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In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Electronic health records are a rich source of clinical data but identifying associations with outcomes is complex. Here, the authors propose a modelling framework ‘InfEHR’ that identifies patient trajectories in electronic health records and generates a likelihood for clinical phenotypes.

Evaluating long-term immunogenicity and safety, this study shows that fractional and standard dose boosting with Pfizer and AstraZeneca vaccines following CoronaVac or AstraZeneca priming produces adequate immune responses, informing COVID-19 booster vaccination policy.

Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

An outstanding question about the iron-based superconductors has been whether or not their magnetic characteristics are dominated by itinerant or localized magnetic moments. Absolute measurements and calculations of the magnetic response of undoped and Ni-doped BaFe₂As₂ indicate the latter.

Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassium channel blockers.

Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased changes in striatal astrocytes, marked by transcriptional repression, inflammation, and impaired neuronal interactions.

This paper presents TDAC-seq, a targeted chromatin-accessibility-profiling method using cytidine deaminases and long-read sequencing, to resolve the effects of CRISPR edits on single chromatin fibers.

Here the authors use sex-stratified genetic analyses in mice and humans to uncover hidden trait influences, revealing many undetected loci and cautioning against misleading genetic interactions from widespread effects.

Massively parallel reporter assay in primary human CD4⁺ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate T cell gene expression and proliferation.

Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.

Advances have been made in thin-film piezoelectrics; however, the linearity of electric-field-induced strain with frequency and temperature still requires improvement. Here, by growing interlocked monoclinic and tetragonal polar nanoregions in (K,Na)NbO₃ thin films, highly linear strains of up to 1.1% are reported at frequencies up to 10⁵ Hz.

BioID detection of Ebola virus–host interactions when computationally integrated with existing host protein-protein networks, revealed functional cell protein complexes supporting infection, including the RNA decapping complex.

The functional organization of the posterior parietal cortex (PPC) for guiding eye movements has remained unknown. Here, the authors use functional ultrasound neuroimaging to reveal small, tuned clusters in PPC that reliably encode where we look over months to years.

Electrochemical CO_x reduction to multi-carbon products is hindered by low energy efficiency, in part due to sluggish ion transport across charge-selective membranes used in electrolysers. Here the authors use a porous, non-charge-selective separator that enhances ion transport and improves performance for CO electrolysis.

Two-qubit operations exceeding 99% fidelity have been demonstrated by silicon devices made with standard semiconductor tooling in a 300-mm foundry environment.

This study found higher RSV antibody levels were associated with lower RSV risk in children outside the hospital. An earlier rise in incidence and higher incidence rates were observed among children <5 years compared to older children and adults.

This work presents SCIGEN, a machine learning framework integrating geometric constraints into material generation. The framework enables the discovery of stable quantum material candidates, and the authors synthesize two predicted magnetic materials.

An untethered jamming mechanism uses magnetic fields to control interactions between soft-ferromagnetic composites with designed magnetization profiles. Stiffness, damping, and shapelocking are tuned for programmable robotic materials.

Continental shelves have become a substantial sink of anthropogenic mercury since the onset of the Industrial Revolution. However, human activities and climate-related processes can remobilize mercury-bearing sediment, potentially transforming this mercury sink into a marine source.

Above-bandgap femtosecond laser pulses generate a coherent phonon flatband in a GaAs/AlAs superlattice captured using ultrafast X-ray diffraction, providing a way to control atomic vibrations for future electronic and quantum technologies.

Surgery is currently the only treatment option for cataract. Here, the authors report on ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase as a potential anti-cataract therapy, which ameliorates cataract development in two rat cataract models.

Here the authors use a range of approaches to examine the interplay between genetic variants linked to risk for polygenic skin diseases and transcription factors (TFs) important for skin homeostasis. The findings implicate dysregulated binding of specific TF families in risk for diverse skin diseases.

Crystal structures of HIV Env trimer with native glycosylation in complex with neutralizing antibodies reveal a glycan shield of high-mannose and complex-type N-glycan and indicate a path for germline-targeting vaccine design.

The antibiotic polymyxin B requires bacterial metabolic activity to cause sufficient damage to the outer membrane to access the inner membrane, which it permeabilizes via an energy-independent mechanism to kill the cell.

