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High kinetic inductance materials are widely used in superconducting circuits, yet their loss mechanisms are not fully understood. Here the authors study quantum circuits incorporating nanowires made of quasi-2D disordered superconductor WSi and identify localized quasiparticles as the dominant source of loss.

Short HBpep peptides assemble into micron-size coacervates that are efficiently taken up by various cell types and stably retained for days. Nanobodies and bioPROTACs loaded in the coacervates enable interaction with native targets and these hubs can function as a bioreactor for target degradation

Biocatalysis of the chemotherapy drug, doxorubicin, relies on the cytochrome P450 DoxA, which is inefficient. Here, the authors ameliorated the biosynthetic limitations by identifying DoxA redox partners and DnrV, which prevents product inhibition, helping improve microbial production.

In this work, the authors propose and experimentally test a framework to analyse the fundamental limits of quantum detector tomography, i.e., the limits to extractable information from probing unknown quantum measurements. They introduce the detector quantum Fisher information, which physically connects measurement structure to quantum advantage, complementing previously known state and channel metrics.

Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to Parkinson’s disease pathology.

A high-temperature immiscible blend of two dipolar polymers that self-assemble into three-dimensional all-polymer nanocomposites allows markedly enhanced dielectric and energy storage performances over a broad temperature range.

Baracchini et al. reveal that temporal variability in fMRI brain signals encodes biologically meaningful information across spatial and temporal scales, highlighting its role in healthy brain function and systems-level organization.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

A distinctive population with high hunter-gatherer ancestry persisted 3,000 years later than in most European regions, contributing to later Lower Rhine–Meuse Bell Beaker users.

Transition of superfluid to insulator is observed in the layer-imbalanced regime of bilayer magnetoexcitons.

The electronic behaviour of complex oxides such as LaNiO₃ depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO₃ films.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.

By using superconducting quantum interference device arrays as microwave impedance transformers, piezoelectric microwave–acoustic transduction operating close to the maximal efficiency–bandwidth product of lithium niobate can be achieved.

Nitrogen-vacancy (NV) centers in diamond are among leading candidates for solid-state qubit implementation. Here, with scanning tunneling microscopy, the authors image and manipulate the charge-state of NV centers at the atomic-scale for the first time.

Li et al. reveal projection neuron-type-specific dynamics that coordinate corticothalamic communication during reach-to-consume behavior in mice.

Biochemical, behavioural, electrophysiological, and spine analyses show that female APP/PS1 mice have reduced PSD-95 palmitoylation as well as memory and synaptic deficits. Palm B treatment rescued these impairments, revealing a potential AD therapy.

By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Performance of solid-state triplet fusion upconversion films is enhanced by surface plasmons, intensity threshold is reduced by a factor of 17 and external quantum efficiency is enhanced by a factor of 19. A white-emitting organic light-emitting diode featuring upconverted blue emission—rather than blue electroluminescence—is demonstrated, with a colour rendering index of up to 86.2.

Examples of materials with non-trivial band topology in the presence of strong electron correlations are rare. Now it is shown that quantum fluctuations near a quantum phase transition can promote topological phases in a heavy-fermion compound.

Tokamak walls suffer erosion from steady and bursty heat loads. Here, the authors demonstrate that optimizing 3D magnetic field and cooling gas injection can tame destructive plasma bursts while enabling cooler, safer exhaust conditions.

This study examines long-term changes in species richness across tropical forests in the Andes and Amazon. Hotter, drier and more seasonal forests in the eastern and southern Amazon are losing species, while Northern Andean forests are accumulating species, acting as a refuge for climate-displaced species.

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

The T-cell receptor (TCR) activation mechanism has remained uncertain. Here, the authors present molecular structures for the apo and ligand-bound human TCR–CD3 complex in lipid nanodiscs, revealing large conformational changes during activation.

The authors identify two coexisting incommensurate charge density waves whose interplay leads to joint commensuration and a long-period moiré structure.

Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing their respiratory or cardiac effects.

Base editor off-target effects are profiled with high precision in a tailored approach.

MultiCell is a deep learning method to capture complex cell dynamics during multicellular development.

Anisotropic hybridization between conduction and unpaired f electrons is rarely observed. Now, a lanthanide-based two-dimensional compound exhibits nodal hybridization, giving rise to heavy-fermion behaviour.

SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.

Scanning dielectric microscopy of nanocapillaries filled with water reveals that interfacial and strongly confined water exhibits a large in-plane dielectric constant and an in-plane conductivity approaching superionic values. 

Dynamic cellular changes within the tumor immune microenvironment inform clinical responses. Two studies now present automated tools that analyze complex spatial patterns to discern prognostic spatial features of triple-negative breast cancer specific to cell interactions at the tumor border or metastatic site.

Amazonian fog samples contain viable microbes, suggesting fog plays a role microbial dispersal, colonization and nutrient cycling, according to analyses of fog samples from a tall tower observatory.

This study reports a machine learning decoder that efficiently corrects errors in quantum logical circuits with entangling gates. The Multi-Core Circuit Decoder achieves competitive accuracy while running much faster than conventional methods.

Thirty years of forest demographic data, combined with recent ecophysiological measurements, reveal that intense Amazon droughts sharply increase tree mortality once soil moisture falls below a threshold, and that these hot droughts will become more frequent and intense as Earth warms towards hypertropical conditions.

The annual flood of Tonle Sap Lake supports over 20 million people’s livelihoods. Riverbed lowering due to sand mining and sediment diversion has substantially reduced the annual flood pulse and is projected to worsen if business continues as usual.

Applications of rare-earth nickelates are hampered by lack of global understanding of the interplay among various degrees of freedom. Here, Mercy et al. propose that the metal-insulator transition of nickelates arises from the softening of an oxygen breathing distortion, providing a united picture of electronic, structural and magnetic properties.

Mutations in the PBAF chromatin-remodeling complex cause various neurodevelopmental disorders. This study shows that PBAF shapes distinct motor neuron identities, revealing how its disruption impairs movement and offering insight into neurodevelopmental disorders caused by PBAF mutations.

Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Here they show that KROX20 marks a stem cell pool in the eyelid’s Meibomian glands whose development and homeostasis is regulated via Notch pathway signaling, thus offering a potential therapeutic target for dry eye disease.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Spin–orbital quantum liquids are exotic quantum phases in frustrated magnets that arise if frustrated spin and orbital degrees of freedom are coupled. Here, the authors find a dynamical spin–orbital state in the frustrated magnet Ba₃CuSb₂O₉, which indicates the formation of a spin–orbital quantum liquid.