence-assisted assessment and circuit reconstruction, can extend device lifetimes while reducing waste and supporting a circular and lower carbon power electronics industry.

Fabricating semiconductor devices with dimensions below 10 nm presents significant challenges. Here, Liu et al. use controlled electron irradiation to remove atoms in an MoS₂ sheet, creating Mo₅S₄nanoribbons with a uniform width of 0.35 nm and a theoretical band gap of 0.77 eV.

Determining uterine receptivity before embryo transfers is a major barrier in IVF. Here they identify a FOXA2-dependent preimplantation differentiation process in uterine glands that yields expanded branching, and which could be a useful measure of uterine receptivity.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Social status mediates individual differences in methamphetamine-seeking by modulating dopaminergic pathways. In subordinate rodents, the mesolimbic pathway is stronger, and the mesocortical pathway is weaker, whereas dominant rodents show the opposite pattern.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

The heterodimer of METTL1-WDR4 is responsible for adding methylation group to the N7 atom of guanine (m7G) in tRNA molecules. Here the authors show how the tRNA m7G modification mediates tRNA stability to control proteostasis by maintaining efficient protein synthesis, which is important for preventing premature senescence and aging.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

Metabolic rewiring of cytotoxic T lymphocytes (CTLs) can impair their antitumor functions. Sun and colleagues demonstrate that CTL-intrinsic activity of the kinase NIK is essential for CTL metabolic fitness in the tumor microenvironment.

A combination of multiview imaging, structured illumination, reconstruction algorithms and deep-learning predictions realizes spatial- and temporal-resolution improvements in fluorescence microscopy to produce super-resolution images from diffraction-limited input images.

Zhao et al. report that the Z compartment protein HERD-1 regulates transgenerational epigenetic inheritance in Caenorhabditis elegans at least in part by preventing the mixing of germ granule condensates.

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

Mechanisms responsible for the electron acceleration to near relativistic energies in Earth’s foreshock remains elusive. Here, the authors show that the combination of resonant scattering by distinct wave modes with known acceleration mechanisms explains the formation of observed electron fluxes up to and above 200 keV.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.

Approaches are needed to explore regulatory RNA motifs in plants. An interpretable RNA foundation model is developed, trained on thousands of plant transcriptomes, which achieves superior performance in plant RNA biology tasks and enables the discovery of functional RNA sequence and structure motifs across transcriptomes.

Cellular metabolism is altered in many cancer types and the advent of metabolomics has allowed us to understand more about how this is dysregulated. Here, the authors report a method named CARVE to analyse the arterial supply and venous drainage of glioma patients during surgery and identify the metabolites that may be consumed and produced by the cancer.

Cyclopentadienyl ligands are central to organometallic lanthanide chemistry as their electron-donating ability enables fine-tuning for various applications including catalysis, luminescent materials, and single molecule magnets. Here, the authors report the synthesis and characterization of the lanthanide complexes featuring η⁵-coordinating heterocyclic stibolyl and bismolyl ligands.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

The role of aggresomes in tumorigenesis and cancer progression remains to be explored. Here, the authors perform multi-omics and reveal that aggresome formation supports ovarian cancer stem cell properties via OTUD1 and ASK1/JNK signalling activation.

Microglia are activated in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Here Shao-Cong Sun and colleagues demonstrate that the E3 ubiquitin ligase Peli1 is expressed in microglia and is required for their activation and expression of inflammatory cytokines and chemokines after the induction of EAE. Disease severity is reduced in Peli1-deficient mice, partly through the effects of Peli1 on TLR signaling and Traf3 degradation.

MyoD is a transcription factor expressed in skeletal muscle that plays a critical role in determining myogenic cell fate. Here, Hu et al. reveal a metabolic role of MyoD in orchestrating systemic energy homeostasis by mediating muscle-fat crosstalk through the muscle-secreted lipokine DLPC.

Papaver species P. setigerum, P. rhoeas, and P. somniferum accumulates different levels of morphine and noscapine. Here, the authors report the improved genome assembly of P. somniferum and de novo assembly of the other two species, and reveal the evolution of the benzylisoquinoline alkaloids biosynthetic pathway.

IL-15 has important functions in the activation and homeostasis of cytotoxic T lymphocytes (CTLs) and NK cells. Sun and colleagues demonstrate that the deubiquitinase Otub1 controls CTLs and NK cells in a cell-intrinsic manner by negatively regulating IL-15 signaling.

The kinase NIK activates a noncanonical NF-κB2 signaling pathway. Shao-Cong Sun and colleagues show that conditional loss of NIK in dendritic cells alters gut microbiome composition and T_H17 cell responses, as a result of reduced expression of IL-23, pIgR and fecal IgA transcytosis.

Lanthanide sandwich complexes display interesting properties for diverse applications. Here, the authors synthesize monomeric and polymeric yttrium and erbium complexes ligated by cyclooctatetraendiide and stannolediide ligands and explore the magnetic properties of the erbium compounds.

DEL-1 protein interferes with leukocyte adhesion to prevent inflammation. Chavakis and colleagues now show that DEL-1 contributes to tissue resolution after inflammation by promoting macrophage-mediated efferocytosis and M2-like pro-resolving activities.

Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.