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The authors present bioinspired solid-state proton diode membranes that achieve rectified proton transport by constructing an inherent water-content gradient and asymmetric transport pathways, enables efficient force-electric conversion.

Alport syndrome has diverse genetic causes that are often hard to detect. Here, the authors use a layered sequencing strategy in a large Chinese cohort to uncover coding and noncoding variants, including novel structural types, refining the genetic diagnosis of inherited kidney disease.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Maintaining nanocatalysts under extreme heat is a major challenge due to structural disintegration. Pre-filling support vacancies creates a confinement field that anchors rhodium nanoparticles, preserving their integrity and activity during methane oxidation.

Here, the authors report the fabrication of broadband flexible photodetectors based on composite graphene-copper phthalocyanine heterojunctions, showing that a moderate external pressure can enhance the performance of the devices. The detectors were also applied for simultaneous contact sensing and non-contact perception as electronic skin sensors.

Extreme environments host diverse microbes, yet their global diversity remains underexplored. Here, the authors analyze both isolate genomes and metagenomes from various extreme habitats to construct a microbial genomic catalog, and use protein language models to identify antimicrobial peptides active against drug-resistant pathogens.

Elevated exposure to 4-hydroxyphenanthrene (4-OHPhe) is positively associated with obesity risk. Here, the authors show that exposure to 4-OHPhe downregulates expression of hydroxylamine reductase genes in Bacteroides uniformis, leading to altered gut microbiota-bile acid-FXR axis and suppression of adipose thermogenesis.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

Designing complex carbon frameworks for specific applications often relies on trial-and-error. Here, authors integrate machine learning and interfacial mechanisms to evolve graphene quantum dot carbon frameworks, enabling selective detection and clearance of metabolically reprogrammed senescent cells.

Hyperbolic topological states have attracted broad interest but are thus far limited to static and spatial topological states in type-I hyperbolic lattices. Here, the authors report a comprehensive study of spatial and spatiotemporal topological states in newly discovered type-II hyperbolic lattices.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

A plausible hypothesis for the origin of biological homochirality invokes chiral symmetry breaking, transfer, and amplification driven by autocatalysis. Here, the authors experimentally demonstrate that crystallization-driven template autocatalysis induces mirror symmetry breaking and amplification in helices.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Scaling is a major challenge in engineered systems. This study employs in situ synchrotron X-ray scattering to reveal how organic matter alters nucleation and crystallization pathways, thereby regulating gypsum scaling on desalination membranes.

Introns, non-coding parts of genes, can hide critical functions. Here, the authors find a 9-nucleotide intronic RNA element that acts as a sensor, reading cell growth signals to control alternative splicing and fly ovarian development via a mechanism also conserved in human cells.

Lithium-metal batteries promise high energy but dendrites limit life. Here, authors introduce a 90 wt.% lithium multicomponent solid solution alloy negative electrode that drives lithium into the bulk, enabling 3100 mAh g − 1 capacity and a 385 Wh kg−1 pouch cell that retains 82% capacity after 600 cycles.

Here, a pulsed Joule heating strategy for the synthesis of high-quality graphite is developed achieving a growth rate of up to 730 nm min^-1, an order of magnitude faster than conventional approaches, and producing large-area films with excellent thermal conductivity.

Metal phthalocyanines are promising molecular electrocatalysts for CO₂ conversion, but the rate-limiting step remains unresolved. Here, the authors show that it depends on catalyst dispersion, shifting from protonation in molecularly dispersed catalysts to CO₂ adsorption in molecular aggregates.

This study comprehensively maps neuropeptide systems in the human brain to elucidate their organizational principles and shows how neuropeptide architecture is linked to behavior and evolution.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

TME is a critical determinant of therapeutic outcomes, yet its dynamic changes during OSCC progression remain poorly understood. The authors here find that redistribution of MDSCs mediated by ANXA1-FPRs contributes to suppression of CD8⁺ T cells. Blocking FPR2 prevents MDSCs infiltration and enhances immune checkpoint therapy.

The uplift of the Altaid Plateau during the Late Triassic drove major climatic shifts that triggered glaciation, stronger monsoons, and ultimately the collapse of regional alpine and terrestrial ecosystems, according to tectonic, sedimentological, and biogeochemical analyses.

Deposition fluxes of nitrate and ammonium on Tibetan glaciers have accelerated since 2000 due to growing anthropogenic emissions in South Asia, according to geochemical analyses of two ice cores from the southern Tibetan Plateau and back-trajectory analysis.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

The authors present a wearable MXene-based sensing-processing-visualizing integrated system for tactile-visual recognition, multisensory interaction, trajectory recognition, and real-time feedback.

Aging boosts diabetic kidney disease risk via shared renal pathology. Renal RORγ is downregulated in diabetes/aging; its tubule-specific loss worsens injury, and overexpression protects. RORγ stabilizes INSIG1 via YOD1/CAB39, blocking SREBP2/STING.

Studying the intrinsic shear properties of Ti₃C₂T_x under in-plane shear loading is crucial for the stability of 2D flexible electronics. This work reports a high in-plane shear modulus of 0.279 ± 0.007 TPa, along with stable wrinkle resistance

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Antibodies against SARS-CoV-2 continue to evolve 6 to 12 months after infection in patients who have recovered from COVID-19, increasing in potency and breadth with time.

Slow sulfur redox limits the development of wide-temperature-range Na-S batteries. Here, authors prepare Sn-doped CoNiS multipods catalyst with amorphous–crystalline interfaces that accelerate polysulfides conversion, enabling high-capacity and long-life batteries operated from −20 to 50 °C.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

A Dirac-vortex topological photonic crystal fiber is experimentally realized with broadband single polarization single-mode properties.

Photons carrying orbital angular momentum inherit chirality from their twisted wavefront. Here, authors propose a twisted bilayer photonic structure - consisting of semiconductor membrane metasurfaces - where helical wavefronts are combined with non-Hermitian coupling, yielding orbital chiral lasing at telecom wavelengths.