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Large potentials required for C(sp³)-H bond activation and low water solubility make electrochemical functionalization of alkanes challenging. Here, the authors report that Pt/IrO_x enables selective generation of Cl free radicals for chlorination of cyclohexane at industrially relevant rates.

Ischaemic heart disease, which poses a severe threat to human health, is characterized by mitochondria damage and energy metabolism disorder. Here mitochondria were orally transplanted to the heart using nanomotors to restore energy metabolism by non-invasive administration.

A genome-wide study based on three-dimensional facial images identifies new loci associated with facial morphology in East Asian populations. Comparison with data from European populations identifies variants related to facial shape differences between these populations.

Jiang et al. propose a kirigami-based, mechanically reconfigurable metasurface that utilizes simple uniform stretching to achieve unexpected and dynamic beam steering functions. This unique approach modifies the geometric phase and lattice constant synchronously based on the rotation of anisotropic meta-atoms, exhibiting extended degree of freedom and wave-tuning ranges.

Remote epitaxy is a technique enabling the growth of exfoliable crystalline membranes, but its application to oxide materials is challenging. Here, the authors report the remote epitaxial growth of wafer-scale VO₂ nanomembranes, showing their application for the fabrication of multi-shaped freestanding infrared bolometers.

Direct electroreduction of dilute CO₂ in flue gas streams is challenging due to the presence of O₂ impurities. Here the authors demonstrate that an acidic electrolyte can overcome this challenge, enabling the generation of multicarbon products from simulated flue gas at reasonable rates.

By using liquid metal electrodes and selectively doped self-healing materials, the authors make devices with high performance, modular assembly, and application potential in wearable electronics.

Modulating interfacial electric fields provides a means to control electrocatalyst activity for a broad range of reactions. Here the authors show that this can be achieved by tuning the nanocurvature of carbon supported single-atom catalysts.

A novel scanning single-electron charging spectroscopy enables nanometre-scale imaging of quasiparticle excitations and thermodynamic gaps in generalized Wigner crystals.

Copy number alteration (CNA) analysis of single-cell and bulk tissue data of hepatocellular carcinoma (HCC) patients reveals potential false-positive CNAs in bulk samples and outlines the evolutionary trajectory of CNA signatures in HCC.

Zhang et al. report a quasistatic multilevel finite element model to predict the 3D structures assembled by 2D nanomembranes, validated by large-scale, high-yield, and configurable fabrication. 3D Si/Cr photodetectors assisted by neural network are employed to resolve the incident light angle.

Chen et al. develop a fast chemical reprogramming system that promotes the transition towards pluripotency through a unique diapause-like state.

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

The authors combine laser excitation and scanning tunnelling spectroscopy to visualize the electron and hole distributions in photoexcited moiré excitons in twisted bilayer WS₂. This photocurrent tunnelling microscopy approach enables the study of photoexcited non-equilibrium moiré phenomena at atomic scales.

Little is known about the long-term effectiveness of risk-based target-to-treat cholesterol-lowering interventions on cardiovascular risk. Here, the authors show that treat-to-target cholesterol-lowering interventions could exert an equivalent protective effect of statin therapeutic trials using data from a 29-year cohort study.

Photoreceptors are specialized neurons of the retina that are sensitive to systemic metabolic stresses. Here, the authors combine in vivo photoreceptor assessment with multisystem health readouts and circulating metabolomics to predict multi-disease risk.

Through inelastic light scattering chiral spin-2 long-wavelength magnetorotons are observed, revealing chiral graviton modes in fractional quantum Hall states and aiding in understanding the quantum metric impacts in topological correlated systems.

The development of new methodologies to convert plastics into fuels without relying on noble metal-based catalysts is desirable. Now it is shown that a layered self-pillared zeolite enables the conversion of polyethylene to gasoline with a selectivity of 99% and yields of >80% without the need to use external hydrogen.

Large-scale generative photonic computing suffers from poor data accessibility, accuracy and hardware feasibility. Here, authors harness random light scattering in disordered media as a native noise source and leverage large-scale diffractive optical computing to generate images from above noise.

In order to be used on a large scale, unclonable tags for anti-counterfeiting should allow mass production at low cost, as well as fast and easy authentication. Here, the authors show how to use one-step annealing of gold films to quickly realize robust tags with high capacity, allowing fast deep-learning based authentication via smartphone readout.

It is a challenge to develop molecular switches with time-dependent probabilities. Here, the authors present a molecular switch based on proton-coupled electron transfer reaction with demonstration of dynamical and environment-specific modulation of giant negative differential resistance and memory effects.

Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.

To achieve efficient photocatalytic non-oxidative methane coupling, a strong polarization environment with abundant activation sites for C-H scissoring is needed. This can be created through the fabrication of high-density frustrated Lewis pairs on lamellar Nb₂O₅ using a thermal-reduction promoted phase-transition process.

ASB7 acts as the substrate receptor for cullin 5 RING E3 ubiquitin ligase (CRL5), targeting the internal α-helix degron for degradation. Here, the authors elucidate the molecular mechanism of substrate recognition by ASB7 using structural, biochemical and cellular analyses.

Stereoselective catalysts impact polymer’s properties, but discovering such catalysts is expensive and based on trial-and-error. Here, the authors develop a machine-learning tool to guide catalyst discovery and reveal mechanistic features affecting stereoselectivity.

Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients.

Development of real-time sensing capability in artificial vision system requires an integration that allow sensing, computation, and storage, whilst remain energy efficient and compact. Here, the authors mimic the lobula giant movement detector to achieve this objective via light-mediated threshold switching memristor.

Smart monitoring devices with integrated mechanical protection and piezoelectric induction are limited. Here, the authors report a strategy to grow piezoelectric Rochelle salt crystals in 3D-printed cuttlebone-inspired structures to produce smart monitoring devices with integrated mechanical protection and electrical sensing capability.

Extensive genomic analyses of the chromatin architecture in acute myeloid leukaemia reveals several characteristics, including subtype-specific distal enhancers and silencers, that may represent new anticancer therapeutic targets.

DNA mutations occurring at low frequencies can be more easily detected by first excising wild-type DNA strands via the endonuclease deoxyribonuclease I, guided by single-stranded phosphorothioated DNA.

A seed consists of an embryo, endosperm, and seed coat. Here the authors show that autophagy plays a crucial role in regulating timely programmed cell death in the innermost seed coat, thereby influencing embryo pattern formation and seed viability.

2D transition metal ditellurides exhibit nontrivial topological phases, but the controlled bottom-up synthesis of these materials is still challenging. Here, the authors report the layer-by-layer growth of large-area bilayer and trilayer 1T’ MoTe2 films, showing thickness-dependent ferroelectricity and nonlinear Hall effect.

Evidence for a quantum magnetic analogue of a supersolid appears in a recently synthesized antiferromagnet showing a strong magnetocaloric effect of the spin supersolid phase with potential for applications in sub-kelvin refrigeration.

Non-Hermitian systems have many physical properties without Hermitian counterparts. Here, the authors demonstrate a non-Hermitian topolectrical circuit hosting continuous bound states under pseudomagnetic fields with no counterparts in Hermitian systems.

It is still unclear whether and how quantum computing might prove useful in solving known large-scale classical machine learning problems. Here, the authors show that variants of known quantum algorithms for solving differential equations can provide an advantage in solving some instances of stochastic gradient descent dynamics.

All-organic perovskites exhibit structural tunability and solution-processability, but are disadvantaged by a lower coercive field compared to inorganic ones. Here, the authors demonstrate that modulating hydrogen bond strength in such perovskites can generate a large coercive field.