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Organic electrode materials offer a versatile and sustainable route for lithium-ion batteries, but their application is hindered by low working voltages and poor cycling stability. Now, it has been shown that dissolving halide electrolytes into organic electrodes effectively tunes the working voltage and enhances the electrochemical performance of all-solid-state batteries.

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

The spatiotemporal relationship between neuromodulator and neurotransmitter dynamics and neuronal activity remains unclear. Here, the authors performed dual-color imaging of calcium and ACh/5-HT signals across the fly brain, revealing a key role of ACh dynamics in stable odor representation.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

This new β-Li₃N solid-state electrolyte demonstrates a vacancy-mediated superionic diffusion mechanism, achieving high ionic conductivity (2.14 × 10⁻³ S cm⁻¹) and effectively suppressing lithium dendrite growth. Its high compatibility with lithium and air stability promises improved safety and performance in all-solid-state lithium metal batteries, making it ideal for advanced energy storage applications.

By analyzing large materials database using computation, researchers identified key structural features and design principles for sodium superionic and discovered materials with improved ionic conductivity.

The authors report the mechanical stress-induced dielectric strength weakening of hBN nanosheets with thinner nanosheets showing more remarkable weakening, as evidenced by lower breakdown strength, shorter breakdown time, and larger leakage current.

All-solid-state lithium sulfur batteries may avoid some of the drawbacks of their liquid electrolyte counterparts. Here, the authors elucidate the composition of discharge products in all-solid-state cells using spectroscopic techniques and propose a strategy to control the discharge product.

A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

Vascular calcification, a key risk factor of cardiovascular diseases, involves smooth muscle cells shifting to osteogenic phenotype. Here, the authors show that NEXN inhibits this process and protects against calcification by stabilizing SERCA2.

Understanding global methane trends remains limited, especially from a consumption view. This study shows rising emissions, limited decoupling, and shifting trade patterns involving more emerging and developing economies.

The high electronic conductivity of solid-state electrolytes leads to Li dendrite growth, thus hindering the commercialization of solid-state batteries. Here, the authors propose a flexible electron-blocking interface to protect garnet electrolytes from the electronic degradation.

Alterations in myocardial mitochondrial metabolism following myocardial infarction (MI) lead to structural and functional abnormalities of the heart. Here, the author shows that inhibiting the palmitoylation of CD36 alleviates lipid metabolism disorders and mitochondrial dysfunction in cardiomyocytes post-MI.

Room-temperature nonlinear Hall effect has been observed in wafer-scale (001)-oriented SnTe thin films, enabling wireless, ultrabroadband and low-power rectification at zero electrical bias and zero magnetic field.

The authors develop a miniaturized Mg3Bi2-based thermoelectric cooler, achieving a high cooling power density of 5.7 W cm-2 and a cooling speed of 65 K s-1, demonstrating great promise for localized thermal management in electronics.

Developing amorphous solid electrolytes for solid state lithium batteries is challenging due to limited understanding of disordered structures. Here, the authors report a family of oxychloride amorphous solid electrolytes with high ionic conductivities and promising electrochemical characteristics.

The authors enable recording of circuit-scale neuronal voltage dynamics at > 5 kHz sampling rate by using an acquisition pipeline for voltage imaging that assigns each region of interest to a single pixel in the detector, enabling optimally compressed acquisition of intensity traces.

The fabrication of artificial crystals by reassembling monolayer semiconductors enables on-demand engineering of their excitonic properties. Here, the authors report an efficient stacking method to fabricate millimetre-scale van der Waals homo-/hetero-crystals, demonstrating enhanced monolayer-like photoluminescence emission and quadrupolar interlayer exciton emission.

Aqueous zinc batteries offer a safe and low-cost energy storage option but have a limited lifespan. Here, authors develop a multi-halogen mediated high entropy electrolyte that restructures ion interactions, enabling high energy batteries with extended cycle life and low electrolyte cost.

Microplastics interacting with cyanobacteria can alter microbial communities and functional genes, impacting carbon and nitrogen cycles in seagrass meadows and posing ecological risks, according to an in-situ incubation experiment in seagrass meadow at Swan Lake, China.

Chemical reactions with incompatible mechanisms are usually difficult to perform simultaneously in one-pot. Here the authors report a method where cationic ring-opening polymerization of 2-oxazolines and anionic ring-opening polymerization of cyclic esters can be initiated sequentially and propagate simultaneously in one-pot, using bismuth salts as the initial initiators.

Engineered TadA variants in cytosine base editors (CBEs) offer advantages like smaller size and reduced off-target effects. Here, authors develop an advanced CBE (aTdCBE) through ortholog screening and protein engineering, successfully enabling exon skipping in Duchenne muscular dystrophy model.

The authors demonstrate an AI-enhanced imaging method combining lipid-specific dyes and super-resolution microscopy enables simultaneous tracking of up to 15 organelles in living cells, revealing dynamic interactions across diverse biological systems.

GPR156 has been identified as a regulator in auditory hair cells. Here, authors present the cryo-EM structures of human apo GPR156 and the GPR156–G_i3 complex to reveal the activation mechanism of GPR156 in maintaining auditory function.

