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The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Accurately mapping diverse cell types in complex tissues remains a challenge for spatial transcriptomics. Here, the authors present UCASpatial, an entropy-weighted algorithm that enables ultra-precision deconvolution to resolve fine-grained immune landscapes and explore intercellular mechanisms.

The study presents NMR-Solver, an automated framework that determines small-molecule structures from NMR spectra by combining large-scale spectral matching with physics-guided optimization, enabling accurate and interpretable structure elucidation.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Hydrogen can permeate two-dimensional crystals like graphene in the form of protons at high rates, involving catalytic dissociation and recombination steps, with permeability tunable by material type, metal nanoparticles, or atmosphere, offering insights for separation membranes and energy technologies.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

Rare cells in single-cell and spatial omics are often hidden within dominant populations. Here, the authors introduce RareQ, a small-world-inspired graph method that uses neighborhood cliquishness (Q) to detect rare cell types and reveal fine-grained spatial structures.

The authors reveal how two insect-selective animal peptide toxins engage distinct sites on an insect sodium channel to disrupt fast inactivation and leverage these structural insights to AI-design a more potent toxin for biopesticide development.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

Photovoltaic modules are susceptible to hot spots and output decline issue under partial shading. To address this challenge, Tang et al. report a silicon solar cell architecture with in-cell reverse conductivity channels, which mitigates thermal damage and stabilizes output without compromising power conversion efficiency

While previous studies of Kondo physics have largely focused on electronic properties, the authors here investigate magnon damping in the d-electron van der Waals magnet Fe₃GeTe₂. They observe logarithmic scaling of the damping at low temperatures and a minimum at an intermediate temperature, which they attribute to Kondo coupling between itinerant electrons and local moments.

Spatial omics maps cell positions, but how they hierarchically assemble into functional tissues remains unclear. Here, the authors present HRCHY-CytoCommunity, a tool that decodes these multi-level organisations, linking them to biological mechanisms and clinical outcomes.

Aging is companied by a progressive decline of physiological functions. Here, the authors report that dihydromyricetin, a plant derived dietary supplement, generates senotherapeutic effects and shows great promise to ameliorate age-related conditions via pharmaceutical intervention.

The template-free synthesis of colloidal assemblies with molecule-like architectures from colloidal quantum dots holds promise for optical applications but remains challenging. Here we report a one-pot synthesis of geometries resembling sp-, sp²-, and sp³-hybridized orbitals.

How do avian eyes fulfill the intense metabolic activity of thick, high-acuity retinas in the absence of direct vascular support? The study finds that birds’ rapid, oscillating saccadic eye movements pump glucose from the pecten to the avascular retina, sustaining nutrient supply and boosting visual responses in the brain; especially when driven by dynamic visual stimuli.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

A soft three-dimensional core–shell cable can form reliable free-standing interconnects between soft, rigid and hybrid electronic components, and can be stretched by up to around 800%.

This study reveals that BCAA-derived BCKAs impair glucose-induced insulin secretion via activation of LDHA, a disallowed enzyme in pancreatic β-cells. Blocking this signalling axis restores insulin secretion, offering a new target against diabetes.

The electrosynthesis of amino acids is hindered by inefficient oxime intermediate conversion. Here, a relayed electron transfer mechanism is proposed using an ionic-liquid@Bi catalyst. Electrons are accepted by the ionic liquid to generate related radicals, which then transfer electrons to oxime, enabling efficient amino acid production.

Polar molecule-based magnetic materials capable of multistate switching have garnered significant interest for their potential applications in next-generation memory devices, sensors, and energy conversion. Here the authors report a trinuclear cyanide-bridged FeCo compound that exhibits photo- and thermo-induced ferroelectric phase transition and solvent-switched on-off ferroelectricity.

Here, Zhang et al. show that the gut bacterium Blautia coccoides promotes intestinal repair by activating regenerative stem cells through indole lactic acid, providing a potential therapeutic avenue for inflammatory bowel disease.

The reprocessability of covalent adaptable networks often comes at the expense of mechanical performance and thermomechanical stability. Herein, the authors introduce a dynamic N-hydroxyphthalimide-urethane bond to achieve thermomechanical stability and reprocessability in covalent adaptable networks.

Interfacial charge recombination losses limit solar cell efficiency. Gao et al. mitigate these losses through front and rear-contact engineering, achieving efficiencies of 26.34% and 32.73% in tunnel oxide passivating contact single-junction and tandem solar cells.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model

Numerous feathered dinosaurs and early birds have been discovered from the Jurassic and Cretaceous, but the early evolution of feather-feeding insects is not clear. Here, Gao et al. describe a new family of ectoparasitic insects from 10 specimens found associated with feathers in mid-Cretaceous amber.

This work effectively addresses the long-standing challenge of competitive kinetics in heterogeneous Fenton-like systems through the synergistic interaction between nitrogen vacancies (Nv) and Fe sites on carbon nitride.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

Ge, Liu et al. develop and validate a survival model (SM-CRT) using multicentre data from 30,947 cancer patients to predict catheter-related thrombosis (CRT) risk. The model accurately identifies high-risk patients and high-risk time periods, supporting personalised thromboprophylaxis and optimised catheter removal timing.

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Labdane derived hapmnioide-type diterpenoids, which have been identified as chemical markers for Haplomitrium liverwort, show potent anti-inflammatory and allelopathic activities. Here, the authors report the total synthesis of seven typical Haplomitrium diterpenoids through late-stage biomimetic skeletal reorganization.

This study reveals that the rice false smut fungus disrupts floret development and suppresses immunity by secreting the effector Sxp1, which targets a lipid transfer protein and interferes with lipid signalling required for pollen fertility and immune responses.

Deposition fluxes of nitrate and ammonium on Tibetan glaciers have accelerated since 2000 due to growing anthropogenic emissions in South Asia, according to geochemical analyses of two ice cores from the southern Tibetan Plateau and back-trajectory analysis.

Soil microbes recycle nutrients, but their global nutrient use efficiency is poorly understood. This study finds microbial nitrogen-use efficiency is nearly twice phosphorus-use efficiency, driven by soil carbon content, and is lowest in tundra and boreal forests.

Machine learning was used to screen a library of diverse lipids on the basis of their spatial conformation and identify an LNP formulation that enabled organ-targeted mRNA delivery and tumour suppression. The work highlights the critical role of ionizable lipid conformation in LNP engineering.