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The implementation of non-negative matrix factorization–a powerful technique finding hidden patterns in high-dimensional data – remains challenging due to computational complexity. Wang et al. report an in-memory analogy solver, enabling accurate factorization with fast operation at low power consumption.

The spatial organisation of the tumour microenvironment (TME) can affect immune responses that control tumour growth. Here, the authors use single-cell transcriptomics and spatial transcriptomics to identify a lymphocyte aggregated region (LAR) in gastric cancer and compare its cellular and molecular composition with the neighbouring TME.

There are similarities in airway inflammatory endotype between eosinophilic granulomatosis with polyangiitis (EGPA) and type 2 eosinophilic asthma. Here, the authors perform single-cell transcriptomics to compare EGPA with severe eosinophilic asthma and find differences in the innate immune cell populations and use mouse models to characterise the function and phenotype of these cells.

The catalytic enantioconvergent N-alkylation of hydrazine derivatives with alkyl halides offers an attractive route to chiral hydrazines, but remains challenging due to the lack of efficient asymmetric catalytic systems and the difficulty in achieving regioselectivity. Herein, the authors report the copper-catalyzed enantioconvergent N-alkylation of hydrazine derivatives with racemic α-haloamides.

The efficient mass transport is the key factor to advancing the flow-electrocatalytic chemosynthesis. Here, the authors design a flow-through architecture in flow electrolyzer, reinforcing mass transport in the electrolyte to achieve the high efficiency of continuous oxime electrosynthesis.

Conventional closed batteries are constrained by the electrical energy efficiency of 100%. Here, authors develop an open decoupled battery with an efficiency of 375% at 10 mA cm−2 through a three electrodynamic-potential design, realizing waste-to-energy conversion and electricity amplification.

Sclerostin impairs whole-body lipidandglucosemetabolism. Here, the authors further demonstrate that adipocytic sclerostin loop3-LRP4 interactionparticipatesin the impairment effect of sclerostin on whole-body lipid and glucose metabolism.

Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Synthetic methylotrophic S. cerevisiae often faces energetic constrains during one-carbon assimilation. Here, the authors address this issue by engineering of heterologous methanol-formate-formaldehyde oxidation pathways to enable CO₂ assimilation via non-native Calvin cycle during methanol fermentation.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Formamidinium lead iodide perovskite holds promise for high-efficiency solar cells, but the kinetic instability of its α-phase crystallization remains an issue. He et al. report a strategy for directing the crystallization process in a n-i-p architecture and champion power conversion efficiency of 26.18%.

O-GlcNAc chromatin modifications dynamically reshape the transcriptional program of oncogene-induced senescence, forming complexes that activate SASP genes and repress cell-cycle genes; JUN and GATAD2A are identified as key regulators.

Under light, nickel and iridium on the catalyst reconstruct into NiIr nanoisland alloys that efficiently turn methane and carbon dioxide into synthesis gas, suggesting a promising way to recycle greenhouse gases.

Man-made electronics often face trade-offs among biological-like plasticity, electrical performance, and structural integrity. The authors show that ion-specific effects in biology can be leveraged to create reconfigurable materials for bionic electronics.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

Prostate cancer incidence and mortality rates vary across males from diverse populations. Here, the authors perform a proteome-wide association study across different populations and establish population-specific genetic prediction models.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Amorphous sulfurized polyacrylonitrile suppresses polysulfide shuttling in Li–S batteries, enabling long cycle life, but the structural processes involved during synthesis and initial cycling remained unclear. An operando pair distribution function, wide-angle scattering and sulfur absorption spectroscopy reveal S–C bond formation, π–π stacking and sulfur-chain shortening, which enable reversible sulfur redox.

LipoID profiles lipid droplet interactions and identifies interorganelle regulators.

Non-traditional luminescent polymers are materials without extended π-conjugation. Here the authors develop highly luminescent supramolecular polymers using dynamic quadruple hydrogenbonded motifs with potential for sensing and fluorescent adhesives.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects.

A global synthesis of >600 studies finds that across agro-ecosystems, grasslands and forests in temperate and tropical zones, increasing plant diversity has a consistently positive effect on plant performance and the suppression of antagonists.

Quantum error mitigation refers to techniques that reduce, rather than correct, errors in quantum computing. Here the authors demonstrate zero-noise extrapolation applied to quantum error correction circuits on superconducting processors, effectively reducing logical errors and advancing early fault-tolerant quantum computing.

Soil microbial populations bloom and then die-off in ecosystems with seasonal snowpack. This study showed that distinct taxa utilize different N sources for growth or energy during the microbial bloom and alter the fate of N after snowmelt.

Analysis of Middle Devonian plant cuticles reveals abundant surface resins, markedly pushing back the origin of plant resin production and demonstrating that these resins played a key role in early plant adaptation to terrestrial environments.

Self-sustained resistance oscillation states in VO₂ thin films are of significant interest for information encoding applications but the underlying mechanism remains elusive. Using scattering-type scanning near-field optical microscopy, Tiwari et al. uncover the distinct current-induced phase transition pathways and realize the visualization of the nanoscale phase percolation dynamics in a VO₂ oscillator.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

How TGF-β regulates liver metastasis remains further investigation. The authors here find that TβRI blockade in hepatocytes decreases liver metastatic progression via revitalizing stem-like CD8⁺ Tex subsets, and an LNP encapsulated with the TβRI inhibitor Galunisertib synergizes with αPD-1 to ameliorate liver metastasis

Researchers demonstrate an 8×240 Gbps DWDM transmitter on a thin-film lithium tantalate platform for the O-band, using a novel flat-top optical filter based on coupled Fabry–Perot cavities. It achieves low insertion loss (0.1–0.4 dB), a high extinction ratio (~26 dB), and a 12 nm free spectral range, showing promise for high-capacity optical links in AI and data centers.

When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.

T cells have been shown to have a function in chronic lung inflammation in COPD. Here the authors characterise the single cell transcriptional profile of T cells after smoke inhalation in mouse models showing changes in TCR repertoire and Il17a expression in γδ T cells, suggesting smoke-associated γδ T cells are involved in COPD inflammation and implicating γδT17 cells as a possible target for early prevention and treatment of COPD.

The fabrication of conventional artificial chemoreceptors are difficult to scale up. Here a wafer scale cell-on-memristor chemoreceptive array is reported, allowing for self-powered biosensing and in situ spike encoding.

Periodic marine oxygen oscillations occurred throughout the middle Ediacaran Gaskiers Glaciation, probably stemming from increased organic carbon burial destabilizing ocean redox systems, according to geochemical constraints and modelling.

Addressing how the nitrogen-induced changes in plant diversity differ from those in soil organisms is critical. This global meta-analysis suggests that nitrogen enrichment has stronger negative effects on plant diversity but modest to negligible effects on soil bacterial and fungal diversity.