Search

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

Limited heat dissipation at perovskite interfaces causes local overheating and accelerates degradation in perovskite photovoltaics. Now a solution-processable alkynyl-porphyrin conjugated polymer is inserted between the perovskite and hole-transport layers to enhance interfacial heat dissipation while maintaining efficient charge transport. This thermal and electronic management boosts device efficiency and operational stability.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Flexible thermoelectric devices with high optical transparency may enable new applications; however, the lack of a p-type counterpart has hitherto hindered its development. Yanget al., report a transparent p-type thermoelectric based on polycrystalline copper iodide thin film with record performance.

Achieving high power scaling in ultrawide bandgap electronics remains challenging. Here, the authors present a Ga₂O₃ module using a high permittivity interface that enables fast megawatt pulsed switching with improved thermal performance.

A dual interfacial hydrogen-bond passivation strategy and a hybrid copper–iodide are used to fabricate deep-blue light-emitting diodes with excellent external quantum efficiency and lifetime.

The design of metal-free carbon catalysts is limited by unclear active sites and defects. Here, the authors combine statistical analysis with theoretical calculations to identify effective sites, guiding the synthesis of nitrogen and fluorine co-doped carbons for efficient hydrogen peroxide production.

Electrochemical urea oxidation enables sustainable hydrogen production but suffers from some catalyst instability. Here the authors create ligand vacancies to induce metal dimerization, stabilizing the framework while achieving stable industrial-scale operation with low energy consumption.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Formate dehydrogenases (FDH) offer a route for carbon fixation but are limited by interfacial-intramolecular electron transfer (IIET) and oxygen sensitivity. Here the authors mine an FDH from S. oneidensis MR-1 featuring oxygen compatibility and direct-electron-transfer electrocatalytic performances.

Solution-processed copper–iodide clusters are employed as efficient emitters for warm white LEDs with external quantum efficiency of 19.1%.

The template-free synthesis of colloidal assemblies with molecule-like architectures from colloidal quantum dots holds promise for optical applications but remains challenging. Here we report a one-pot synthesis of geometries resembling sp-, sp²-, and sp³-hybridized orbitals.

Biomass-derived hard carbon negative electrodes can cut cost, but properties vary by feedstock. Here, authors use data-driven intelligent carbonization to unify performance across diverse biomass, yielding high-capacity, long-life negative electrodes with lower footprints.

The authors propose a synergistic nitrogen and endohedral MoCl₅ doping strategy that produces lightweight carbon nanotube fibers with high specific electrical conductivity surpassing copper, while maintaining excellent environmental stability.

This study shows how the anti-cancer drug Actinomycin D blocks RNA polymerase II transcription and reveals why it preferentially targets CTG and CAG repeats, thereby providing a basis for modifying ACTD to target DNA repeat-associated disorders.

Enantioselective oxidative cross-coupling of unactivated C(sp³)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp³)-H bonds via radical intermediates.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Plant nitrogen availability constrains ecosystem productivity, yet its decadal-scale dynamics remain unclear. Using global foliar δ¹⁵N data (1980–2020) and machine learning, this study suggests that nitrogen availability initially declined and then stabilized, as the dominant driver shifted from atmospheric CO₂ to precipitation.

Quantum geometry effects in condensed matter physics are a topic of growing interest. Here, the authors show that the quantum geometry associated with excitons can generate detectable shift currents in a wide-gap semiconductor.

As the properties of polymer gels are influenced by solvent as well as the network, choice of solvent is important for determination of properties. Here, the authors report the use of polyethylene glycol as a solvent for the formation of a dissipative gel, with coupling of elasticity and viscosity.

Polar molecule-based magnetic materials capable of multistate switching have garnered significant interest for their potential applications in next-generation memory devices, sensors, and energy conversion. Here the authors report a trinuclear cyanide-bridged FeCo compound that exhibits photo- and thermo-induced ferroelectric phase transition and solvent-switched on-off ferroelectricity.

Plants commonly experience root damage, but whether microplastics can enter roots via wounds is still unclear. This study suggests that microplastics can enter roots via wound entry mode and move to aerial parts, potentially contaminating plant-based foods and posing health risks.

The photonic spin-Hall effect usually manifests as correlations between circularly polarised light and directional excitation of evanescent waves. By attaching chiral gold nanocubes to silver nanowires, here, authors demonstrate directional propagation of surface plasmon polaritons under linearly polarised excitation.

The 2025 Materials Research Society (MRS) Fall Meeting highlighted the latest developments at the frontiers of materials research. This report focuses on multimodal operando/in situ methods employed to probe dynamic evolution of catalysts under far-from-equilibrium operating conditions — a key challenge in advancing catalyst development.

The authors provide experimental evidence that Eu substitution in the spacer layer of Nd_1-xEu_xNiO₂ thin films enhances the superconducting gap, driving the system toward a strong-coupling regime. The Eu substitution also introduces exchange coupling between Eu 4f magnetic moments and Ni 3d_x²−y² electrons, leading to magnetic-field-enhanced “re-entrant” superconductivity.

Here the authors introduce a radical-based approach for the generation of allylic copper(III) complexes, enabling the efficient synthesis of allylic amines in the presence of alkyl/aryl amines.

The yin–yang codec transcoding algorithm is proposed to improve the practicality and robustness of DNA data storage.

Kaiqiao Yang and colleagues propose a differentiable geometric optimization framework for manipulating electromagnetic fields. The approach enables automated shape design by coupling ray-based electromagnetic modelling with gradient-based optimization.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

Ge, Liu et al. develop and validate a survival model (SM-CRT) using multicentre data from 30,947 cancer patients to predict catheter-related thrombosis (CRT) risk. The model accurately identifies high-risk patients and high-risk time periods, supporting personalised thromboprophylaxis and optimised catheter removal timing.

A fluorochromic metal–organic framework sensor enables real-time visualization of thorium adsorption and exhibits a higher selectivity than other tetravalent cations.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

Zhou, Ho and colleagues show that, in mice, a schizophrenia-associated mutation impairs belief updating by weakening mediodorsal (MD) thalamus activity. Boosting this activity restored flexible decision-making, suggesting MD thalamus as a potential therapeutic target.

Random access memory has multiple data registers and uses addresses to specify which register should be read or modified. Now a quantum random access memory has been demonstrated that uses quantum addresses to return data in superposition.

Polygenic background effects can confound transcriptome-wide association studies aimed at identifying causal genes. Here, the authors show that TGVIS improves gene and variant prioritisation by accounting for infinitesimal effects in multivariate TWAS across tissues.

CO₂ electroreduction to multicarbon products is desirable but challenging. Now, self-pressurizing nanoscale capsule catalysts are synthesized. The self-pressurising capsules harness high-pressure CO environments for selective acetate or propanol production via a CO–CO₂ coupling pathway.

DGAT1 controls sex-specific CD8⁺ T cell responses in tumours, reducing mitochondrial function and tumour control in female mice, but protecting against oxidative stress and tumour growth in male mice through androgen receptor signalling.

Combining metal catalysis and organocatalysis can be difficult, especially when dealing with strongly coordinating organic compounds such as N-heterocyclic carbenes. Here, the authors combine copper and N-heterocyclic carbene catalysis for the generation of ketimines and their use in stereoselective reactions.

Li, Cui, Yang, Lu, Jiang, Zhang and colleagues identify a lactate transport mechanism from tumour-associated macrophages that regulates DNA repair and immune cell infiltration, which could be targeted to enhance immunotherapy efficacy in glioblastoma models.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact.