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The precision synthesis of uniform oligoethylenes with chain lengths of up to 576 carbon atoms is achieved via an iterative growth approach based on the Julia–Kocienski reaction. The oligoethylenes are used as building blocks to prepare high-density polyethylene-like materials with regularly spaced ester linkages.

Planar oxygen-doped carbon quantum rings (OD-CQRs) are prepared through one-pot solid-state reactions. The synthesized OD-CQRs exhibit a fluorescence peak centre at 393 nm, a full-width at half-maximum of 18 nm and a photoluminescence quantum yield of 95%. Electroluminescent light emitting diodes based on OD-CQRs demonstrate high-colour-purity violet emission.

Yersinia pseudotuberculosis senses fungal tyrosol signalling through EnvZ–OmpR which triggers T6SS activation and antifungal effector release to reduce fungal competitors in the mouse gut.

Luminescent materials with narrowband emissions are vital for optoelectronic applications. Here, the authors achieve room temperature phosphorescence with a FWHM of 30 nm through the multiple resonance effect and showcase its practical application in X-ray imaging.

KP.3.1.1 S S31del confers enhanced immune escape and increased infectivity, which is counterbalanced by NSP10 S33C. The opposing effects of these mutations highlight the complex interplay of viral genomic elements in shaping their overall fitness.

Profiling RNA modifications is essential to understanding their functions. Here, authors present DirectRM, a nanopore sequencing analytical tool that simultaneously detects six RNA modifications, revealing that modifications cluster at the transcript level but exclude each other on individual RNA molecules.

Thoracic vertebral segment-specific spinal cord organoids transplanted in a spinal cord injury mouse model can precisely match the transplantation site, establish synaptic connections, enhance in vivo neuroelectric conduction and restore motor function.

Developing efficient methods for the formation and cleavage of amide species is a primary research goal, but the amide C–N bond cleavage is exceptionally challenging. Here, the authors report the development of an organocatalyst that can effectively catalyze the atroposelective ring-opening of biaryl lactams via amide C–N bond cleavage.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

This study shows that Galectin-3 promotes wound healing by binding to and undergoing phase separation with integrin α5β1, a process disrupted by AGEs in pre-clinical models of diabetes. Topical Galectin-3 restored healing in synergy with insulin.

The evolution of superconductivity in LiFeAs with respect to pressure or strain remains elusive. Here, the authors observe different response of superconducting states due to different orientations of local wrinkles on the surface of LiFeAs.

The structure of the mitochondrial inner membrane, or cristae, is important for functional oxidative phosphorylation and energy production. Here, the authors show that loss of myosin 19 impairs cristae structure as well as energy production, connecting motor activity to membrane potential.

Zika virus impairs male fertility by utilizing its NS2A protein to block the translation of CYP17A1 mRNA in Leydig cells, thereby suppressing testosterone synthesis and sperm production in vivo.

Laser pulse multiplication is desired in many applications but has been challenging to realize by gain medium. Here Guo et al. achieve double-pulsed stimulated emission in quasi-2D metal-halide perovskites due to the two-channel carrier funneling effect in their multiple-quantum-wells structure.

Ferroelectric materials are broadly applicable to wearable electronics, but it is challenging to design polymers which are stable without compromising stability. Here the authors designed a ferroelectric elastomer optimizing these properties for wearable electronics.

An ongoing effort aims to transform the clonally propagated tetraploid potato to a seed-propagated diploid crop, but our understanding of it disomic inheritance is limited. Here, the authors report genetic basis of heterosis in the elite hybrid potato and identify a male fertility-related PME gene with dominance heterotic effect.

Open-shell organic radicals possess narrow energy gaps making them efficient solar absorbers. Here the authors synthesize robust triarylamine radicals enabling near unity absorption of the full solar spectrum for efficient photothermal applications.

Maize kernels have long intrigued researchers due to their complex structure. Through microscopic sectioning and spatial transcriptomics, the authors observed the spatial distribution of RNA through electronic RNA in situ hybridization maps and discovered how storage accumulation occurs.

Organic afterglow materials have potential in self-monitoring applications but it is challenging to design materials with desired properties. Here, the authors report the development of a lifetime tunable organic afterglow system for use in mechanical self-monitoring 3D printed structures.

Higher order topological insulators (HOTIs) can provide an extension of the bulk-boundary correspondence associated with topological insulators, with more exotic physics behind localization of excitations at their boundaries and corners. Here, the authors propose a method for creating a class of HOTIs with unconventional boundary truncations, where the emergence of localized boundary modes of topological origin is associated with fractional Wannier centers and occurs across much broader parameter space in comparison with usual HOTIs.

Macrophages with a reparative phenotype are important for tissue repair and have distinctive metabolic features. Here authors show that metabolic rewiring of macrophages during wound healing involves dephosphorylation of the transcription factor PPARγ, which results in activation of target genes that regulate lipid biosynthesis.

DSS1 is crucial for BRCA2 dependent genome repair. Here, the authors reveal how DSS1 restricts the dsDNA binding ability of BRCA2 to ensure BRCA2/RAD51 loading on ssDNA. Mutations in DSS1 disrupt this regulation, leading to impaired DNA repair, replication fork protection and R-loop suppression.

Pendrin SLC26A4 plays an important role for anion balance. Here, authors resolve cryo-EM structures of pendrin performing co-incident uptake and secretion of anions, providing a structural basis of this anion exchange mechanism.

Researchers present the evidence and mechanism of distinct phase transformation pathways in MAX phases under ion irradiation, providing a new theory and predictive method for phase behavior based on composition, advancing understanding of materials in extreme conditions.

The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound PLpro crystal structure and NMR studies.

Respiratory complications after a COVID infection are a growing concern, but follow-up chest CT scans of COVID-19 survivors hardly present any recognizable lesions. A deep learning-based method was developed that calculates a scan-specific optimal window and removes irrelevant tissues such as airways and blood vessels from images with segmentation models, so that subvisual abnormalities in lung scans become visible.

An artificial nerve that is based on a vertical n-type organic electrochemical transistor with a gradient-intermixed bicontinuous structure can operate at high frequencies and mimic basic conditioned reflex behaviour in animals.

High-quality genome assemblies of four Solanum Americanum accessions lead to the identification of three NLR-encoding genes, Rpi-amr4, R02860 and R04373, that recognize potato late blight pathogen Phytophthora infestans effectors.

The pan-genome of 17 wheat cultivars grown in China is explored, providing insights into the breeding history of wheat in East Asia.

Demand for data recovery from monolithic storage devices is high but current methods are inefficient. Here, authors develop a robotic OCT-guided inspection and microsurgery method, minimizing damage to device and enhancing data recovery efficiency.