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APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Circulating tumor cell (CTC) clusters are much more likely to produce viable metastasis than single CTCs. Here the authors find that the transmembrane protein Plexin-B2 (PLXNB2) mediates homotypic and heterotypic CTC cluster formation, driving lung metastasis in breast cancer mouse models.

The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

Phosphorus mononitride is highly unstable under atmospheric conditions and its utility for constructing elusive P–N π-bonded motifs has remained uncertain. Here, the authors show that Na(OCP) can transfer a P atom to an electrophilic osmium nitride complex to form a metal-bound P≡N ligand.

Four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms persist, although populations of several organisms have begun to re-establish despite persistent physical changes at the seafloor.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Arginylation is a post-translational modification that is difficult to distinguish from arginine residues using mass spectrometry. Now a method has been developed to profile protein arginylation ex vivo and is tested on different samples, revealing 235 unique arginylation sites in the human proteomes.

CRAF is one of three RAF-family kinases and is mutated in cancer and RASopathies. Jang et al. report structural and mechanistic studies of CRAF/MEK1/14-3-3 complexes that explain distinct features of CRAF regulation.

Atucha et al. provide evidence that noradrenergic activation of the basolateral amygdala facilitates the formation of discrete memories of similar events experienced close in time via a miR-134-regulated consolidation process within the hippocampus.

Here, the authors investigate the interaction of pigment distribution and cuticle density within butterfly wing scales. They use ptychographic X-ray computed tomography to find that pigments can impact cuticle properties and thus color in Junonia orithya and Bicyclus anynana.

A large-scale mouse study reveals that while existing epigenomic data detect many developmental enhancers, a substantial fraction is missed - highlighting the need for expanded resources to fully annotate enhancers genome-wide.

This study estimates global suicide mortality trends from 1990 to 2021 and projects future rates until 2050 using a locally weighted scatter-plot smoother and Bayesian age–period–cohort models, revealing substantial declines and highlighting socioeconomic factors influencing variations across high- and low-income countries.

A single dose of an adeno-associated virus vector encoding an HIV-1 broadly neutralizing antibody given shortly after birth results in persistent antibody expression and protection from infection in rhesus macaque models of human HIV-1 transmission through breastfeeding and sexual intercourse.

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Azetidines are four-membered saturated N-heterocycles that are of interest in drug discovery and medicinal chemistry. Here the authors report how sulfamoyl fluoride substituents tune the reactivity of acyclic imine-derived triplet intermediates for the synthesis of azetidines via a [2 + 2] photocycloaddition reaction with alkenes.

Magnetic interactions in solids are usually short-range or else they involve itinerant electrons. Here, the authors evidence a long-range magnetic coupling mediated by orbital moments in a polar spacer layer of nonmagnetic insulating oxide, with a sign which oscillates with spacer thickness.

Beading combines soft, compliant threads with discrete, rigid elements to make architected materials. Here, authors show how geometry, tension, and friction together enable programmable shape and tunable mechanical behavior.

O-GlcNAc transferase (OGT) mediates antiviral host immune response. Here, the authors identify a catalytic activity-independent function of OGT in restraining influenza A virus replication by translocating to lipid droplets and limiting their accumulation following interaction with viral RNA.

Antibiotic resistance poses a critical global health threat. Here, the authors identify a carbapenem resistant clone of uropathogenic Escherichia coli with atypical virulence features as an increasing cause of urinary tract infection

This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture before and after treatment, is feasible and safe and enabled in-depth translational investigation of safusidenib treatment-induced changes in the tumor, including electrophysiological effects.

Artificial magnetic fields enable topological transport in metamaterials. Here, authors realize a programmable optomechanical metamaterial where laser-induced synthetic magnetism gives rise to chiral phonon edge states characteristic of quantum-Hall-like behavior.

The relative importance of facilitative and competitive interactions in long-term community dynamics is debated. Here, the authors show that indirect reciprocal facilitation during recruitment in woody plant communities is widespread and linked with species richness, and explore its role in the coexistence of species.

