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Here, the authors develop a microneedle system that converts 5-ALA photodynamic byproducts into therapeutic fuel, enhancing ferroptosis and improving hypertrophic scar treatment.

Natural disasters induce power outages with unequal impacts on poverty and non-poverty counties in China. Climate change will further exacerbate this disparity.

Researchers realize watt-class frequency modulation using compact coherent optical transmitters based on frequency-modulated photonic-crystal surface-emitting lasers. The system has implications for long-distance free-space optical communications.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

By exploiting an optical thermodynamic framework, researchers demonstrate universal routing of light. Specifically, light launched into any input port of a nonlinear array is universally channelled into a tightly localized ground state. The principles of optical thermodynamics demonstrated may enable new optical functionalities.

Animals are often thought to follow simple alignment rules, but this study explores how collective behavior could instead emerge from neural ring-attractor networks encoding allocentric and egocentric bearings. The results show that group motion arises spontaneously when allocentric bearings are used, with rapid switching between the two representations further boosting coordination.

Some mafic rocks have a ⁴⁰K/³⁹K ratio lower than all other terrestrial samples, according to isotopic composition analyses, suggesting parts of Earth’s mantle have retained their composition prior to the Moon-forming impact to the present day.

The experimental demonstration of many-body signal amplification in a solid-state, room-temperature quantum sensor is reported.

Benchmarking greenhouse gas emissions from wastewater treatment plants is an essential step in developing mitigation strategies. This is now achieved for the USA by modelling over 15,000 facilities using Monte Carlo simulations to obtain a national baseline.

The magnetoelastic coupling at a ferroelectric-ferromagnetic interface is shown to be dominated by shear-strain effects. Using polarised x-ray microscopy to simultaneously image the ferroic domain structures, the authors demonstrate an anomalous coupling in the ultrathin film limit.

The authors report on the implementation of a data-efficient machine learning approach to predict plasma dynamics. This enables offline design of robust trajectories to terminate the plasma without disruptive instabilities. Experimental results at the TCV tokamak show statistically significant improvements in key figures of merit and the ability to a priori predict the dynamics of key plasma properties.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

Authors present a flexible antenna array with a processor that stabilizes beams in real-time, addressing errors from dynamic deformation. It uses a cost-effective copper ink for printing, ensuring stable performance under strain and temperature changes, suitable for wearable and portable devices.

The authors report a new species of theropod dinosaur from the Triassic Period of Argentina. Despite being one of the earliest theropods, Anteavis crurilongus has derived features more in line with Neotheropoda.

Simultaneous profiling of spatial transcriptomics (ST) and metabolomics (SM) offers a novel way to decode tissue microenvironment heterogeneity. Here, the authors present SpatialMETA, a conditional variational autoencoder-based framework designed for the integration of ST and SM data.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Extensive measurements of the emissions of methane, nitrous oxide and ammonia from wastewater treatment facilities in the USA present higher values than are currently stated in national inventories. The results of this analysis show that greenhouse gas and nitrogenous emissions from the wastewater sector are often overlooked and that their impact on climate should be reassessed.

The interplay between chirality, light and spin is an emerging frontier with broad impact. This study reveals chirality-induced spin polarization and ultrafast dynamic chirality in semiconductors, unlocking new pathways for coherent spin manipulation.

Spin-enhanced lateral flow tests use nanodiamonds for the sensitive, robust detection of disease biomarkers. Here, authors report a clinical evaluation of a test for SARS-CoV-2 antigen, finding 95.1% sensitivity (Ct ≤ 30) and 100% specificity, with detection 2.0 days earlier than conventional tests.

Adoptive regulatory T cell (Treg) therapy holds promise for the treatment of a range of immunopathological conditions. Here the authors explore the HLA engineering of allogenic Treg products that avoid T cell and NK cell attack and maintain immunomodulatory function in a human skin-xenograft model.

How changes in species’ native occupancy over time relate to global naturalization success remains unclear. Here, the authors show that species with both high occupancy decades ago and increasing native occupancy ever since are more likely to become naturalized elsewhere.

The authors model regional electricity grid coordination, which enables access to geographically dispersed resources. Results suggest grid integration can reduce planning uncertainty region-wide but may impact individual countries differently.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

Neutralising antibody levels are an important correlate of protection for pre-exposure prophylaxis against COVID-19, but it can be difficult to account for immune evasion of emerging virus variants. Here the authors present a variant-adjusted threshold of protection model, developed and validated with data from two clinical trials, which can be used to infer efficacy against any SARS-CoV-2 variant.

Natural and sexual selection can be in opposition favouring different trait sizes, but disentangling these processes empirically is difficult. Here Okada et al. show that predation on males shifts the balance of selection in experimentally evolving beetle populations, disfavoring a sexually-selected male trait but increasing female fitness.

Above-bandgap femtosecond laser pulses generate a coherent phonon flatband in a GaAs/AlAs superlattice captured using ultrafast X-ray diffraction, providing a way to control atomic vibrations for future electronic and quantum technologies.

CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.

The authors significantly enhance the high-temperature energy storage performance of bismuth sodium titanate-based relaxor ferroelectric multilayer ceramic capacitors via entropy modulated strain heterogeneity.

Liang et al. estimate the prevalence of text modified by large language models in recent scientific papers and preprints, finding widespread use (up to 17.5% of papers in computer science).

Perception can occur in the absence of report. Here, the authors use intracranial recordings to show that sequential sampling of sensory evidence in the ventral visual cortex supports perception beyond report.

Recently, the quantum anomalous Hall effect has been successfully achieved in the intrinsic magnetic topological insulator MnBi₂Te₄, but zero-field quantization has proved difficult to achieve due to poor sample quality. Here, the authors report zero-field quantization and chiral edge states in five-septuple-layer MnBi₂Te₄.

Psychometric network models have become increasingly popular in psychology and the social sciences. Huth et al. show that a large proportion of reported network findings are based on weak or inconclusive evidence inviting caution when interpreting results.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

LARGE1 glycosyltransferase synthesizes matriglycan (xylose-glucuronate)_n on dystroglycan, and short matriglycan can cause neuromuscular disorders. Authors show that LARGE1 processively polymerizes matriglycan of defined length on prodystroglycan.

Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample is needed. The method enables individualized, well-calibrated predictions.

Li et al. identify a previously uncharacterized transcription factor dumpless1 as a critical effector of ecdysone signaling in stretch follicle cell, bridging somatic-germline communication through the integrin βPS-Rho1-p-MLC axis to facilitate dumping.

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Hall resistance quantization measurements in the quantum anomalous Hall effect regime on a device based on the magnetic topological insulator V-doped (Bi,Sb)₂Te₃ show that the system can provide a zero external magnetic field quantum standard of resistance.

A complementary analysis of DESI DR2 distance measurements along with supernova and CMB data shows consistent, moderate evidence that dark energy changes over time rather than behaving as a simple cosmological constant.

The Yamaji effect is a modulation of the electronic transport as the angle of an applied magnetic field is changed. This has been observed in a model cuprate and sheds light on the geometry of the Fermi surface and the nature of the pseudogap.

A modeling approach to assess the global risk of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions identifies ten priority African countries for surveillance and could inform malaria control policies.

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.