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Anisotropic hybridization between conduction and unpaired f electrons is rarely observed. Now, a lanthanide-based two-dimensional compound exhibits nodal hybridization, giving rise to heavy-fermion behaviour.

The authors identify two coexisting incommensurate charge density waves whose interplay leads to joint commensuration and a long-period moiré structure.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Reducing non-radiative recombination at the perovskite/electron transport layer interface remains a critical challenge for achieving efficient perovskite/TOPCon silicon tandem solar cells. Here, authors employ bilayer passivation using AlOx/PDAI2 treatment, achieving device efficiency of 31.6%.

Systems with strong photon-photon interactions enable advanced quantum optical applications as well as the study of highly correlated light-matter states. Here the authors report strong coupling between single- and two-photon states in a superconducting circuit, enabling a new regime of nonlinear quantum optics.

Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.

Covalent polymers with helical conformations offer an adaptive scaffold for smart materials, but polymer-to-monomer deconstruction is inhibited by the covalent backbone. Now it has been shown that poly(disulfide)s can be folded into helices driven by side-chain hydrogen-bonding self-assembly, resulting in a synthetic helical polymer that can be fully recycled.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

The electronic behaviour of complex oxides such as LaNiO₃ depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO₃ films.

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

The precise role of the spinal cord in copulatory behavior remains not fully understood. Here, authors identify a population of spinal galanin-expressing neurons that regulate sexual arousal and mating in male mice, revealing a broader role for spinal circuits in copulation than previously acknowledged.

Ice is not piezoelectric, despite the polarity of water molecules, but bending ice may produce electricity. This has now been experimentally demonstrated, with a flexoelectric coefficient comparable to that of common ceramic materials.

Efficient electro-optic conversion is central to photonic computing, and thin-film lithium niobate (TFLN) offers this capability. Here, the authors demonstrate computing circuits on the TFLN platform, enabling the next generation of photonic computing systems featuring both high-speed and low-power.

Recently, an orbital Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state was predicted and identified in thin flakes of the transition metal dichalcogenide superconductor 2H-NbSe₂. Here, the authors present experimental evidence of the formation of this orbital FFLO state in bulk 2H-NbSe₂ samples.

The detection of the auroral footprint of Jupiter’s moon Callisto is challenging, but a shift in Jupiter’s bright main auroral oval could provide an opportunity for potential detections. Here, the authors show observation of the ultraviolet footprint of Callisto using Juno spacecraft data, benefiting from such opportunity.

There are many quantum systems that act as high-quality quantum harmonic oscillators, and they can be used to store quantum information using the Gottesman–Kitaev–Preskill code. Entangling gates have now been demonstrated between two of these qubits.

The growth of wafer-scale single-crystalline 2D semiconductors on sapphire is important for their electronic applications, but the underlying mechanisms are not yet fully understood. Here, the authors study the influence of air-induced sapphire surface hydrolysis on the growth process of 2D WS₂ and propose an ultraviolet light healing method to repair the degraded substrates.

Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploinsufficient mice and human neurons.

Bennu comprises components of intra- and extra-Solar System origins. The parent bodies of Bennu, Ryugu and CI chondrites likely formed from a shared but heterogeneous reservoir in the outer parts of the solar protoplanetary disk.

Engineering a mutant-specific customized base editor precisely corrects a mutation while minimizing bystander edits, leading to substantial phenotypic recovery in mouse models of multisystemic smooth muscle dysfunction syndrome.

Malaria control and elimination require environmentally safe strategies. Here, the authors propose L-DOPA, a naturally occurring tyrosine derivative, as a mosquito dietary intervention that can shorten lifespan and reduce malaria parasite burden of female Anopheles gambiae mosquitoes.

By doping ice with NaCl, it is shown that a flexoelectric coefficient of up to 10 μC m⁻¹ is generated, enabling effective piezoelectric coefficients that are comparable to those of ceramics. This arises from the streaming current of quasi-liquid flow through grain boundaries from one side of the sample to the other.

Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

This study analyses how older adults across the USA access key services such as health care, food and housing, revealing geographic disparities and highlighting the need for more equitable planning as the population continues to age.

High-content screening datasets are integrated within a shared latent space, enabling cross-dataset predictions.

Using the well-established foundry-based lithium niobate nanophotonics platform, a general electro-optic digital-to-analogue link with ultrahigh bandwidth (>150 Gb s⁻¹) and ultralow power consumption (0.058 pJ b⁻¹) is demonstrated, providing a direct, energy-efficient, high-speed and scalable solution for interfacing digital electronics and photonics.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

An ultra-low-loss integrated photonic chip fabricated on a customized multilayer silicon nitride 300-mm wafer platform, coupled over fibre with high-efficiency photon number resolving detectors, is used to generate Gottesman–Kitaev–Preskill qubit states.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This study reveals how pre-mRNA processing factors in Arabidopsis distinctly coordinate cleavage and transcription termination, highlighting complex roles of CPSF, CstF, PAPS1, BORDER proteins, and FPA in efficient mRNA maturation.

GenomePAM compares activities and fidelities among different Cas nucleases on thousands of match and mismatch sites across the genome using a single gRNA.

Passive immunisation for respiratory syncytial virus for infants is recommended by the World Health Organization but products currently available have limited duration of protection. Here, the authors investigate the age distribution of infant hospitalisation for respiratory syncytial virus to inform optimal timing of immunisation.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

This work reports on high-resolution inelastic X-ray scattering experiments revealing a striking renormalization of the phonon spectra of high-T_c cuprates associated with the formation of charge density waves. Their origin is attributed to the hybridization of phonons with dispersive collective excitations of the charge density waves, providing insights in the role of electron-phonon interaction in high temperature superconductors.

Applications of rare-earth nickelates are hampered by lack of global understanding of the interplay among various degrees of freedom. Here, Mercy et al. propose that the metal-insulator transition of nickelates arises from the softening of an oxygen breathing distortion, providing a united picture of electronic, structural and magnetic properties.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The Connectome 2.0 MRI scanner reconstructs the fine fibres in the human brain and determines cellular and axonal size at an ultra-high resolution.

Solid-state electrolytes that operate at a temperature of 300 °C suffer from a H⁺ concentration–conductivity trade-off. Here heavy Sc doping of cubic perovskites is shown to bypass this trade-off, enabling a proton conductivity of 0.01 S cm⁻¹ that arises from rapid proton diffusion along ScO₆ octahedra.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Allergen specific immunotherapy (AIT) is both, safe and effective in reducing systemic symptoms of venom allergy in individuals. Here the authors examine the underlying immune cell changes after venom specific AIT in early time points after therapy initiation showing indicative changes in specific immune cell populations.

The nature of unconventional charge density wave in kagome metals is currently under intense debate. Here the authors report the coexistence of the 2 × 2 × 1 charge density wave in the kagome sublattice and the Sb 5p-electron assisted 2 × 2 × 2 charge density waves in CsV₃Sb₅.

Spin–orbital quantum liquids are exotic quantum phases in frustrated magnets that arise if frustrated spin and orbital degrees of freedom are coupled. Here, the authors find a dynamical spin–orbital state in the frustrated magnet Ba₃CuSb₂O₉, which indicates the formation of a spin–orbital quantum liquid.

Applying high pressures to a crystalline material usually dramatically alters its properties. Feng et al.now demonstrate, however, that antiferromagnetism in gadolinium-silicon is robust even under pressures that are large enough to compress the volume of the crystal by one seventh.

Electrically induced single-photon emission and spin initialization of a silicon T centre in photonic structures is a promising step towards integrated spin–photon interfaces for quantum networks.