The combination of electricity and light can provide a sustainable route to drive challenging synthetic transformations, but current catalysts are plagued by poor stability and mechanistic ambiguity. Now it has been shown that recyclable, polymer-based electrophotocatalysts mediate electron transfer to chloroarenes to enable their conversion into valuable products.

Montoliu-Gaya, Salvadó et al. develop a blood-based model using tau biomarkers measured in a single analysis enabling biological staging of Alzheimer’s disease to support the diagnosis, prognosis and identification of patients likely to benefit from targeted therapies.

Here, the authors introduce carbon-to-carbon metal migration as a platform for dynamic association and show how such migrations, in combination with the incorporation of a simple hydrocarbon, can be harnessed to achieve autonomous directional translational motion of a metal centre along the length of a polyaromatic thread.

Head and neck cancer patients could greatly benefit from personalised treatment, but a lack of large public datasets hampers this potential. Here, the authors present HANCOCK, a multimodal dataset that integrates demographical, clinical, and histopathological data for 763 head and neck cancer patients that empowers machine learning models for clinical outcome prediction.

The Mre11-Rad50 complex, key in eukaryotic DNA damage response, was resolved at 3.2 Å by cryo-EM. The study defines critical residues for assembly and DNA binding, and shows Rad50’s coiled coil affects ATP hydrolysis over distance.

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Glucocorticoid (GC) induced osteoporosis (GIOP) remains a significant clinical problem. Here, the authors find that GCs disrupt skeletal stem cell–endothelial crosstalk via Basigin that can be targeted as a potential therapy for GIOP.

The use of complementary, alternative and integrative medicine (CAIM) is highly prevalent among autistic individuals. This umbrella review finds that there is no high-quality evidence to support the efficacy of any CAIM for core or associated symptoms of autism. Although several CAIMs showed promising results, they were supported by very low-quality evidence.

An optical sieve—an array of optically resonant voids in gallium arsenide—enables sorting, detecting and counting nanoplastics as small as a few hundreds of nanometres at concentrations as low as 150 μg ml⁻¹ in lake water samples.

Cratonic roots formed over 2.5 Ga ago show unusual orthopyroxene and Si enrichment but Ti depletion. These peridotites have high volatile (H, F and Cl) contents, suggesting a key role in subducted slab fluids craton evolution and diamond formation.

Solid-state quantum devices can suffer from decoherence caused by fluctuating electron spins in the surrounding material. Operating in a regime where the electron spins become magnetically ordered produces substantially longer coherence times.

Online cognitive testing combined with the reach of a digital patient registry revealed a subtype of people with Multiple Sclerosis with significant cognitive impairment but no motor deficits. This hidden disability is often underestimated and left untreated.

In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma mansoni infection, designed to reflect the reinfection cycles common in endemic areas, shows that repeated exposure induces mixed worm-specific CD4⁺ T cell responses similar to those seen in endemic infection.

A combination of ancestral reconstruction and deep mutational scanning to examine the genotype–phenotype maps of steroid receptors shows that the properties of ancestral genotype–phenotype maps determine the lineage-specific evolution of DNA specificity.

CSF total tau (t-tau), often used as a marker of neuronal damage, is more strongly linked to synaptic degeneration. Here, the authors show that t-tau better reflects synaptic dysfunction than axonal or neuronal loss in Alzheimer’s disease.

This paper explores how voltage-gated potassium channels can plug the pore to prevent the conductance of ions during inactivation.

The study of the relationship between particle speed and negative kinetic energy, arising in regions in which, according to classical mechanics, particles are not allowed to enter, reveals behaviour that appears to contradict the predictions of Bohmian mechanics.

Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after they began, suggesting that hypoxia may protect neurons.

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Gatemons, or gate-tunable transmons, are superconducting qubits based on hybrid Josephson junctions, which typically use extended quantum conductors as weak links. Here the authors report a gatemon made with a carbon-nanotube-based junction, showing improved coherence time compared to graphene-based devices.

The approval of first line immune checkpoint blockade (ICB) has improved outcomes for patients with metastatic non-small cell lung cancer (mNSCLC), however, whether patients would benefit more from ICB alone or alongside chemotherapy is unclear. Here, the authors develop a machine-learning based approach to help guide individual treatment selection patients with mNSCLC.