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Here they show that ATF7IP/SETDB1-mediated epigenetic programming governs T lymphoid progenitor trafficking and differentiation, providing important insights into the pathogenesis of human T lymphoid diseases.

Fast panoramic rotational ultrasound tomography and photoacoustic tomography are integrated for hybrid rotational ultrasound and photoacoustic tomography, for three-dimensional dual-contrast imaging of soft tissue and vasculature across the human body.

Due to the complexity of controlling factors and the diversity of reaction components, accurately delineating the bond formation mechanisms for copper-catalyzed radical transformations poses a challenge. Here, the authors reveal the linear free energy relationships for the C–C bond formation of Cu-catalyzed radical transformations.

Group 2 innate lymphoid cells (ILC2) are known to contribute to the pathology of allergic asthma but the molecular mechanism by which they are getting activated are not fully known. Here authors show that the mTORC1 pathway, partly via neuromedin U receptor 1 (NMUR1), plays a pivotal role in ILC2 cell activation, and that inhibition of this signalling alleviates allergic asthma in mice.

Chen et al. report the design and characterization of a systemically injectable oncolytic virus with tumor-targeting and low-immunogenic properties, engineered to induce tumor cell pyroptosis under local mild hyperthermia.

The inter-system crossing induced by selenium may undesirably enhance formation of triplet excitons in non-fullerene acceptors, leading to increased non-radiative losses. Here, the authors introduce achiral N-alkyl substituents, achieving maximum efficiency of 20.4% for ternary organic solar cells.

A protocol to isolate small intracellular vesicles from human cells is reported; these are molecularly distinct from small extracellular vesicles and show superior therapeutic potential in retinal degeneration and drug delivery.

Phosphorylation-dephosphorylation and ubiquitination tune TCR signaling to avoid self-reactivity. Kim and colleagues show that acetylation also modulates TCR signaling.

Optical heterostructures have potential in integrated photonics and optoelectronics but are challenging to prepare in single-component systems. Here, the authors report an intrinsic optical heterostructure in an organic nanosheet, with enhanced fluorescence in an inner zone.

Mineral carbonation offers a scalable route for CO₂ removal. Here, the authors develop a water-thinning strategy to engineer confined interfacial sites that enable carbonation of calcium hydroxide under ambient conditions.

Negative refraction—light bending opposite to conventional refraction—and a hyperlens effect is observed in an excitonic system in the two-dimensional magnet CrSBr. The effect is mediated by the magnetic order of the material.

Protein conformational changes are crucial for signal transduction in cells, yet tracking these changes in living cells remains challenging. Here, the authors develop BIOSCE (BIOprobe based on Steric Confinement-induced Emission) by binding a steric sensitive fluorophore (MTPABP-Cl) to a HaloTag, which uses steric confinement-induced luminescence to monitor protein conformations in living cells with millisecond resolution.

The genome of Arundinella anomala, a C₄ grass with variant Kranz anatomy and interveinal distinctive cells, is sequenced and annotated, followed by single-cell transcriptomes for comparative analyses between C₄ bundle sheath cells and interveinal distinctive cells.

By coupling volatile memristors with short-term dynamics and non-volatile memristors with long-term dynamics, spiking neural network hardware can be created that exhibits fatigue spike-timing-dependent plasticity learning.

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

A combination of biochemical, cell biological and electron microscopy analyses reveal a ‘nucleotide code’ that coordinates Lis1–dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition.

Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

Breastfeeding is inversely associated with cardiometabolic disease; however, the metabolic pathways underlying these associations remain largely unknown. Here, the authors show plasma metabolite profiles in mid-life associated with breastfeeding duration, which is also linked to CVD and T2D risk.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene regulatory networks to identify lineage restriction within multilineage progenitors.

Engineered bacteria sense gut bleeding and secrete repair materials.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Peritoneal metastasis remains a major clinical challenge due to the lack of effective therapeutic options. In this study, the authors present intraperitoneal programming of tailored chimeric antigen receptor macrophages (CAR-Ms) as a strategy against peritoneal metastasis.

A modular nanobody-based approach assembles combination vaccines by stably attaching diverse antigens to hepatitis E virus-like particles, preserving native immunogenicity and inducing broad protection against respiratory pathogens.

The authors report the time-reversal symmetry breaking superconductivity in the thin-flake kagome material RbV3Sb5, manifesting primarily as an unconventional form of hysteresis that is not observed in CsV3Sb5. They also observe reentrance of superconductivity during an in-plane field-sweeping process at 400 mK.

Although the generation of skyrmions in magnets by optical vortices has been predicted, the mechanism has remained unclear. Here, the authors resolve this by showing that the interplay of light’s angular momenta creates the chiral magnetic fields, while the light’s intensity governs the final number of skyrmions.

A single-strand deaminase-assisted platform simultaneously rewrites multiple bases within a single RNA transcript.

Deep crustal melt accumulation controls the shallow melt volumes and hence the eruptive capacity of polygenetic volcanoes, according to geophysical and petrological analysis.

Organic heterojunction nanoparticles composed of all-small-molecule photovoltaic materials achieve (sub)nanometer-scale diameters, overcoming the size constraints of widely used polymer nanoparticles and enabling enhanced photocatalytic performance.

PMAK integrates pre-trained enzyme and reaction representations with residue-aware attention to improve kcat prediction, demonstrating robust generalization under warm- and cold-start settings and highlighting the value of full reaction context for unseen enzymes.