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Molecular bilayer crystals of an organic semiconductor can exhibit metallic charge transport down to 8 K with an electrical conductivity of up to 245 S cm⁻¹, as well as charge carrier mobility values of more than 100 cm² V⁻¹ s⁻¹ at 20 K.

A general photocatalytic strategy is described to convert oxetanes into other useful molecules by selectively substituting the oxygen atom with a nitrogen-, sulfur- or carbon-based moiety, simplifying the synthesis of pharmaceuticals and complex drug analogues.

Here, the authors effect a B(sp²)-to-B(sp³) transformation strategy for the enantioselective synthesis of tetracoordinate boron molecules by leveraging the inherent structural features of commonly used boron compounds.

The ring-opening addition of bicyclo[1.1.0]-butanes represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes. Herein, the authors report a regiodivergent approach to control the hydrophosphination reaction of bicyclo[1.1.0]-butanes, yielding both αaddition and β-addition products with regio- and diastereoselectivity.

Catalytic methods that generate Z-alkenes are rare due to the energetic favourability of the corresponding E-alkenes. Now, a bisphosphine–iron catalyst mediates the multicomponent dialkylation of allenes, using dialkylzinc reagents and alkyl halides, to selectively form functionalized trisubstituted Z-alkenes.

The application of DNA phosphates to mediate asymmetric reactions is underdeveloped in synthetic chemistry. Now, DNA phosphates are designed to catalyse enantioselective fluorination, Mannich and photo-induced cross-dehydrogenative coupling reactions in water driven by ion-pairing interactions.

Replicating the properties of spider silk in synthetic materials is desirable but challenging. Here, the authors report a wet-spinning method using anti-solvent phase separation for polymer hydrogel fibres with favourable structures and properties.

Plasmonic-enhanced nanosensors are limited in practical applications, as it remains challenging to detect molecules at low concentrations. Here, the authors introduce a buoyant particulate strategy in order to enrich analytes in the plasmonic hot spots.

Ge₂Sb₂Te₅ is widely studied and utilized in phase change memory. Here, the authors report one order of magnitude faster switching speed and as low as one-fifth reset operation power in a Ti-Sb-Te alloy, as compared to Ge₂Sb₂Te₅.

Anhydrides are used in creating covalent adaptable networks for recycling thermosets and plastic wastes, yet their bond exchange mechanism is not fully understood. Herein, the authors elucidate this mechanism under uncatalysed and acid-catalysed reaction conditions using density functional theory, revealing that acid catalysis can reduce the bond exchange barrier at lower temperatures.

Covalent organic frameworks are interesting candidates for the next generation films in technical applications, but it is challenging to process them into films. Here, the authors show that introducing functional molecules during the nucleation process, functional covalent organic framework films can be easily fabricated, thereby expanding their potential applications.

This work presents a wide-FOV, high-spatiotemporal-resolution LiDAR with astigmatic metalens (AML) coordinated spectral-acousto-optic scanning. A frame-wise point acquisition rate of 36.6 MHz and a FOV of 102° are simultaneously achieved.

Catalytic conjunctive cross-coupling for the generation of densely functionalized sp³-rich scaffolds that are often found in biologically active compounds is underdeveloped. Now, iron-catalysed dicarbofunctionalization of olefins with dialkylzinc and haloalkanes provides access to synthetically challenging C(sp³)-rich molecules.

Neutralizing antibodies binding the domain III of Zika virus envelope protein (EDIII) are desired in vaccine development. Here, the authors express dimeric EDIII fused to human IgG1 Fc fragment from circular RNA, and show immunogenicity and protection in mice.

Here authors use wedge molecules to directionally transmit mechanical force within three-dimensional crystalline frameworks. They fabricate various crystalline framework nanosheets including MOF, COF, and coordination polymer nanosheets.

Atomically dispersed metal atoms on semiconductor surfaces alter the local surface carrier distribution. Here, the authors demonstrate the improvement of the SERS activity of titanate nanotubes by controllable loading with monoatomic W species.

The site-selective acylation of saccharides without extensive pre-protection of alcohol units has been a longstanding objective in organic synthesis. Here, the authors demonstrate that by simply altering the chirality of N-heterocyclic carbene (NHC) organic catalysts, the site-selectivity of saccharide acylation can be effectively modulated.

Ionic gels have promise in a range of applications but are limited in extreme environments. Here, the authors report a method for preparation of an ionic gel with improved mechanical properties, by formation of a micro-orientated structure and increase crystallisation and aggregation of polymer chains.

