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The authors realize two- and three-site Kitaev chains in semiconducting quantum dots coupled via superconductors and tune them to the sweet spot where zero-energy Majorana modes appear at the chain ends. To assess Majorana localization, they couple the system to an additional quantum dot.

The authors released NSD-synthetic, a dataset of 7T fMRI responses from the same eight NSD participants for 284 out-of-distribution synthetic images, to facilitate the development of more robust models of visual processing.

The open interfaces of a three-dimensional all-dielectric photonic topological insulator operate as effective metasurfaces with helical surface states, enabling spin-dependent steering and directional control of far-field surface state emission.

Kinks are topological solitons and central to many physical systems. Here, the authors experimentally demonstrate control and generation of zero-energy kinks in a topological mechanical metamaterial via acoustic waves and numerically show rich acoustic-wavekink dynamics in highly discrete systems.

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

Human exploration behaviour is studied using cognitive tasks where information seeking competes with reward seeking. Here the authors describe how humans discover the structure of new and uncertain environments outside this explore-exploit tradeoff.

A measurement strategy is described that is able to read out the parity of minimal two-site Kitaev chains in real time, by coupling two Majoranas and resolving their quantum capacitance.

This study of magic-angle twisted trilayer graphene moiré superconductors using scanning tunnelling microscopy and spectroscopy identifies two energy gaps that develop from many-body resonance in this highly tunable class of materials.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Authors study links between amyloid secondary nucleation and growth defects, demonstrating these sites on Aβ40/Aβ42 fibrils are rare compared to the number of protein molecules. Re-analysis of published data suggests that defects may also drive secondary nucleation generally.

Genome-wide analyses in the Norwegian HUNT study with replication in Swedish and Finnish cohorts identify host genetic variants associated with gut microbiome features and provide evidence of a causal effect of body mass index on gut microbiota composition.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

EuCo₂Al₉ is identified as a metallic spin supersolid with high thermal conductivity, exhibiting coexisting spin orders, strong quantum fluctuations and a giant magnetocaloric effect enabling efficient sub-Kelvin refrigeration.

Optical switching of a moiré Chern ferromagnet is demonstrated in twisted molybdenum ditelluride bilayers using continuous-wave circularly polarized light, paving the way for dissipationless spintronics and quantized Chern junction devices.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Three-dimensional chiral magnetic tubes created via two-photon lithography and nickel film deposition exhibit chiral spin textures and non-reciprocal magnon transport.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Non-equilibrium two-dimensional melting is less understood than its equilibrium counterpart. Now it is shown that topologically driven melting in a two-dimensional crystal of charged colloids is the same irrespective of the mechanisms that generate the defects

High energy use in controlled environment agriculture clouds its potential as a lower-carbon option for agri-food transformations. The authors find that using a Maximum Energy-use Threshold in specific contexts can provide a potential solution.

Chlorine electrosynthesis from seawater is limited by poor selectivity and stability under industrial-scale conditions. Here atomic-step-enriched ultrafine high-entropy alloy nanowires enable highly efficient chlorine evolution at 10 kA m⁻² for over 5,500 h through dynamic Pt–O active sites, reducing electricity consumption and feedstock costs for next-generation chlor-alkali processes.

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples from diverse ancestries in cancer genomics studies.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

Certifying multipartite entanglement can benchmark quantum devices. Here, authors introduce versatile tests that can certify genuine multipartite entanglement and k-inseparability using only few-body measurements, enabling noise-robust benchmarking of large photonic and superconducting graph states.

Crohn’s disease is associated with disturbances in the B-cell compartment and secreted antibodies. Here, the authors reveal impaired colonic dimeric IgA responses in patients with Crohn’s disease and verify this phenotype in murine models, demonstrating that mitochondrial dysfunction drives defective mucosal humoral immunity.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

Using 63 globally distributed grassland and shrubland sites from the International Drought Experiment, this study identified plant traits linked to drought resistance after 1 year of extreme drought across growth forms, lifespans and climate.

Natural and sexual selection can be in opposition favouring different trait sizes, but disentangling these processes empirically is difficult. Here Okada et al. show that predation on males shifts the balance of selection in experimentally evolving beetle populations, disfavoring a sexually-selected male trait but increasing female fitness.

The study shows a micron-scale polariton structure where an artificial gauge field creates topological, non-reciprocal edge transport without strong magnetic fields, overcoming key limits for topological polariton lasers and devices.

Microscopic imaging and biochemical studies show that sinuses in mouse and human form a highly dynamic surface that regulates fluid movement and immune cell surveillance via RAMP1-dependent regulation of smooth muscle contraction and RAMP2-dependent regulation of the sinus endothelial barrier.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

Self-DNA has been implicated in the activation of cGAS/STING/IFN-I responses in autoimmunity and inflammatory diseases. Here the authors show that macrophage uses a process termed ‘nucleocytosis’ to extract nuclear DNA from lysosome-impaired, dying target cells, thereby activating downstream cGAS-STING signaling and IFN-I production.

Mechanosensitive PIEZO channels sense and open through membrane tension, but their dynamic gating mechanisms at the molecular level remain unclear. A hybrid all-atom and coarse-grained molecular dynamics simulation approach and electrophysiology reveal a clockwork mechanism for PIEZO2 involving two open states.

Bright electron bunches power particle physics and photon science. Here, reproducible bunches were generated in a plasma with simultaneous high charge per unit energy and low emittance, advancing a scheme to produce ultra-bright bunches in future.

A general protocol for high-dimensional entangling gates is developed and applied for two four-dimensional qudits encoded in orbital angular momentum (OAM). The phase-locking technique stabilizes OAM sorters, leading to a process fidelity within a range from 0.71 to 0.85.

This study analyses whole-genome sequencing data of cancer samples from 10,983 patients and explores relationships among mutational signatures, various biomarkers and clinical outcomes.

The authors show that plasma AT(N) biomarkers can distinguish Alzheimer’s disease and frontotemporal lobar degeneration in diverse Latin American populations. Using machine learning and integrating neuroimaging, significant diagnostic accuracy was achieved, enhancing clinical assessments of these conditions in Latin America.

CRISPR–Cas9 in Streptococcus pyogenes prevents self-cleavage through abasic CRISPR RNA oxidations that suppress off-target activity. Inspired by a natural mechanism, Gu and Kim et al. designed chemically modified abasic guide RNAs to enhance genome-editing specificity of SpCas9, suppressing off-target toxicity in in vivo applications.

In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

Greenwald, Nederlof and colleagues developed a computational pipeline analyzing multiplex imaging data and established spatial patterns within breast cancer microenvironment that are predictive of immune checkpoint blockade response across treatment time course.

New research finds that policymakers coleading energy scenario design has the potential both to better align scenarios with policymakers’ priorities and to question current policy, by substantially reducing energy use at half of the cost of technology-focused approaches.

A follow-up analysis of a clinical trial that evaluated anti-PD-1 therapy in patients with cancer who are living with HIV provides mechanistic insights into transcriptomic, cellular and cytokine changes related to immune checkpoint inhibitor treatment and identifies a signature associated with clinical response.

Oxytocin promotes social behaviors, but its cortical targets remain unclear. Here, authors show that oxytocin activates local interneurons in the rat prefrontal cortex, enhancing sociability through top-down control of the basolateral amygdala.

Vaziri et al. examined how humans detect changes in auditory pitch, revealing that listeners rely on correlations in sound intensity over frequency and time, processing that is reminiscent of visual motion detection.

A wearable that continuously measures the concentration of a drug is demonstrated in humans.