Thermoelectric plastics with a high figure of merit, suppressed thermal conductivity and an enhanced power factor are realized by combining layered and bulk heterojunctions to create a polymeric multi-heterojunction.

The severe fever with thrombocytopenia syndrome virus (SFTSV, officially named Dabie bandavirus) is a tick-borne human-infecting bunyavirus. Here, the authors report the cryo-EM structure of SFTSV virion, and discuss the mechanisms of viral assembly, membrane fusion and antibody neutralization.

Stress shielding, a common cause of orthopedic implant failure, reduces the activity of intracellular mechanotransduction molecules, which are also regulated by nociceptors. Here, Wang et al. develop a small, implantable, wirelessly rechargeable device for optogenetic regulation of mechanosensitive nociceptors to investigate and improve implant osseointegration.

Translation and rotation are the two most fundamental forms of diffusion. Here, the authors provide evidence of the coupling between rotation and translation under confinement, and find that asymmetric rotations disrupt the order of molecular diffusion in zeolites, which can be applied to studies of selective separation.

Protein-protein interactions (PPIs) stabilization with molecular glues plays a crucial role in drug discovery. Here, the authors propose a dual-site approach for the design of clyclin K molecular glues, targeting the PPI region and its dynamic surroundings, and report a dual-site molecular glue for the cyclin-dependent kinase 12 - DNA damage-binding protein 1 complex, resulting in further cyclin K degradation.

The authors introduce ZS-DeconvNet, an unsupervised computational super-resolution method for multiple types of microscopes, that enhances image resolution by more than 1.5 times over the diffraction limit with 10 times lower fluorescence than regular superresolution imaging conditions.

The dissatisfied delivery efficiency of drugs to lungs and other metastatic sites limit the corresponding therapeutic efficacy. Here this group reports an inhalable surfactant-based nanoliposome system to co-deliver Osimertinib and DNA plasmid which is capable of fusing into pulmonary surfactant, penetrating through physiological barriers and targeted accumulating in lung tissues.

EvoScan combines EvolvR mutagenesis and phage selection to explore the protein sequence space in different dimensions, identifying anchor points with critical mutations. Next, EvoAI, a deep learning-based method, uses these anchor points to accurately reconstruct the protein sequence space and design new proteins.

The authors obtain the TiCoSb-based single-crystals with a dimension exceeding 1 cm, leading to an extraordinary enhancement in electron mobility and consequently, an average power factor of 37 W cm⁻¹ K⁻² in the Nb-doped TiCoSb single-crystal.

Sliding ferroelectricity with finite conductance can yield ferroelectric hysteresis with concomitant Coulomb screening in monolayer graphene containing van der Waals heterostructures of various compositions.

Computational framework of RFD-based CDIs.

The global supply chain and demand for export goods can lead to relocated emissions. Goods produced in China for foreign markets have lead to an increase of domestic non-methane volatile organic compounds emissions by 3.5 million tons in 2013 resulting in potentially an estimated 16,889 premature deaths annually.

All-solid-state sodium-ion batteries are promising candidates for grid-scale energy storage, but they require superior solid-state electrolytes (SSEs). Here sodium-ion SSEs based on dual-anion frameworks of oxychloride are studied and found to show high ionic conductivity and electrochemical oxidative stability with mechanical softness.

The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early miscarriage.

Subsoils are vital for ecosystem sustainability due to their nutrient stocks and microbial diversity. This study across 40 agricultural sites in China found that, compared with topsoils, subsoils are more sensitive and variable under disturbance, highlighting the need to manage both layers in sustainability efforts.

Thermoelectric therapy is promising for cancer treatment, but is limited by the lack of effective spatiotemporal control of thermoelectric effect in vivo. Here, the authors report a spatiotemporally controllable nanodevice that allows a precise and efficient magnetic-thermo-electric cascade energy conversion in vivo to mediate the thermoelectric/chemodynamic/immunotherapy of colorectal cancer.

Here, the authors identify a form of central iris hypoplasia affecting the pupillary zone. They suggest that noncoding structural variations can lead to Mendelian diseases by disrupting the 3D genome structure and resulting in altered gene expression.

This study shows that climate-driven hydrology primarily controls subsurface rock carbon weathering, with the groundwater table regulating the weathering depth and subsurface water fluxes determining the transported forms and rates of carbon released from rocks, based on measurements in the East River watershed, Rocky Mountains, United States.

Optical aberrations can hinder fluorescence imaging of thick samples, reducing image signal, contrast, and resolution. Here, the authors introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition or introducing more optics.

Electromagnetic waves, which are either artificially introduced or present in the immediate surroundings, can couple to the surface of the human body, creating a power transmission and energy harvesting method that can be used to provide sustainable power to wearable devices all around the body.

Deletion of cellular NAD+ via Sir2-depentent NADase provides immunity against phage infection in the Sir2-HerA immune system. Here the authors reveal supramolecular assembly for the allosteric activation on Sir2 NADase function in the Sir2-HerA antiphage system.