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A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Achieving efficiency by approaching the theoretical limit in silicon heterojunction solar cells remains challenging. Here, the authors fabricate devices using rear-side polishing and progressive RF/VHF PECVD film deposition schemes for doping layers, realizing a certified cell efficiency of 27.0%.

The longevity of leaves determines the overall duration of photosynthesis for plants. This study suggests that climate change drives leaf longevity convergence toward intermediate ranges, which, by altering leaf traits and enhancing photosynthetic capacity, strengthens ecosystem stability and is closely linked to vegetation diversity.

Organic molecular crystals with controllable bending angles are crucial interconnectors in integrated optoelectronic chips but current methods of tailoring bent geometric features in molecular crystals without fracturing remain limited. Here the authors proposing a molecular cocrystal strategy that introduces directional non-covalent interactions into molecular systems to weaken the original interactions triggering the spontaneous deformation.

Intermolecular cyclization reactions using nitrogen-containing building blocks are scarce. Now, bifunctional sulfilimines have been shown to enable the modular construction of a diverse range of N-heterocycles by reacting with alkenes in a single photocatalysed step. Both sulfilimines and alkenes are easily accessible, providing access to a wide range of N-heterocycles with different ring types, ring sizes and substituents on the skeleton.

LRBA deficiency is associated with autoimmune disease and CTLA4 loss; this study identifies LRBA as a negative regulator of antitumor immunity and introduces LC427 as a promising small-molecule inhibitor of the CTLA4-LRBA interaction for cancer immunotherapy.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

Enhancing the arsenal of E3 ligases is important for PROTACs development. Here, the authors identify a non-inhibitory aptameric ligand to CRL2^ZYG11B E3 ligase, and develop a general, modular, and straightforward aptamer-based PROTAC platform, termed ZATAC, providing insights for untapped E3 ligases.

Silent speech interfaces rely on a wide range of sensing technologies to decode articulatory and neural signals without sound. This Review compares off-, on- and in-body modalities and outlines emerging sensor–AI integration trends for scalable silent speech interfaces.

Type I interferon-dependent immunity is crucial for antiviral defense but must be tightly regulated to prevent tissue damage. Here, the authors present RNF167 as a negative regulator of RLR-triggered IFN activation, mediating K6- and K11-linked ubiquitination of RIG-I/MDA5 to promote proteasomal and autophagic degradation.

Site-selective installation of fluorine (¹⁹F) and its radioisotope (¹⁸F) in aromatic molecules can lead to high-value products, but methods for this purpose are not without limitations. Now, using photochemistry, a ¹⁹F- and ¹⁸F- labelling strategy is reported that complements traditional approaches.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients.

Neural networks have become a useful approach for predicting biological function from large-scale DNA and protein sequence data; however, researchers are often unable to understand which features in an input sequence are important for a given model, making it difficult to explain predictions in terms of known biology. The authors introduce scrambler networks, a feature attribution method tailor-made for discrete sequence inputs.

Shapiro, Chang, et al. identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression of key mTORC1 pathway components.

Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal pathology and inflammation in a mouse model of IBD.

Photon-driven dinitrogen reduction to ammonia is a promising but challenging reaction. Now it has been shown that lithium hydride undergoes photolysis upon ultraviolet illumination to yield long-lived photon-generated electrons residing in hydrogen vacancies, favouring the activation of the N≡N bond and achieving photocatalytic ammonia synthesis.

Sun et al. identify a stem cell population of CD133⁺ endothelial-like cells (ELCs) that contribute to neovascularization. ELCs become dysfunctional with age, but ELC supplementation or pamidronate treatment to counter ELC aging promotes longevity.

A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.

A photoredox-mediated S_NAr reaction has now been developed for the direct radiofluorination of unactivated aryl halides. A series of arenes can be radiofluorinated in a site-selective manner from readily available aryl halide precursors under mild conditions. This strategy allows efficient ¹⁹F/¹⁸F isotopic exchange, enabling rapid PET probe diversification and clinical tracer preparation.

Wheat stripe (yellow) rust is a devastating disease posing a threat to global production. Here, the authors report the cloning of a wheat stripe rust resistance gene encoding a protein with a NAM domain and a ZnF-BED domain using a strategy called sequencing trait-associated mutations (STAM).

The authors report on a 2D anion-rich NaCl₂ crystal with a Na:Cl ratio of approximately 1:2, which exhibits room-temperature ferromagnetism originating from the spin polarization of electrons in the Cl elements of these crystals.

A large light-receiving angle in planar solar cells is crucial for flexible installation of distributed photovoltaics. Here, authors report sequential-processed all-polymer solar cells with nano-sized phase separation integrated in micro-sized surface topology and maximum efficiency of over 19%.

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.