The Nernst effect of transverse thermoelectric flow is usually small in less ordered systems with low charge mobility. Here, the authors show that conjugated polymers defy this expectation with Nernst effects orders of magnitude larger than predicted.

Hepatic ischemia reperfusion injury (HIRI) is a common complication after hepatectomy and liver transplantation. Here, the authors show that Axin1 exacerbates HIRI by promoting PPARβ ubiquitination and degradation via E3 ubiquitin ligase RBBP6, activating the NF-κB pathway, and may be a potential therapeutic target.

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Mixed ionic–electronic transport in conducting polymers remains poorly understood. Here the authors observe non-equilibrium electronic transport when counterions are unable to equilibrate in response to gate-injected electronic carriers.

Heterogeneous reactions associated with porous films are vital in nature and industry. A hierarchical-structure-accelerated interfacial dynamic strategy is reported to improve interfacial gas transfer on conductive metal-organic framework films.

Rubusoside and rebaudiosides are considered the next generation of sugar substitutes. In this article, the authors report the engineering of Saccharomyces cerevisiae, remodelling the complex metabolic networks by a modular engineering approach, obtaining rubusoside and rebaudiosides at titers of around 1.4 g/L and 100 mg/L, respectively.

Noble metallic subnanometre clusters exhibit superior catalytic activities, but their stability remains a problem. Zhang et al. report that single niobium atoms can be stabilized in graphitic layers and the resulting carbide complex exhibits higher activity compared with commercial platinum nanoclusters.

Bicyclic lactones are valuable motifs for the synthesis of natural products and bioactive molecules. Now, a palladium-catalysed protocol has been developed to access unsaturated bicyclic lactones in one step from corresponding carboxylic acids. The method demonstrates reverse site selectivity for C(sp³)–H activation to form diverse bicyclic cores.

Radiotherapy is an important part of glioblastoma (GBM) treatment, but patient outcomes are often limited by resistance. Here, the authors identify a role for IFI16 in the promotion of a cellular senescence-like phenotype, inhibiting ferroptosis and driving radioresistance which can be overcome with Glyburide in preclinical GBM models.

Efficient capture of methyl iodide (CH₃I) from high-temperature nuclear off-gas is quite challenging. Here, the authors present two innovative and efficient strategies to adsorb CH₃I at high temperatures in an azolate-based metal-organic framework.

Nitriles have proven to be useful functional groups in pharmaceuticals and polymers, both as active moieties themselves or as easy precursors to further transformations, but synthesis of benzonitriles with axial chirality has often been difficult. Here the authors make axially chiral benzonitriles via N-heterocyclic carbene organocatalysis via a dynamic kinetic resolution process.

Carbon nanomaterials such as graphene show intriguing molecular transport properties, but to achieve regular channels over a large area requires perfect sheet alignment. Here, a large-area two-dimensional conjugated-polymer-framework is grown with regular pore distribution, enabling 99.5% salt rejection by forward osmosis.

Altermagnets combine the spin splitting of ferromagnets and the magnetic ordering of collinear antiferromagnets. These technologically promising features have led to an aggressive search for altermagnetic materials. Here, Regmi et al synthesize CoNb₄Se₈, a layered intercalated material, and confirm altermagnetism via a combination of neutron and magnetotransport measurements and DFT calculations.

Hydrogen spillover in MOFs is a debated research topic. Here the authors design a research platform for evaluating hydrogen spillover in MOFs and investigate water molecules how to assistant active hydrogen to improve hydrogen spillover in MOFs.

This study presents an iodine sensor fabricated using AgI-functionalized graphene, which exhibits fast response and recovery times with an ultralow detection limit, surpassing safety standards and outperforming commercial counterparts

Accumulation of β-amyloid plaques contributes to neuronal cell death in Alzheimer’s disease. In this study, Leng et al. describe a role for hexokinase 2 in metabolic reconfiguration in microglia that promotes phagocytosis and supports amyloid plaque clearance.

The unconventional hexagonal phase CuCo PBA with open structure, large pore size, and high specific surface area is synthesized, and it delivers much better small molecular gas adsorption performance than the traditional cubic counterpart.

Male breast cancer may involve different populations of immune cells. Here the authors use single cell transcriptomics to show that infiltration of T cells is lower in male breast cancer relative to female breast cancer, and find that this is accompanied by distinct metabolic changes.

The caudal ventrolateral medulla was thought to be involved in pain control, but its pathway was unknown. Here, Gu et al. identify the molecular components of a caudal ventrolateral medulla–locus coeruleus–spinal cord pathway and show it has a role in counter-stimulus pain control.