Search

This study proposes a contact-dominated, field-enhanced design for capacitive sensors, achieving high response, strong linearity, and high sensitivity over a broad range, demonstrating great potential for functionalized flexible electronics and artificial intelligence robotic applications

Protein C receptor (PROCR) has been proposed as a cancer stem cell marker in different types of cancer. Here the authors report that PROCR upregulation in cancer cells is associated with resistance to radiotherapy and reduced anti-tumour immunity.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Generalizable Pathology Foundation Model (GPFM) consolidates expertise from a variety of existing models for use in a broad spectrum of computational pathology tasks.

Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.

Here, authors design and test synthetic nano-kirigami structures with Archimedean spirals to achieve large-range, bi-directional deformations. These results in high-performance optical modulation and high-resolution dynamic information displays, addressing limitations in existing nano-kirigami deformability.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Here Chang et al. found that two kinesins, HUG1 and HUG2, form a kinesin cage encasing the vegetative nucleus and a distinctive double-layered kinesin microtubule cage around the generative cell, tethering them into a male germ unit and aiding sperm delivery.

Immunotherapy holds great potential, although strategies for durable responses against solid tumors are still needed. Here, the authors combine oncolytic virus (OV) engineering and reprogramming of the IL-18 pathway, showing that armed OVs expressing a decoy-resistant IL-18 elicit anti-tumor immunity and long-term immunological memory against multiple refractory tumors in mice.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

A method to synthesize non-van der Waals MAX phases and van der Waals layered early transition metal Xide chalcogenides (TMXCs) is developed through editing of covalent M–A/M–X sublayers. Exfoliated monolayer TMXCs resemble MXenes but feature tunable oxidation states, making the materials promising for applications in energy storage and catalysis.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

Radiation-induced liver damage is an important side-effect of radiation as a cancer therapy. Here, the authors identify pyroptosis protein gasdermin D as a key driver of liver injury and a potential therapeutic target to alleviate this damage.

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

An antibody–polysialic acid conjugate induces calcification on the surface of methicillin-resistant Staphylococcus aureus and boosts immunogenicity in mice.

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Unfairness in AI healthcare models arise from biased correlations between sensitive attributes and disease data. Here, the authors show that the Attribute Neutral Framework reduces these biases and enhances fairness without compromising diagnostic accuracy.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The mechanisms underlying virus perception and immune activation in plants remain poorly understood. Recent work shows that in rice, an E3 ubiquitin ligase senses viral coat proteins to activate the jasmonate signalling pathway by degrading NINJA3, and triggers downstream antiviral defence responses.

Macroscopic mechanical systems typically respond linearly to external force, and generating nonlinearity is challenging. Here, the authors generate nonlinearity in a macroscopic mechanical resonator by linking it to a gold contact and exploiting the anharmonicity in the chemical bonding interactions.

Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.

The commercialization of organic solar cells has been hindered by the limited device stability. Here, authors show that the connectivity of electron transport network is a key factor determining electron transport and device stability, with polymeric acceptors likely to establish such a network.

This work demonstrates an efficient electrochemical exfoliation approach to achieve high recovery rate for few-layered halogenated MXenes by leveraging gaseous propylene molecules as ‘physical scissors’, to enable advanced tribovoltaic nanogenerators.

vdW assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. Here, the authors report on the structural collapse of CNTs in conjunction with a metal-semiconductor junction induced by the VdW encapsulation.

Although most patients achieve complete response after standard-of-care treatment, residual disease in patients with nasopharyngeal carcinoma is associated with poor prognosis. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus capecitabine for patients with residual nasopharyngeal carcinoma.

Ultrahigh-efficiency and low-threshold yet tunable and compact laser devices are at the base of new functional devices. Here the authors harness a new temperature degree of freedom to realize a tunable photon-phonon collaboratively pumped laser.

Dirac semimetals have been proposed as parent materials for other topologically non-trivial phases such as Weyl semimetals, achieved by the breaking of time reversal symmetry. Here the authors use transport measurements to evidence such behaviour in single crystal Cd₃As₂under an applied magnetic field.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Nie et al. show that myocardial CCDC25 detects doxorubicin-induced neutrophil extracellular trap DNA and activates reactive oxygen species production and autophagy, leading to cardiotoxicity. Targeting CCDC25 exerts a cardioprotective effect without impacting the antitumor activity of doxorubicin in lymphoma and breast cancer models.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

The environmental threats posed by PET waste have spurred interest in biodegradable technologies. Here, the authors develop VenusMine, a deep learning pipeline, to discover KbPETase, a highly efficient and thermostable PET hydrolase and elucidated the molecular basis underlying its performance