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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Self-assembled hole-selective molecules can enable high performance in perovskite solar cells, but controlling the hole extraction efficiency is challenging. Tianyu Li et al. address this by designing molecules that adopt a quasi-random orientation on the substrate.

The authors report magneto-transport experiments on La₂PrNi₂O₇ thin films under pulsed magnetic fields up to 64 T to suppress the superconductivity. They find that the normal state is a highly renormalised Fermi liquid.

Macrophage-dependent phagocytosis elicits robust antitumor immunity. Nevertheless, therapeutic strategies harnessing phagocytosis have been met with limited success. Here the authors demonstrate that dual-phagocytosis checkpoint blockade, achieved by simultaneously targeting CD47 and CD24, greatly enhances tumor cell phagocytosis thus increasing antigen-presentation capacity, cGAS-STING activation and T cell infiltration into the tumor microenvironment, ultimately fostering robust antitumor immunity in preclinical mouse models of glioblastoma.

This study uses two large fundus cohorts to show that retinal foundation models generalize well across populations but exhibit age-related fairness gaps. It highlights how pre-training data composition shapes model generalisability and fairness.

Here, the authors show that two genes encoding KATANIN p60 in maize promote growth and fertility via proper cell expansion and division. Aberrant microtubule organization in mutants alters cell shape, delays G1, and disrupts preprophase band formation and nuclear positioning.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Predicting antimicrobial resistance from bacterial genomic data is challenging. Here, the authors introduce AMR-GNN, a graph neural network that integrates multiple genomic representations to improve prediction, reduce clonal bias, and identify biomarkers.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

This study uses the inception loop framework to map neuronal invariances in mouse V1, revealing a bipartite receptive-field organization linked to segmentation and a synaptic-level hierarchy of increasing invariance supported by the MICrONS dataset.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical samples.

A global study of 1602 soil samples identifies dominant bacterial plant pathogens and reveals microbial traits, soil carbon and climate that promote natural suppression, while climate change may increase disease risks in many regional hotspots.

Soil microbes recycle nutrients, but their global nutrient use efficiency is poorly understood. This study finds microbial nitrogen-use efficiency is nearly twice phosphorus-use efficiency, driven by soil carbon content, and is lowest in tundra and boreal forests.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Wide-field quantum sensing shows μm-scale inhomogeneous superconductivity in high-pressure La₃Ni₂O₇, linking local diamagnetic response to stress and stoichiometry and clarifying mechanisms that suppress or enhance superconductivity.

Antibodies against SARS-CoV-2 continue to evolve 6 to 12 months after infection in patients who have recovered from COVID-19, increasing in potency and breadth with time.

Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and energetic framework to explain cold sensitivity.

The morphology of hole-selective contacts is key to the stability of perovskite solar cells. Feng et al. use self-assembled molecules with extended conjugation and hydroxyl groups to form dense, amorphous films that suppress degradation induced by ion migration.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

This study reveals that some bacteria living in the phycosphere of marine diatoms and dinoflagellates are host-specific with genomic functions matching their hosts, while some termed as ‘foundation’ bacteria can span both phycosphere types.

This study shows that rising incomes and hotter climates are driving a boom in air conditioning use, which adds to global warming. This highlights the need for clean, efficient and equitable cooling solutions.

The linear dispersion and massless behaviour of excitons have been predicted for two-dimensional materials but have not been experimentally demonstrated. Now this behaviour is observed using momentum-resolved electron energy-loss spectroscopy.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distinct molecular mechanisms and targets of adaptation in the two species.

Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger RNA complexes and polyubiquitylate AGO.

Self-assembled monolayers are efficient hole-selective contacts but suffer from aggregation and adhesion issues. To address these, Wang et al. introduce a dimeric molecular design that forms a hydrogen-bond network, enabling 28.4% certified efficiency in all-perovskite tandem solar cells.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Genetic predictors of health outcomes often drop in accuracy when applied to people dissimilar to participants of large genetic studies. Here, the authors investigate the root causes and highlight open questions underlying this problem.

Clean energy transitions have reduced atmospheric heavy metal pollution in Chinese cities and future efforts can create further reductions of 10.25% to 30.38% according to downscaled data and emissions trajectories modelling.

Urban-adapted mammals host a wide spectrum of zoonotic viruses, some posing high risks of human infection. These species may act as unmonitored reservoirs for viruses of public health concern.

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples from diverse ancestries in cancer genomics studies.

Dormant microbes dominate soils across China, accounting for about 95% of cells and varying from forests to deserts, with water-holding capacity, enzyme activity, and carbon pools regulating dormancy patterns, based on analyses of 591 samples from 197 sites.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.