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

A systematic review and meta-analysis of clinical trials investigating the efficacy and safety of obesity management medications reported tirzepatide and semaglutide to be the most effective in reducing body weight and obesity-related complications.

Transposons are repetitive DNA sequences that are hard to identify and map accurately. TEtrimmer automates key manual steps, enabling faster and more reliable annotation of transposable elements in any genome.

To address the phase instability issue of perovskites, ammonium propionic acid is introduced to enhance the phase stability of both perovskite layers in perovskite/perovskite/silicon triple-junction solar cells, resulting in improved efficiency and reproducibility.

The gut microbiota can influence the severity of pneumonia through the production of metabolites. In this translational study, the authors investigate the effects of tryptophan metabolites, specifically indole-3-acetic acid (IAA), on pneumonia.

Castleman disease encompasses a group of disorders characterised by abnormal lymph node morphology. Here the authors use single cell and spatial transcriptomics to assess the stromal, immune and interaction architecture of different subtypes of Castleman disease, indicating potential ligand-receptor interactions between immune cells.

Turbulence onset in shear flows is often modeled as a memoryless directed percolation (DP) transition. The authors show that in channel flow, turbulent stripes age near the critical point, questioning the DP analogy and revealing geometry-dependent transition dynamics.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

Engineering of semiconductor nanocrystals requires a detailed understanding of their formation. Here, the authors use signal-enhanced NMR and theoretical calculations to decode the structural transition from metastable CdSe clusters to mature quantum dots.

Researchers reveal widespread, newly formed seafloor seeps along Antarctica’s Ross Sea coast. Methane-rich flows alter local ecosystems and may influence warming. The drivers remain unknown, warranting coordinated study.

Two regions of superconductivity are observed in the phase diagram of magic-angle twisted trilayer graphene. This may yield insight into the superconducting mechanism in moiré materials.

iExoKras^G12D are engineered exosomes for the delivery of siRNA targeting KRAS^G12D. Here the authors describe the results of a phase I trial of iExoKrasG12D in patients with metastatic pancreatic cancer, reporting safety and clinical activity, as well as immunological correlates informing on tumor immune microenvironment reprograming and future combination with immune checkpoint inhibitors.’

Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly synthesized proteins in diverse bacteria, including ESKAPE pathogens. The substrate polyspecificity of the aaRS mutants enables pulse-chase BONCAT and differential tagging of temporally distinct nascent proteomes in cells.

Long-range interactions are challenging for machine learning interatomic potentials (MLIPs). Here, authors show that, by just learning from energies and forces, MLIPs can accurately capture electrostatics and predict atomic charges.

This Expert Recommendation provides tools to help researchers in 2D materials improve reproducibility in their work and practical guidance on how to engage constructively with funders, publishers and industry to create a stronger basis for reproducibility, transparency and trust in the field.

Interim trial results of MYR-101, a novel recombinant vector with selective tropism for oligodendrocytes, support its tolerability and indicate improved myelination and reduced cerebrospinal fluid N-acetyl-aspartic acid concentrations in children with Canavan disease.

PLD4 loss-of-function mutations in patients with systemic lupus erythematosus leads to excessive activation of TLR7 and TLR9.

Current CO electrolyzers using anion exchange membranes suffer from poor stability in the presence of organic intermediates. Here, the authors demonstrate that low-cost Zirfon diaphragms enable durable and scalable CO electrolysis toward multicarbon products.

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

Cells must coordinate cell division with genome replication. Here, the authors combine rapid protein depletion, clinical CDK4/6 inhibitors, and genome-wide EdU sequencing to reveal that the CDK4/6-RB axis ensures timely loading of DNA replication factors in G1 phase in human cells.

The precise role of the spinal cord in copulatory behavior remains not fully understood. Here, authors identify a population of spinal galanin-expressing neurons that regulate sexual arousal and mating in male mice, revealing a broader role for spinal circuits in copulation than previously acknowledged.

The functional roles of circular RNAs (circRNAs) in the progression of colorectal cancer remain to be studied. Here the authors report that an alternatively-circularized circMAN1A2(2,3,4,5) promotes colorectal cancer cell proliferation via enhancing target mRNA stability.