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Electrically modulated metasurfaces manipulate light fields but suffer from high operating voltages, low tuning sensitivity, and a reliance on telecommunication bands. This work shows designs of electrically modulated plasmonic metasurfaces that enable continuous and reversible wavelength modulation with a tuning sensitivity up to ~ 1 nm/V at a CMOS-compatible voltage below 5 V in the visible and near-infrared light regime.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

NPM3 promotes histone lactylation (H3K18la/K27la) and drives FASN transcription and cardiomyocyte necroptosis in diabetic cardiomyopathy. Targeting this pathway with dihydroartemisinin alleviates cardiac dysfunction.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Interfacial charge recombination losses limit solar cell efficiency. Gao et al. mitigate these losses through front and rear-contact engineering, achieving efficiencies of 26.34% and 32.73% in tunnel oxide passivating contact single-junction and tandem solar cells.

Using sunlight to turn carbon dioxide into fuels is appealing, but reactions are often inefficient. This study shows a photothermal catalyst that lets hydrogen move between sites, enabling selective conversion of carbon dioxide to methane.

Xiang, Wang, Tian et al. report that during nutrient insufficiency, inflammatory cytokines promote a ZBTB5-mediated mechanism to activate mTORC1 signalling, thereby enhancing amino acid uptake in tumour cells and restricting antitumour immune response.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

Crystallizing the perovskite layer on thin tunnel oxide passivated contact silicon cells is challenging due to rapid heat transfer. Zhou et al. address this issue using a 2-mercaptobenzothiazole additive, achieving a tandem cell efficiency of 32.76%.

Yang, Zeng et al. investigate associations between maternal metabolic profiles during early pregnancy and offspring development using untargeted metabolomics in the Shanghai Birth Cohort. Several metabolites are associated with offspring birth weight and cognitive development in childhood and reflect sex-specific patterns.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Functional-group translocation allows modification of molecular architectures and functional group positions, but methodologies capable of achieving precise stereocontrol during such migrations are limited. Here, the authors present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol.

Quantum photonic integrated circuits are fabricated on a Si₃N₄ chip. Squeezed light sources, quantum gates and a homodyne detection system are monolithically integrated. Individual qumodes and multi-qumode cluster states with high phase stability and fidelity are generated.

In the presence of a sufficient magnetic field, magnetofluids can resist high-speed blood flow, offering a personalized and complete strategy for left atrial appendage occlusion.

Florets of indica rice open earlier than japonica rice, hindering utilization of the cross subspecies heterosis. Here, the authors show that an OsMYB8-OsJAR1 module regulates diurnal floret opening time divergences between the two subspecies.

This study reveals that the rice false smut fungus disrupts floret development and suppresses immunity by secreting the effector Sxp1, which targets a lipid transfer protein and interferes with lipid signalling required for pollen fertility and immune responses.

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

Efficiency loss in thick film organic solar cells is a bottleneck for scalable manufacturing. Here, the authors present an exciton spin-manipulation strategy to extend exciton diffusion length and reduce non-radiative recombination losses.

A lab-scale proof-of-principle demonstration of a quantum network comprising one server chip and 20 client photonic chips implementing twin-field quantum key distribution shows excellent scalability and reliability and yields a pathway towards future large-scale networks.

Existing nickel-catalysed enantioconvergent cross-coupling methods largely rely on Ni(I)/Ni(III) manifolds. Now, a mechanistically distinct platform involving a Ni(II)/Ni(IV) redox cycle enables highly enantioselective difluoromethylation of unactivated alkyl iodides.

N input and warming alter plant traits and mycorrhizal communities, reducing belowground C inputs and stable soil organic C while accelerating decomposition, highlighting root–mycorrhizal interactions as key regulators of soil C under global change.

More environmentally friendly methods of extracting uranium from alternative sources are needed for the sustainable development of the nuclear power industry. This work proposes a spontaneous extraction process driven by droplet falling that enables the extraction of uranium from salt lakes.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease diagnosis.

Uneven urbanization in China leaves strong legacy effects on urban bird communities, creating widespread extinction debts and colonization credits across taxonomic, functional and phylogenetic diversity. Historical vegetation and human pressures shape these lags, mediated by species’ life-history traits.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Chen et al. identify that the extreme C-terminal region of Sororin directly locks the cohesin DNA-exit gate to stabilize sister-chromatid cohesion, a mechanism distinct from its established role in antagonizing Wapl binding to Pds5.

Tunnel oxide passivating contact silicon solar cells are a promising next-generation photovoltaic technology. Yang et al. engineer the front and back contact, further increasing the power conversion efficiency to 26.66%.

The authors developed self-incompatible diploid potatoes via haploid breeding. The resulting F₁ hybrids prevent fruit set, redirect photoassimilates to tubers, increase the harvest index and enable scalable hybrid seed production.

A smartphone-controlled ingestible capsule can have a two-way communication with engineered microbes inside the gut via light-induced signals.

In this study, the authors identify two biologically distinct subtypes of adolescent major depressive disorder by analyzing interactions between sensory and higher-order association brain regions, offering new insights for the development of targeted diagnostic and therapeutic approaches.